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Protein

Methionine--tRNA ligase, cytoplasmic

Gene

MARS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA.1 Publication

Catalytic activityi

ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met).1 Publication

Activity regulationi

Enzyme activity is increased by spermidine, EEF1A1, and when the Mg2+ concentration is increased from 5 mM to 13 mM (in vitro), possibly by promoting the dissociation of the complex between the enzyme and its product.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei596ATPBy similarity1

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • methionine-tRNA ligase activity Source: UniProtKB
  • tRNA binding Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase, RNA-binding, tRNA-binding
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi6.1.1.10 2681
ReactomeiR-HSA-2408517 SeMet incorporation into proteins
R-HSA-379716 Cytosolic tRNA aminoacylation
SignaLinkiP56192
SIGNORiP56192

Protein family/group databases

MoonProtiP56192

Names & Taxonomyi

Protein namesi
Recommended name:
Methionine--tRNA ligase, cytoplasmic (EC:6.1.1.101 Publication)
Alternative name(s):
Methionyl-tRNA synthetase
Short name:
MetRS
Gene namesi
Name:MARS
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000166986.12
HGNCiHGNC:6898 MARS
MIMi156560 gene
neXtProtiNX_P56192

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Involvement in diseasei

Interstitial lung and liver disease (ILLD)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive, life-threatening disorder characterized by respiratory insufficiency and progressive liver disease with onset in infancy or early childhood. Clinical features include failure to thrive, hypotonia, intermittent lactic acidosis, aminoaciduria, hypothyroidism, interstitial lung disease, pulmonary alveolar proteinosis, anemia, and liver canalicular cholestasis, steatosis, and iron deposition.
See also OMIM:615486
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_075361344Y → C in ILLD; when assayed in yeast, induces a slight growth retardation and reduction in methionine incorporation; may interfere with efficient substrate binding. 1 PublicationCorresponds to variant dbSNP:rs766466297EnsemblClinVar.1
Natural variantiVAR_070872370F → L in ILLD. 1 PublicationCorresponds to variant dbSNP:rs140467171EnsemblClinVar.1
Natural variantiVAR_075362393A → T in ILLD; may act as a disease modifier aggravating the phenotype; found in patients that carried additional mutations C-344 and/or L-567; when assayed in yeast, does not exhibit any phenotype; when assayed in yeast in association with L-567, increases L-567-induced growth retardation and reduction in methionine incorporation. 1 PublicationCorresponds to variant dbSNP:rs141340466EnsemblClinVar.1
Natural variantiVAR_070873523I → T in ILLD. 1 PublicationCorresponds to variant dbSNP:rs201555303EnsemblClinVar.1
Natural variantiVAR_075363567S → L in ILLD; when assayed in yeast, reduces methionine incorporation; when assayed in yeast in association with T-393, induces growth retardation and strong reduction in methionine incorporation; may interfere with efficient substrate binding. 1 PublicationCorresponds to variant dbSNP:rs143592405EnsemblClinVar.1
Natural variantiVAR_075364605D → V in ILLD; when assayed in yeast, induces a slight growth retardation and reduction in methionine incorporation; may interfere with efficient substrate binding. 1 PublicationCorresponds to variant dbSNP:rs756021768EnsemblClinVar.1
Charcot-Marie-Tooth disease 2U (CMT2U)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn axonal form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies (designated CMT1 when they are dominantly inherited) and primary peripheral axonal neuropathies (CMT2). Neuropathies of the CMT2 group are characterized by signs of axonal degeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and atrophy. CMT2U is a slowly progressive, autosomal dominant form characterized by late-adult onset.
See also OMIM:616280
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_073377618R → C in CMT2U; loss of function mutation. 1 PublicationCorresponds to variant dbSNP:rs587777718EnsemblClinVar.1
Natural variantiVAR_073378800P → T in CMT2U. 1 PublicationCorresponds to variant dbSNP:rs781249411EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi64A → R: Loss of interaction with EEF1E1. 1 Publication1
Mutagenesisi86E → R: Loss of interaction with EEF1E1. 1 Publication1
Mutagenesisi857R → A: No effect on enzyme activity. 1 Publication1
Mutagenesisi860K → A: Strongly decreased affinity for tRNA. 1 Publication1
Mutagenesisi863K → A: Slightly decreased enzyme activity. 1 Publication1
Mutagenesisi866K → A: Slightly decreased enzyme activity. 1 Publication1
Mutagenesisi880K → A: Strongly decreased affinity for tRNA. 1 Publication1

