UniProtKB - P56270 (MAZ_HUMAN)
Myc-associated zinc finger protein
MAZ
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 190 – 212 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 279 – 301 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 307 – 329 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 337 – 360 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 366 – 388 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 392 – 413 | C2H2-type 6; atypicalPROSITE-ProRule annotationAdd BLAST | 22 |
GO - Molecular functioni
- DNA-binding transcription factor activity Source: GO_Central
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: ARUK-UCL
- metal ion binding Source: UniProtKB-KW
- RNA binding Source: UniProtKB
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: UniProtKB
GO - Biological processi
- negative regulation of apoptotic signaling pathway Source: ARUK-UCL
- negative regulation of transcription by RNA polymerase II Source: UniProtKB
- positive regulation of cell migration Source: ARUK-UCL
- positive regulation of cell population proliferation Source: ARUK-UCL
- positive regulation of gene expression Source: ARUK-UCL
- positive regulation of phosphatidylinositol 3-kinase signaling Source: ARUK-UCL
- positive regulation of protein kinase B signaling Source: ARUK-UCL
- positive regulation of transcription, DNA-templated Source: ARUK-UCL
- regulation of transcription by RNA polymerase II Source: GO_Central
- termination of RNA polymerase II transcription Source: UniProtKB
- transcription initiation from RNA polymerase II promoter Source: UniProtKB
Keywordsi
Molecular function | DNA-binding, RNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | P56270 |
SignaLinki | P56270 |
SIGNORi | P56270 |
Names & Taxonomyi
Protein namesi | Recommended name: Myc-associated zinc finger proteinShort name: MAZI Alternative name(s): Pur-1 Purine-binding transcription factor Serum amyloid A-activating factor-1 Short name: SAF-1 Transcription factor Zif87 ZF87 Zinc finger protein 801 |
Gene namesi | Name:MAZ Synonyms:ZNF801 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6914, MAZ |
MIMi | 600999, gene |
neXtProti | NX_P56270 |
VEuPathDBi | HostDB:ENSG00000103495.13 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Note: In brains of Alzheimer disease patients, present in a plaque-like structures.
Nucleus
- nucleus Source: UniProtKB
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 4150 |
OpenTargetsi | ENSG00000103495 |
PharmGKBi | PA30657 |
Miscellaneous databases
Pharosi | P56270, Tbio |
Genetic variation databases
BioMutai | MAZ |
DMDMi | 3024110 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047215 | 1 – 477 | Myc-associated zinc finger proteinAdd BLAST | 477 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 361 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | P56270 |
MassIVEi | P56270 |
MaxQBi | P56270 |
PaxDbi | P56270 |
PeptideAtlasi | P56270 |
PRIDEi | P56270 |
ProteomicsDBi | 33810 41756 56907 [P56270-1] 7603 |
PTM databases
iPTMneti | P56270 |
PhosphoSitePlusi | P56270 |
SwissPalmi | P56270 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000103495, Expressed in ventricular zone and 249 other tissues |
ExpressionAtlasi | P56270, baseline and differential |
Genevisiblei | P56270, HS |
Organism-specific databases
HPAi | ENSG00000103495, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with BPTF.
1 PublicationForms a heterodimer with MAZ isoform 2; the interaction inhibits MAZ isoform 1-mediated transcription activation.
1 PublicationForms a heterodimer with MAZ isoform 1; the interaction inhibits MAZ isoform 1-mediated transcription activation.
