Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - P56270 (MAZ_HUMAN)

Entry version 179 (22 Apr 2020)
Sequence version 1 (15 Jul 1998)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Myc-associated zinc finger protein

Gene

MAZ

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May function as a transcription factor with dual roles in transcription initiation and termination. Binds to two sites, ME1a1 and ME1a2, within the MYC promoter having greater affinity for the former. Also binds to multiple G/C-rich sites within the promoter of the Sp1 family of transcription factors. Regulates inflammation-induced expression of serum amyloid A proteins.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri190 – 212C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri279 – 301C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri307 – 329C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri337 – 360C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri366 – 388C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri392 – 413C2H2-type 6; atypicalPROSITE-ProRule annotationAdd BLAST22

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, RNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P56270

SIGNOR Signaling Network Open Resource

More...SIGNORi		P56270

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Myc-associated zinc finger protein
Short name:
MAZI
Alternative name(s):
Pur-1
Purine-binding transcription factor
Serum amyloid A-activating factor-1
Short name:
SAF-1
Transcription factor Zif87
ZF87
Zinc finger protein 801
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MAZ
Synonyms:ZNF801
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:6914 MAZ

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		600999 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P56270

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		4150

Open Targets

More...OpenTargetsi		ENSG00000103495

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA30657

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P56270 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		MAZ

Domain mapping of disease mutations (DMDM)

More...DMDMi		3024110

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000472151 – 477Myc-associated zinc finger proteinAdd BLAST477

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei361PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P56270

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P56270

MaxQB - The MaxQuant DataBase

More...MaxQBi		P56270

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P56270

PeptideAtlas

More...PeptideAtlasi		P56270

PRoteomics IDEntifications database

More...PRIDEi		P56270

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		33810
41756
56907 [P56270-1]
7603

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P56270

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P56270

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P56270

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Present in kidney, liver and brain. In the brain, highest levels are found in motor cortex and midfrontal cortex (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000103495 Expressed in vagina and 235 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P56270 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P56270 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000103495 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with BPTF.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		110320, 24 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P56270

Protein interaction database and analysis system

More...IntActi		P56270, 24 interactors

Molecular INTeraction database

More...MINTi		P56270

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000219782

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P56270 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P56270

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi96 – 108Poly-AlaAdd BLAST13
Compositional biasi133 – 139Poly-Pro7
Compositional biasi157 – 161Poly-Ala5
Compositional biasi245 – 249Poly-Gly5
Compositional biasi435 – 449Poly-AlaAdd BLAST15

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri190 – 212C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri279 – 301C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri307 – 329C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri337 – 360C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri366 – 388C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri392 – 413C2H2-type 6; atypicalPROSITE-ProRule annotationAdd BLAST22

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158525

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_042232_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P56270

Database of Orthologous Groups

More...OrthoDBi		1318335at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P56270

TreeFam database of animal gene trees

More...TreeFami		TF331686

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00096 zf-C2H2, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00355 ZnF_C2H2, 6 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF57667 SSF57667, 3 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 5 hits
PS50157 ZINC_FINGER_C2H2_2, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P56270-1) [UniParc]FASTAAdd to basket
Also known as: SAF-1

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFPVFPCTLL APPFPVLGLD SRGVGGLMNS FPPPQGHAQN PLQVGAELQS 
        60         70         80         90        100
RFFASQGCAQ SPFQAAPAPP PTPQAPAAEP LQVDLLPVLA AAQESAAAAA 
       110        120        130        140        150
AAAAAAAAVA AAPPAPAAAS TVDTAALKQP PAPPPPPPPV SAPAAEAAPP 
       160        170        180        190        200
ASAATIAAAA ATAVVAPTST VAVAPVASAL EKKTKSKGPY ICALCAKEFK 
       210        220        230        240        250
NGYNLRRHEA IHTGAKAGRV PSGAMKMPTM VPLSLLSVPQ LSGAGGGGGE 
       260        270        280        290        300
AGAGGGAAAV AAGGVVTTTA SGKRIRKNHA CEMCGKAFRD VYHLNRHKLS 
       310        320        330        340        350
HSDEKPYQCP VCQQRFKRKD RMSYHVRSHD GAVHKPYNCS HCGKSFSRPD 
       360        370        380        390        400
HLNSHVRQVH STERPFKCEK CEAAFATKDR LRAHTVRHEE KVPCHVCGKM 
       410        420        430        440        450
LSSAYISDHM KVHSQGPHHV CELCNKGTGE VCPMAAAAAA AAAAAAAAVA 
       460        470 
APPTAVGSLS GAEGVPVSSQ PLPSQPW
Length:477
Mass (Da):48,608
Last modified:July 15, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC04C80F32C3C6825
GO
Isoform 2 (identifier: P56270-2) [UniParc]FASTAAdd to basket
Also known as: SAF-2

