UniProtKB - P56223 (PO6F1_RAT)
Protein
POU domain, class 6, transcription factor 1
Gene
Pou6f1
Organism
Rattus norvegicus (Rat)
Status
Functioni
Transcription factor that binds preferentially to a variant of the octamer motif (5'-ATGATAAT-3').
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 234 – 293 | HomeoboxPROSITE-ProRule annotationAdd BLAST | 60 |
GO - Molecular functioni
- DNA binding Source: RGD
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: RGD
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: RGD
- sequence-specific DNA binding Source: RGD
- sequence-specific double-stranded DNA binding Source: RGD
GO - Biological processi
- negative regulation of transcription by RNA polymerase II Source: RGD
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: POU domain, class 6, transcription factor 1Alternative name(s): Brain-specific homeobox/POU domain protein 5 Short name: Brain-5 Short name: Brn-5 |
Gene namesi | Name:Pou6f1 Synonyms:Brn5 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 620615, Pou6f1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000100761 | 1 – 301 | POU domain, class 6, transcription factor 1Add BLAST | 301 |
Proteomic databases
PaxDbi | P56223 |
PRIDEi | P56223 |
Expressioni
Tissue specificityi
In the embryo, widely expressed, with highest levels in the developing brain and spinal cord. In the adult, mostly found in the brain, where it is diffusely expressed with the exception of an enrichment in layer IV of the neocortex. Also found in kidney, lung, heart, adrenal, skin, and placenta. Low levels in spleen, muscle, liver, anterior pituitary, testis and ovary.
Gene expression databases
Bgeei | ENSRNOG00000004595, Expressed in frontal cortex and 21 other tissues |
Genevisiblei | P56223, RN |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 11 – 17 | 1 | 7 | |
Repeati | 50 – 56 | 2 | 7 | |
Domaini | 139 – 213 | POU-specificPROSITE-ProRule annotationAdd BLAST | 75 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 11 – 56 | 2 X 7 AA repeats of N-A-Q-G-Q-V-IAdd BLAST | 46 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 139 | Gln/Pro-richAdd BLAST | 139 |
Domaini
Contains two direct repeats of 7 amino acids in the N-terminus.
Sequence similaritiesi
Keywords - Domaini
Homeobox, RepeatPhylogenomic databases
eggNOGi | KOG3802, Eukaryota |
GeneTreei | ENSGT00940000160106 |
HOGENOMi | CLU_013065_6_0_1 |
InParanoidi | P56223 |
OMAi | FNTQGQI |
OrthoDBi | 474850at2759 |
PhylomeDBi | P56223 |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
Gene3Di | 1.10.260.40, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR001356, Homeobox_dom IPR010982, Lambda_DNA-bd_dom_sf IPR013847, POU IPR000327, POU_dom |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit PF00157, Pou, 1 hit |
PRINTSi | PR00028, POUDOMAIN |
SMARTi | View protein in SMART SM00389, HOX, 1 hit SM00352, POU, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit SSF47413, SSF47413, 1 hit |
PROSITEi | View protein in PROSITE PS50071, HOMEOBOX_2, 1 hit PS00035, POU_1, 1 hit PS00465, POU_2, 1 hit PS51179, POU_3, 1 hit |
i Sequence
Sequence statusi: Complete.
P56223-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPGISSPILT NAQGQVIGAL PWVVNSASVA TPAPAQSLQV QAVTPQLLLN
60 70 80 90 100
AQGQVIATLA SSPLPQPVAV RKPSTPESPA KSEVQPIQPT QAVPPPAVIL
110 120 130 140 150
TSPAPALKPS ASAPIPITCS ETPTVSQLVS KPHTPSLDED GINLEEIREF
160 170 180 190 200
AKNFKIRRLS LGLTQTQVGQ ALTATEGPAY SQSAICRFEK LDITPKSAQK
210 220 230 240 250
LKPVLEKWLN EAELRNQEGQ QNLMEFVGGE PSKKRKRRTS FTPQAIEALN
260 270 280 290 300
AYFEKNPLPT GQEITEIAKE LNYDREVVRV WFCNRRQTLK NTSKLNVFQI
P
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L23204 mRNA No translation available. |
PIRi | A48880 |
RefSeqi | NP_001099216.1, NM_001105746.1 XP_017450058.1, XM_017594569.1 XP_017450059.1, XM_017594570.1 XP_017450060.1, XM_017594571.1 |
Genome annotation databases
Ensembli | ENSRNOT00000006095; ENSRNOP00000006095; ENSRNOG00000004595 |
GeneIDi | 116545 |
KEGGi | rno:116545 |
UCSCi | RGD:620615, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L23204 mRNA No translation available. |
PIRi | A48880 |
RefSeqi | NP_001099216.1, NM_001105746.1 XP_017450058.1, XM_017594569.1 XP_017450059.1, XM_017594570.1 XP_017450060.1, XM_017594571.1 |
3D structure databases
SMRi | P56223 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000006095 |
Proteomic databases
PaxDbi | P56223 |
PRIDEi | P56223 |
Genome annotation databases
Ensembli | ENSRNOT00000006095; ENSRNOP00000006095; ENSRNOG00000004595 |
GeneIDi | 116545 |
KEGGi | rno:116545 |
UCSCi | RGD:620615, rat |
Organism-specific databases
CTDi | 5463 |
RGDi | 620615, Pou6f1 |
Phylogenomic databases
eggNOGi | KOG3802, Eukaryota |
GeneTreei | ENSGT00940000160106 |
HOGENOMi | CLU_013065_6_0_1 |
InParanoidi | P56223 |
OMAi | FNTQGQI |
OrthoDBi | 474850at2759 |
PhylomeDBi | P56223 |
Miscellaneous databases
PROi | PR:P56223 |
Gene expression databases
Bgeei | ENSRNOG00000004595, Expressed in frontal cortex and 21 other tissues |
Genevisiblei | P56223, RN |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
Gene3Di | 1.10.260.40, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR001356, Homeobox_dom IPR010982, Lambda_DNA-bd_dom_sf IPR013847, POU IPR000327, POU_dom |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit PF00157, Pou, 1 hit |
PRINTSi | PR00028, POUDOMAIN |
SMARTi | View protein in SMART SM00389, HOX, 1 hit SM00352, POU, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit SSF47413, SSF47413, 1 hit |
PROSITEi | View protein in PROSITE PS50071, HOMEOBOX_2, 1 hit PS00035, POU_1, 1 hit PS00465, POU_2, 1 hit PS51179, POU_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PO6F1_RAT | |
Accessioni | P56223Primary (citable) accession number: P56223 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | July 15, 1998 | |
Last modified: | April 7, 2021 | |
This is version 153 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families