1 PublicationBinary interactionsi
Hide detailsP56270
With | #Exp. | IntAct |
---|---|---|
DCC [P43146] | 4 | EBI-1809742,EBI-1222919 |
Dcc [P70211] from Mus musculus. | 2 | EBI-1809742,EBI-1798863 |
dcc.L [Q91562] from Xenopus laevis. | 2 | EBI-1809742,EBI-1809954 |
Isoform 2 [P56270-2]
With | #Exp. | IntAct |
---|---|---|
HTT [P42858] | 3 | EBI-12068586,EBI-466029 |
KRTAP10-9 [P60411] | 3 | EBI-12068586,EBI-10172052 |
PICK1 [Q9NRD5] | 3 | EBI-12068586,EBI-79165 |
Protein-protein interaction databases
BioGRIDi | 110320, 39 interactors |
CORUMi | P56270 |
IntActi | P56270, 27 interactors |
MINTi | P56270 |
STRINGi | 9606.ENSP00000219782 |
Miscellaneous databases
RNActi | P56270, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 96 – 108 | Poly-AlaAdd BLAST | 13 | |
Compositional biasi | 133 – 139 | Poly-Pro | 7 | |
Compositional biasi | 157 – 161 | Poly-Ala | 5 | |
Compositional biasi | 245 – 249 | Poly-Gly | 5 | |
Compositional biasi | 435 – 449 | Poly-AlaAdd BLAST | 15 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 190 – 212 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 279 – 301 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 307 – 329 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 337 – 360 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 366 – 388 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 392 – 413 | C2H2-type 6; atypicalPROSITE-ProRule annotationAdd BLAST | 22 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000158525 |
HOGENOMi | CLU_042232_0_0_1 |
InParanoidi | P56270 |
OrthoDBi | 1318335at2759 |
PhylomeDBi | P56270 |
TreeFami | TF331686 |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 2 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 6 hits |
SUPFAMi | SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 5 hits PS50157, ZINC_FINGER_C2H2_2, 5 hits |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MFPVFPCTLL APPFPVLGLD SRGVGGLMNS FPPPQGHAQN PLQVGAELQS
60 70 80 90 100
RFFASQGCAQ SPFQAAPAPP PTPQAPAAEP LQVDLLPVLA AAQESAAAAA
110 120 130 140 150
AAAAAAAAVA AAPPAPAAAS TVDTAALKQP PAPPPPPPPV SAPAAEAAPP
160 170 180 190 200
ASAATIAAAA ATAVVAPTST VAVAPVASAL EKKTKSKGPY ICALCAKEFK
210 220 230 240 250
NGYNLRRHEA IHTGAKAGRV PSGAMKMPTM VPLSLLSVPQ LSGAGGGGGE
260 270 280 290 300
AGAGGGAAAV AAGGVVTTTA SGKRIRKNHA CEMCGKAFRD VYHLNRHKLS
310 320 330 340 350
HSDEKPYQCP VCQQRFKRKD RMSYHVRSHD GAVHKPYNCS HCGKSFSRPD
360 370 380 390 400
HLNSHVRQVH STERPFKCEK CEAAFATKDR LRAHTVRHEE KVPCHVCGKM
410 420 430 440 450
LSSAYISDHM KVHSQGPHHV CELCNKGTGE VCPMAAAAAA AAAAAAAAVA
460 470
APPTAVGSLS GAEGVPVSSQ PLPSQPW
The sequence of this isoform differs from the canonical sequence as follows:
428-477: TGEVCPMAAA...SSQPLPSQPW → FTTAAYLRIH...GDAPQPQPTC
The sequence of this isoform differs from the canonical sequence as follows:
1-34: MFPVFPCTLLAPPFPVLGLDSRGVGGLMNSFPPP → MDPSNWSSFIF
Computationally mapped potential isoform sequencesi
There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH3BTS8 | H3BTS8_HUMAN | Myc-associated zinc finger protein | MAZ | 186 | Annotation score: | ||
A0A087WWR2 | A0A087WWR2_HUMAN | Myc-associated zinc finger protein | MAZ | 252 | Annotation score: | ||
