UniProtKB - P56192 (SYMC_HUMAN)
Methionine--tRNA ligase, cytoplasmic
MARS1
Functioni
Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA (PubMed:11714285).
Plays a role in the synthesis of ribosomal RNA in the nucleolus (PubMed:10791971).
2 PublicationsCatalytic activityi
- EC:6.1.1.101 Publication
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 596 | ATPBy similarity | 1 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- methionine-tRNA ligase activity Source: UniProtKB
- tRNA binding Source: UniProtKB-KW
GO - Biological processi
- cellular response to epidermal growth factor stimulus Source: CAFA
- cellular response to insulin stimulus Source: CAFA
- cellular response to platelet-derived growth factor stimulus Source: CAFA
- cellular response to starvation Source: CAFA
- methionyl-tRNA aminoacylation Source: UniProtKB
- positive regulation of transcription of nucleolar large rRNA by RNA polymerase I Source: CAFA
- rRNA transcription Source: CAFA
- tRNA aminoacylation for protein translation Source: GO_Central
Keywordsi
Molecular function | Aminoacyl-tRNA synthetase, Ligase, RNA-binding, tRNA-binding |
Biological process | Protein biosynthesis |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 6.1.1.10, 2681 |
PathwayCommonsi | P56192 |
Reactomei | R-HSA-2408522, Selenoamino acid metabolism R-HSA-379716, Cytosolic tRNA aminoacylation |
SignaLinki | P56192 |
SIGNORi | P56192 |
Protein family/group databases
MoonProti | P56192 |
Names & Taxonomyi
Protein namesi | Recommended name: Methionine--tRNA ligase, cytoplasmic (EC:6.1.1.101 Publication)Alternative name(s): Methionyl-tRNA synthetase Short name: MetRS |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6898, MARS1 |
MIMi | 156560, gene |
neXtProti | NX_P56192 |
VEuPathDBi | HostDB:ENSG00000166986 |
Subcellular locationi
Cytosol
- cytosol Source: UniProtKB
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Nucleus
- nucleolus Source: CAFA
Other locations
- aminoacyl-tRNA synthetase multienzyme complex Source: UniProtKB
- cytoplasm Source: CAFA
- membrane Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Involvement in diseasei
Interstitial lung and liver disease (ILLD)2 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_075361 | 344 | Y → C in ILLD; when assayed in yeast, induces a slight growth retardation and reduction in methionine incorporation; may interfere with efficient substrate binding. 1 PublicationCorresponds to variant dbSNP:rs766466297EnsemblClinVar. | 1 | |
Natural variantiVAR_070872 | 370 | F → L in ILLD. 1 PublicationCorresponds to variant dbSNP:rs140467171EnsemblClinVar. | 1 | |
Natural variantiVAR_075362 | 393 | A → T in ILLD; may act as a disease modifier aggravating the phenotype; found in patients that carried additional mutations C-344 and/or L-567; when assayed in yeast, does not exhibit any phenotype; when assayed in yeast in association with L-567, increases L-567-induced growth retardation and reduction in methionine incorporation. 1 PublicationCorresponds to variant dbSNP:rs141340466EnsemblClinVar. | 1 | |
Natural variantiVAR_070873 | 523 | I → T in ILLD. 1 PublicationCorresponds to variant dbSNP:rs201555303EnsemblClinVar. | 1 | |
Natural variantiVAR_075363 | 567 | S → L in ILLD; when assayed in yeast, reduces methionine incorporation; when assayed in yeast in association with T-393, induces growth retardation and strong reduction in methionine incorporation; may interfere with efficient substrate binding. 1 PublicationCorresponds to variant dbSNP:rs143592405EnsemblClinVar. | 1 | |
