We will be switching to the new UniProt website soon. Please explore and share your feedback.
Take me to the new website.
UniProtKB - P56279 (TCL1A_HUMAN)
Protein
T-cell leukemia/lymphoma protein 1A
Gene
TCL1A
Organism
Homo sapiens (Human)
Status
Functioni
Enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of AKT1. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival.
4 PublicationsGO - Molecular functioni
- identical protein binding Source: UniProtKB
- protein kinase binding Source: UniProtKB
- protein serine/threonine kinase activator activity Source: UniProtKB
GO - Biological processi
- cellular response to tumor necrosis factor Source: UniProtKB
- multicellular organism development Source: ProtInc
- negative regulation of apoptotic process Source: UniProtKB
- positive regulation of cell population proliferation Source: UniProtKB
- positive regulation of mitochondrial membrane potential Source: UniProtKB
- positive regulation of peptidyl-serine phosphorylation Source: UniProtKB
- positive regulation of protein-containing complex assembly Source: UniProtKB
- positive regulation of protein serine/threonine kinase activity Source: UniProtKB
Enzyme and pathway databases
PathwayCommonsi | P56279 |
SignaLinki | P56279 |
SIGNORi | P56279 |
Names & Taxonomyi
Protein namesi | Recommended name: T-cell leukemia/lymphoma protein 1AAlternative name(s): Oncogene TCL-1 Short name: Oncogene TCL1 Protein p14 TCL1 |
Gene namesi | Name:TCL1A Synonyms:TCL1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11648, TCL1A |
MIMi | 186960, gene |
neXtProti | NX_P56279 |
VEuPathDBi | HostDB:ENSG00000100721 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Cytoplasm and Cytosol
- Cytoplasm By similarity
Endoplasmic reticulum
- Microsome 1 Publication
- Endoplasmic reticulum 1 Publication
Note: Microsomal fraction.
Cytosol
- cytosol Source: HPA
Endoplasmic reticulum
- endoplasmic reticulum Source: HPA
Nucleus
- nucleoplasm Source: HPA
Other locations
- protein-containing complex Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, Endoplasmic reticulum, Microsome, NucleusPathology & Biotechi
Involvement in diseasei
Chromosomal aberrations activating TCL1A are found in chronic T-cell leukemias (T-CLL). Translocation t(14;14)(q11;q32); translocation t(7;14)(q35;q32); inversion inv(14)(q11;q32) that involves the T-cell receptor alpha/delta loci.
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 16 | D → G: Greatly reduced binding to AKT1, AKT2 and AKT3. Abolishes nuclear transport of AKT1. 1 Publication | 1 | |
Mutagenesisi | 30 | K → M: Slightly reduced binding to AKT2. 1 Publication | 1 | |
Mutagenesisi | 36 – 38 | PLT → AAA: Unable to homodimerize but has no effect on interaction with AKT1, AKT2 or AKT3. 1 Publication | 3 | |
Mutagenesisi | 46 | Q → R: Slightly increased binding to AKT2. 1 Publication | 1 | |
Mutagenesisi | 74 | I → V: Greatly reduced binding to AKT2. Abolishes nuclear transport of AKT1. 1 Publication | 1 | |
Mutagenesisi | 106 | M → V: Slightly increased binding to AKT2. 1 Publication | 1 |
Keywords - Diseasei
Proto-oncogeneOrganism-specific databases
DisGeNETi | 8115 |
MalaCardsi | TCL1A |
OpenTargetsi | ENSG00000100721 |
Orphaneti | 99861, Precursor T-cell acute lymphoblastic leukemia |
PharmGKBi | PA36400 |
Miscellaneous databases
Pharosi | P56279, Tbio |
Genetic variation databases
BioMutai | TCL1A |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000184488 | 1 – 114 | T-cell leukemia/lymphoma protein 1AAdd BLAST | 114 |
Proteomic databases
MassIVEi | P56279 |
MaxQBi | P56279 |
PaxDbi | P56279 |
PeptideAtlasi | P56279 |
PRIDEi | P56279 |
ProteomicsDBi | 56910 |
PTM databases
iPTMneti | P56279 |
PhosphoSitePlusi | P56279 |
Expressioni
Tissue specificityi
Restricted in the T-cell lineage to immature thymocytes and activated peripheral lymphocytes. Preferentially expressed early in T- and B-lymphocyte differentiation.
