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Entry version 186 (13 Feb 2019)
Sequence version 2 (23 Jan 2007)
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Protein

Integrin alpha-1

Gene

ITGA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi498 – 506Sequence analysis9
Calcium bindingi580 – 588Sequence analysis9
Calcium bindingi642 – 650Sequence analysis9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • collagen binding Source: UniProtKB
  • collagen binding involved in cell-matrix adhesion Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW
  • protein phosphatase binding Source: UniProtKB
  • signaling receptor binding Source: Ensembl

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIntegrin, Receptor
Biological processCell adhesion
LigandCalcium, Magnesium, Metal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-216083 Integrin cell surface interactions
R-HSA-3000157 Laminin interactions
R-HSA-416700 Other semaphorin interactions
R-HSA-445355 Smooth Muscle Contraction
R-HSA-447041 CHL1 interactions
R-HSA-75892 Platelet Adhesion to exposed collagen

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
P56199

SIGNOR Signaling Network Open Resource

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SIGNORi
P56199

Protein family/group databases

Transport Classification Database

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TCDBi
8.A.54.1.1 the integrin (integrin) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Integrin alpha-1
Alternative name(s):
CD49 antigen-like family member A
Laminin and collagen receptor
VLA-1
CD_antigen: CD49a
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ITGA1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000213949.8

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6134 ITGA1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
192968 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_P56199

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini29 – 1141ExtracellularSequence analysisAdd BLAST1113
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1142 – 1164HelicalSequence analysisAdd BLAST23
Topological domaini1165 – 1179CytoplasmicSequence analysisAdd BLAST15

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
3672

Open Targets

More...
OpenTargetsi
ENSG00000213949

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA29935

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3682

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
2437

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ITGA1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
124056463

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 28Sequence analysisAdd BLAST28
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000017421529 – 1179Integrin alpha-1Add BLAST1151

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi74N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi82 ↔ 92By similarity
Glycosylationi100N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi105N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi112N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi217N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi317N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi341N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi402N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi418N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi460N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi532N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi688 ↔ 697By similarity
Glycosylationi699N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi703 ↔ 756By similarity
Glycosylationi748N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi780N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi808 ↔ 814By similarity
Glycosylationi840N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi878 ↔ 886By similarity
Glycosylationi883N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi908N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi915N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi939N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi966N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi974N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi1008N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi1030 ↔ 1062By similarity
Disulfide bondi1065 ↔ 1072By similarity
Glycosylationi1073N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1083N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1102N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1113N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P56199

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P56199

MaxQB - The MaxQuant DataBase

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MaxQBi
P56199

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P56199

PeptideAtlas

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PeptideAtlasi
P56199

PRoteomics IDEntifications database

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PRIDEi
P56199

ProteomicsDB human proteome resource

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ProteomicsDBi
56903

PTM databases

GlyConnect protein glycosylation platform

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GlyConnecti
1405

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P56199

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P56199

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000213949 Expressed in 200 organ(s), highest expression level in adrenal tissue

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P56199 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA042555

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer of an alpha and a beta subunit. Alpha-1 associates with beta-1. Interacts with RAB21. Interacts (via cytoplasmic domain) with PTPN2; activates PTPN2 phosphatase activity towards EGFR and negatively regulates EGF signaling.2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
P045122EBI-2554465,EBI-15711650From Rotavirus A (strain RVA/SA11-Both/G3P5B[2]).

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
109879, 21 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-1798 Integrin alpha1-beta1 complex

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P56199

Database of interacting proteins

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DIPi
DIP-206N

Protein interaction database and analysis system

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IntActi
P56199, 16 interactors

Molecular INTeraction database

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MINTi
P56199

STRING: functional protein association networks

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STRINGi
9606.ENSP00000282588

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
P56199

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11179
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PT6X-ray1.87A/B166-366[»]
1QC5X-ray2.00A/B168-359[»]
1QCYX-ray2.30A169-361[»]
2L8SNMR-A1135-1179[»]
2M32NMR-A168-359[»]
4A0QX-ray1.90A/B166-366[»]
5HGJX-ray1.40A/B170-364[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P56199

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P56199

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P56199

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati30 – 91FG-GAP 1PROSITE-ProRule annotationAdd BLAST62
Repeati101 – 160FG-GAP 2PROSITE-ProRule annotationAdd BLAST60
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini161 – 360VWFAPROSITE-ProRule annotationAdd BLAST200
Repeati365 – 417FG-GAP 3PROSITE-ProRule annotationAdd BLAST53
Repeati422 – 475FG-GAP 4PROSITE-ProRule annotationAdd BLAST54
Repeati476 – 538FG-GAP 5PROSITE-ProRule annotationAdd BLAST63
Repeati557 – 615FG-GAP 6PROSITE-ProRule annotationAdd BLAST59
Repeati619 – 679FG-GAP 7PROSITE-ProRule annotationAdd BLAST61

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1167 – 1171GFFKR motif5

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the integrin alpha chain family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IPB7 Eukaryota
ENOG410YEM8 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157646

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000059610

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG006185

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P56199

KEGG Orthology (KO)

