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Entry version 168 (22 Apr 2020)
Sequence version 2 (15 Dec 1998)
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Protein

DNA polymerase epsilon subunit 2

Gene

POLE2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Accessory component of the DNA polymerase epsilon complex (PubMed:10801849). Participates in DNA repair and in chromosomal DNA replication (By similarity).By similarity1 Publication

Miscellaneous

In eukaryotes there are five DNA polymerases: alpha, beta, gamma, delta, and epsilon which are responsible for different reactions of DNA synthesis.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processDNA replication

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-110314 Recognition of DNA damage by PCNA-containing replication complex
R-HSA-174430 Telomere C-strand synthesis initiation
R-HSA-5651801 PCNA-Dependent Long Patch Base Excision Repair
R-HSA-5656169 Termination of translesion DNA synthesis
R-HSA-5685942 HDR through Homologous Recombination (HRR)
R-HSA-5696397 Gap-filling DNA repair synthesis and ligation in GG-NER
R-HSA-5696400 Dual Incision in GG-NER
R-HSA-6782135 Dual incision in TC-NER
R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
R-HSA-68952 DNA replication initiation
R-HSA-68962 Activation of the pre-replicative complex

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA polymerase epsilon subunit 2
Alternative name(s):
DNA polymerase II subunit 2
DNA polymerase epsilon subunit B
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:POLE2
Synonyms:DPE2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:9178 POLE2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
602670 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P56282

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000100479

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA278

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P56282 Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2363042

Drug and drug target database

More...
DrugBanki
DB00242 Cladribine

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
POLE2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
3915676

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000715621 – 527DNA polymerase epsilon subunit 2Add BLAST527

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P56282

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P56282

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P56282

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P56282

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P56282

PeptideAtlas

More...
PeptideAtlasi
P56282

PRoteomics IDEntifications database

More...
PRIDEi
P56282

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
56911 [P56282-1]
56912 [P56282-2]
56913 [P56282-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P56282

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P56282

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000100479 Expressed in kidney and 133 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P56282 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P56282 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000100479 Tissue enhanced (bone marrow, lymphoid tissue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the DNA polymerase epsilon complex consisting of four subunits: the catalytic subunit POLE and the accessory subunits POLE2, POLE3 and POLE4.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
111423, 45 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-2108 epsilon DNA polymerase complex

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P56282

Protein interaction database and analysis system

More...
IntActi
P56282, 32 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000216367

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P56282 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1527
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P56282

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P56282

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3818 Eukaryota
ENOG410XP7N LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000012435

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_010628_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P56282

KEGG Orthology (KO)

More...
KOi
K02325

Identification of Orthologs from Complete Genome Data

More...
OMAi
CRLQYCT

Database of Orthologous Groups

More...
OrthoDBi
375960at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P56282

TreeFam database of animal gene trees

More...
TreeFami
TF103007

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007185 DNA_pol_a/d/e_bsu
IPR024639 DNA_pol_e_bsu_N
IPR016266 POLE2

The PANTHER Classification System

More...
PANTHERi
PTHR12708 PTHR12708, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04042 DNA_pol_E_B, 1 hit
PF12213 Dpoe2NT, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000799 DNA_pol_eps_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P56282-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAPERLRSRA LSAFKLRGLL LRGEAIKYLT EALQSISELE LEDKLEKIIN
60 70 80 90 100
AVEKQPLSSN MIERSVVEAA VQECSQSVDE TIEHVFNIIG AFDIPRFVYN
110 120 130 140 150
SERKKFLPLL MTNHPAPNLF GTPRDKAEMF RERYTILHQR THRHELFTPP
160 170 180 190 200
VIGSHPDESG SKFQLKTIET LLGSTTKIGD AIVLGMITQL KEGKFFLEDP
210 220 230 240 250
TGTVQLDLSK AQFHSGLYTE ACFVLAEGWF EDQVFHVNAF GFPPTEPSST
260 270 280 290 300
TRAYYGNINF FGGPSNTSVK TSAKLKQLEE ENKDAMFVFL SDVWLDQVEV
310 320 330 340 350
LEKLRIMFAG YSPAPPTCFI LCGNFSSAPY GKNQVQALKD SLKTLADIIC
360 370 380 390 400
EYPDIHQSSR FVFVPGPEDP GFGSILPRPP LAESITNEFR QRVPFSVFTT
410 420 430 440 450
NPCRIQYCTQ EITVFREDLV NKMCRNCVRF PSSNLAIPNH FVKTILSQGH
460 470 480 490 500
LTPLPLYVCP VYWAYDYALR VYPVPDLLVI ADKYDPFTTT NTECLCINPG
510 520
SFPRSGFSFK VFYPSNKTVE DSKLQGF
Length:527
Mass (Da):59,537
Last modified:December 15, 1998 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAFA7AF7C2C0BFF15
GO
Isoform 2 (identifier: P56282-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     83-108: Missing.

