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UniProtKB - P56279 (TCL1A_HUMAN)

Entry version 188 (02 Jun 2021)
Sequence version 1 (15 Jul 1998)
Previous versions | rss
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Protein

T-cell leukemia/lymphoma protein 1A

Gene

TCL1A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of AKT1. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival.

4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • identical protein binding Source: UniProtKB
  • protein kinase binding Source: UniProtKB
  • protein serine/threonine kinase activator activity Source: UniProtKB
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P56279

SIGNOR Signaling Network Open Resource

More...SIGNORi		P56279

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
T-cell leukemia/lymphoma protein 1A
Alternative name(s):
Oncogene TCL-1
Short name:
Oncogene TCL1
Protein p14 TCL1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TCL1A
Synonyms:TCL1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:11648, TCL1A

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		186960, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P56279

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000100721.10

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Microsome, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Chromosomal aberrations activating TCL1A are found in chronic T-cell leukemias (T-CLL). Translocation t(14;14)(q11;q32); translocation t(7;14)(q35;q32); inversion inv(14)(q11;q32) that involves the T-cell receptor alpha/delta loci.

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi16D → G: Greatly reduced binding to AKT1, AKT2 and AKT3. Abolishes nuclear transport of AKT1. 1 Publication1
Mutagenesisi30K → M: Slightly reduced binding to AKT2. 1 Publication1
Mutagenesisi36 – 38PLT → AAA: Unable to homodimerize but has no effect on interaction with AKT1, AKT2 or AKT3. 1 Publication3
Mutagenesisi46Q → R: Slightly increased binding to AKT2. 1 Publication1
Mutagenesisi74I → V: Greatly reduced binding to AKT2. Abolishes nuclear transport of AKT1. 1 Publication1
Mutagenesisi106M → V: Slightly increased binding to AKT2. 1 Publication1

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNET

More...DisGeNETi		8115

MalaCards human disease database

More...MalaCardsi		TCL1A

Open Targets

More...OpenTargetsi		ENSG00000100721

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		99861, Precursor T-cell acute lymphoblastic leukemia

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA36400

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P56279, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TCL1A

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001844881 – 114T-cell leukemia/lymphoma protein 1AAdd BLAST114

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P56279

MaxQB - The MaxQuant DataBase

More...MaxQBi		P56279

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P56279

PeptideAtlas

More...PeptideAtlasi		P56279

PRoteomics IDEntifications database

More...PRIDEi		P56279

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		56910

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P56279

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P56279

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Restricted in the T-cell lineage to immature thymocytes and activated peripheral lymphocytes. Preferentially expressed early in T- and B-lymphocyte differentiation.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000100721, Expressed in oocyte and 121 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P56279, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P56279, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000100721, Group enriched (blood, lymphoid tissue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

Interacts with AKT1, AKT2 and AKT3 (via PH domain).

Interacts with PNPT1; the interaction has no effect on PNPT1 exonuclease activity.