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KOi
K06480

Identification of Orthologs from Complete Genome Data

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OMAi
IRKSGHF

Database of Orthologous Groups

More...
OrthoDBi
66046at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P56199

TreeFam database of animal gene trees

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TreeFami
TF105391

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.130, 1 hit
3.40.50.410, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013517 FG-GAP
IPR013519 Int_alpha_beta-p
IPR000413 Integrin_alpha
IPR013649 Integrin_alpha-2
IPR018184 Integrin_alpha_C_CS
IPR028994 Integrin_alpha_N
IPR032695 Integrin_dom_sf
IPR002035 VWF_A
IPR036465 vWFA_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01839 FG-GAP, 2 hits
PF08441 Integrin_alpha2, 1 hit
PF00092 VWA, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR01185 INTEGRINA

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00191 Int_alpha, 5 hits
SM00327 VWA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53300 SSF53300, 1 hit
SSF69179 SSF69179, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51470 FG_GAP, 7 hits
PS00242 INTEGRIN_ALPHA, 1 hit
PS50234 VWFA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P56199-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPRPRARPG VAVACCWLLT VVLRCCVSFN VDVKNSMTFS GPVEDMFGYT
60 70 80 90 100
VQQYENEEGK WVLIGSPLVG QPKNRTGDVY KCPVGRGESL PCVKLDLPVN
110 120 130 140 150
TSIPNVTEVK ENMTFGSTLV TNPNGGFLAC GPLYAYRCGH LHYTTGICSD
160 170 180 190 200
VSPTFQVVNS IAPVQECSTQ LDIVIVLDGS NSIYPWDSVT AFLNDLLERM
210 220 230 240 250
DIGPKQTQVG IVQYGENVTH EFNLNKYSST EEVLVAAKKI VQRGGRQTMT
260 270 280 290 300
ALGIDTARKE AFTEARGARR GVKKVMVIVT DGESHDNHRL KKVIQDCEDE
310 320 330 340 350
NIQRFSIAIL GSYNRGNLST EKFVEEIKSI ASEPTEKHFF NVSDELALVT
360 370 380 390 400
IVKTLGERIF ALEATADQSA ASFEMEMSQT GFSAHYSQDW VMLGAVGAYD
410 420 430 440 450
WNGTVVMQKA SQIIIPRNTT FNVESTKKNE PLASYLGYTV NSATASSGDV
460 470 480 490 500
LYIAGQPRYN HTGQVIIYRM EDGNIKILQT LSGEQIGSYF GSILTTTDID
510 520 530 540 550
KDSNTDILLV GAPMYMGTEK EEQGKVYVYA LNQTRFEYQM SLEPIKQTCC
560 570 580 590 600
SSRQHNSCTT ENKNEPCGAR FGTAIAAVKD LNLDGFNDIV IGAPLEDDHG
610 620 630 640 650
GAVYIYHGSG KTIRKEYAQR IPSGGDGKTL KFFGQSIHGE MDLNGDGLTD
660 670 680 690 700
VTIGGLGGAA LFWSRDVAVV KVTMNFEPNK VNIQKKNCHM EGKETVCINA
710 720 730 740 750
TVCFDVKLKS KEDTIYEADL QYRVTLDSLR QISRSFFSGT QERKVQRNIT
760 770 780 790 800
VRKSECTKHS FYMLDKHDFQ DSVRITLDFN LTDPENGPVL DDSLPNSVHE
810 820 830 840 850
YIPFAKDCGN KEKCISDLSL HVATTEKDLL IVRSQNDKFN VSLTVKNTKD
860 870 880 890 900
SAYNTRTIVH YSPNLVFSGI EAIQKDSCES NHNITCKVGY PFLRRGEMVT
910 920 930 940 950
FKILFQFNTS YLMENVTIYL SATSDSEEPP ETLSDNVVNI SIPVKYEVGL
960 970 980 990 1000
QFYSSASEYH ISIAANETVP EVINSTEDIG NEINIFYLIR KSGSFPMPEL
1010 1020 1030 1040 1050
KLSISFPNMT SNGYPVLYPT GLSSSENANC RPHIFEDPFS INSGKKMTTS
1060 1070 1080 1090 1100
TDHLKRGTIL DCNTCKFATI TCNLTSSDIS QVNVSLILWK PTFIKSYFSS
1110 1120 1130 1140 1150
LNLTIRGELR SENASLVLSS SNQKRELAIQ ISKDGLPGRV PLWVILLSAF
1160 1170
AGLLLLMLLI LALWKIGFFK RPLKKKMEK
Length:1,179
Mass (Da):130,848
Last modified:January 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1A86F30FD916C845
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti198E → K (PubMed:8428973).Curated1
Sequence conflicti254I → T (PubMed:8428973).Curated1
Sequence conflicti705D → E (PubMed:8428973).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_034022480T → M. Corresponds to variant dbSNP:rs4145748Ensembl.1
Natural variantiVAR_049630670V → I. Corresponds to variant dbSNP:rs2279587Ensembl.1
Natural variantiVAR_034023961I → M. Corresponds to variant dbSNP:rs12520591Ensembl.1
Natural variantiVAR_0340241108E → G. Corresponds to variant dbSNP:rs988574Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AC027326 Genomic DNA No translation available.
AC022133 Genomic DNA No translation available.
AC025180 Genomic DNA No translation available.
BC137121 mRNA Translation: AAI37122.1
BC137122 mRNA Translation: AAI37123.1
X68742 mRNA No translation available.