Show »
Length:501
Mass (Da):56,418
Checksum:iECB4BFD1E2FDAE1C
GO
Isoform 3 (identifier: P56282-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     500-527: GSFPRSGFSFKVFYPSNKTVEDSKLQGF → VRM

Show »
Length:502
Mass (Da):56,784
Checksum:i0F3391E93AB14483
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
U3KQ22U3KQ22_HUMAN
DNA polymerase epsilon subunit 2
POLE2
96Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti11L → P in AAC51920 (PubMed:9405441).Curated1
Sequence conflicti359Missing in AAC51920 (PubMed:9405441).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04437984H → P1 PublicationCorresponds to variant dbSNP:rs34857719Ensembl.1
Natural variantiVAR_044380456L → V. Corresponds to variant dbSNP:rs34574266Ensembl.1
Natural variantiVAR_044381514P → L1 PublicationCorresponds to variant dbSNP:rs45515094Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04255183 – 108Missing in isoform 2. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_043796500 – 527GSFPR…KLQGF → VRM in isoform 3. 1 PublicationAdd BLAST28

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF025840 mRNA Translation: AAC51920.1
AF036899 mRNA Translation: AAC39610.1
AF387034 AF387033 Genomic DNA Translation: AAK72254.1
EF506887 Genomic DNA Translation: ABO43040.1
AK293163 mRNA Translation: BAG56707.1
AL139099 Genomic DNA No translation available.
AL591767 Genomic DNA No translation available.
BC112962 mRNA Translation: AAI12963.1
BC126218 mRNA Translation: AAI26219.1
BC126220 mRNA Translation: AAI26221.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS32073.1 [P56282-1]
CCDS55914.1 [P56282-2]
CCDS55915.1 [P56282-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001184259.1, NM_001197330.1 [P56282-2]
NP_001184260.1, NM_001197331.1 [P56282-3]
NP_001335313.1, NM_001348384.1
NP_002683.2, NM_002692.3 [P56282-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000216367; ENSP00000216367; ENSG00000100479 [P56282-1]
ENST00000539565; ENSP00000446313; ENSG00000100479 [P56282-2]
ENST00000554396; ENSP00000451621; ENSG00000100479 [P56282-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5427

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:5427

UCSC genome browser

More...
UCSCi
uc001wwu.4 human [P56282-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF025840 mRNA Translation: AAC51920.1
AF036899 mRNA Translation: AAC39610.1
AF387034 AF387033 Genomic DNA Translation: AAK72254.1
EF506887 Genomic DNA Translation: ABO43040.1
AK293163 mRNA Translation: BAG56707.1
AL139099 Genomic DNA No translation available.
AL591767 Genomic DNA No translation available.
BC112962 mRNA Translation: AAI12963.1
BC126218 mRNA Translation: AAI26219.1
BC126220 mRNA Translation: AAI26221.1
CCDSiCCDS32073.1 [P56282-1]
CCDS55914.1 [P56282-2]
CCDS55915.1 [P56282-3]
RefSeqiNP_001184259.1, NM_001197330.1 [P56282-2]
NP_001184260.1, NM_001197331.1 [P56282-3]
NP_001335313.1, NM_001348384.1
NP_002683.2, NM_002692.3 [P56282-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2V6ZNMR-M1-73[»]
5VBNX-ray2.35A/E1-527[»]
SMRiP56282
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi111423, 45 interactors
ComplexPortaliCPX-2108 epsilon DNA polymerase complex
CORUMiP56282
IntActiP56282, 32 interactors
STRINGi9606.ENSP00000216367

