UniProtKB - P56181 (NDUV3_HUMAN)
Protein
NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial
Gene
NDUFV3
Organism
Homo sapiens (Human)
Status
Functioni
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. May be the terminally assembled subunit of Complex I.1 Publication
GO - Molecular functioni
- NADH dehydrogenase (ubiquinone) activity Source: ProtInc
- RNA binding Source: UniProtKB
GO - Biological processi
- mitochondrial ATP synthesis coupled electron transport Source: CAFA
- mitochondrial electron transport, NADH to ubiquinone Source: Reactome
- mitochondrial respiratory chain complex I assembly Source: Reactome
Keywordsi
Biological process | Electron transport, Respiratory chain, Transport |
Enzyme and pathway databases
BioCyci | MetaCyc:HS08459-MONOMER |
PathwayCommonsi | P56181 |
Reactomei | R-HSA-611105, Respiratory electron transport R-HSA-6799198, Complex I biogenesis |
SIGNORi | P56181 |
Names & Taxonomyi
Protein namesi | Recommended name: NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrialAlternative name(s): Complex I-9kD Short name: CI-9kD NADH-ubiquinone oxidoreductase 9 kDa subunit Renal carcinoma antigen NY-REN-4 |
Gene namesi | Name:NDUFV3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:7719, NDUFV3 |
MIMi | 602184, gene |
neXtProti | NX_P56181 |
VEuPathDBi | HostDB:ENSG00000160194.17 |
Subcellular locationi
Mitochondrion
- Mitochondrion inner membrane 1 Publication; Peripheral membrane protein Curated; Matrix side Curated
Mitochondrion
- mitochondrial inner membrane Source: Reactome
- mitochondrial respiratory chain complex I Source: UniProtKB
- mitochondrion Source: HPA
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membranePathology & Biotechi
Organism-specific databases
DisGeNETi | 4731 |
OpenTargetsi | ENSG00000160194 |
PharmGKBi | PA31529 |
Miscellaneous databases
Pharosi | P56181, Tclin |
Chemistry databases
ChEMBLi | CHEMBL2363065 |
DrugBanki | DB00157, NADH DB09270, Ubidecarenone |
DrugCentrali | P56181 |
Genetic variation databases
BioMutai | NDUFV3 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 34 | MitochondrionBy similarityAdd BLAST | 34 | |
ChainiPRO_0000020025 | 35 – 108 | NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrialAdd BLAST | 74 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Modified residuei | 105 | PhosphoserineCombined sources | 1 | ||
Isoform 2 (identifier: P56181-2) | |||||
Modified residuei | 160 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 162 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 164 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | P56181 |
jPOSTi | P56181 |
MassIVEi | P56181 |
MaxQBi | P56181 |
PaxDbi | P56181 |
PeptideAtlasi | P56181 |
PRIDEi | P56181 |
ProteomicsDBi | 56899 [P56181-1] 56900 [P56181-2] |
TopDownProteomicsi | P56181-1 [P56181-1] |
PTM databases
iPTMneti | P56181 |
PhosphoSitePlusi | P56181 |
Expressioni
Gene expression databases
Bgeei | ENSG00000160194, Expressed in quadriceps femoris and 216 other tissues |
Genevisiblei | P56181, HS |
Organism-specific databases
HPAi | ENSG00000160194, Tissue enhanced (skeletal) |
Interactioni
Subunit structurei
Complex I is composed of 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme.