The Consensus CDS (CCDS) project

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CCDSi
CCDS3955.1

Protein sequence database of the Protein Information Resource

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PIRi
A45226

NCBI Reference Sequences

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RefSeqi
NP_852478.1, NM_181501.1

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.644352

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000282588; ENSP00000282588; ENSG00000213949

Database of genes from NCBI RefSeq genomes

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GeneIDi
3672

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:3672

UCSC genome browser

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UCSCi
uc003jou.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC027326 Genomic DNA No translation available.
AC022133 Genomic DNA No translation available.
AC025180 Genomic DNA No translation available.
BC137121 mRNA Translation: AAI37122.1
BC137122 mRNA Translation: AAI37123.1
X68742 mRNA No translation available.
CCDSiCCDS3955.1
PIRiA45226
RefSeqiNP_852478.1, NM_181501.1
UniGeneiHs.644352

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PT6X-ray1.87A/B166-366[»]
1QC5X-ray2.00A/B168-359[»]
1QCYX-ray2.30A169-361[»]
2L8SNMR-A1135-1179[»]
2M32NMR-A168-359[»]
4A0QX-ray1.90A/B166-366[»]
5HGJX-ray1.40A/B170-364[»]
ProteinModelPortaliP56199
SMRiP56199
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109879, 21 interactors
ComplexPortaliCPX-1798 Integrin alpha1-beta1 complex
CORUMiP56199
DIPiDIP-206N
IntActiP56199, 16 interactors
MINTiP56199
STRINGi9606.ENSP00000282588

Chemistry databases

BindingDBiP56199
ChEMBLiCHEMBL3682
GuidetoPHARMACOLOGYi2437

Protein family/group databases

TCDBi8.A.54.1.1 the integrin (integrin) family

PTM databases

GlyConnecti1405
iPTMnetiP56199
PhosphoSitePlusiP56199

Polymorphism and mutation databases

BioMutaiITGA1
DMDMi124056463

Proteomic databases

EPDiP56199
jPOSTiP56199
MaxQBiP56199
PaxDbiP56199
PeptideAtlasiP56199
PRIDEiP56199
ProteomicsDBi56903

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000282588; ENSP00000282588; ENSG00000213949
GeneIDi3672
KEGGihsa:3672
UCSCiuc003jou.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
3672
DisGeNETi3672
EuPathDBiHostDB:ENSG00000213949.8

GeneCards: human genes, protein and diseases

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GeneCardsi
ITGA1
HGNCiHGNC:6134 ITGA1
HPAiHPA042555
MIMi192968 gene
neXtProtiNX_P56199
OpenTargetsiENSG00000213949
PharmGKBiPA29935

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IPB7 Eukaryota
ENOG410YEM8 LUCA
GeneTreeiENSGT00940000157646
HOGENOMiHOG000059610
HOVERGENiHBG006185
InParanoidiP56199
KOiK06480
OMAiIRKSGHF
OrthoDBi66046at2759
PhylomeDBiP56199
TreeFamiTF105391

Enzyme and pathway databases

ReactomeiR-HSA-216083 Integrin cell surface interactions
R-HSA-3000157 Laminin interactions
R-HSA-416700 Other semaphorin interactions
R-HSA-445355 Smooth Muscle Contraction
R-HSA-447041 CHL1 interactions
R-HSA-75892 Platelet Adhesion to exposed collagen
SignaLinkiP56199
SIGNORiP56199

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ITGA1 human
EvolutionaryTraceiP56199

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
CD49a

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
3672

Protein Ontology

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PROi
PR:P56199

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000213949 Expressed in 200 organ(s), highest expression level in adrenal tissue
GenevisibleiP56199 HS

Family and domain databases

Gene3Di2.130.10.130, 1 hit
3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR013517 FG-GAP
IPR013519 Int_alpha_beta-p
IPR000413 Integrin_alpha
IPR013649 Integrin_alpha-2
IPR018184 Integrin_alpha_C_CS
IPR028994 Integrin_alpha_N
IPR032695 Integrin_dom_sf
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PfamiView protein in Pfam
PF01839 FG-GAP, 2 hits
PF08441 Integrin_alpha2, 1 hit
PF00092 VWA, 1 hit
PRINTSiPR01185 INTEGRINA
SMARTiView protein in SMART
SM00191 Int_alpha, 5 hits
SM00327 VWA, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
SSF69179 SSF69179, 3 hits
PROSITEiView protein in PROSITE
PS51470 FG_GAP, 7 hits
PS00242 INTEGRIN_ALPHA, 1 hit
PS50234 VWFA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiITA1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P56199
Secondary accession number(s): B2RNU0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: February 13, 2019
This is version 186 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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