Natural variantiVAR_075364 | 605 | D → V in ILLD; when assayed in yeast, induces a slight growth retardation and reduction in methionine incorporation; may interfere with efficient substrate binding. 1 PublicationCorresponds to variant dbSNP:rs756021768EnsemblClinVar. | 1 |
Charcot-Marie-Tooth disease 2U (CMT2U)2 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_073377 | 618 | R → C in CMT2U; loss of function mutation. 1 PublicationCorresponds to variant dbSNP:rs587777718EnsemblClinVar. | 1 | |
Natural variantiVAR_073378 | 800 | P → T in CMT2U. 1 PublicationCorresponds to variant dbSNP:rs781249411EnsemblClinVar. | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 64 | A → R: Loss of interaction with EEF1E1. 1 Publication | 1 | |
Mutagenesisi | 86 | E → R: Loss of interaction with EEF1E1. 1 Publication | 1 | |
Mutagenesisi | 857 | R → A: No effect on enzyme activity. 1 Publication | 1 | |
Mutagenesisi | 860 | K → A: Strongly decreased affinity for tRNA. 1 Publication | 1 | |
Mutagenesisi | 863 | K → A: Slightly decreased enzyme activity. 1 Publication | 1 | |
Mutagenesisi | 866 | K → A: Slightly decreased enzyme activity. 1 Publication | 1 | |
Mutagenesisi | 880 | K → A: Strongly decreased affinity for tRNA. 1 Publication | 1 |
Keywords - Diseasei
Charcot-Marie-Tooth disease, Disease variant, Neurodegeneration, NeuropathyOrganism-specific databases
DisGeNETi | 4141 |
GeneReviewsi | MARS1 |
MalaCardsi | MARS1 |
MIMi | 615486, phenotype 616280, phenotype |
OpenTargetsi | ENSG00000166986 |
Orphaneti | 397735, Autosomal dominant Charcot-Marie-Tooth disease type 2U 401835, Autosomal recessive spastic paraplegia type 70 440427, Severe early-onset pulmonary alveolar proteinosis due to MARS deficiency |
PharmGKBi | PA30642 |
Miscellaneous databases
Pharosi | P56192, Tchem |
Chemistry databases
ChEMBLi | CHEMBL2870 |
DrugBanki | DB00134, Methionine |
Genetic variation databases
BioMutai | MARS |
DMDMi | 20178332 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000139262 | 1 – 900 | Methionine--tRNA ligase, cytoplasmicAdd BLAST | 900 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 825 | PhosphoserineBy similarity | 1 | |
Modified residuei | 835 | PhosphothreonineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
CPTACi | CPTAC-538 CPTAC-539 |
EPDi | P56192 |
jPOSTi | P56192 |
MassIVEi | P56192 |
MaxQBi | P56192 |
PaxDbi | P56192 |
PeptideAtlasi | P56192 |
PRIDEi | P56192 |
ProteomicsDBi | 3760 56902 [P56192-1] |
PTM databases
CarbonylDBi | P56192 |
GlyGeni | P56192, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P56192 |
MetOSitei | P56192 |
PhosphoSitePlusi | P56192 |
SwissPalmi | P56192 |
Expressioni
Gene expression databases
Bgeei | ENSG00000166986, Expressed in cerebellar hemisphere and 249 other tissues |
ExpressionAtlasi | P56192, baseline and differential |
Genevisiblei | P56192, HS |
Organism-specific databases
HPAi | ENSG00000166986, Low tissue specificity |
Interactioni
Subunit structurei
Monomer (PubMed:11714285).
Part of a multisubunit complex that groups tRNA ligases for Arg (RARS1), Asp (DARS1), Gln (QARS1), Ile (IARS1), Leu (LARS1), Lys (KARS1), Met (MARS1) the bifunctional ligase for Glu and Pro (EPRS1) and the auxiliary subunits AIMP1/p43, AIMP2/p38 and EEF1E1/p18 (PubMed:19131329, PubMed:19289464, Ref. 24, PubMed:26472928).
Forms a linear complex that contains MARS1, EEF1E1, EPRS1 and AIMP2 that is at the core of the multisubunit complex (PubMed:26472928).
