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UniProtKB - P56181 (NDUV3_HUMAN)

Entry version 166 (02 Jun 2021)
Sequence version 2 (16 Apr 2002)
Previous versions | rss
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Protein

NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial

Gene

NDUFV3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. May be the terminally assembled subunit of Complex I.

1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processElectron transport, Respiratory chain, Transport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		MetaCyc:HS08459-MONOMER

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P56181

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-611105, Respiratory electron transport
R-HSA-6799198, Complex I biogenesis

SIGNOR Signaling Network Open Resource

More...SIGNORi		P56181

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial
Alternative name(s):
Complex I-9kD
Short name:
CI-9kD
NADH-ubiquinone oxidoreductase 9 kDa subunit
Renal carcinoma antigen NY-REN-4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NDUFV3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 21

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:7719, NDUFV3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		602184, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P56181

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000160194.17

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		4731

Open Targets

More...OpenTargetsi		ENSG00000160194

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA31529

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P56181, Tclin

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL2363065

Drug and drug target database

More...DrugBanki		DB00157, NADH
DB09270, Ubidecarenone

DrugCentral

More...DrugCentrali		P56181

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		NDUFV3

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 34MitochondrionBy similarityAdd BLAST34
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002002535 – 108NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrialAdd BLAST74

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei105PhosphoserineCombined sources1
Isoform 2 (identifier: P56181-2)
Modified residuei160PhosphoserineCombined sources1
Modified residuei162PhosphoserineCombined sources1
Modified residuei164PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P56181

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P56181

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P56181

MaxQB - The MaxQuant DataBase

More...MaxQBi		P56181

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P56181

PeptideAtlas

More...PeptideAtlasi		P56181

PRoteomics IDEntifications database

More...PRIDEi		P56181

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		56899 [P56181-1]
56900 [P56181-2]

Consortium for Top Down Proteomics

More...TopDownProteomicsi		P56181-1 [P56181-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P56181

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P56181

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000160194, Expressed in quadriceps femoris and 217 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P56181, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000160194, Tissue enhanced (skeletal)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Complex I is composed of 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		110809, 135 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-577, Mitochondrial respiratory chain complex I

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P56181

Protein interaction database and analysis system

More...IntActi		P56181, 43 interactors

Molecular INTeraction database

More...MINTi		P56181

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000346196

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P56181

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P56181, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1108
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P56181

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni33 – 72DisorderedSequence analysisAdd BLAST40

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi33 – 52Polar residuesSequence analysisAdd BLAST20

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the complex I NDUFV3 subunit family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502S46A, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000012196

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_045834_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P56181

Identification of Orthologs from Complete Genome Data

More...OMAi		YPEKPRQ

Database of Orthologous Groups

More...OrthoDBi		1132013at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P56181

TreeFam database of animal gene trees

More...TreeFami		TF338771

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR026193, NDUFV3

The PANTHER Classification System

More...PANTHERi		PTHR17117, PTHR17117, 2 hits

Pfam protein domain database

More...Pfami		View protein in Pfam
PF15880, NDUFV3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P56181-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAPCLLRQG RAGALKTMLQ EAQVFRGLAS TVSLSAESGK SEKGQPQNSK 
        60         70         80         90        100
KQSPPKKPAP VPAEPFDNTT YKNLQHHDYS TYTFLDLNLE LSKFRMPQPS 

SGRESPRH
Length:108
Mass (Da):11,941
Last modified:April 16, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBD7375474AB0B1EC
GO
Isoform 2 (identifier: P56181-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     56-57: KK → KNVVEPKERG...PGDDRGGTQE

Show »
Length:473
Mass (Da):50,984
Checksum:iBCC3F2E545CA738A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti9Q → K in CAB56704 (PubMed:9344673).Curated1
Isoform 2 (identifier: P56181-2)
Sequence conflicti415D → N in AAH21217 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_03855256 – 57KK → KNVVEPKERGKLLATQTAAE LSKNLSSPSSYPPAVNKGRK VASPSPSGSVLFTDEGVPKF LSRKTLVEFPQKVLSPFRKQ GSDSEARQVGRKVTSPSSSS SSSSSDSESDDEADVSEVTP RVVSKGRGGLRKPEASHSFE NRAPRVTVSAKEKTLLQKPH VDITDPEKPHQPKKKGSPAK PSEGRENARPKTTMPRSQVD EEFLKQSLKEKQLQKTFRLN EIDKESQKPFEVKGPLPVHT KSGLSAPPKGSPAPAVLAEE ARAEGQLQASPPGAAEGHLE KPVPEPQRKAAPPLPRKETS GTQGIEGHLKGGQAIVEDQI PPSNLETVPVENNHGFHEKT AALKLEAEGEAMEDAAAPGD DRGGTQE in isoform 2. 1 Publication2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X99726, X99727, X99728 Genomic DNA Translation: CAB56704.1
AB038163 Genomic DNA Translation: BAB13732.1
CR542174 mRNA Translation: CAG46971.1
CR542190 mRNA Translation: CAG46987.1
AK289586 mRNA Translation: BAF82275.1
AP001629 Genomic DNA No translation available.
CH471079 Genomic DNA Translation: EAX09524.1
CH471079 Genomic DNA Translation: EAX09526.1
BC021217 mRNA Translation: AAH21217.2
BC033766 mRNA Translation: AAH33766.1
BC054016 mRNA Translation: AAH54016.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS33572.1 [P56181-2]
CCDS33573.1 [P56181-1]

