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Protein

T-cell leukemia/lymphoma protein 1A

Gene

TCL1A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of AKT1. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival.4 Publications

GO - Molecular functioni

  • identical protein binding Source: UniProtKB
  • protein kinase binding Source: UniProtKB
  • protein serine/threonine kinase activator activity Source: UniProtKB

GO - Biological processi

Enzyme and pathway databases

SIGNORiP56279

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell leukemia/lymphoma protein 1A
Alternative name(s):
Oncogene TCL-1
Short name:
Oncogene TCL1
Protein p14 TCL1
Gene namesi
Name:TCL1A
Synonyms:TCL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000100721.10
HGNCiHGNC:11648 TCL1A
MIMi186960 gene
neXtProtiNX_P56279

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Microsome, Nucleus

Pathology & Biotechi

Involvement in diseasei

Chromosomal aberrations activating TCL1A are found in chronic T-cell leukemias (T-CLL). Translocation t(14;14)(q11;q32); translocation t(7;14)(q35;q32); inversion inv(14)(q11;q32) that involves the T-cell receptor alpha/delta loci.

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi16D → G: Greatly reduced binding to AKT1, AKT2 and AKT3. Abolishes nuclear transport of AKT1. 1 Publication1
Mutagenesisi30K → M: Slightly reduced binding to AKT2. 1 Publication1
Mutagenesisi36 – 38PLT → AAA: Unable to homodimerize but has no effect on interaction with AKT1, AKT2 or AKT3. 1 Publication3
Mutagenesisi46Q → R: Slightly increased binding to AKT2. 1 Publication1
Mutagenesisi74I → V: Greatly reduced binding to AKT2. Abolishes nuclear transport of AKT1. 1 Publication1
Mutagenesisi106M → V: Slightly increased binding to AKT2. 1 Publication1

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNETi8115
MalaCardsiTCL1A
OpenTargetsiENSG00000100721
Orphaneti99861 Precursor T-cell acute lymphoblastic leukemia
PharmGKBiPA36400

Polymorphism and mutation databases

BioMutaiTCL1A

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001844881 – 114T-cell leukemia/lymphoma protein 1AAdd BLAST114

Proteomic databases

MaxQBiP56279
PaxDbiP56279
PeptideAtlasiP56279
PRIDEiP56279
ProteomicsDBi56910

PTM databases

iPTMnetiP56279
PhosphoSitePlusiP56279

Expressioni

Tissue specificityi

Restricted in the T-cell lineage to immature thymocytes and activated peripheral lymphocytes. Preferentially expressed early in T- and B-lymphocyte differentiation.

Gene expression databases

BgeeiENSG00000100721 Expressed in 94 organ(s), highest expression level in oocyte
CleanExiHS_TCL1A
ExpressionAtlasiP56279 baseline and differential
GenevisibleiP56279 HS

Organism-specific databases

HPAiCAB004045
HPA016604

Interactioni

Subunit structurei

Homodimer. Interacts with AKT1, AKT2 and AKT3 (via PH domain). Interacts with PNPT1; the interaction has no effect on PNPT1 exonuclease activity.5 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi113783, 29 interactors
CORUMiP56279
DIPiDIP-60787N
IntActiP56279, 41 interactors
MINTiP56279
STRINGi9606.ENSP00000385036

Structurei

Secondary structure

1114
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP56279
SMRiP56279
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP56279

Family & Domainsi

Sequence similaritiesi

Belongs to the TCL1 family.Curated

Phylogenomic databases

eggNOGiENOG410JEFE Eukaryota
ENOG4111B9D LUCA
GeneTreeiENSGT00390000006885
HOGENOMiHOG000037945
HOVERGENiHBG052523
InParanoidiP56279
KOiK10167
OMAiNQRTWLP
OrthoDBiEOG091G0ZI2
PhylomeDBiP56279
TreeFamiTF337903