Keywords - Diseasei

Charcot-Marie-Tooth disease, Disease mutation, Neurodegeneration, Neuropathy

Organism-specific databases

DisGeNETi4141
MalaCardsiMARS
MIMi615486 phenotype
616280 phenotype
OpenTargetsiENSG00000166986
Orphaneti397735 Autosomal dominant Charcot-Marie-Tooth disease type 2U
401835 Autosomal recessive spastic paraplegia type 70
440427 Severe early-onset pulmonary alveolar proteinosis due to MARS deficiency
PharmGKBiPA30642

Chemistry databases

ChEMBLiCHEMBL2870
DrugBankiDB00134 L-Methionine

Polymorphism and mutation databases

BioMutaiMARS
DMDMi20178332

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001392621 – 900Methionine--tRNA ligase, cytoplasmicAdd BLAST900

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei825PhosphoserineBy similarity1
Modified residuei835PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP56192
MaxQBiP56192
PaxDbiP56192
PeptideAtlasiP56192
PRIDEiP56192
ProteomicsDBi56902

PTM databases

CarbonylDBiP56192
iPTMnetiP56192
PhosphoSitePlusiP56192
SwissPalmiP56192

Expressioni

Gene expression databases

BgeeiENSG00000166986 Expressed in 239 organ(s), highest expression level in cerebellar hemisphere
CleanExiHS_MARS
ExpressionAtlasiP56192 baseline and differential
GenevisibleiP56192 HS

Organism-specific databases

HPAiCAB017097
HPA004125

Interactioni

Subunit structurei

Monomer (PubMed:11714285). Part of a multisubunit complex that groups tRNA ligases for Arg (RARS), Asp (DARS), Gln (QARS), Ile (IARS), Leu (LARS), Lys (KARS), Met (MARS) the bifunctional ligase for Glu and Pro (EPRS) and the auxiliary subunits AIMP1/p43, AIMP2/p38 and EEF1E1/p18 (PubMed:19131329, PubMed:19289464, Ref. 23, PubMed:26472928). Forms a linear complex that contains MARS, EEF1E1, EPRS and AIMP2 that is at the core of the multisubunit complex (PubMed:26472928).5 Publications

Protein-protein interaction databases

BioGridi110311, 157 interactors
CORUMiP56192
DIPiDIP-38164N
IntActiP56192, 30 interactors
MINTiP56192
STRINGi9606.ENSP00000262027

Chemistry databases

BindingDBiP56192

Structurei

Secondary structure

1900
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP56192
SMRiP56192
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP56192

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini74 – 198GST C-terminalAdd BLAST125
Domaini841 – 897WHEP-TRSAdd BLAST57

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi273 – 283"HIGH" regionAdd BLAST11
Motifi593 – 597"KMSKS" region5

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0867 Eukaryota
KOG1247 Eukaryota
COG0143 LUCA
GeneTreeiENSGT00550000075017
HOGENOMiHOG000200402
HOVERGENiHBG036191
InParanoidiP56192
KOiK01874
OMAiHAVHSEV
OrthoDBiEOG091G020Y
PhylomeDBiP56192
TreeFamiTF300526

