UniProtKB - P56203 (CATW_MOUSE)
Protein
Cathepsin W
Gene
Ctsw
Organism
Mus musculus (Mouse)
Status
Functioni
May have a specific function in the mechanism or regulation of T-cell cytolytic activity.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 151 | By similarity | 1 | |
Active sitei | 289 | By similarity | 1 | |
Active sitei | 326 | By similarity | 1 |
GO - Molecular functioni
- cysteine-type endopeptidase activity Source: GO_Central
GO - Biological processi
- proteolysis involved in cellular protein catabolic process Source: GO_Central
Keywordsi
Molecular function | Hydrolase, Protease, Thiol protease |
Enzyme and pathway databases
Reactomei | R-MMU-114608, Platelet degranulation |
Protein family/group databases
MEROPSi | C01.037 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:Ctsw |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1338045, Ctsw |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum By similarity
Endoplasmic reticulum
- endoplasmic reticulum Source: UniProtKB-SubCell
Extracellular region or secreted
- extracellular space Source: GO_Central
Lysosome
- lysosome Source: GO_Central
Keywords - Cellular componenti
Endoplasmic reticulumPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | Sequence analysisAdd BLAST | 21 | |
PropeptideiPRO_0000026329 | 22 – 125 | Sequence analysisAdd BLAST | 104 | |
ChainiPRO_0000026330 | 126 – 371 | Cathepsin WAdd BLAST | 246 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 48 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 112 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 148 ↔ 189 | By similarity | ||
Disulfide bondi | 182 ↔ 224 | By similarity | ||
Glycosylationi | 203 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 282 ↔ 347 | By similarity | ||
Glycosylationi | 344 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, ZymogenProteomic databases
EPDi | P56203 |
PaxDbi | P56203 |
PRIDEi | P56203 |
PTM databases
GlyGeni | P56203, 4 sites |
PhosphoSitePlusi | P56203 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000024910, Expressed in blood and 86 other tissues |
ExpressionAtlasi | P56203, baseline and differential |
Genevisiblei | P56203, MM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 198977, 1 interactor |
STRINGi | 10090.ENSMUSP00000025844 |
Miscellaneous databases
RNActi | P56203, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the peptidase C1 family.PROSITE-ProRule annotation
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG1542, Eukaryota |
GeneTreei | ENSGT00940000161630 |
HOGENOMi | CLU_012184_4_1_1 |
InParanoidi | P56203 |
OMAi | TCGITKY |
OrthoDBi | 1264766at2759 |
TreeFami | TF337736 |
Family and domain databases
CDDi | cd02248, Peptidase_C1A, 1 hit |
InterProi | View protein in InterPro IPR033158, Cathepsin_W IPR038765, Papain-like_cys_pep_sf IPR025661, Pept_asp_AS IPR025660, Pept_his_AS IPR000668, Peptidase_C1A_C IPR039417, Peptidase_C1A_papain-like IPR013201, Prot_inhib_I29 |
PANTHERi | PTHR12411:SF101, PTHR12411:SF101, 1 hit |
Pfami | View protein in Pfam PF08246, Inhibitor_I29, 1 hit PF00112, Peptidase_C1, 1 hit |
PRINTSi | PR00705, PAPAIN |
SMARTi | View protein in SMART SM00848, Inhibitor_I29, 1 hit SM00645, Pept_C1, 1 hit |
SUPFAMi | SSF54001, SSF54001, 1 hit |
PROSITEi | View protein in PROSITE PS00640, THIOL_PROTEASE_ASN, 1 hit PS00639, THIOL_PROTEASE_HIS, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P56203-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTLTAHLSYF LVLLLAGQGL SDSLLTKDAG PRPLELKEVF KLFQIRFNRS
60 70 80 90 100
