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Protein

cAMP-regulated phosphoprotein 19

Gene

ARPP19

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. May indirectly enhance GAP-43 expression.1 Publication

GO - Molecular functioni

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • G2/M transition of mitotic cell cycle Source: UniProtKB
  • mitotic cell cycle Source: UniProtKB
  • negative regulation of protein dephosphorylation Source: GO_Central
  • positive regulation of gluconeogenesis Source: UniProtKB
  • positive regulation of glucose import Source: UniProtKB

Keywordsi

Molecular functionProtein phosphatase inhibitor
Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

ReactomeiR-HSA-2465910 MASTL Facilitates Mitotic Progression
SIGNORiP56211

Names & Taxonomyi

Protein namesi
Recommended name:
cAMP-regulated phosphoprotein 19
Short name:
ARPP-19
Gene namesi
Name:ARPP19
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000128989.10
HGNCiHGNC:16967 ARPP19
MIMi605487 gene
neXtProtiNX_P56211

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi10776
OpenTargetsiENSG00000128989
PharmGKBiPA165478498

Polymorphism and mutation databases

BioMutaiARPP19

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000080412 – 112cAMP-regulated phosphoprotein 19Add BLAST111

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei2PhosphoserineCombined sources1
Modified residuei23PhosphoserineCombined sources1
Modified residuei62Phosphoserine; by GWLCurated1
Modified residuei104PhosphoserineCombined sources1
Modified residuei109N6-acetyllysineCombined sources1
Isoform ARPP-16 (identifier: P56211-2)
Modified residuei1N-acetylmethionineBy similarity1

Post-translational modificationi

Phosphorylation at Ser-62 by GWL during mitosis is essential for interaction with PPP2R2D (PR55-delta) and subsequent inactivation of PP2A (By similarity). Phosphorylated by PKA.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP56211
MaxQBiP56211
PaxDbiP56211
PeptideAtlasiP56211
PRIDEiP56211
ProteomicsDBi56905
56906 [P56211-2]
TopDownProteomicsiP56211-1 [P56211-1]

PTM databases

iPTMnetiP56211
PhosphoSitePlusiP56211

Expressioni

Inductioni

Expression may be regulated by miR-451.1 Publication

Gene expression databases

BgeeiENSG00000128989 Expressed in 240 organ(s), highest expression level in caudate nucleus
ExpressionAtlasiP56211 baseline and differential
GenevisibleiP56211 HS

Organism-specific databases

HPAiHPA056851

Interactioni

Subunit structurei

Interacts (when phosphorylated at Ser-62) with PPP2R2D (By similarity). Interacts with SNCA.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi115994, 9 interactors
IntActiP56211, 2 interactors
STRINGi9606.ENSP00000249822

Structurei

3D structure databases

ProteinModelPortaliP56211
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the endosulfine family.Curated

Phylogenomic databases

eggNOGiKOG4076 Eukaryota
ENOG4112586 LUCA
GeneTreeiENSGT00390000010139
HOGENOMiHOG000232115
HOVERGENiHBG000297
InParanoidiP56211
PhylomeDBiP56211
TreeFamiTF314718

Family and domain databases

InterProiView protein in InterPro
IPR006760 Endosulphine
PANTHERiPTHR10358 PTHR10358, 1 hit
PfamiView protein in Pfam
PF04667 Endosulfine, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform ARPP-19 (identifier: P56211-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSAEVPEAAS AEEQKEMEDK VTSPEKAEEA KLKARYPHLG QKPGGSDFLR
60 70 80 90 100
KRLQKGQKYF DSGDYNMAKA KMKNKQLPTA APDKTEVTGD HIPTPQDLPQ
110
RKPSLVASKL AG
Length:112
Mass (Da):12,323
Last modified:January 23, 2007 - v2
Checksum:iF19652B545C839AB
GO
Isoform ARPP-16 (identifier: P56211-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: Missing.

Show »
Length:96
Mass (Da):10,635
Checksum:iE29FF03CFF5DB609
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BMD8H3BMD8_HUMAN
cAMP-regulated phosphoprotein 19
ARPP19
131Annotation score:
H3BTD3H3BTD3_HUMAN
cAMP-regulated phosphoprotein 19
ARPP19
72Annotation score:
H3BQ52H3BQ52_HUMAN
cAMP-regulated phosphoprotein 19
ARPP19
71Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0185551 – 16Missing in isoform ARPP-16. 1 PublicationAdd BLAST16

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ223091 mRNA Translation: CAA11115.1
AF084555 mRNA Translation: AAD52044.1
CR457132 mRNA Translation: CAG33413.1
AL833077 mRNA Translation: CAD89929.1
AK311751 mRNA Translation: BAG34694.1
AC025917 Genomic DNA No translation available.
CH471082 Genomic DNA Translation: EAW77454.1
BC003418 mRNA Translation: AAH03418.1
BC100015 mRNA Translation: AAI00016.1
CCDSiCCDS32242.1 [P56211-1]
CCDS81883.1 [P56211-2]
RefSeqiNP_001293120.1, NM_001306191.1
NP_001293124.1, NM_001306195.1 [P56211-1]
NP_001293125.1, NM_001306196.1
NP_001317238.1, NM_001330309.1 [P56211-2]
NP_006619.1, NM_006628.5 [P56211-1]
XP_016877357.1, XM_017021868.1
XP_016877359.1, XM_017021870.1 [P56211-2]
UniGeneiHs.512908