Family and domain databases

CDDicd00814 MetRS_core, 1 hit
Gene3Di2.20.28.20, 1 hit
3.40.50.620, 1 hit
HAMAPiMF_00098 Met_tRNA_synth_type1, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR004046 GST_C
IPR023458 Met-tRNA_ligase_1
IPR014758 Met-tRNA_synth
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR033911 MetRS_core
IPR029038 MetRS_Zn
IPR014729 Rossmann-like_a/b/a_fold
IPR009068 S15_NS1_RNA-bd
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR000738 WHEP-TRS_dom
PfamiView protein in Pfam
PF00043 GST_C, 1 hit
PF09334 tRNA-synt_1g, 1 hit
PF00458 WHEP-TRS, 1 hit
PRINTSiPR01041 TRNASYNTHMET
SMARTiView protein in SMART
SM00991 WHEP-TRS, 1 hit
SUPFAMiSSF47060 SSF47060, 1 hit
SSF47323 SSF47323, 1 hit
SSF47616 SSF47616, 1 hit
SSF57770 SSF57770, 1 hit
TIGRFAMsiTIGR00398 metG, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit
PS50405 GST_CTER, 1 hit
PS00762 WHEP_TRS_1, 1 hit
PS51185 WHEP_TRS_2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 12 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P56192-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRLFVSDGVP GCLPVLAAAG RARGRAEVLI STVGPEDCVV PFLTRPKVPV
60 70 80 90 100
LQLDSGNYLF STSAICRYFF LLSGWEQDDL TNQWLEWEAT ELQPALSAAL
110 120 130 140 150
YYLVVQGKKG EDVLGSVRRA LTHIDHSLSR QNCPFLAGET ESLADIVLWG
160 170 180 190 200
ALYPLLQDPA YLPEELSALH SWFQTLSTQE PCQRAAETVL KQQGVLALRP
210 220 230 240 250
YLQKQPQPSP AEGRAVTNEP EEEELATLSE EEIAMAVTAW EKGLESLPPL
260 270 280 290 300
RPQQNPVLPV AGERNVLITS ALPYVNNVPH LGNIIGCVLS ADVFARYSRL
310 320 330 340 350
RQWNTLYLCG TDEYGTATET KALEEGLTPQ EICDKYHIIH ADIYRWFNIS
360 370 380 390 400
FDIFGRTTTP QQTKITQDIF QQLLKRGFVL QDTVEQLRCE HCARFLADRF
410 420 430 440 450
VEGVCPFCGY EEARGDQCDK CGKLINAVEL KKPQCKVCRS CPVVQSSQHL
460 470 480 490 500
FLDLPKLEKR LEEWLGRTLP GSDWTPNAQF ITRSWLRDGL KPRCITRDLK
510 520 530 540 550
WGTPVPLEGF EDKVFYVWFD ATIGYLSITA NYTDQWERWW KNPEQVDLYQ
560 570 580 590 600
FMAKDNVPFH SLVFPCSALG AEDNYTLVSH LIATEYLNYE DGKFSKSRGV
610 620 630 640 650
GVFGDMAQDT GIPADIWRFY LLYIRPEGQD SAFSWTDLLL KNNSELLNNL
660 670 680 690 700
GNFINRAGMF VSKFFGGYVP EMVLTPDDQR LLAHVTLELQ HYHQLLEKVR
710 720 730 740 750
IRDALRSILT ISRHGNQYIQ VNEPWKRIKG SEADRQRAGT VTGLAVNIAA
760 770 780 790 800
LLSVMLQPYM PTVSATIQAQ LQLPPPACSI LLTNFLCTLP AGHQIGTVSP
810 820 830 840 850
LFQKLENDQI ESLRQRFGGG QAKTSPKPAV VETVTTAKPQ QIQALMDEVT
860 870 880 890 900
KQGNIVRELK AQKADKNEVA AEVAKLLDLK KQLAVAEGKP PEAPKGKKKK
Length:900
Mass (Da):101,116
Last modified:April 16, 2002 - v2
Checksum:i3D687C77E17C5C96
GO
Isoform 2 (identifier: P56192-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     546-546: V → P
     547-900: Missing.

Note: No experimental confirmation available.
Show »
Length:546
Mass (Da):61,816
Checksum:iED19F00468D3C6AB
GO