I3L0M3 | I3L0M3_HUMAN | MYC-associated zinc finger protein ... | MAZ hCG_2039830 | 94 | Annotation score: | ||
H3BQS2 | H3BQS2_HUMAN | Myc-associated zinc finger protein | MAZ | 152 | Annotation score: | ||
H3BPU3 | H3BPU3_HUMAN | MYC-associated zinc finger protein ... | MAZ hCG_2039830 | 78 | Annotation score: | ||
H3BRC5 | H3BRC5_HUMAN | Myc-associated zinc finger protein | MAZ | 84 | Annotation score: | ||
I3L2Z5 | I3L2Z5_HUMAN | Myc-associated zinc finger protein | MAZ | 202 | Annotation score: | ||
H3BQI4 | H3BQI4_HUMAN | Myc-associated zinc finger protein | MAZ | 196 | Annotation score: | ||
I3L4Y2 | I3L4Y2_HUMAN | Myc-associated zinc finger protein | MAZ | 78 | Annotation score: | ||
I3L411 | I3L411_HUMAN | Myc-associated zinc finger protein | MAZ | 53 | Annotation score: | ||
There is more potential isoformShow all |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 259 | Missing in BAA12728 (PubMed:8831693).Curated | 1 | |
Sequence conflicti | 389 | E → K in AAN03800 (PubMed:12270922).Curated | 1 | |
Sequence conflicti | 395 – 396 | HV → PW in AAN03800 (PubMed:12270922).Curated | 2 | |
Sequence conflicti | 401 | L → M (PubMed:1567856).Curated | 1 | |
Sequence conflicti | 401 | L → M (PubMed:8626793).Curated | 1 | |
Sequence conflicti | 443 – 447 | Missing (PubMed:8831693).Curated | 5 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_047560 | 1 – 34 | MFPVF…SFPPP → MDPSNWSSFIF in isoform 3. 1 PublicationAdd BLAST | 34 | |
Alternative sequenceiVSP_055108 | 65 – 369 | Missing in isoform 4. CuratedAdd BLAST | 305 | |
Alternative sequenceiVSP_044561 | 428 – 477 | TGEVC…PSQPW → FTTAAYLRIHAVKDHGLQAP RADRILCKLCSVHCKTPAQL AGHMQTHLGGAAPPVPGDAP QPQPTC in isoform 2. 1 PublicationAdd BLAST | 50 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M94046 mRNA No translation available. M93339 mRNA No translation available. D85131 mRNA Translation: BAA12728.1 Different initiation. U33819 mRNA Translation: AAB04121.1 Different initiation. AB017335 Genomic DNA Translation: BAA33064.1 AF489858 mRNA Translation: AAN03800.1 EF059746 mRNA Translation: ABN80996.1 FJ532357 mRNA Translation: ACS26236.1 AC009133 Genomic DNA No translation available. CH471238 Genomic DNA Translation: EAW79996.1 CH471238 Genomic DNA Translation: EAW79997.1 |
CCDSi | CCDS42143.1 [P56270-1] CCDS42144.1 [P56270-2] CCDS61902.1 [P56270-3] CCDS61903.1 [P56270-4] |
PIRi | A42170 JC5076 |
RefSeqi | NP_001036004.1, NM_001042539.2 [P56270-2] NP_001263204.1, NM_001276275.1 [P56270-3] NP_001263205.1, NM_001276276.1 [P56270-4] NP_002374.2, NM_002383.3 [P56270-1] |
Genome annotation databases
Ensembli | ENST00000219782; ENSP00000219782; ENSG00000103495 [P56270-2] ENST00000322945; ENSP00000313362; ENSG00000103495 [P56270-1] ENST00000545521; ENSP00000443956; ENSG00000103495 [P56270-3] ENST00000562337; ENSP00000455726; ENSG00000103495 [P56270-4] |
GeneIDi | 4150 |
KEGGi | hsa:4150 |