5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details
P56279
With#Exp.IntAct
AKT1 [A0A0S2Z3D6]3EBI-749995,EBI-16430470
AKT1 [B0LPE5]3EBI-749995,EBI-10175397
AKT1 [P31749]8EBI-749995,EBI-296087
CADPS [A2RRN7]6EBI-749995,EBI-10179719
CALCOCO2 [Q13137]10EBI-749995,EBI-739580
CARD9 [Q9H257]3EBI-749995,EBI-751319
CARD9 - isoform 2 [Q9H257-2]3EBI-749995,EBI-11530605
CCDC13 [Q8IYE1]3EBI-749995,EBI-10961312
CEP55 [Q53EZ4]6EBI-749995,EBI-747776
DDIT4L [Q96D03]3EBI-749995,EBI-742054
DNMT3A [Q9Y6K1]10EBI-749995,EBI-923653
EP300 [Q09472]4EBI-749995,EBI-447295
FLACC1 [Q96Q35]3EBI-749995,EBI-750451
FOS [P01100]4EBI-749995,EBI-852851
GOLGA2 [Q08379]8EBI-749995,EBI-618309
INCA1 [Q0VD86]3EBI-749995,EBI-6509505
JUN [P05412]6EBI-749995,EBI-852823
JUNB [P17275]2EBI-749995,EBI-748062
LNX1 [Q8TBB1]3EBI-749995,EBI-739832
LSM3 [P62310]6EBI-749995,EBI-348239
NFKBIA [P25963]3EBI-749995,EBI-307386
NFKBID [Q8NI38]3EBI-749995,EBI-10271199
NIF3L1 [Q9GZT8]5EBI-749995,EBI-740897
NTAQ1 [Q96HA8]5EBI-749995,EBI-741158
PPP1R13B [Q96KQ4]3EBI-749995,EBI-1105153
PRTFDC1 [Q9NRG1]6EBI-749995,EBI-739759
REL - isoform 2 [Q04864-2]3EBI-749995,EBI-10829018
TAX1BP1 [Q86VP1]3EBI-749995,EBI-529518
TCF4 [P15884]3EBI-749995,EBI-533224
itself4EBI-749995,EBI-749995
TEPSIN [Q96N21]3EBI-749995,EBI-11139477
TNKS [O95271]3EBI-749995,EBI-1105254
TP53BP2 - isoform 3 [Q13625-3]3EBI-749995,EBI-10175039
TRAF1 [Q13077]8EBI-749995,EBI-359224
TRAF2 [Q12933]3EBI-749995,EBI-355744
TRMT61A [Q96FX7]3EBI-749995,EBI-934042
TTC33 [Q6PID6]7EBI-749995,EBI-2555404
TXLNA [P40222]6EBI-749995,EBI-359793
TXLNB [Q8N3L3]3EBI-749995,EBI-6116822
WDR47 [O94967]3EBI-749995,EBI-723239

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		113783, 46 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P56279

Database of interacting proteins

More...DIPi		DIP-60787N

Protein interaction database and analysis system

More...IntActi		P56279, 41 interactors

Molecular INTeraction database

More...MINTi		P56279

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000385036

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P56279, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1114
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P56279

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P56279

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TCL1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502TDVJ, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000006885

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_168379_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P56279

Identification of Orthologs from Complete Genome Data

More...OMAi		PVMWQLY

Database of Orthologous Groups

More...OrthoDBi		1496659at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P56279

TreeFam database of animal gene trees

More...TreeFami		TF337903

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.40.15.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR004832, TCL1_MTCP1
IPR036672, TCL1_MTCP1_sf

The PANTHER Classification System

More...PANTHERi		PTHR14060, PTHR14060, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01840, TCL1_MTCP1, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50904, SSF50904, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P56279-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAECPTLGEA VTDHPDRLWA WEKFVYLDEK QHAWLPLTIE IKDRLQLRVL 
        60         70         80         90        100
LRREDVVLGR PMTPTQIGPS LLPIMWQLYP DGRYRSSDSS FWRLVYHIKI 
       110 
DGVEDMLLEL LPDD
Length:114
Mass (Da):13,460
Last modified:July 15, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i90D55ABC97C36D04
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V4T4G3V4T4_HUMAN
T-cell leukemia/lymphoma protein 1A
TCL1A
46Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YJR9H0YJR9_HUMAN
T-cell leukemia/lymphoma protein 1A
TCL1A
53Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti106M → V in CAG33077 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05371856V → I. Corresponds to variant dbSNP:rs17093294Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X82240 mRNA Translation: CAA57708.1
CR456796 mRNA Translation: CAG33077.1
BC003574 mRNA Translation: AAH03574.1
BC005831 mRNA Translation: AAH05831.1
BC014024 mRNA Translation: AAH14024.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS9941.1