Computationally mapped potential isoform sequencesi

There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YHV5H0YHV5_HUMAN
Methionine--tRNA ligase, cytoplasmi...
MARS
233Annotation score:
H0YIP0H0YIP0_HUMAN
Methionine--tRNA ligase, cytoplasmi...
MARS
219Annotation score:
H0YI27H0YI27_HUMAN
Methionine--tRNA ligase, cytoplasmi...
MARS
124Annotation score:
H0YI94H0YI94_HUMAN
Methionine--tRNA ligase, cytoplasmi...
MARS
119Annotation score:
H0YIC2H0YIC2_HUMAN
Methionine--tRNA ligase, cytoplasmi...
MARS
58Annotation score:
H0YHL6H0YHL6_HUMAN
Methionine--tRNA ligase, cytoplasmi...
MARS
81Annotation score:
F5H2V6F5H2V6_HUMAN
Methionine--tRNA ligase, cytoplasmi...
MARS
140Annotation score:
F8W0M7F8W0M7_HUMAN
Methionine--tRNA ligase, cytoplasmi...
MARS
95Annotation score:
F8VZZ9F8VZZ9_HUMAN
Methionine--tRNA ligase, cytoplasmi...
MARS
114Annotation score:
F8W0S4F8W0S4_HUMAN
Methionine--tRNA ligase, cytoplasmi...
MARS
110Annotation score:
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti53L → V in CAA64381 (PubMed:8921912).Curated1
Sequence conflicti99A → P in CAA64381 (PubMed:8921912).Curated1
Sequence conflicti152L → Q in CAA64381 (PubMed:8921912).Curated1
Sequence conflicti172W → S in AAH15011 (PubMed:15489334).Curated1
Sequence conflicti250L → P in BAD96487 (Ref. 5) Curated1
Sequence conflicti683A → G in CAA64381 (PubMed:8921912).Curated1
Sequence conflicti683A → G in CAA89153 (PubMed:8921912).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0778485V → M Found in a patient with spastic paraplegia; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs587777227EnsemblClinVar.1
Natural variantiVAR_075360206P → L1 PublicationCorresponds to variant dbSNP:rs138776588EnsemblClinVar.1
Natural variantiVAR_075361344Y → C in ILLD; when assayed in yeast, induces a slight growth retardation and reduction in methionine incorporation; may interfere with efficient substrate binding. 1 PublicationCorresponds to variant dbSNP:rs766466297EnsemblClinVar.1
Natural variantiVAR_070872370F → L in ILLD. 1 PublicationCorresponds to variant dbSNP:rs140467171EnsemblClinVar.1
Natural variantiVAR_075362393A → T in ILLD; may act as a disease modifier aggravating the phenotype; found in patients that carried additional mutations C-344 and/or L-567; when assayed in yeast, does not exhibit any phenotype; when assayed in yeast in association with L-567, increases L-567-induced growth retardation and reduction in methionine incorporation. 1 PublicationCorresponds to variant dbSNP:rs141340466EnsemblClinVar.1
Natural variantiVAR_070873523I → T in ILLD. 1 PublicationCorresponds to variant dbSNP:rs201555303EnsemblClinVar.1
Natural variantiVAR_075363567S → L in ILLD; when assayed in yeast, reduces methionine incorporation; when assayed in yeast in association with T-393, induces growth retardation and strong reduction in methionine incorporation; may interfere with efficient substrate binding. 1 PublicationCorresponds to variant dbSNP:rs143592405EnsemblClinVar.1
Natural variantiVAR_075364605D → V in ILLD; when assayed in yeast, induces a slight growth retardation and reduction in methionine incorporation; may interfere with efficient substrate binding. 1 PublicationCorresponds to variant dbSNP:rs756021768EnsemblClinVar.1
Natural variantiVAR_073377618R → C in CMT2U; loss of function mutation. 1 PublicationCorresponds to variant dbSNP:rs587777718EnsemblClinVar.1
Natural variantiVAR_020459683A → D. Corresponds to variant dbSNP:rs1054403Ensembl.1
Natural variantiVAR_077849702R → W Found in a patient with spastic paraplegia; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs587777228EnsemblClinVar.1
Natural variantiVAR_075365727R → Q1 PublicationCorresponds to variant dbSNP:rs113808165EnsemblClinVar.1
Natural variantiVAR_073378800P → T in CMT2U. 1 PublicationCorresponds to variant dbSNP:rs781249411EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_056563546V → P in isoform 2. 1 Publication1
Alternative sequenceiVSP_056564547 – 900Missing in isoform 2. 1 PublicationAdd BLAST354

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X94754 mRNA Translation: CAA64381.1
Z49216 mRNA Translation: CAA89153.1
D84224 mRNA Translation: BAA95668.1
BT007338 mRNA Translation: AAP36002.1
AK122956 mRNA Translation: BAG53819.1
AK222767 mRNA Translation: BAD96487.1
AC022506 Genomic DNA No translation available.
BC002384 mRNA Translation: AAH02384.1
BC006328 mRNA Translation: AAH06328.1
BC011639 mRNA Translation: AAH11639.1
BC011849 mRNA Translation: AAH11849.1
BC015011 mRNA Translation: AAH15011.1
CCDSiCCDS8942.1 [P56192-1]
PIRiJC5224
RefSeqiNP_004981.2, NM_004990.3 [P56192-1]
UniGeneiHs.632707

Genome annotation databases

EnsembliENST00000262027; ENSP00000262027; ENSG00000166986 [P56192-1]
ENST00000537638; ENSP00000446168; ENSG00000166986 [P56192-2]
GeneIDi4141
KEGGihsa:4141
UCSCiuc001sof.2 human [P56192-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X94754 mRNA Translation: CAA64381.1
Z49216 mRNA Translation: CAA89153.1
D84224 mRNA Translation: BAA95668.1
BT007338 mRNA Translation: AAP36002.1
AK122956 mRNA Translation: BAG53819.1
AK222767 mRNA Translation: BAD96487.1
AC022506 Genomic DNA No translation available.
BC002384 mRNA Translation: AAH02384.1
BC006328 mRNA Translation: AAH06328.1
BC011639 mRNA Translation: AAH11639.1
BC011849 mRNA Translation: AAH11849.1
BC015011 mRNA Translation: AAH15011.1
CCDSiCCDS8942.1 [P56192-1]
PIRiJC5224
RefSeqiNP_004981.2, NM_004990.3 [P56192-1]
UniGeneiHs.632707