NCBI Reference Sequences

More...RefSeqi		NP_001001503.1, NM_001001503.1 [P56181-1]
NP_066553.3, NM_021075.3 [P56181-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000340344; ENSP00000342895; ENSG00000160194 [P56181-1]
ENST00000354250; ENSP00000346196; ENSG00000160194 [P56181-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		4731

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:4731

UCSC genome browser

More...UCSCi		uc002zcm.4, human [P56181-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99726, X99727, X99728 Genomic DNA Translation: CAB56704.1
AB038163 Genomic DNA Translation: BAB13732.1
CR542174 mRNA Translation: CAG46971.1
CR542190 mRNA Translation: CAG46987.1
AK289586 mRNA Translation: BAF82275.1
AP001629 Genomic DNA No translation available.
CH471079 Genomic DNA Translation: EAX09524.1
CH471079 Genomic DNA Translation: EAX09526.1
BC021217 mRNA Translation: AAH21217.2
BC033766 mRNA Translation: AAH33766.1
BC054016 mRNA Translation: AAH54016.1
CCDSiCCDS33572.1 [P56181-2]
CCDS33573.1 [P56181-1]
RefSeqiNP_001001503.1, NM_001001503.1 [P56181-1]
NP_066553.3, NM_021075.3 [P56181-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5XTBelectron microscopy3.40K74-106[»]
5XTDelectron microscopy3.70K74-106[»]
5XTHelectron microscopy3.90K74-106[»]
5XTIelectron microscopy17.40BK/K74-106[»]
SMRiP56181
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi110809, 135 interactors
ComplexPortaliCPX-577, Mitochondrial respiratory chain complex I
CORUMiP56181
IntActiP56181, 43 interactors
MINTiP56181
STRINGi9606.ENSP00000346196

Chemistry databases

BindingDBiP56181
ChEMBLiCHEMBL2363065
DrugBankiDB00157, NADH
DB09270, Ubidecarenone
DrugCentraliP56181

PTM databases

iPTMnetiP56181
PhosphoSitePlusiP56181

Genetic variation databases

BioMutaiNDUFV3

Proteomic databases

EPDiP56181
jPOSTiP56181
MassIVEiP56181
MaxQBiP56181
PaxDbiP56181
PeptideAtlasiP56181
PRIDEiP56181
ProteomicsDBi56899 [P56181-1]
56900 [P56181-2]
TopDownProteomicsiP56181-1 [P56181-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		9794, 150 antibodies

The DNASU plasmid repository

More...DNASUi		4731

Genome annotation databases

EnsembliENST00000340344; ENSP00000342895; ENSG00000160194 [P56181-1]
ENST00000354250; ENSP00000346196; ENSG00000160194 [P56181-2]
GeneIDi4731
KEGGihsa:4731
UCSCiuc002zcm.4, human [P56181-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		4731
DisGeNETi4731

GeneCards: human genes, protein and diseases

More...GeneCardsi		NDUFV3
HGNCiHGNC:7719, NDUFV3
HPAiENSG00000160194, Tissue enhanced (skeletal)
MIMi602184, gene
neXtProtiNX_P56181
OpenTargetsiENSG00000160194
PharmGKBiPA31529
VEuPathDBiHostDB:ENSG00000160194.17

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502S46A, Eukaryota
GeneTreeiENSGT00390000012196
HOGENOMiCLU_045834_0_0_1
InParanoidiP56181
OMAiYPEKPRQ
OrthoDBi1132013at2759
PhylomeDBiP56181
TreeFamiTF338771

Enzyme and pathway databases

BioCyciMetaCyc:HS08459-MONOMER
PathwayCommonsiP56181
ReactomeiR-HSA-611105, Respiratory electron transport
R-HSA-6799198, Complex I biogenesis
SIGNORiP56181

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		4731, 2 hits in 1000 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		NDUFV3, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		NDUFV3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		4731
PharosiP56181, Tclin

Protein Ontology

More...PROi		PR:P56181
RNActiP56181, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000160194, Expressed in quadriceps femoris and 217 other tissues
GenevisibleiP56181, HS

Family and domain databases

InterProiView protein in InterPro
IPR026193, NDUFV3
PANTHERiPTHR17117, PTHR17117, 2 hits
PfamiView protein in Pfam
PF15880, NDUFV3, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNDUV3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P56181
Secondary accession number(s): A8K0M1
, J3KNX7, Q6FGD3, Q8WU60, Q9HCR5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: April 16, 2002
Last modified: June 2, 2021
This is version 166 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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