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UniProtKB - P56280 (TCL1A_MOUSE)
Protein
T-cell leukemia/lymphoma protein 1A
Gene
Tcl1a
Organism
Mus musculus (Mouse)
Status
Functioni
Enhances the phosphorylation and activation of AKT1 and AKT2. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival (By similarity).
By similarityGO - Molecular functioni
- identical protein binding Source: MGI
- protein kinase binding Source: MGI
- protein serine/threonine kinase activator activity Source: MGI
GO - Biological processi
- activation of protein kinase B activity Source: CACAO
- cellular response to tumor necrosis factor Source: MGI
- negative regulation of apoptotic process Source: MGI
- negative regulation of gene expression Source: MGI
- positive regulation of cell population proliferation Source: MGI
- positive regulation of mitochondrial membrane potential Source: MGI
- positive regulation of peptidyl-serine phosphorylation Source: MGI
- positive regulation of protein-containing complex assembly Source: MGI
- positive regulation of protein serine/threonine kinase activity Source: MGI
- regulation of stem cell population maintenance Source: MGI
- stem cell population maintenance Source: MGI
Names & Taxonomyi
Protein namesi | Recommended name: T-cell leukemia/lymphoma protein 1AAlternative name(s): Oncogene TCL-1 Short name: Oncogene TCL1 Protein p14 TCL1 |
Gene namesi | Name:Tcl1a Synonyms:Tcl1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1097166, Tcl1 |
VEuPathDBi | HostDB:ENSMUSG00000041359 |
Subcellular locationi
Endoplasmic reticulum
- Microsome By similarity
- Endoplasmic reticulum By similarity
Nucleus
- Nucleus 1 Publication
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Note: Microsomal fraction.By similarity
Cytosol
- cytosol Source: MGI
Endoplasmic reticulum
- endoplasmic reticulum Source: MGI
Nucleus
- nucleoplasm Source: MGI
- nucleus Source: MGI
- pronucleus Source: MGI
Other locations
- cell cortex Source: MGI
- protein-containing complex Source: MGI
Keywords - Cellular componenti
Cytoplasm, Endoplasmic reticulum, Microsome, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000184489 | 1 – 116 | T-cell leukemia/lymphoma protein 1AAdd BLAST | 116 |
Proteomic databases
PaxDbi | P56280 |
PRIDEi | P56280 |
2D gel databases
REPRODUCTION-2DPAGEi | P56280 |
PTM databases
iPTMneti | P56280 |
PhosphoSitePlusi | P56280 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000041359, Expressed in primary oocyte and 43 other tissues |
ExpressionAtlasi | P56280, baseline and differential |
Genevisiblei | P56280, MM |
Interactioni
Subunit structurei
Homodimer.
Interacts with AKT1, AKT2 and AKT3 (via PH domain).
Interacts with PNPT1; the interaction has no effect on PNPT1 exonuclease activity (By similarity).