5 PublicationsProtein-protein interaction databases
BioGRIDi | 110311, 235 interactors |
CORUMi | P56192 |
DIPi | DIP-38164N |
IntActi | P56192, 54 interactors |
MINTi | P56192 |
STRINGi | 9606.ENSP00000262027 |
Chemistry databases
BindingDBi | P56192 |
Miscellaneous databases
RNActi | P56192, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | P56192 |
BMRBi | P56192 |
SMRi | P56192 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P56192 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 74 – 198 | GST C-terminalAdd BLAST | 125 | |
Domaini | 841 – 897 | WHEP-TRSAdd BLAST | 57 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 273 – 283 | 'HIGH' regionAdd BLAST | 11 | |
Motifi | 593 – 597 | 'KMSKS' region | 5 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0867, Eukaryota KOG1247, Eukaryota |
GeneTreei | ENSGT00550000075017 |
HOGENOMi | CLU_009710_3_2_1 |
InParanoidi | P56192 |
OMAi | HGNGYMQ |
OrthoDBi | 333013at2759 |
PhylomeDBi | P56192 |
TreeFami | TF300526 |
Family and domain databases
CDDi | cd07957, Anticodon_Ia_Met, 1 hit cd00814, MetRS_core, 1 hit |
Gene3Di | 2.20.28.20, 1 hit 3.40.50.620, 1 hit |
HAMAPi | MF_00098, Met_tRNA_synth_type1, 1 hit |
InterProi | View protein in InterPro IPR001412, aa-tRNA-synth_I_CS IPR041872, Anticodon_Met IPR010987, Glutathione-S-Trfase_C-like IPR036282, Glutathione-S-Trfase_C_sf IPR004046, GST_C IPR041598, MARS_N IPR023458, Met-tRNA_ligase_1 IPR014758, Met-tRNA_synth IPR015413, Methionyl/Leucyl_tRNA_Synth IPR033911, MetRS_core IPR029038, MetRS_Zn IPR014729, Rossmann-like_a/b/a_fold IPR009068, S15_NS1_RNA-bd IPR009080, tRNAsynth_Ia_anticodon-bd IPR000738, WHEP-TRS_dom |
PANTHERi | PTHR45765, PTHR45765, 1 hit |
Pfami | View protein in Pfam PF19303, Anticodon_3, 1 hit PF00043, GST_C, 1 hit PF18485, GST_N_5, 1 hit PF09334, tRNA-synt_1g, 1 hit PF00458, WHEP-TRS, 1 hit |
PRINTSi | PR01041, TRNASYNTHMET |
SMARTi | View protein in SMART SM00991, WHEP-TRS, 1 hit |
SUPFAMi | SSF47060, SSF47060, 1 hit SSF47323, SSF47323, 1 hit SSF47616, SSF47616, 1 hit SSF57770, SSF57770, 1 hit |
TIGRFAMsi | TIGR00398, metG, 1 hit |
PROSITEi | View protein in PROSITE PS00178, AA_TRNA_LIGASE_I, 1 hit PS50405, GST_CTER, 1 hit PS00762, WHEP_TRS_1, 1 hit PS51185, WHEP_TRS_2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 12 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MRLFVSDGVP GCLPVLAAAG RARGRAEVLI STVGPEDCVV PFLTRPKVPV
60 70 80 90 100
LQLDSGNYLF STSAICRYFF LLSGWEQDDL TNQWLEWEAT ELQPALSAAL
110 120 130 140 150
YYLVVQGKKG EDVLGSVRRA LTHIDHSLSR QNCPFLAGET ESLADIVLWG
160 170 180 190 200
ALYPLLQDPA YLPEELSALH SWFQTLSTQE PCQRAAETVL KQQGVLALRP
210 220 230 240 250
YLQKQPQPSP AEGRAVTNEP EEEELATLSE EEIAMAVTAW EKGLESLPPL
260 270 280 290 300
RPQQNPVLPV AGERNVLITS ALPYVNNVPH LGNIIGCVLS ADVFARYSRL
310 320 330 340 350
RQWNTLYLCG TDEYGTATET KALEEGLTPQ EICDKYHIIH ADIYRWFNIS
360 370 380 390 400
FDIFGRTTTP QQTKITQDIF QQLLKRGFVL QDTVEQLRCE HCARFLADRF
410 420 430 440 450