The sequence of this isoform differs from the canonical sequence as follows:
     428-477: TGEVCPMAAA...SSQPLPSQPW → FTTAAYLRIH...GDAPQPQPTC

Note: May act as a dominant negative of isoform 1. Reduced expression during inflammatory conditions.Curated
Show »
Length:493
Mass (Da):51,073
Checksum:iAEC386D7CC718E50
GO
Isoform 3 (identifier: P56270-3) [UniParc]FASTAAdd to basket
Also known as: SAF-3

The sequence of this isoform differs from the canonical sequence as follows:
     1-34: MFPVFPCTLLAPPFPVLGLDSRGVGGLMNSFPPP → MDPSNWSSFIF

Note: Very low expression in normal tissues, but high expression during inflammation. The transactivation potential of SAF-3 is much greater than that of the predominantly expressed form 1.Curated
Show »
Length:454
Mass (Da):46,366
Checksum:i4DD5531A4AD4846D
GO
Isoform 4 (identifier: P56270-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     65-369: Missing.

Show »
Length:172
Mass (Da):17,763
Checksum:iC972B7CF156DA9EB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WWR2A0A087WWR2_HUMAN
Myc-associated zinc finger protein
MAZ
252Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BTS8H3BTS8_HUMAN
Myc-associated zinc finger protein
MAZ
186Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BQS2H3BQS2_HUMAN
Myc-associated zinc finger protein
MAZ
152Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L0M3I3L0M3_HUMAN
MYC-associated zinc finger protein ...
MAZ hCG_2039830
94Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L2Z5I3L2Z5_HUMAN
Myc-associated zinc finger protein
MAZ
202Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BQI4H3BQI4_HUMAN
Myc-associated zinc finger protein
MAZ
196Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L4Y2I3L4Y2_HUMAN
Myc-associated zinc finger protein
MAZ
78Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BRC5H3BRC5_HUMAN
Myc-associated zinc finger protein
MAZ
84Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BPU3H3BPU3_HUMAN
MYC-associated zinc finger protein ...
MAZ hCG_2039830
78Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L411I3L411_HUMAN
Myc-associated zinc finger protein
MAZ
53Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There is more potential isoformShow all

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB04121 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA12728 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti259Missing in BAA12728 (PubMed:8831693).Curated1
Sequence conflicti389E → K in AAN03800 (PubMed:12270922).Curated1
Sequence conflicti395 – 396HV → PW in AAN03800 (PubMed:12270922).Curated2
Sequence conflicti401L → M (PubMed:1567856).Curated1
Sequence conflicti401L → M (PubMed:8626793).Curated1
Sequence conflicti443 – 447Missing (PubMed:8831693).Curated5

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0475601 – 34MFPVF…SFPPP → MDPSNWSSFIF in isoform 3. 1 PublicationAdd BLAST34
Alternative sequenceiVSP_05510865 – 369Missing in isoform 4. CuratedAdd BLAST305
Alternative sequenceiVSP_044561428 – 477TGEVC…PSQPW → FTTAAYLRIHAVKDHGLQAP RADRILCKLCSVHCKTPAQL AGHMQTHLGGAAPPVPGDAP QPQPTC in isoform 2. 1 PublicationAdd BLAST50

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M94046 mRNA No translation available.
M93339 mRNA No translation available.
D85131 mRNA Translation: BAA12728.1 Different initiation.
U33819 mRNA Translation: AAB04121.1 Different initiation.
AB017335 Genomic DNA Translation: BAA33064.1
AF489858 mRNA Translation: AAN03800.1
EF059746 mRNA Translation: ABN80996.1
FJ532357 mRNA Translation: ACS26236.1
AC009133 Genomic DNA No translation available.
CH471238 Genomic DNA Translation: EAW79996.1
CH471238 Genomic DNA Translation: EAW79997.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS42143.1 [P56270-1]
CCDS42144.1 [P56270-2]
CCDS61902.1 [P56270-3]
CCDS61903.1 [P56270-4]