Chemistry databases

ChEMBLiCHEMBL2363042
DrugBankiDB00242 Cladribine

PTM databases

iPTMnetiP56282
PhosphoSitePlusiP56282

Polymorphism and mutation databases

BioMutaiPOLE2
DMDMi3915676

Proteomic databases

EPDiP56282
jPOSTiP56282
MassIVEiP56282
MaxQBiP56282
PaxDbiP56282
PeptideAtlasiP56282
PRIDEiP56282
ProteomicsDBi56911 [P56282-1]
56912 [P56282-2]
56913 [P56282-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
23530 125 antibodies

The DNASU plasmid repository

More...
DNASUi
5427

Genome annotation databases

EnsembliENST00000216367; ENSP00000216367; ENSG00000100479 [P56282-1]
ENST00000539565; ENSP00000446313; ENSG00000100479 [P56282-2]
ENST00000554396; ENSP00000451621; ENSG00000100479 [P56282-3]
GeneIDi5427
KEGGihsa:5427
UCSCiuc001wwu.4 human [P56282-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
5427

GeneCards: human genes, protein and diseases

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GeneCardsi
POLE2
HGNCiHGNC:9178 POLE2
HPAiENSG00000100479 Tissue enhanced (bone marrow, lymphoid tissue)
MIMi602670 gene
neXtProtiNX_P56282
OpenTargetsiENSG00000100479
PharmGKBiPA278

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG3818 Eukaryota
ENOG410XP7N LUCA
GeneTreeiENSGT00390000012435
HOGENOMiCLU_010628_2_0_1
InParanoidiP56282
KOiK02325
OMAiCRLQYCT
OrthoDBi375960at2759
PhylomeDBiP56282
TreeFamiTF103007

Enzyme and pathway databases

ReactomeiR-HSA-110314 Recognition of DNA damage by PCNA-containing replication complex
R-HSA-174430 Telomere C-strand synthesis initiation
R-HSA-5651801 PCNA-Dependent Long Patch Base Excision Repair
R-HSA-5656169 Termination of translesion DNA synthesis
R-HSA-5685942 HDR through Homologous Recombination (HRR)
R-HSA-5696397 Gap-filling DNA repair synthesis and ligation in GG-NER
R-HSA-5696400 Dual Incision in GG-NER
R-HSA-6782135 Dual incision in TC-NER
R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
R-HSA-68952 DNA replication initiation
R-HSA-68962 Activation of the pre-replicative complex

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
POLE2 human
EvolutionaryTraceiP56282

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
POLE2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
5427
PharosiP56282 Tbio

Protein Ontology

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PROi
PR:P56282
RNActiP56282 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000100479 Expressed in kidney and 133 other tissues
ExpressionAtlasiP56282 baseline and differential
GenevisibleiP56282 HS

Family and domain databases

InterProiView protein in InterPro
IPR007185 DNA_pol_a/d/e_bsu
IPR024639 DNA_pol_e_bsu_N
IPR016266 POLE2
PANTHERiPTHR12708 PTHR12708, 1 hit
PfamiView protein in Pfam
PF04042 DNA_pol_E_B, 1 hit
PF12213 Dpoe2NT, 1 hit
PIRSFiPIRSF000799 DNA_pol_eps_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDPOE2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P56282
Secondary accession number(s): A0AV55
, A4FU92, A4LBB7, A6NH58, B4DDE6, O43560
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: December 15, 1998
Last modified: April 22, 2020
This is version 168 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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