VEGVCPFCGY EEARGDQCDK CGKLINAVEL KKPQCKVCRS CPVVQSSQHL
460 470 480 490 500
FLDLPKLEKR LEEWLGRTLP GSDWTPNAQF ITRSWLRDGL KPRCITRDLK
510 520 530 540 550
WGTPVPLEGF EDKVFYVWFD ATIGYLSITA NYTDQWERWW KNPEQVDLYQ
560 570 580 590 600
FMAKDNVPFH SLVFPCSALG AEDNYTLVSH LIATEYLNYE DGKFSKSRGV
610 620 630 640 650
GVFGDMAQDT GIPADIWRFY LLYIRPEGQD SAFSWTDLLL KNNSELLNNL
660 670 680 690 700
GNFINRAGMF VSKFFGGYVP EMVLTPDDQR LLAHVTLELQ HYHQLLEKVR
710 720 730 740 750
IRDALRSILT ISRHGNQYIQ VNEPWKRIKG SEADRQRAGT VTGLAVNIAA
760 770 780 790 800
LLSVMLQPYM PTVSATIQAQ LQLPPPACSI LLTNFLCTLP AGHQIGTVSP
810 820 830 840 850
LFQKLENDQI ESLRQRFGGG QAKTSPKPAV VETVTTAKPQ QIQALMDEVT
860 870 880 890 900
KQGNIVRELK AQKADKNEVA AEVAKLLDLK KQLAVAEGKP PEAPKGKKKK
Computationally mapped potential isoform sequencesi
There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0YHV5 | H0YHV5_HUMAN | Methionine--tRNA ligase, cytoplasmi... | MARS1 | 233 | Annotation score: | ||
H0YIC2 | H0YIC2_HUMAN | Methionine--tRNA ligase, cytoplasmi... | MARS1 | 58 | Annotation score: | ||
H0YIP0 | H0YIP0_HUMAN | Methionine--tRNA ligase, cytoplasmi... | MARS1 | 219 | Annotation score: | ||
H0YHL6 | H0YHL6_HUMAN | Methionine--tRNA ligase, cytoplasmi... | MARS1 | 81 | Annotation score: | ||
H0YI94 | H0YI94_HUMAN | Methionine--tRNA ligase, cytoplasmi... | MARS1 | 119 | Annotation score: | ||
H0YI27 | H0YI27_HUMAN | Methionine--tRNA ligase, cytoplasmi... | MARS1 | 124 | Annotation score: | ||
F8VPL7 | F8VPL7_HUMAN | Methionine--tRNA ligase, cytoplasmi... | MARS1 | 60 | Annotation score: | ||
F5H2V6 | F5H2V6_HUMAN | Methionine--tRNA ligase, cytoplasmi... | MARS1 | 140 | Annotation score: | ||
F8VZZ9 | F8VZZ9_HUMAN | Methionine--tRNA ligase, cytoplasmi... | MARS1 | 114 | Annotation score: | ||
F8W0S4 | F8W0S4_HUMAN | Methionine--tRNA ligase, cytoplasmi... | MARS1 | 110 | Annotation score: | ||
There are more potential isoformsShow all |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 53 | L → V in CAA64381 (PubMed:8921912).Curated | 1 | |
Sequence conflicti | 99 | A → P in CAA64381 (PubMed:8921912).Curated | 1 | |
Sequence conflicti | 152 | L → Q in CAA64381 (PubMed:8921912).Curated | 1 | |
Sequence conflicti | 172 | W → S in AAH15011 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 250 | L → P in BAD96487 (Ref. 5) Curated | 1 | |
Sequence conflicti | 683 | A → G in CAA64381 (PubMed:8921912).Curated | 1 | |
Sequence conflicti | 683 | A → G in CAA89153 (PubMed:8921912).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_077848 | 5 | V → M Found in a patient with spastic paraplegia; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs587777227EnsemblClinVar. | 1 | |
Natural variantiVAR_075360 | 206 | P → L1 PublicationCorresponds to variant dbSNP:rs138776588EnsemblClinVar. | 1 | |
Natural variantiVAR_075361 | 344 | Y → C in ILLD; when assayed in yeast, induces a slight growth retardation and reduction in methionine incorporation; may interfere with efficient substrate binding. 1 PublicationCorresponds to variant dbSNP:rs766466297EnsemblClinVar. | 1 | |