Protein sequence database of the Protein Information Resource

More...PIRi		A42170
JC5076

NCBI Reference Sequences

More...RefSeqi		NP_001036004.1, NM_001042539.2 [P56270-2]
NP_001263204.1, NM_001276275.1 [P56270-3]
NP_001263205.1, NM_001276276.1 [P56270-4]
NP_002374.2, NM_002383.3 [P56270-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000219782; ENSP00000219782; ENSG00000103495 [P56270-2]
ENST00000322945; ENSP00000313362; ENSG00000103495 [P56270-1]
ENST00000545521; ENSP00000443956; ENSG00000103495 [P56270-3]
ENST00000562337; ENSP00000455726; ENSG00000103495 [P56270-4]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		4150

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:4150

UCSC genome browser

More...UCSCi		uc002dtx.5 human [P56270-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M94046 mRNA No translation available.
M93339 mRNA No translation available.
D85131 mRNA Translation: BAA12728.1 Different initiation.
U33819 mRNA Translation: AAB04121.1 Different initiation.
AB017335 Genomic DNA Translation: BAA33064.1
AF489858 mRNA Translation: AAN03800.1
EF059746 mRNA Translation: ABN80996.1
FJ532357 mRNA Translation: ACS26236.1
AC009133 Genomic DNA No translation available.
CH471238 Genomic DNA Translation: EAW79996.1
CH471238 Genomic DNA Translation: EAW79997.1
CCDSiCCDS42143.1 [P56270-1]
CCDS42144.1 [P56270-2]
CCDS61902.1 [P56270-3]
CCDS61903.1 [P56270-4]
PIRiA42170
JC5076
RefSeqiNP_001036004.1, NM_001042539.2 [P56270-2]
NP_001263204.1, NM_001276275.1 [P56270-3]
NP_001263205.1, NM_001276276.1 [P56270-4]
NP_002374.2, NM_002383.3 [P56270-1]

3D structure databases

SMRiP56270
ModBaseiSearch...

Protein-protein interaction databases

BioGridi110320, 24 interactors
CORUMiP56270
IntActiP56270, 24 interactors
MINTiP56270
STRINGi9606.ENSP00000219782

PTM databases

iPTMnetiP56270
PhosphoSitePlusiP56270
SwissPalmiP56270

Polymorphism and mutation databases

BioMutaiMAZ
DMDMi3024110

Proteomic databases

jPOSTiP56270
MassIVEiP56270
MaxQBiP56270
PaxDbiP56270
PeptideAtlasiP56270
PRIDEiP56270
ProteomicsDBi33810
41756
56907 [P56270-1]
7603

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		26824 292 antibodies

Genome annotation databases

EnsembliENST00000219782; ENSP00000219782; ENSG00000103495 [P56270-2]
ENST00000322945; ENSP00000313362; ENSG00000103495 [P56270-1]
ENST00000545521; ENSP00000443956; ENSG00000103495 [P56270-3]
ENST00000562337; ENSP00000455726; ENSG00000103495 [P56270-4]
GeneIDi4150
KEGGihsa:4150
UCSCiuc002dtx.5 human [P56270-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		4150
DisGeNETi4150

GeneCards: human genes, protein and diseases

More...GeneCardsi		MAZ
HGNCiHGNC:6914 MAZ
HPAiENSG00000103495 Low tissue specificity
MIMi600999 gene
neXtProtiNX_P56270
OpenTargetsiENSG00000103495
PharmGKBiPA30657

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000158525
HOGENOMiCLU_042232_0_0_1
InParanoidiP56270
OrthoDBi1318335at2759
PhylomeDBiP56270
TreeFamiTF331686

Enzyme and pathway databases

SignaLinkiP56270
SIGNORiP56270

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		MAZ human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		MAZ_(gene)

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		4150
PharosiP56270 Tbio

Protein Ontology

More...PROi		PR:P56270
RNActiP56270 protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000103495 Expressed in vagina and 235 other tissues
ExpressionAtlasiP56270 baseline and differential
GenevisibleiP56270 HS

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 2 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 6 hits
SUPFAMiSSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 5 hits
PS50157 ZINC_FINGER_C2H2_2, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMAZ_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P56270
Secondary accession number(s): A8QJL9
, C6G496, G5E927, H3BQD6, Q15703, Q8NFN7, Q99443
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: April 22, 2020
This is version 179 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again