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Protein

T-cell leukemia/lymphoma protein 1A

Gene

Tcl1a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Enhances the phosphorylation and activation of AKT1 and AKT2. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell leukemia/lymphoma protein 1A
Alternative name(s):
Oncogene TCL-1
Short name:
Oncogene TCL1
Protein p14 TCL1
Gene namesi
Name:Tcl1a
Synonyms:Tcl1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1097166 Tcl1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Microsome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001844891 – 116T-cell leukemia/lymphoma protein 1AAdd BLAST116

Proteomic databases

PaxDbiP56280
PRIDEiP56280

2D gel databases

REPRODUCTION-2DPAGEiP56280

PTM databases

iPTMnetiP56280
PhosphoSitePlusiP56280

Expressioni

Gene expression databases

BgeeiENSMUSG00000041359 Expressed in 31 organ(s), highest expression level in primary oocyte
CleanExiMM_TCL1
ExpressionAtlasiP56280 baseline and differential
GenevisibleiP56280 MM

Interactioni

Subunit structurei

Homodimer. Interacts with AKT1, AKT2 and AKT3 (via PH domain). Interacts with PNPT1; the interaction has no effect on PNPT1 exonuclease activity (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi204023, 1 interactor
STRINGi10090.ENSMUSP00000036066

Structurei

Secondary structure

1116
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP56280
SMRiP56280
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP56280

Family & Domainsi

Sequence similaritiesi

Belongs to the TCL1 family.Curated

Phylogenomic databases

eggNOGiENOG410JEFE Eukaryota
ENOG4111B9D LUCA
GeneTreeiENSGT00390000006885
HOGENOMiHOG000037945
HOVERGENiHBG052523
InParanoidiP56280
KOiK10167
PhylomeDBiP56280
TreeFamiTF337903

Family and domain databases

Gene3Di2.40.15.10, 1 hit
InterProiView protein in InterPro
IPR004832 TCL1_MTCP1
IPR036672 TCL1_MTCP1_sf
PANTHERiPTHR14060 PTHR14060, 1 hit
PfamiView protein in Pfam
PF01840 TCL1_MTCP1, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD015575 TCL1_MTCP1, 1 hit
SUPFAMiSSF50904 SSF50904, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

P56280-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATQRAHRAE TPAHPNRLWI WEKHVYLDEF RRSWLPVVIK SNEKFQVILR
60 70 80 90 100
QEDVTLGEAM SPSQLVPYEL PLMWQLYPKD RYRSCDSMYW QILYHIKFRD
110
VEDMLLELID SESNDE
Length:116
Mass (Da):14,112
Last modified:July 15, 1998 - v1
Checksum:i46DEED2F973F389A
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BJP6H3BJP6_MOUSE
T cell lymphoma breakpoint 1
Tcl1
91Annotation score:
Q3UES7Q3UES7_MOUSE
T cell lymphoma breakpoint 1
Tcl1
193Annotation score:
H3BJA0H3BJA0_MOUSE
T cell lymphoma breakpoint 1
Tcl1
107Annotation score:
H3BJ18H3BJ18_MOUSE
T cell lymphoma breakpoint 1
Tcl1
59Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF031956 mRNA Translation: AAB87461.1
Y15376 mRNA Translation: CAA75599.1
BC052336 mRNA Translation: AAH52336.1
CCDSiCCDS36549.1
RefSeqiNP_033363.1, NM_009337.3
UniGeneiMm.18154

Genome annotation databases

EnsembliENSMUST00000041316; ENSMUSP00000036066; ENSMUSG00000041359
GeneIDi21432
KEGGimmu:21432
UCSCiuc007oyd.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF031956 mRNA Translation: AAB87461.1
Y15376 mRNA Translation: CAA75599.1
BC052336 mRNA Translation: AAH52336.1
CCDSiCCDS36549.1
RefSeqiNP_033363.1, NM_009337.3
UniGeneiMm.18154

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JNPX-ray2.50A/B1-116[»]
ProteinModelPortaliP56280
SMRiP56280
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204023, 1 interactor
STRINGi10090.ENSMUSP00000036066

PTM databases

iPTMnetiP56280
PhosphoSitePlusiP56280

2D gel databases

REPRODUCTION-2DPAGEiP56280

Proteomic databases

PaxDbiP56280
PRIDEiP56280

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000041316; ENSMUSP00000036066; ENSMUSG00000041359
GeneIDi21432
KEGGimmu:21432
UCSCiuc007oyd.2 mouse

Organism-specific databases

CTDi21432
MGIiMGI:1097166 Tcl1

Phylogenomic databases

eggNOGiENOG410JEFE Eukaryota
ENOG4111B9D LUCA
GeneTreeiENSGT00390000006885
HOGENOMiHOG000037945
HOVERGENiHBG052523
InParanoidiP56280
KOiK10167
PhylomeDBiP56280
TreeFamiTF337903

Miscellaneous databases

EvolutionaryTraceiP56280
PROiPR:P56280
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000041359 Expressed in 31 organ(s), highest expression level in primary oocyte
CleanExiMM_TCL1
ExpressionAtlasiP56280 baseline and differential
GenevisibleiP56280 MM

Family and domain databases

Gene3Di2.40.15.10, 1 hit
InterProiView protein in InterPro
IPR004832 TCL1_MTCP1
IPR036672 TCL1_MTCP1_sf
PANTHERiPTHR14060 PTHR14060, 1 hit
PfamiView protein in Pfam
PF01840 TCL1_MTCP1, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD015575 TCL1_MTCP1, 1 hit
SUPFAMiSSF50904 SSF50904, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTCL1A_MOUSE
AccessioniPrimary (citable) accession number: P56280
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: September 12, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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