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DJVNMR-A835-900[»]
4BL7X-ray1.89A1-224[»]
4BVXX-ray1.60A1-207[»]
4BVYX-ray1.99A1-225[»]
5GL7X-ray2.01A221-834[»]
5GOYX-ray2.28A221-834[»]
5Y6LX-ray2.90A1-224[»]
ProteinModelPortaliP56192
SMRiP56192
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110311, 157 interactors
CORUMiP56192
DIPiDIP-38164N
IntActiP56192, 30 interactors
MINTiP56192
STRINGi9606.ENSP00000262027

Chemistry databases

BindingDBiP56192
ChEMBLiCHEMBL2870
DrugBankiDB00134 L-Methionine

Protein family/group databases

MoonProtiP56192

PTM databases

CarbonylDBiP56192
iPTMnetiP56192
PhosphoSitePlusiP56192
SwissPalmiP56192

Polymorphism and mutation databases

BioMutaiMARS
DMDMi20178332

Proteomic databases

EPDiP56192
MaxQBiP56192
PaxDbiP56192
PeptideAtlasiP56192
PRIDEiP56192
ProteomicsDBi56902

Protocols and materials databases

DNASUi4141
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262027; ENSP00000262027; ENSG00000166986 [P56192-1]
ENST00000537638; ENSP00000446168; ENSG00000166986 [P56192-2]
GeneIDi4141
KEGGihsa:4141
UCSCiuc001sof.2 human [P56192-1]

Organism-specific databases

CTDi4141
DisGeNETi4141
EuPathDBiHostDB:ENSG00000166986.12
GeneCardsiMARS
HGNCiHGNC:6898 MARS
HPAiCAB017097
HPA004125
MalaCardsiMARS
MIMi156560 gene
615486 phenotype
616280 phenotype
neXtProtiNX_P56192
OpenTargetsiENSG00000166986
Orphaneti397735 Autosomal dominant Charcot-Marie-Tooth disease type 2U
401835 Autosomal recessive spastic paraplegia type 70
440427 Severe early-onset pulmonary alveolar proteinosis due to MARS deficiency
PharmGKBiPA30642
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0867 Eukaryota
KOG1247 Eukaryota
COG0143 LUCA
GeneTreeiENSGT00550000075017
HOGENOMiHOG000200402
HOVERGENiHBG036191
InParanoidiP56192
KOiK01874
OMAiHAVHSEV
OrthoDBiEOG091G020Y
PhylomeDBiP56192
TreeFamiTF300526

Enzyme and pathway databases

BRENDAi6.1.1.10 2681
ReactomeiR-HSA-2408517 SeMet incorporation into proteins
R-HSA-379716 Cytosolic tRNA aminoacylation
SignaLinkiP56192
SIGNORiP56192

Miscellaneous databases

ChiTaRSiMARS human
EvolutionaryTraceiP56192
GeneWikiiMARS_(gene)
GenomeRNAii4141
PROiPR:P56192
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000166986 Expressed in 239 organ(s), highest expression level in cerebellar hemisphere
CleanExiHS_MARS
ExpressionAtlasiP56192 baseline and differential
GenevisibleiP56192 HS

Family and domain databases

CDDicd00814 MetRS_core, 1 hit
Gene3Di2.20.28.20, 1 hit
3.40.50.620, 1 hit
HAMAPiMF_00098 Met_tRNA_synth_type1, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR004046 GST_C
IPR023458 Met-tRNA_ligase_1
IPR014758 Met-tRNA_synth
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR033911 MetRS_core
IPR029038 MetRS_Zn
IPR014729 Rossmann-like_a/b/a_fold
IPR009068 S15_NS1_RNA-bd
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR000738 WHEP-TRS_dom
PfamiView protein in Pfam
PF00043 GST_C, 1 hit
PF09334 tRNA-synt_1g, 1 hit
PF00458 WHEP-TRS, 1 hit
PRINTSiPR01041 TRNASYNTHMET
SMARTiView protein in SMART
SM00991 WHEP-TRS, 1 hit
SUPFAMiSSF47060 SSF47060, 1 hit
SSF47323 SSF47323, 1 hit
SSF47616 SSF47616, 1 hit
SSF57770 SSF57770, 1 hit
TIGRFAMsiTIGR00398 metG, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit
PS50405 GST_CTER, 1 hit
PS00762 WHEP_TRS_1, 1 hit
PS51185 WHEP_TRS_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSYMC_HUMAN
AccessioniPrimary (citable) accession number: P56192
Secondary accession number(s): B3KVK7
, Q14895, Q53H14, Q96A15, Q96BZ0, Q9NSE0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: April 16, 2002
Last modified: November 7, 2018
This is version 197 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  7. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
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