Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - P56192 (SYMC_HUMAN)

Entry version 204 (16 Oct 2019)
Sequence version 2 (16 Apr 2002)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Methionine--tRNA ligase, cytoplasmic

Gene

MARS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA (PubMed:11714285). Plays a role in the synthesis of ribosomal RNA in the nucleolus (PubMed:10791971).2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Enzyme activity is increased by spermidine, EEF1A1, and when the Mg2+ concentration is increased from 5 mM to 13 mM (in vitro), possibly by promoting the dissociation of the complex between the enzyme and its product.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei596ATPBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • methionine-tRNA ligase activity Source: UniProtKB
  • tRNA binding Source: UniProtKB-KW
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase, RNA-binding, tRNA-binding
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		6.1.1.10 2681

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-2408522 Selenoamino acid metabolism
R-HSA-379716 Cytosolic tRNA aminoacylation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P56192

SIGNOR Signaling Network Open Resource

More...SIGNORi		P56192

Protein family/group databases

MoonProt database of moonlighting proteins

More...MoonProti		P56192

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Methionine--tRNA ligase, cytoplasmic (EC:6.1.1.101 Publication)
Alternative name(s):
Methionyl-tRNA synthetase
Short name:
MetRS
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MARS
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:6898 MARS

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		156560 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P56192

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Interstitial lung and liver disease (ILLD)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive, life-threatening disorder characterized by respiratory insufficiency and progressive liver disease with onset in infancy or early childhood. Clinical features include failure to thrive, hypotonia, intermittent lactic acidosis, aminoaciduria, hypothyroidism, interstitial lung disease, pulmonary alveolar proteinosis, anemia, and liver canalicular cholestasis, steatosis, and iron deposition.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_075361344Y → C in ILLD; when assayed in yeast, induces a slight growth retardation and reduction in methionine incorporation; may interfere with efficient substrate binding. 1 PublicationCorresponds to variant dbSNP:rs766466297EnsemblClinVar.1
Natural variantiVAR_070872370F → L in ILLD. 1 PublicationCorresponds to variant dbSNP:rs140467171EnsemblClinVar.1
Natural variantiVAR_075362393A → T in ILLD; may act as a disease modifier aggravating the phenotype; found in patients that carried additional mutations C-344 and/or L-567; when assayed in yeast, does not exhibit any phenotype; when assayed in yeast in association with L-567, increases L-567-induced growth retardation and reduction in methionine incorporation. 1 PublicationCorresponds to variant dbSNP:rs141340466EnsemblClinVar.1
Natural variantiVAR_070873523I → T in ILLD. 1 PublicationCorresponds to variant dbSNP:rs201555303EnsemblClinVar.1
Natural variantiVAR_075363567S → L in ILLD; when assayed in yeast, reduces methionine incorporation; when assayed in yeast in association with T-393, induces growth retardation and strong reduction in methionine incorporation; may interfere with efficient substrate binding. 1 PublicationCorresponds to variant dbSNP:rs143592405EnsemblClinVar.1
Natural variantiVAR_075364605D → V in ILLD; when assayed in yeast, induces a slight growth retardation and reduction in methionine incorporation; may interfere with efficient substrate binding. 1 PublicationCorresponds to variant dbSNP:rs756021768EnsemblClinVar.1
Charcot-Marie-Tooth disease 2U (CMT2U)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn axonal form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies (designated CMT1 when they are dominantly inherited) and primary peripheral axonal neuropathies (CMT2). Neuropathies of the CMT2 group are characterized by signs of axonal degeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and atrophy. CMT2U is a slowly progressive, autosomal dominant form characterized by late-adult onset.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_073377618R → C in CMT2U; loss of function mutation. 1 PublicationCorresponds to variant dbSNP:rs587777718EnsemblClinVar.1
Natural variantiVAR_073378800P → T in CMT2U. 1 PublicationCorresponds to variant dbSNP:rs781249411EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi64A → R: Loss of interaction with EEF1E1. 1 Publication1
Mutagenesisi86E → R: Loss of interaction with EEF1E1. 1 Publication1
Mutagenesisi857R → A: No effect on enzyme activity. 1 Publication1
Mutagenesisi860K → A: Strongly decreased affinity for tRNA. 1 Publication1
Mutagenesisi863K → A: Slightly decreased enzyme activity. 1 Publication1
Mutagenesisi866K → A: Slightly decreased enzyme activity. 1 Publication1
Mutagenesisi880K → A: Strongly decreased affinity for tRNA. 1 Publication1