Genome annotation databases

EnsembliENST00000249822; ENSP00000249822; ENSG00000128989 [P56211-1]
ENST00000561650; ENSP00000454234; ENSG00000128989 [P56211-2]
ENST00000563277; ENSP00000455986; ENSG00000128989 [P56211-2]
ENST00000563566; ENSP00000457631; ENSG00000128989 [P56211-2]
ENST00000566423; ENSP00000455625; ENSG00000128989 [P56211-1]
ENST00000567669; ENSP00000455151; ENSG00000128989 [P56211-1]
ENST00000568196; ENSP00000457805; ENSG00000128989 [P56211-2]
ENST00000569281; ENSP00000454297; ENSG00000128989 [P56211-1]
GeneIDi10776
KEGGihsa:10776
UCSCiuc002acd.2 human [P56211-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ223091 mRNA Translation: CAA11115.1
AF084555 mRNA Translation: AAD52044.1
CR457132 mRNA Translation: CAG33413.1
AL833077 mRNA Translation: CAD89929.1
AK311751 mRNA Translation: BAG34694.1
AC025917 Genomic DNA No translation available.
CH471082 Genomic DNA Translation: EAW77454.1
BC003418 mRNA Translation: AAH03418.1
BC100015 mRNA Translation: AAI00016.1
CCDSiCCDS32242.1 [P56211-1]
CCDS81883.1 [P56211-2]
RefSeqiNP_001293120.1, NM_001306191.1
NP_001293124.1, NM_001306195.1 [P56211-1]
NP_001293125.1, NM_001306196.1
NP_001317238.1, NM_001330309.1 [P56211-2]
NP_006619.1, NM_006628.5 [P56211-1]
XP_016877357.1, XM_017021868.1
XP_016877359.1, XM_017021870.1 [P56211-2]
UniGeneiHs.512908

3D structure databases

ProteinModelPortaliP56211
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115994, 9 interactors
IntActiP56211, 2 interactors
STRINGi9606.ENSP00000249822

PTM databases

iPTMnetiP56211
PhosphoSitePlusiP56211

Polymorphism and mutation databases

BioMutaiARPP19

Proteomic databases

EPDiP56211
MaxQBiP56211
PaxDbiP56211
PeptideAtlasiP56211
PRIDEiP56211
ProteomicsDBi56905
56906 [P56211-2]
TopDownProteomicsiP56211-1 [P56211-1]

Protocols and materials databases

DNASUi10776
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000249822; ENSP00000249822; ENSG00000128989 [P56211-1]
ENST00000561650; ENSP00000454234; ENSG00000128989 [P56211-2]
ENST00000563277; ENSP00000455986; ENSG00000128989 [P56211-2]
ENST00000563566; ENSP00000457631; ENSG00000128989 [P56211-2]
ENST00000566423; ENSP00000455625; ENSG00000128989 [P56211-1]
ENST00000567669; ENSP00000455151; ENSG00000128989 [P56211-1]
ENST00000568196; ENSP00000457805; ENSG00000128989 [P56211-2]
ENST00000569281; ENSP00000454297; ENSG00000128989 [P56211-1]
GeneIDi10776
KEGGihsa:10776
UCSCiuc002acd.2 human [P56211-1]

Organism-specific databases

CTDi10776
DisGeNETi10776
EuPathDBiHostDB:ENSG00000128989.10
GeneCardsiARPP19
HGNCiHGNC:16967 ARPP19
HPAiHPA056851
MIMi605487 gene
neXtProtiNX_P56211
OpenTargetsiENSG00000128989
PharmGKBiPA165478498
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4076 Eukaryota
ENOG4112586 LUCA
GeneTreeiENSGT00390000010139
HOGENOMiHOG000232115
HOVERGENiHBG000297
InParanoidiP56211
PhylomeDBiP56211
TreeFamiTF314718

Enzyme and pathway databases

ReactomeiR-HSA-2465910 MASTL Facilitates Mitotic Progression
SIGNORiP56211

Miscellaneous databases

ChiTaRSiARPP19 human
GeneWikiiARPP-19
GenomeRNAii10776
PROiPR:P56211
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000128989 Expressed in 240 organ(s), highest expression level in caudate nucleus
ExpressionAtlasiP56211 baseline and differential
GenevisibleiP56211 HS

Family and domain databases

InterProiView protein in InterPro
IPR006760 Endosulphine
PANTHERiPTHR10358 PTHR10358, 1 hit
PfamiView protein in Pfam
PF04667 Endosulfine, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiARP19_HUMAN
AccessioniPrimary (citable) accession number: P56211
Secondary accession number(s): B2R497
, Q6IAM2, Q86TA6, Q9UD70
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 23, 2007
Last modified: October 10, 2018
This is version 158 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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