Natural variantiVAR_070872 | 370 | F → L in ILLD. 1 PublicationCorresponds to variant dbSNP:rs140467171EnsemblClinVar. | 1 | |
Natural variantiVAR_075362 | 393 | A → T in ILLD; may act as a disease modifier aggravating the phenotype; found in patients that carried additional mutations C-344 and/or L-567; when assayed in yeast, does not exhibit any phenotype; when assayed in yeast in association with L-567, increases L-567-induced growth retardation and reduction in methionine incorporation. 1 PublicationCorresponds to variant dbSNP:rs141340466EnsemblClinVar. | 1 | |
Natural variantiVAR_070873 | 523 | I → T in ILLD. 1 PublicationCorresponds to variant dbSNP:rs201555303EnsemblClinVar. | 1 | |
Natural variantiVAR_075363 | 567 | S → L in ILLD; when assayed in yeast, reduces methionine incorporation; when assayed in yeast in association with T-393, induces growth retardation and strong reduction in methionine incorporation; may interfere with efficient substrate binding. 1 PublicationCorresponds to variant dbSNP:rs143592405EnsemblClinVar. | 1 | |
Natural variantiVAR_075364 | 605 | D → V in ILLD; when assayed in yeast, induces a slight growth retardation and reduction in methionine incorporation; may interfere with efficient substrate binding. 1 PublicationCorresponds to variant dbSNP:rs756021768EnsemblClinVar. | 1 | |
Natural variantiVAR_073377 | 618 | R → C in CMT2U; loss of function mutation. 1 PublicationCorresponds to variant dbSNP:rs587777718EnsemblClinVar. | 1 | |
Natural variantiVAR_020459 | 683 | A → D. Corresponds to variant dbSNP:rs1054403Ensembl. | 1 | |
Natural variantiVAR_077849 | 702 | R → W Found in a patient with spastic paraplegia; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs587777228EnsemblClinVar. | 1 | |
Natural variantiVAR_075365 | 727 | R → Q1 PublicationCorresponds to variant dbSNP:rs113808165EnsemblClinVar. | 1 | |
Natural variantiVAR_073378 | 800 | P → T in CMT2U. 1 PublicationCorresponds to variant dbSNP:rs781249411EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_056563 | 546 | V → P in isoform 2. 1 Publication | 1 | |
Alternative sequenceiVSP_056564 | 547 – 900 | Missing in isoform 2. 1 PublicationAdd BLAST | 354 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X94754 mRNA Translation: CAA64381.1 Z49216 mRNA Translation: CAA89153.1 D84224 mRNA Translation: BAA95668.1 BT007338 mRNA Translation: AAP36002.1 AK122956 mRNA Translation: BAG53819.1 AK222767 mRNA Translation: BAD96487.1 AC022506 Genomic DNA No translation available. BC002384 mRNA Translation: AAH02384.1 BC006328 mRNA Translation: AAH06328.1 BC011639 mRNA Translation: AAH11639.1 BC011849 mRNA Translation: AAH11849.1 BC015011 mRNA Translation: AAH15011.1 |
CCDSi | CCDS8942.1 [P56192-1] |
PIRi | JC5224 |
RefSeqi | NP_004981.2, NM_004990.3 [P56192-1] |
Genome annotation databases