Keywords - Diseasei

Charcot-Marie-Tooth disease, Disease mutation, Neurodegeneration, Neuropathy

Organism-specific databases

DisGeNET

More...DisGeNETi		4141

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...GeneReviewsi		MARS

MalaCards human disease database

More...MalaCardsi		MARS
MIMi615486 phenotype
616280 phenotype

Open Targets

More...OpenTargetsi		ENSG00000166986

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		397735 Autosomal dominant Charcot-Marie-Tooth disease type 2U
401835 Autosomal recessive spastic paraplegia type 70
440427 Severe early-onset pulmonary alveolar proteinosis due to MARS deficiency

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA30642

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P56192

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL2870

Drug and drug target database

More...DrugBanki		DB00134 Methionine

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		MARS

Domain mapping of disease mutations (DMDM)

More...DMDMi		20178332

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001392621 – 900Methionine--tRNA ligase, cytoplasmicAdd BLAST900

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei825PhosphoserineBy similarity1
Modified residuei835PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

The CPTAC Assay portal

More...CPTACi		CPTAC-538
CPTAC-539

Encyclopedia of Proteome Dynamics

More...EPDi		P56192

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P56192

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P56192

MaxQB - The MaxQuant DataBase

More...MaxQBi		P56192

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P56192

PeptideAtlas

More...PeptideAtlasi		P56192

PRoteomics IDEntifications database

More...PRIDEi		P56192

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		3760
56902 [P56192-1]

PTM databases

CarbonylDB database of protein carbonylation sites

More...CarbonylDBi		P56192

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P56192

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P56192

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P56192

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000166986 Expressed in 239 organ(s), highest expression level in cerebellar hemisphere

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P56192 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P56192 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		CAB017097
HPA004125

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer (PubMed:11714285).

Part of a multisubunit complex that groups tRNA ligases for Arg (RARS), Asp (DARS), Gln (QARS), Ile (IARS), Leu (LARS), Lys (KARS1), Met (MARS) the bifunctional ligase for Glu and Pro (EPRS) and the auxiliary subunits AIMP1/p43, AIMP2/p38 and EEF1E1/p18 (PubMed:19131329, PubMed:19289464, Ref. 24, PubMed:26472928).

Forms a linear complex that contains MARS, EEF1E1, EPRS and AIMP2 that is at the core of the multisubunit complex (PubMed:26472928).

5 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		110311, 177 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P56192

Database of interacting proteins

More...DIPi		DIP-38164N

Protein interaction database and analysis system

More...IntActi		P56192, 43 interactors

Molecular INTeraction database

More...MINTi		P56192

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000262027

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P56192

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1900
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P56192

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P56192

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini74 – 198GST C-terminalAdd BLAST125
Domaini841 – 897WHEP-TRSAdd BLAST57

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi273 – 283'HIGH' regionAdd BLAST11
Motifi593 – 597'KMSKS' region5

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0867 Eukaryota
KOG1247 Eukaryota
COG0143 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00550000075017

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000200402

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P56192

KEGG Orthology (KO)

More...KOi		K01874

Identification of Orthologs from Complete Genome Data

More...OMAi		CANIACL

Database of Orthologous Groups

More...OrthoDBi		333013at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P56192