By similarityGO - Molecular functioni
- identical protein binding Source: MGI
- protein kinase binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 204023, 1 interactor |
STRINGi | 10090.ENSMUSP00000036066 |
Miscellaneous databases
RNActi | P56280, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | P56280 |
SMRi | P56280 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P56280 |
Family & Domainsi
Sequence similaritiesi
Belongs to the TCL1 family.Curated
Phylogenomic databases
eggNOGi | ENOG502TDVJ, Eukaryota |
GeneTreei | ENSGT00390000006885 |
HOGENOMi | CLU_168379_0_1_1 |
InParanoidi | P56280 |
OMAi | LWIWERS |
PhylomeDBi | P56280 |
TreeFami | TF337903 |
Family and domain databases
Gene3Di | 2.40.15.10, 1 hit |
InterProi | View protein in InterPro IPR004832, TCL1_MTCP1 IPR036672, TCL1_MTCP1_sf |
PANTHERi | PTHR14060, PTHR14060, 1 hit |
Pfami | View protein in Pfam PF01840, TCL1_MTCP1, 1 hit |
SUPFAMi | SSF50904, SSF50904, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
P56280-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MATQRAHRAE TPAHPNRLWI WEKHVYLDEF RRSWLPVVIK SNEKFQVILR
60 70 80 90 100
QEDVTLGEAM SPSQLVPYEL PLMWQLYPKD RYRSCDSMYW QILYHIKFRD
110
VEDMLLELID SESNDE
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ3UES7 | Q3UES7_MOUSE | T cell lymphoma breakpoint 1 | Tcl1 | 193 | Annotation score: | ||
H3BJP6 | H3BJP6_MOUSE | T cell lymphoma breakpoint 1 | Tcl1 | 91 | Annotation score: | ||
H3BJ18 | H3BJ18_MOUSE | T cell lymphoma breakpoint 1 | Tcl1 | 59 | Annotation score: | ||
H3BJA0 | H3BJA0_MOUSE | T cell lymphoma breakpoint 1 | Tcl1 | 107 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF031956 mRNA Translation: AAB87461.1 Y15376 mRNA Translation: CAA75599.1 BC052336 mRNA Translation: AAH52336.1 |
CCDSi | CCDS36549.1 |
RefSeqi | NP_033363.1, NM_009337.3 |
Genome annotation databases
Ensembli | ENSMUST00000041316; ENSMUSP00000036066; ENSMUSG00000041359 |
GeneIDi | 21432 |
KEGGi | mmu:21432 |
UCSCi | uc007oyd.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF031956 mRNA Translation: AAB87461.1 Y15376 mRNA Translation: CAA75599.1 BC052336 mRNA Translation: AAH52336.1 |
CCDSi | CCDS36549.1 |
RefSeqi | NP_033363.1, NM_009337.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1JNP | X-ray | 2.50 | A/B | 1-116 | [»] | |
AlphaFoldDBi | P56280 | |||||
SMRi | P56280 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 204023, 1 interactor |
STRINGi | 10090.ENSMUSP00000036066 |
PTM databases
iPTMneti | P56280 |
PhosphoSitePlusi | P56280 |
2D gel databases
REPRODUCTION-2DPAGEi | P56280 |
Proteomic databases
PaxDbi | P56280 |
PRIDEi | P56280 |
Protocols and materials databases
Antibodypediai | 65, 422 antibodies from 40 providers |
DNASUi | 21432 |
Genome annotation databases
Ensembli | ENSMUST00000041316; ENSMUSP00000036066; ENSMUSG00000041359 |
GeneIDi | 21432 |
KEGGi | mmu:21432 |
UCSCi | uc007oyd.2, mouse |
Organism-specific databases
CTDi | 21432 |
MGIi | MGI:1097166, Tcl1 |
VEuPathDBi | HostDB:ENSMUSG00000041359 |
Phylogenomic databases
eggNOGi | ENOG502TDVJ, Eukaryota |
GeneTreei | ENSGT00390000006885 |
HOGENOMi | CLU_168379_0_1_1 |
InParanoidi | P56280 |
OMAi | LWIWERS |
PhylomeDBi | P56280 |
TreeFami | TF337903 |
Miscellaneous databases
BioGRID-ORCSi | 21432, 2 hits in 73 CRISPR screens |
ChiTaRSi | Tcl1, mouse |
EvolutionaryTracei | P56280 |
PROi | PR:P56280 |
RNActi | P56280, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000041359, Expressed in primary oocyte and 43 other tissues |
ExpressionAtlasi | P56280, baseline and differential |
Genevisiblei | P56280, MM |
Family and domain databases
Gene3Di | 2.40.15.10, 1 hit |
InterProi | View protein in InterPro IPR004832, TCL1_MTCP1 IPR036672, TCL1_MTCP1_sf |
PANTHERi | PTHR14060, PTHR14060, 1 hit |
Pfami | View protein in Pfam PF01840, TCL1_MTCP1, 1 hit |
SUPFAMi | SSF50904, SSF50904, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TCL1A_MOUSE | |
Accessioni | P56280Primary (citable) accession number: P56280 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | July 15, 1998 | |
Last modified: | May 25, 2022 | |
This is version 138 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families