Family and domain databases

Gene3Di2.40.15.10, 1 hit
InterProiView protein in InterPro
IPR004832 TCL1_MTCP1
IPR036672 TCL1_MTCP1_sf
PANTHERiPTHR14060 PTHR14060, 1 hit
PfamiView protein in Pfam
PF01840 TCL1_MTCP1, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD015575 TCL1_MTCP1, 1 hit
SUPFAMiSSF50904 SSF50904, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P56279-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAECPTLGEA VTDHPDRLWA WEKFVYLDEK QHAWLPLTIE IKDRLQLRVL
60 70 80 90 100
LRREDVVLGR PMTPTQIGPS LLPIMWQLYP DGRYRSSDSS FWRLVYHIKI
110
DGVEDMLLEL LPDD
Length:114
Mass (Da):13,460
Last modified:July 15, 1998 - v1
Checksum:i90D55ABC97C36D04
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YJR9H0YJR9_HUMAN
T-cell leukemia/lymphoma protein 1A
TCL1A
53Annotation score:
G3V4T4G3V4T4_HUMAN
T-cell leukemia/lymphoma protein 1A
TCL1A
46Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti106M → V in CAG33077 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05371856V → I. Corresponds to variant dbSNP:rs17093294Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X82240 mRNA Translation: CAA57708.1
CR456796 mRNA Translation: CAG33077.1
BC003574 mRNA Translation: AAH03574.1
BC005831 mRNA Translation: AAH05831.1
BC014024 mRNA Translation: AAH14024.1
CCDSiCCDS9941.1
PIRiI38286
RefSeqiNP_001092195.1, NM_001098725.1
NP_068801.1, NM_021966.2
XP_016877165.1, XM_017021676.1
XP_016877166.1, XM_017021677.1
UniGeneiHs.2484

Genome annotation databases

EnsembliENST00000402399; ENSP00000385036; ENSG00000100721
ENST00000554012; ENSP00000451506; ENSG00000100721
ENST00000555202; ENSP00000450496; ENSG00000100721
ENST00000556450; ENSP00000450701; ENSG00000100721
GeneIDi8115
KEGGihsa:8115
UCSCiuc001yfb.5 human

Keywords - Coding sequence diversityi

Chromosomal rearrangement, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X82240 mRNA Translation: CAA57708.1
CR456796 mRNA Translation: CAG33077.1
BC003574 mRNA Translation: AAH03574.1
BC005831 mRNA Translation: AAH05831.1
BC014024 mRNA Translation: AAH14024.1
CCDSiCCDS9941.1
PIRiI38286
RefSeqiNP_001092195.1, NM_001098725.1
NP_068801.1, NM_021966.2
XP_016877165.1, XM_017021676.1
XP_016877166.1, XM_017021677.1
UniGeneiHs.2484

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JSGX-ray2.50A1-114[»]
ProteinModelPortaliP56279
SMRiP56279
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113783, 29 interactors
CORUMiP56279
DIPiDIP-60787N
IntActiP56279, 41 interactors
MINTiP56279
STRINGi9606.ENSP00000385036

PTM databases

iPTMnetiP56279
PhosphoSitePlusiP56279

Polymorphism and mutation databases

BioMutaiTCL1A

Proteomic databases

MaxQBiP56279
PaxDbiP56279
PeptideAtlasiP56279
PRIDEiP56279
ProteomicsDBi56910

Protocols and materials databases

DNASUi8115
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000402399; ENSP00000385036; ENSG00000100721
ENST00000554012; ENSP00000451506; ENSG00000100721
ENST00000555202; ENSP00000450496; ENSG00000100721
ENST00000556450; ENSP00000450701; ENSG00000100721
GeneIDi8115
KEGGihsa:8115
UCSCiuc001yfb.5 human

Organism-specific databases

CTDi8115
DisGeNETi8115
EuPathDBiHostDB:ENSG00000100721.10
GeneCardsiTCL1A
HGNCiHGNC:11648 TCL1A
HPAiCAB004045
HPA016604
MalaCardsiTCL1A
MIMi186960 gene
neXtProtiNX_P56279
OpenTargetsiENSG00000100721
Orphaneti99861 Precursor T-cell acute lymphoblastic leukemia
PharmGKBiPA36400
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JEFE Eukaryota
ENOG4111B9D LUCA
GeneTreeiENSGT00390000006885
HOGENOMiHOG000037945
HOVERGENiHBG052523
InParanoidiP56279
KOiK10167
OMAiNQRTWLP
OrthoDBiEOG091G0ZI2
PhylomeDBiP56279
TreeFamiTF337903

Enzyme and pathway databases

SIGNORiP56279

Miscellaneous databases

ChiTaRSiTCL1A human
EvolutionaryTraceiP56279
GeneWikiiTCL1A
GenomeRNAii8115
PROiPR:P56279
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000100721 Expressed in 94 organ(s), highest expression level in oocyte
CleanExiHS_TCL1A
ExpressionAtlasiP56279 baseline and differential
GenevisibleiP56279 HS

Family and domain databases

Gene3Di2.40.15.10, 1 hit
InterProiView protein in InterPro
IPR004832 TCL1_MTCP1
IPR036672 TCL1_MTCP1_sf
PANTHERiPTHR14060 PTHR14060, 1 hit
PfamiView protein in Pfam
PF01840 TCL1_MTCP1, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD015575 TCL1_MTCP1, 1 hit
SUPFAMiSSF50904 SSF50904, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTCL1A_HUMAN
AccessioniPrimary (citable) accession number: P56279
Secondary accession number(s): Q6IBK7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: September 12, 2018
This is version 169 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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