Ensembli | ENST00000262027.10; ENSP00000262027.5; ENSG00000166986.15 ENST00000537638.6; ENSP00000446168.2; ENSG00000166986.15 [P56192-2] |
GeneIDi | 4141 |
KEGGi | hsa:4141 |
MANE-Selecti | ENST00000262027.10; ENSP00000262027.5; NM_004990.4; NP_004981.2 |
UCSCi | uc001sof.2, human [P56192-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X94754 mRNA Translation: CAA64381.1 Z49216 mRNA Translation: CAA89153.1 D84224 mRNA Translation: BAA95668.1 BT007338 mRNA Translation: AAP36002.1 AK122956 mRNA Translation: BAG53819.1 AK222767 mRNA Translation: BAD96487.1 AC022506 Genomic DNA No translation available. BC002384 mRNA Translation: AAH02384.1 BC006328 mRNA Translation: AAH06328.1 BC011639 mRNA Translation: AAH11639.1 BC011849 mRNA Translation: AAH11849.1 BC015011 mRNA Translation: AAH15011.1 |
CCDSi | CCDS8942.1 [P56192-1] |
PIRi | JC5224 |
RefSeqi | NP_004981.2, NM_004990.3 [P56192-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2DJV | NMR | - | A | 835-900 | [»] | |
4BL7 | X-ray | 1.89 | A | 1-224 | [»] | |
4BVX | X-ray | 1.60 | A | 1-207 | [»] | |
4BVY | X-ray | 1.99 | A | 1-225 | [»] | |
5GL7 | X-ray | 2.01 | A | 221-834 | [»] | |
5GOY | X-ray | 2.28 | A | 221-834 | [»] | |
5Y6L | X-ray | 2.90 | A | 1-224 | [»] | |
AlphaFoldDBi | P56192 | |||||
BMRBi | P56192 | |||||
SMRi | P56192 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 110311, 235 interactors |
CORUMi | P56192 |
DIPi | DIP-38164N |
IntActi | P56192, 54 interactors |
MINTi | P56192 |
STRINGi | 9606.ENSP00000262027 |
Chemistry databases
BindingDBi | P56192 |
ChEMBLi | CHEMBL2870 |
DrugBanki | DB00134, Methionine |
Protein family/group databases
MoonProti | P56192 |
PTM databases
CarbonylDBi | P56192 |
GlyGeni | P56192, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P56192 |
MetOSitei | P56192 |
PhosphoSitePlusi | P56192 |
SwissPalmi | P56192 |
Genetic variation databases
BioMutai | MARS |
DMDMi | 20178332 |
Proteomic databases
CPTACi | CPTAC-538 CPTAC-539 |
EPDi | P56192 |
jPOSTi | P56192 |
MassIVEi | P56192 |
MaxQBi | P56192 |
PaxDbi | P56192 |
PeptideAtlasi | P56192 |
PRIDEi | P56192 |
ProteomicsDBi | 3760 56902 [P56192-1] |
Protocols and materials databases
ABCDi | P56192, 1 sequenced antibody |
Antibodypediai | 1110, 166 antibodies from 29 providers |
DNASUi | 4141 |
Genome annotation databases
Ensembli | ENST00000262027.10; ENSP00000262027.5; ENSG00000166986.15 ENST00000537638.6; ENSP00000446168.2; ENSG00000166986.15 [P56192-2] |
GeneIDi | 4141 |
KEGGi | hsa:4141 |
MANE-Selecti | ENST00000262027.10; ENSP00000262027.5; NM_004990.4; NP_004981.2 |
UCSCi | uc001sof.2, human [P56192-1] |
Organism-specific databases
CTDi | 4141 |
DisGeNETi | 4141 |
GeneCardsi | MARS1 |
GeneReviewsi | MARS1 |
HGNCi | HGNC:6898, MARS1 |
HPAi | ENSG00000166986, Low tissue specificity |
MalaCardsi | MARS1 |
MIMi | 156560, gene 615486, phenotype 616280, phenotype |
neXtProti | NX_P56192 |
OpenTargetsi | ENSG00000166986 |