Gene expression databases
Bgeei | ENSG00000100721, Expressed in oocyte and 121 other tissues |
ExpressionAtlasi | P56279, baseline and differential |
Genevisiblei | P56279, HS |
Organism-specific databases
HPAi | ENSG00000100721, Tissue enriched (lymphoid) |
Interactioni
Subunit structurei
Homodimer.
Interacts with AKT1, AKT2 and AKT3 (via PH domain).
Interacts with PNPT1; the interaction has no effect on PNPT1 exonuclease activity.
5 PublicationsBinary interactionsi
P56279
GO - Molecular functioni
- identical protein binding Source: UniProtKB
- protein kinase binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 113783, 60 interactors |
CORUMi | P56279 |
DIPi | DIP-60787N |
IntActi | P56279, 42 interactors |
MINTi | P56279 |
STRINGi | 9606.ENSP00000385036 |
Miscellaneous databases
RNActi | P56279, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P56279 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P56279 |
Family & Domainsi
Sequence similaritiesi
Belongs to the TCL1 family.Curated
Phylogenomic databases
eggNOGi | ENOG502TDVJ, Eukaryota |
GeneTreei | ENSGT00390000006885 |
HOGENOMi | CLU_168379_0_1_1 |
InParanoidi | P56279 |
OMAi | PVMWQLY |
OrthoDBi | 1496659at2759 |
PhylomeDBi | P56279 |
TreeFami | TF337903 |
Family and domain databases
Gene3Di | 2.40.15.10, 1 hit |
InterProi | View protein in InterPro IPR004832, TCL1_MTCP1 IPR036672, TCL1_MTCP1_sf |
PANTHERi | PTHR14060, PTHR14060, 1 hit |
Pfami | View protein in Pfam PF01840, TCL1_MTCP1, 1 hit |
SUPFAMi | SSF50904, SSF50904, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
P56279-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAECPTLGEA VTDHPDRLWA WEKFVYLDEK QHAWLPLTIE IKDRLQLRVL
60 70 80 90 100
LRREDVVLGR PMTPTQIGPS LLPIMWQLYP DGRYRSSDSS FWRLVYHIKI
110
DGVEDMLLEL LPDD
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0YJR9 | H0YJR9_HUMAN | T-cell leukemia/lymphoma protein 1A | TCL1A | 53 | Annotation score: | ||
G3V4T4 | G3V4T4_HUMAN | T-cell leukemia/lymphoma protein 1A | TCL1A | 46 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 106 | M → V in CAG33077 (Ref. 2) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_053718 | 56 | V → I. Corresponds to variant dbSNP:rs17093294Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X82240 mRNA Translation: CAA57708.1 CR456796 mRNA Translation: CAG33077.1 BC003574 mRNA Translation: AAH03574.1 BC005831 mRNA Translation: AAH05831.1 BC014024 mRNA Translation: AAH14024.1 |
CCDSi | CCDS9941.1 |
PIRi | I38286 |
RefSeqi | NP_001092195.1, NM_001098725.1 NP_068801.1, NM_021966.2 XP_016877165.1, XM_017021676.1 XP_016877166.1, XM_017021677.1 |
Genome annotation databases
Ensembli | ENST00000402399; ENSP00000385036; ENSG00000100721 ENST00000554012; ENSP00000451506; ENSG00000100721 ENST00000555202; ENSP00000450496; ENSG00000100721 ENST00000556450; ENSP00000450701; ENSG00000100721 |
GeneIDi | 8115 |
KEGGi | hsa:8115 |
MANE-Selecti | ENST00000402399.6; ENSP00000385036.1; NM_021966.3; NP_068801.1 |
UCSCi | uc001yfb.5, human |
Keywords - Coding sequence diversityi