YWNPAEYTRR LSIFAHNLAQ AQRLQQEDLG TAEFGETPFS DLTEEEFGQL
110 120 130 140 150
YGQERSPERT PNMTKKVESN TWGESVPRTC DWRKAKNIIS SVKNQGSCKC
160 170 180 190 200
CWAMAAADNI QALWRIKHQQ FVDVSVQELL DCERCGNGCN GGFVWDAYLT
210 220 230 240 250
VLNNSGLASE KDYPFQGDRK PHRCLAKKYK KVAWIQDFTM LSNNEQAIAH
260 270 280 290 300
YLAVHGPITV TINMKLLQHY QKGVIKATPS SCDPRQVDHS VLLVGFGKEK
310 320 330 340 350
EGMQTGTVLS HSRKRRHSSP YWILKNSWGA HWGEKGYFRL YRGNNTCGVT
360 370
KYPFTAQVDS PVKKARTSCP P
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A494BA69 | A0A494BA69_MOUSE | Cathepsin W | Ctsw | 342 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF014941 mRNA Translation: AAB82455.1 AC122861 Genomic DNA No translation available. |
CCDSi | CCDS29465.1 |
RefSeqi | NP_034115.2, NM_009985.5 |
Genome annotation databases
Ensembli | ENSMUST00000025844; ENSMUSP00000025844; ENSMUSG00000024910 |
GeneIDi | 13041 |
KEGGi | mmu:13041 |
UCSCi | uc008gdk.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF014941 mRNA Translation: AAB82455.1 AC122861 Genomic DNA No translation available. |
CCDSi | CCDS29465.1 |
RefSeqi | NP_034115.2, NM_009985.5 |
3D structure databases
SMRi | P56203 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 198977, 1 interactor |
STRINGi | 10090.ENSMUSP00000025844 |
Protein family/group databases
MEROPSi | C01.037 |
PTM databases
GlyGeni | P56203, 4 sites |
PhosphoSitePlusi | P56203 |
Proteomic databases
EPDi | P56203 |
PaxDbi | P56203 |
PRIDEi | P56203 |
Protocols and materials databases
Antibodypediai | 4281, 100 antibodies |
DNASUi | 13041 |
Genome annotation databases
Ensembli | ENSMUST00000025844; ENSMUSP00000025844; ENSMUSG00000024910 |
GeneIDi | 13041 |
KEGGi | mmu:13041 |
UCSCi | uc008gdk.2, mouse |
Organism-specific databases
CTDi | 1521 |
MGIi | MGI:1338045, Ctsw |
Phylogenomic databases
eggNOGi | KOG1542, Eukaryota |
GeneTreei | ENSGT00940000161630 |
HOGENOMi | CLU_012184_4_1_1 |
InParanoidi | P56203 |
OMAi | TCGITKY |
OrthoDBi | 1264766at2759 |
TreeFami | TF337736 |
Enzyme and pathway databases
Reactomei | R-MMU-114608, Platelet degranulation |
Miscellaneous databases
BioGRID-ORCSi | 13041, 0 hits in 17 CRISPR screens |
ChiTaRSi | Ctsw, mouse |
PROi | PR:P56203 |
RNActi | P56203, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000024910, Expressed in blood and 86 other tissues |
ExpressionAtlasi | P56203, baseline and differential |
Genevisiblei | P56203, MM |
Family and domain databases
CDDi | cd02248, Peptidase_C1A, 1 hit |
InterProi | View protein in InterPro IPR033158, Cathepsin_W IPR038765, Papain-like_cys_pep_sf IPR025661, Pept_asp_AS IPR025660, Pept_his_AS IPR000668, Peptidase_C1A_C IPR039417, Peptidase_C1A_papain-like IPR013201, Prot_inhib_I29 |
PANTHERi | PTHR12411:SF101, PTHR12411:SF101, 1 hit |
Pfami | View protein in Pfam PF08246, Inhibitor_I29, 1 hit PF00112, Peptidase_C1, 1 hit |
PRINTSi | PR00705, PAPAIN |
SMARTi | View protein in SMART SM00848, Inhibitor_I29, 1 hit SM00645, Pept_C1, 1 hit |
SUPFAMi | SSF54001, SSF54001, 1 hit |
PROSITEi | View protein in PROSITE PS00640, THIOL_PROTEASE_ASN, 1 hit PS00639, THIOL_PROTEASE_HIS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CATW_MOUSE | |
Accessioni | P56203Primary (citable) accession number: P56203 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | July 27, 2011 | |
Last modified: | February 10, 2021 | |
This is version 138 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Peptidase families
Classification of peptidase families and list of entries - MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families