Protein sequence database of the Protein Information Resource

More...PIRi		I38286

NCBI Reference Sequences

More...RefSeqi		NP_001092195.1, NM_001098725.1
NP_068801.1, NM_021966.2
XP_016877165.1, XM_017021676.1
XP_016877166.1, XM_017021677.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000402399; ENSP00000385036; ENSG00000100721
ENST00000554012; ENSP00000451506; ENSG00000100721
ENST00000555202; ENSP00000450496; ENSG00000100721
ENST00000556450; ENSP00000450701; ENSG00000100721

Database of genes from NCBI RefSeq genomes

More...GeneIDi		8115

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:8115

UCSC genome browser

More...UCSCi		uc001yfb.5, human

Keywords - Coding sequence diversityi

Chromosomal rearrangement

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X82240 mRNA Translation: CAA57708.1
CR456796 mRNA Translation: CAG33077.1
BC003574 mRNA Translation: AAH03574.1
BC005831 mRNA Translation: AAH05831.1
BC014024 mRNA Translation: AAH14024.1
CCDSiCCDS9941.1
PIRiI38286
RefSeqiNP_001092195.1, NM_001098725.1
NP_068801.1, NM_021966.2
XP_016877165.1, XM_017021676.1
XP_016877166.1, XM_017021677.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JSGX-ray2.50A1-114[»]
SMRiP56279
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi113783, 46 interactors
CORUMiP56279
DIPiDIP-60787N
IntActiP56279, 41 interactors
MINTiP56279
STRINGi9606.ENSP00000385036

PTM databases

iPTMnetiP56279
PhosphoSitePlusiP56279

Genetic variation databases

BioMutaiTCL1A

Proteomic databases

MassIVEiP56279
MaxQBiP56279
PaxDbiP56279
PeptideAtlasiP56279
PRIDEiP56279
ProteomicsDBi56910

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		65, 416 antibodies

The DNASU plasmid repository

More...DNASUi		8115

Genome annotation databases

EnsembliENST00000402399; ENSP00000385036; ENSG00000100721
ENST00000554012; ENSP00000451506; ENSG00000100721
ENST00000555202; ENSP00000450496; ENSG00000100721
ENST00000556450; ENSP00000450701; ENSG00000100721
GeneIDi8115
KEGGihsa:8115
UCSCiuc001yfb.5, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		8115
DisGeNETi8115

GeneCards: human genes, protein and diseases

More...GeneCardsi		TCL1A
HGNCiHGNC:11648, TCL1A
HPAiENSG00000100721, Group enriched (blood, lymphoid tissue)
MalaCardsiTCL1A
MIMi186960, gene
neXtProtiNX_P56279
OpenTargetsiENSG00000100721
Orphaneti99861, Precursor T-cell acute lymphoblastic leukemia
PharmGKBiPA36400
VEuPathDBiHostDB:ENSG00000100721.10

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502TDVJ, Eukaryota
GeneTreeiENSGT00390000006885
HOGENOMiCLU_168379_0_1_1
InParanoidiP56279
OMAiPVMWQLY
OrthoDBi1496659at2759
PhylomeDBiP56279
TreeFamiTF337903

Enzyme and pathway databases

PathwayCommonsiP56279
SIGNORiP56279

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		8115, 3 hits in 985 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TCL1A, human
EvolutionaryTraceiP56279

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		TCL1A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		8115
PharosiP56279, Tbio

Protein Ontology

More...PROi		PR:P56279
RNActiP56279, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000100721, Expressed in oocyte and 121 other tissues
ExpressionAtlasiP56279, baseline and differential
GenevisibleiP56279, HS

Family and domain databases

Gene3Di2.40.15.10, 1 hit
InterProiView protein in InterPro
IPR004832, TCL1_MTCP1
IPR036672, TCL1_MTCP1_sf
PANTHERiPTHR14060, PTHR14060, 1 hit
PfamiView protein in Pfam
PF01840, TCL1_MTCP1, 1 hit
SUPFAMiSSF50904, SSF50904, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTCL1A_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P56279
Secondary accession number(s): Q6IBK7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: June 2, 2021
This is version 188 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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