Orphaneti | 397735, Autosomal dominant Charcot-Marie-Tooth disease type 2U 401835, Autosomal recessive spastic paraplegia type 70 440427, Severe early-onset pulmonary alveolar proteinosis due to MARS deficiency |
PharmGKBi | PA30642 |
VEuPathDBi | HostDB:ENSG00000166986 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0867, Eukaryota KOG1247, Eukaryota |
GeneTreei | ENSGT00550000075017 |
HOGENOMi | CLU_009710_3_2_1 |
InParanoidi | P56192 |
OMAi | HGNGYMQ |
OrthoDBi | 333013at2759 |
PhylomeDBi | P56192 |
TreeFami | TF300526 |
Enzyme and pathway databases
BRENDAi | 6.1.1.10, 2681 |
PathwayCommonsi | P56192 |
Reactomei | R-HSA-2408522, Selenoamino acid metabolism R-HSA-379716, Cytosolic tRNA aminoacylation |
SignaLinki | P56192 |
SIGNORi | P56192 |
Miscellaneous databases
BioGRID-ORCSi | 4141, 787 hits in 1084 CRISPR screens |
ChiTaRSi | MARS, human |
EvolutionaryTracei | P56192 |
GeneWikii | MARS_(gene) |
GenomeRNAii | 4141 |
Pharosi | P56192, Tchem |
PROi | PR:P56192 |
RNActi | P56192, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000166986, Expressed in cerebellar hemisphere and 249 other tissues |
ExpressionAtlasi | P56192, baseline and differential |
Genevisiblei | P56192, HS |
Family and domain databases
CDDi | cd07957, Anticodon_Ia_Met, 1 hit cd00814, MetRS_core, 1 hit |
Gene3Di | 2.20.28.20, 1 hit 3.40.50.620, 1 hit |
HAMAPi | MF_00098, Met_tRNA_synth_type1, 1 hit |
InterProi | View protein in InterPro IPR001412, aa-tRNA-synth_I_CS IPR041872, Anticodon_Met IPR010987, Glutathione-S-Trfase_C-like IPR036282, Glutathione-S-Trfase_C_sf IPR004046, GST_C IPR041598, MARS_N IPR023458, Met-tRNA_ligase_1 IPR014758, Met-tRNA_synth IPR015413, Methionyl/Leucyl_tRNA_Synth IPR033911, MetRS_core IPR029038, MetRS_Zn IPR014729, Rossmann-like_a/b/a_fold IPR009068, S15_NS1_RNA-bd IPR009080, tRNAsynth_Ia_anticodon-bd IPR000738, WHEP-TRS_dom |
PANTHERi | PTHR45765, PTHR45765, 1 hit |
Pfami | View protein in Pfam PF19303, Anticodon_3, 1 hit PF00043, GST_C, 1 hit PF18485, GST_N_5, 1 hit PF09334, tRNA-synt_1g, 1 hit PF00458, WHEP-TRS, 1 hit |
PRINTSi | PR01041, TRNASYNTHMET |
SMARTi | View protein in SMART SM00991, WHEP-TRS, 1 hit |
SUPFAMi | SSF47060, SSF47060, 1 hit SSF47323, SSF47323, 1 hit SSF47616, SSF47616, 1 hit SSF57770, SSF57770, 1 hit |
TIGRFAMsi | TIGR00398, metG, 1 hit |
PROSITEi | View protein in PROSITE PS00178, AA_TRNA_LIGASE_I, 1 hit PS50405, GST_CTER, 1 hit PS00762, WHEP_TRS_1, 1 hit PS51185, WHEP_TRS_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SYMC_HUMAN | |
Accessioni | P56192Primary (citable) accession number: P56192 Secondary accession number(s): B3KVK7 Q9NSE0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | April 16, 2002 | |
Last modified: | May 25, 2022 | |
This is version 218 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Aminoacyl-tRNA synthetases
List of aminoacyl-tRNA synthetase entries - Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families