TreeFam database of animal gene trees

More...TreeFami		TF300526

Family and domain databases

Conserved Domains Database

More...CDDi		cd07957 Anticodon_Ia_Met, 1 hit
cd00814 MetRS_core, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.20.28.20, 1 hit
3.40.50.620, 1 hit

HAMAP database of protein families

More...HAMAPi		MF_00098 Met_tRNA_synth_type1, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR041872 Anticodon_Met
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR004046 GST_C
IPR041598 MARS_N
IPR023458 Met-tRNA_ligase_1
IPR014758 Met-tRNA_synth
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR033911 MetRS_core
IPR029038 MetRS_Zn
IPR014729 Rossmann-like_a/b/a_fold
IPR009068 S15_NS1_RNA-bd
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR000738 WHEP-TRS_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00043 GST_C, 1 hit
PF18485 GST_N_5, 1 hit
PF09334 tRNA-synt_1g, 1 hit
PF00458 WHEP-TRS, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01041 TRNASYNTHMET

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00991 WHEP-TRS, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47060 SSF47060, 1 hit
SSF47323 SSF47323, 1 hit
SSF47616 SSF47616, 1 hit
SSF57770 SSF57770, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00398 metG, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit
PS50405 GST_CTER, 1 hit
PS00762 WHEP_TRS_1, 1 hit
PS51185 WHEP_TRS_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 12 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P56192-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRLFVSDGVP GCLPVLAAAG RARGRAEVLI STVGPEDCVV PFLTRPKVPV 
        60         70         80         90        100
LQLDSGNYLF STSAICRYFF LLSGWEQDDL TNQWLEWEAT ELQPALSAAL 
       110        120        130        140        150
YYLVVQGKKG EDVLGSVRRA LTHIDHSLSR QNCPFLAGET ESLADIVLWG 
       160        170        180        190        200
ALYPLLQDPA YLPEELSALH SWFQTLSTQE PCQRAAETVL KQQGVLALRP 
       210        220        230        240        250
YLQKQPQPSP AEGRAVTNEP EEEELATLSE EEIAMAVTAW EKGLESLPPL 
       260        270        280        290        300
RPQQNPVLPV AGERNVLITS ALPYVNNVPH LGNIIGCVLS ADVFARYSRL 
       310        320        330        340        350
RQWNTLYLCG TDEYGTATET KALEEGLTPQ EICDKYHIIH ADIYRWFNIS 
       360        370        380        390        400
FDIFGRTTTP QQTKITQDIF QQLLKRGFVL QDTVEQLRCE HCARFLADRF 
       410        420        430        440        450
VEGVCPFCGY EEARGDQCDK CGKLINAVEL KKPQCKVCRS CPVVQSSQHL 
       460        470        480        490        500
FLDLPKLEKR LEEWLGRTLP GSDWTPNAQF ITRSWLRDGL KPRCITRDLK 
       510        520        530        540        550
WGTPVPLEGF EDKVFYVWFD ATIGYLSITA NYTDQWERWW KNPEQVDLYQ 
       560        570        580        590        600
FMAKDNVPFH SLVFPCSALG AEDNYTLVSH LIATEYLNYE DGKFSKSRGV 
       610        620        630        640        650
GVFGDMAQDT GIPADIWRFY LLYIRPEGQD SAFSWTDLLL KNNSELLNNL 
       660        670        680        690        700
GNFINRAGMF VSKFFGGYVP EMVLTPDDQR LLAHVTLELQ HYHQLLEKVR 
       710        720        730        740        750
IRDALRSILT ISRHGNQYIQ VNEPWKRIKG SEADRQRAGT VTGLAVNIAA 
       760        770        780        790        800
LLSVMLQPYM PTVSATIQAQ LQLPPPACSI LLTNFLCTLP AGHQIGTVSP 
       810        820        830        840        850
LFQKLENDQI ESLRQRFGGG QAKTSPKPAV VETVTTAKPQ QIQALMDEVT 
       860        870        880        890        900
KQGNIVRELK AQKADKNEVA AEVAKLLDLK KQLAVAEGKP PEAPKGKKKK
Length:900
Mass (Da):101,116
Last modified:April 16, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3D687C77E17C5C96
GO
Isoform 2 (identifier: P56192-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     546-546: V → P
     547-900: Missing.

Note: No experimental confirmation available.
Show »
Length:546
Mass (Da):61,816
Checksum:iED19F00468D3C6AB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YHV5H0YHV5_HUMAN
Methionine--tRNA ligase, cytoplasmi...
MARS
233Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YIP0H0YIP0_HUMAN
Methionine--tRNA ligase, cytoplasmi...
MARS
219Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YHL6H0YHL6_HUMAN
Methionine--tRNA ligase, cytoplasmi...
MARS
81Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YI27H0YI27_HUMAN
Methionine--tRNA ligase, cytoplasmi...
MARS
124Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YI94H0YI94_HUMAN
Methionine--tRNA ligase, cytoplasmi...
MARS
119Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YIC2H0YIC2_HUMAN
Methionine--tRNA ligase, cytoplasmi...
MARS
58Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VPL7F8VPL7_HUMAN
Methionine--tRNA ligase, cytoplasmi...
MARS
60Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H2V6F5H2V6_HUMAN
Methionine--tRNA ligase, cytoplasmi...
MARS
140Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W0M7F8W0M7_HUMAN
Methionine--tRNA ligase, cytoplasmi...
MARS
95Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VS26F8VS26_HUMAN
Methionine--tRNA ligase, cytoplasmi...
MARS
71Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti53L → V in CAA64381 (PubMed:8921912).Curated1
Sequence conflicti99A → P in CAA64381 (PubMed:8921912).Curated1
Sequence conflicti152L → Q in CAA64381 (PubMed:8921912).Curated1
Sequence conflicti172W → S in AAH15011 (PubMed:15489334).Curated1
Sequence conflicti250L → P in BAD96487 (Ref. 5) Curated1
Sequence conflicti683A → G in CAA64381 (PubMed:8921912).Curated1
Sequence conflicti683A → G in CAA89153 (PubMed:8921912).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0778485V → M Found in a patient with spastic paraplegia; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs587777227EnsemblClinVar.1
Natural variantiVAR_075360206P → L1 PublicationCorresponds to variant dbSNP:rs138776588EnsemblClinVar.1
Natural variantiVAR_075361344Y → C in ILLD; when assayed in yeast, induces a slight growth retardation and reduction in methionine incorporation; may interfere with efficient substrate binding. 1 PublicationCorresponds to variant dbSNP:rs766466297EnsemblClinVar.1
Natural variantiVAR_070872370F → L in ILLD. 1 PublicationCorresponds to variant dbSNP:rs140467171EnsemblClinVar.1
Natural variantiVAR_075362393A → T in ILLD; may act as a disease modifier aggravating the phenotype; found in patients that carried additional mutations C-344 and/or L-567; when assayed in yeast, does not exhibit any phenotype; when assayed in yeast in association with L-567, increases L-567-induced growth retardation and reduction in methionine incorporation. 1 PublicationCorresponds to variant dbSNP:rs141340466EnsemblClinVar.1
Natural variantiVAR_070873523I → T in ILLD. 1 PublicationCorresponds to variant dbSNP:rs201555303EnsemblClinVar.1
Natural variantiVAR_075363567S → L in ILLD; when assayed in yeast, reduces methionine incorporation; when assayed in yeast in association with T-393, induces growth retardation and strong reduction in methionine incorporation; may interfere with efficient substrate binding. 1 PublicationCorresponds to variant dbSNP:rs143592405EnsemblClinVar.1
Natural variantiVAR_075364605D → V in ILLD; when assayed in yeast, induces a slight growth retardation and reduction in methionine incorporation; may interfere with efficient substrate binding. 1 PublicationCorresponds to variant dbSNP:rs756021768EnsemblClinVar.1
Natural variantiVAR_073377618R → C in CMT2U; loss of function mutation. 1 PublicationCorresponds to variant dbSNP:rs587777718EnsemblClinVar.1
Natural variantiVAR_020459683A → D. Corresponds to variant dbSNP:rs1054403Ensembl.1
Natural variantiVAR_077849702R → W Found in a patient with spastic paraplegia; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs587777228EnsemblClinVar.1
Natural variantiVAR_075365727R → Q1 PublicationCorresponds to variant dbSNP:rs113808165EnsemblClinVar.1
Natural variantiVAR_073378800P → T in CMT2U. 1 PublicationCorresponds to variant dbSNP:rs781249411EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_056563546V → P in isoform 2. 1 Publication1
Alternative sequenceiVSP_056564547 – 900Missing in isoform 2. 1 PublicationAdd BLAST354

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X94754 mRNA Translation: CAA64381.1
Z49216 mRNA Translation: CAA89153.1
D84224 mRNA Translation: BAA95668.1
BT007338 mRNA Translation: AAP36002.1
AK122956 mRNA Translation: BAG53819.1
AK222767 mRNA Translation: BAD96487.1
AC022506 Genomic DNA No translation available.
BC002384 mRNA Translation: AAH02384.1
BC006328 mRNA Translation: AAH06328.1
BC011639 mRNA Translation: AAH11639.1
BC011849 mRNA Translation: AAH11849.1
BC015011 mRNA Translation: AAH15011.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS8942.1 [P56192-1]

Protein sequence database of the Protein Information Resource

More...PIRi		JC5224

NCBI Reference Sequences

More...RefSeqi		NP_004981.2, NM_004990.3 [P56192-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000262027; ENSP00000262027; ENSG00000166986 [P56192-1]
ENST00000537638; ENSP00000446168; ENSG00000166986 [P56192-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		4141

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:4141

UCSC genome browser

More...UCSCi		uc001sof.2 human [P56192-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X94754 mRNA Translation: CAA64381.1
Z49216 mRNA Translation: CAA89153.1
D84224 mRNA Translation: BAA95668.1
BT007338 mRNA Translation: AAP36002.1
AK122956 mRNA Translation: BAG53819.1
AK222767 mRNA Translation: BAD96487.1
AC022506 Genomic DNA No translation available.
BC002384 mRNA Translation: AAH02384.1
BC006328 mRNA Translation: AAH06328.1
BC011639 mRNA Translation: AAH11639.1
BC011849 mRNA Translation: AAH11849.1
BC015011 mRNA Translation: AAH15011.1
CCDSiCCDS8942.1 [P56192-1]
PIRiJC5224
RefSeqiNP_004981.2, NM_004990.3 [P56192-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DJVNMR-A835-900[»]
4BL7X-ray1.89A1-224[»]
4BVXX-ray1.60A1-207[»]
4BVYX-ray1.99A1-225[»]
5GL7X-ray2.01A221-834[»]
5GOYX-ray2.28A221-834[»]
5Y6LX-ray2.90A1-224[»]
SMRiP56192
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi110311, 177 interactors
CORUMiP56192
DIPiDIP-38164N
IntActiP56192, 43 interactors
MINTiP56192
STRINGi9606.ENSP00000262027

Chemistry databases

BindingDBiP56192
ChEMBLiCHEMBL2870
DrugBankiDB00134 Methionine

Protein family/group databases

MoonProtiP56192

PTM databases

CarbonylDBiP56192
iPTMnetiP56192
PhosphoSitePlusiP56192
SwissPalmiP56192

Polymorphism and mutation databases

BioMutaiMARS
DMDMi20178332

Proteomic databases

CPTACiCPTAC-538
CPTAC-539
EPDiP56192
jPOSTiP56192
MassIVEiP56192
MaxQBiP56192
PaxDbiP56192
PeptideAtlasiP56192
PRIDEiP56192
ProteomicsDBi3760
56902 [P56192-1]

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		4141

Genome annotation databases

EnsembliENST00000262027; ENSP00000262027; ENSG00000166986 [P56192-1]
ENST00000537638; ENSP00000446168; ENSG00000166986 [P56192-2]
GeneIDi4141
KEGGihsa:4141
UCSCiuc001sof.2 human [P56192-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		4141
DisGeNETi4141

GeneCards: human genes, protein and diseases

More...GeneCardsi		MARS
GeneReviewsiMARS
HGNCiHGNC:6898 MARS
HPAiCAB017097
HPA004125
MalaCardsiMARS
MIMi156560 gene
615486 phenotype
616280 phenotype
neXtProtiNX_P56192
OpenTargetsiENSG00000166986
Orphaneti397735 Autosomal dominant Charcot-Marie-Tooth disease type 2U
401835 Autosomal recessive spastic paraplegia type 70
440427 Severe early-onset pulmonary alveolar proteinosis due to MARS deficiency
PharmGKBiPA30642

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0867 Eukaryota
KOG1247 Eukaryota
COG0143 LUCA
GeneTreeiENSGT00550000075017
HOGENOMiHOG000200402
InParanoidiP56192
KOiK01874
OMAiCANIACL
OrthoDBi333013at2759
PhylomeDBiP56192
TreeFamiTF300526

Enzyme and pathway databases

BRENDAi6.1.1.10 2681
ReactomeiR-HSA-2408522 Selenoamino acid metabolism
R-HSA-379716 Cytosolic tRNA aminoacylation
SignaLinkiP56192
SIGNORiP56192

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		MARS human
EvolutionaryTraceiP56192

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		MARS_(gene)

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		4141
PharosiP56192

Protein Ontology

More...PROi		PR:P56192

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000166986 Expressed in 239 organ(s), highest expression level in cerebellar hemisphere
ExpressionAtlasiP56192 baseline and differential
GenevisibleiP56192 HS

Family and domain databases

CDDicd07957 Anticodon_Ia_Met, 1 hit
cd00814 MetRS_core, 1 hit
Gene3Di2.20.28.20, 1 hit
3.40.50.620, 1 hit
HAMAPiMF_00098 Met_tRNA_synth_type1, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR041872 Anticodon_Met
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR004046 GST_C
IPR041598 MARS_N
IPR023458 Met-tRNA_ligase_1
IPR014758 Met-tRNA_synth
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR033911 MetRS_core
IPR029038 MetRS_Zn
IPR014729 Rossmann-like_a/b/a_fold
IPR009068 S15_NS1_RNA-bd
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR000738 WHEP-TRS_dom
PfamiView protein in Pfam
PF00043 GST_C, 1 hit
PF18485 GST_N_5, 1 hit
PF09334 tRNA-synt_1g, 1 hit
PF00458 WHEP-TRS, 1 hit
PRINTSiPR01041 TRNASYNTHMET
SMARTiView protein in SMART
SM00991 WHEP-TRS, 1 hit
SUPFAMiSSF47060 SSF47060, 1 hit
SSF47323 SSF47323, 1 hit
SSF47616 SSF47616, 1 hit
SSF57770 SSF57770, 1 hit
TIGRFAMsiTIGR00398 metG, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit
PS50405 GST_CTER, 1 hit
PS00762 WHEP_TRS_1, 1 hit
PS51185 WHEP_TRS_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSYMC_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P56192
Secondary accession number(s): B3KVK7
, Q14895, Q53H14, Q96A15, Q96BZ0, Q9NSE0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: April 16, 2002
Last modified: October 16, 2019
This is version 204 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  7. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again