Chromosomal rearrangementSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X82240 mRNA Translation: CAA57708.1 CR456796 mRNA Translation: CAG33077.1 BC003574 mRNA Translation: AAH03574.1 BC005831 mRNA Translation: AAH05831.1 BC014024 mRNA Translation: AAH14024.1 |
CCDSi | CCDS9941.1 |
PIRi | I38286 |
RefSeqi | NP_001092195.1, NM_001098725.1 NP_068801.1, NM_021966.2 XP_016877165.1, XM_017021676.1 XP_016877166.1, XM_017021677.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1JSG | X-ray | 2.50 | A | 1-114 | [»] | |
SMRi | P56279 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 113783, 60 interactors |
CORUMi | P56279 |
DIPi | DIP-60787N |
IntActi | P56279, 42 interactors |
MINTi | P56279 |
STRINGi | 9606.ENSP00000385036 |
PTM databases
iPTMneti | P56279 |
PhosphoSitePlusi | P56279 |
Genetic variation databases
BioMutai | TCL1A |
Proteomic databases
MassIVEi | P56279 |
MaxQBi | P56279 |
PaxDbi | P56279 |
PeptideAtlasi | P56279 |
PRIDEi | P56279 |
ProteomicsDBi | 56910 |
Protocols and materials databases
Antibodypediai | 65, 422 antibodies from 40 providers |
DNASUi | 8115 |
Genome annotation databases
Ensembli | ENST00000402399; ENSP00000385036; ENSG00000100721 ENST00000554012; ENSP00000451506; ENSG00000100721 ENST00000555202; ENSP00000450496; ENSG00000100721 ENST00000556450; ENSP00000450701; ENSG00000100721 |
GeneIDi | 8115 |
KEGGi | hsa:8115 |
MANE-Selecti | ENST00000402399.6; ENSP00000385036.1; NM_021966.3; NP_068801.1 |
UCSCi | uc001yfb.5, human |
Organism-specific databases
CTDi | 8115 |
DisGeNETi | 8115 |
GeneCardsi | TCL1A |
HGNCi | HGNC:11648, TCL1A |
HPAi | ENSG00000100721, Tissue enriched (lymphoid) |
MalaCardsi | TCL1A |
MIMi | 186960, gene |
neXtProti | NX_P56279 |
OpenTargetsi | ENSG00000100721 |
Orphaneti | 99861, Precursor T-cell acute lymphoblastic leukemia |
PharmGKBi | PA36400 |
VEuPathDBi | HostDB:ENSG00000100721 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502TDVJ, Eukaryota |
GeneTreei | ENSGT00390000006885 |
HOGENOMi | CLU_168379_0_1_1 |
InParanoidi | P56279 |
OMAi | PVMWQLY |
OrthoDBi | 1496659at2759 |
PhylomeDBi | P56279 |
TreeFami | TF337903 |
Enzyme and pathway databases
PathwayCommonsi | P56279 |
SignaLinki | P56279 |
SIGNORi | P56279 |
Miscellaneous databases
BioGRID-ORCSi | 8115, 3 hits in 1037 CRISPR screens |
ChiTaRSi | TCL1A, human |
EvolutionaryTracei | P56279 |
GeneWikii | TCL1A |
GenomeRNAii | 8115 |
Pharosi | P56279, Tbio |
PROi | PR:P56279 |
RNActi | P56279, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000100721, Expressed in oocyte and 121 other tissues |
ExpressionAtlasi | P56279, baseline and differential |
Genevisiblei | P56279, HS |
Family and domain databases
Gene3Di | 2.40.15.10, 1 hit |
InterProi | View protein in InterPro IPR004832, TCL1_MTCP1 IPR036672, TCL1_MTCP1_sf |
PANTHERi | PTHR14060, PTHR14060, 1 hit |
Pfami | View protein in Pfam PF01840, TCL1_MTCP1, 1 hit |
SUPFAMi | SSF50904, SSF50904, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TCL1A_HUMAN | |
Accessioni | P56279Primary (citable) accession number: P56279 Secondary accession number(s): Q6IBK7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | July 15, 1998 | |
Last modified: | February 23, 2022 | |
This is version 190 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families