UCSCi | uc002dtx.5, human [P56270-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M94046 mRNA No translation available. M93339 mRNA No translation available. D85131 mRNA Translation: BAA12728.1 Different initiation. U33819 mRNA Translation: AAB04121.1 Different initiation. AB017335 Genomic DNA Translation: BAA33064.1 AF489858 mRNA Translation: AAN03800.1 EF059746 mRNA Translation: ABN80996.1 FJ532357 mRNA Translation: ACS26236.1 AC009133 Genomic DNA No translation available. CH471238 Genomic DNA Translation: EAW79996.1 CH471238 Genomic DNA Translation: EAW79997.1 |
CCDSi | CCDS42143.1 [P56270-1] CCDS42144.1 [P56270-2] CCDS61902.1 [P56270-3] CCDS61903.1 [P56270-4] |
PIRi | A42170 JC5076 |
RefSeqi | NP_001036004.1, NM_001042539.2 [P56270-2] NP_001263204.1, NM_001276275.1 [P56270-3] NP_001263205.1, NM_001276276.1 [P56270-4] NP_002374.2, NM_002383.3 [P56270-1] |
3D structure databases
SMRi | P56270 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 110320, 39 interactors |
CORUMi | P56270 |
IntActi | P56270, 27 interactors |
MINTi | P56270 |
STRINGi | 9606.ENSP00000219782 |
PTM databases
iPTMneti | P56270 |
PhosphoSitePlusi | P56270 |
SwissPalmi | P56270 |
Genetic variation databases
BioMutai | MAZ |
DMDMi | 3024110 |
Proteomic databases
jPOSTi | P56270 |
MassIVEi | P56270 |
MaxQBi | P56270 |
PaxDbi | P56270 |
PeptideAtlasi | P56270 |
PRIDEi | P56270 |
ProteomicsDBi | 33810 41756 56907 [P56270-1] 7603 |
Protocols and materials databases
Antibodypediai | 26824, 305 antibodies |
Genome annotation databases
Ensembli | ENST00000219782; ENSP00000219782; ENSG00000103495 [P56270-2] ENST00000322945; ENSP00000313362; ENSG00000103495 [P56270-1] ENST00000545521; ENSP00000443956; ENSG00000103495 [P56270-3] ENST00000562337; ENSP00000455726; ENSG00000103495 [P56270-4] |
GeneIDi | 4150 |
KEGGi | hsa:4150 |
UCSCi | uc002dtx.5, human [P56270-1] |
Organism-specific databases
CTDi | 4150 |
DisGeNETi | 4150 |
GeneCardsi | MAZ |
HGNCi | HGNC:6914, MAZ |
HPAi | ENSG00000103495, Low tissue specificity |
MIMi | 600999, gene |
neXtProti | NX_P56270 |
OpenTargetsi | ENSG00000103495 |
PharmGKBi | PA30657 |
VEuPathDBi | HostDB:ENSG00000103495.13 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000158525 |
HOGENOMi | CLU_042232_0_0_1 |
InParanoidi | P56270 |
OrthoDBi | 1318335at2759 |
PhylomeDBi | P56270 |
TreeFami | TF331686 |
Enzyme and pathway databases
PathwayCommonsi | P56270 |
SignaLinki | P56270 |
SIGNORi | P56270 |
Miscellaneous databases
BioGRID-ORCSi | 4150, 24 hits in 1018 CRISPR screens |
ChiTaRSi | MAZ, human |
GeneWikii | MAZ_(gene) |
GenomeRNAii | 4150 |
Pharosi | P56270, Tbio |
PROi | PR:P56270 |
RNActi | P56270, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000103495, Expressed in ventricular zone and 249 other tissues |
ExpressionAtlasi | P56270, baseline and differential |
Genevisiblei | P56270, HS |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 2 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 6 hits |
SUPFAMi | SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 5 hits PS50157, ZINC_FINGER_C2H2_2, 5 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MAZ_HUMAN | |
Accessioni | P56270Primary (citable) accession number: P56270 Secondary accession number(s): A8QJL9 Q99443 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | July 15, 1998 | |
Last modified: | April 7, 2021 | |
This is version 185 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot