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Protein

cAMP-regulated phosphoprotein 19

Gene

Arpp19

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. May indirectly enhance GAP-43 expression by binding to the NGF-regulatory region of its mRNA (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionProtein phosphatase inhibitor
Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

ReactomeiR-MMU-2465910 MASTL Facilitates Mitotic Progression

Names & Taxonomyi

Protein namesi
Recommended name:
cAMP-regulated phosphoprotein 19
Short name:
ARPP-19
Gene namesi
Name:Arpp19
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1891691 Arpp19

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001467622 – 112cAMP-regulated phosphoprotein 19Add BLAST111

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei2PhosphoserineBy similarity1
Modified residuei23PhosphoserineBy similarity1
Modified residuei62Phosphoserine; by GWLBy similarity1
Modified residuei104Phosphoserine; by PKACombined sources1 Publication1
Modified residuei109N6-acetyllysineBy similarity1
Isoform ARPP-16 (identifier: P56212-2)
Modified residuei1N-acetylmethionineBy similarity1

Post-translational modificationi

Phosphorylation at Ser-62 by GWL during mitosis is essential for interaction with PPP2R2D (PR55-delta) and subsequent inactivation of PP2A (By similarity). Phosphorylated by PKA.By similarity2 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP56212
MaxQBiP56212
PaxDbiP56212
PeptideAtlasiP56212
PRIDEiP56212

PTM databases

iPTMnetiP56212
PhosphoSitePlusiP56212

Expressioni

Developmental stagei

Isoform ARPP-19 is highly expressed in the embryo and its levels decrease progressively as development proceeds. In contrast, isoform ARPP-16 appears in the brain at the end of the first postnatal week and increases to reach a plateau.1 Publication

Gene expression databases

BgeeiENSMUSG00000007656
CleanExiMM_ARPP19
ExpressionAtlasiP56212 baseline and differential
GenevisibleiP56212 MM

Interactioni

Subunit structurei

Interacts (when phosphorylated at Ser-62) with PPP2R2D. Interacts with SNCA (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiP56212, 1 interactor
MINTiP56212
STRINGi10090.ENSMUSP00000128921

Structurei

3D structure databases

ProteinModelPortaliP56212
SMRiP56212
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the endosulfine family.Curated

Phylogenomic databases

eggNOGiKOG4076 Eukaryota
ENOG4112586 LUCA
GeneTreeiENSGT00390000010139
HOGENOMiHOG000232115
HOVERGENiHBG000297
InParanoidiP56212
TreeFamiTF314718

Family and domain databases

InterProiView protein in InterPro
IPR006760 Endosulphine
PANTHERiPTHR10358 PTHR10358, 1 hit
PfamiView protein in Pfam
PF04667 Endosulfine, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform ARPP-19 (identifier: P56212-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSAEVPEAAS AEEQKEMEDK VTSPEKAEEA KLKARYPHLG QKPGGSDFLR
60 70 80 90 100
KRLQKGQKYF DSGDYNMAKA KMKNKQLPAA APDKTEVTGD HIPTPQDLPQ
110
RKPSLVASKL AG
Length:112
Mass (Da):12,293
Last modified:January 23, 2007 - v2
Checksum:iF18BE46E35C839AB
GO
Isoform ARPP-16 (identifier: P56212-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: Missing.

Show »
Length:96
Mass (Da):10,605
Checksum:iE28246E78F5DB609
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0185561 – 16Missing in isoform ARPP-16. 1 PublicationAdd BLAST16

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ005983 mRNA Translation: CAA06797.1
AK049760 mRNA Translation: BAC33908.1
BC040206 mRNA Translation: AAH40206.1
CCDSiCCDS23340.1 [P56212-1]
RefSeqiNP_067523.1, NM_021548.4 [P56212-1]
XP_006511390.1, XM_006511327.1
UniGeneiMm.247837

Genome annotation databases

EnsembliENSMUST00000007800; ENSMUSP00000007800; ENSMUSG00000007656 [P56212-1]
ENSMUST00000164467; ENSMUSP00000130730; ENSMUSG00000007656 [P56212-1]
ENSMUST00000166549; ENSMUSP00000131987; ENSMUSG00000007656 [P56212-2]
ENSMUST00000167885; ENSMUSP00000131597; ENSMUSG00000007656 [P56212-2]
ENSMUST00000168166; ENSMUSP00000126618; ENSMUSG00000007656 [P56212-1]
ENSMUST00000170308; ENSMUSP00000132350; ENSMUSG00000007656 [P56212-1]
ENSMUST00000170310; ENSMUSP00000125825; ENSMUSG00000007656 [P56212-2]
GeneIDi59046
KEGGimmu:59046
UCSCiuc009qro.1 mouse [P56212-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiARP19_MOUSE
AccessioniPrimary (citable) accession number: P56212
Secondary accession number(s): Q543L2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 23, 2007
Last modified: June 20, 2018
This is version 131 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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