2 PublicationsBinary interactionsi
P56181
With | #Exp. | IntAct |
---|---|---|
NDUFV1 [P49821] | 2 | EBI-721902,EBI-748312 |
Protein-protein interaction databases
BioGRIDi | 110809, 135 interactors |
ComplexPortali | CPX-577, Mitochondrial respiratory chain complex I |
CORUMi | P56181 |
IntActi | P56181, 43 interactors |
MINTi | P56181 |
STRINGi | 9606.ENSP00000346196 |
Chemistry databases
BindingDBi | P56181 |
Miscellaneous databases
RNActi | P56181, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P56181 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the complex I NDUFV3 subunit family.Curated
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | ENOG502S46A, Eukaryota |
GeneTreei | ENSGT00390000012196 |
HOGENOMi | CLU_045834_0_0_1 |
InParanoidi | P56181 |
OMAi | YPEKPRQ |
OrthoDBi | 1132013at2759 |
PhylomeDBi | P56181 |
TreeFami | TF338771 |
Family and domain databases
InterProi | View protein in InterPro IPR026193, NDUFV3 |
PANTHERi | PTHR17117, PTHR17117, 2 hits |
Pfami | View protein in Pfam PF15880, NDUFV3, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: P56181-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAAPCLLRQG RAGALKTMLQ EAQVFRGLAS TVSLSAESGK SEKGQPQNSK
60 70 80 90 100
KQSPPKKPAP VPAEPFDNTT YKNLQHHDYS TYTFLDLNLE LSKFRMPQPS
SGRESPRH
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Sequence conflicti | 9 | Q → K in CAB56704 (PubMed:9344673).Curated | 1 | ||
Isoform 2 (identifier: P56181-2) | |||||
Sequence conflicti | 415 | D → N in AAH21217 (PubMed:15489334).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_038552 | 56 – 57 | KK → KNVVEPKERGKLLATQTAAE LSKNLSSPSSYPPAVNKGRK VASPSPSGSVLFTDEGVPKF LSRKTLVEFPQKVLSPFRKQ GSDSEARQVGRKVTSPSSSS SSSSSDSESDDEADVSEVTP RVVSKGRGGLRKPEASHSFE NRAPRVTVSAKEKTLLQKPH VDITDPEKPHQPKKKGSPAK PSEGRENARPKTTMPRSQVD EEFLKQSLKEKQLQKTFRLN EIDKESQKPFEVKGPLPVHT KSGLSAPPKGSPAPAVLAEE ARAEGQLQASPPGAAEGHLE KPVPEPQRKAAPPLPRKETS GTQGIEGHLKGGQAIVEDQI PPSNLETVPVENNHGFHEKT AALKLEAEGEAMEDAAAPGD DRGGTQE in isoform 2. 1 Publication | 2 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X99726, X99727, X99728 Genomic DNA Translation: CAB56704.1 AB038163 Genomic DNA Translation: BAB13732.1 CR542174 mRNA Translation: CAG46971.1 CR542190 mRNA Translation: CAG46987.1 AK289586 mRNA Translation: BAF82275.1 AP001629 Genomic DNA No translation available. CH471079 Genomic DNA Translation: EAX09524.1 CH471079 Genomic DNA Translation: EAX09526.1 BC021217 mRNA Translation: AAH21217.2 BC033766 mRNA Translation: AAH33766.1 BC054016 mRNA Translation: AAH54016.1 |
CCDSi | CCDS33572.1 [P56181-2] CCDS33573.1 [P56181-1] |
RefSeqi | NP_001001503.1, NM_001001503.1 [P56181-1] NP_066553.3, NM_021075.3 [P56181-2] |
Genome annotation databases
Ensembli | ENST00000340344; ENSP00000342895; ENSG00000160194 [P56181-1] ENST00000354250; ENSP00000346196; ENSG00000160194 [P56181-2] |
GeneIDi | 4731 |
KEGGi | hsa:4731 |
UCSCi | uc002zcm.4, human [P56181-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X99726, X99727, X99728 Genomic DNA Translation: CAB56704.1 AB038163 Genomic DNA Translation: BAB13732.1 CR542174 mRNA Translation: CAG46971.1 CR542190 mRNA Translation: CAG46987.1 AK289586 mRNA Translation: BAF82275.1 AP001629 Genomic DNA No translation available. CH471079 Genomic DNA Translation: EAX09524.1 CH471079 Genomic DNA Translation: EAX09526.1 BC021217 mRNA Translation: AAH21217.2 BC033766 mRNA Translation: AAH33766.1 BC054016 mRNA Translation: AAH54016.1 |
CCDSi | CCDS33572.1 [P56181-2] CCDS33573.1 [P56181-1] |
RefSeqi | NP_001001503.1, NM_001001503.1 [P56181-1] NP_066553.3, NM_021075.3 [P56181-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5XTB | electron microscopy | 3.40 | K | 74-106 | [»] | |
5XTD | electron microscopy | 3.70 | K | 74-106 | [»] | |
5XTH | electron microscopy | 3.90 | K | 74-106 | [»] | |
5XTI | electron microscopy | 17.40 | BK/K | 74-106 | [»] | |
SMRi | P56181 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 110809, 135 interactors |
ComplexPortali | CPX-577, Mitochondrial respiratory chain complex I |
CORUMi | P56181 |
IntActi | P56181, 43 interactors |
MINTi | P56181 |
STRINGi | 9606.ENSP00000346196 |
Chemistry databases
BindingDBi | P56181 |
ChEMBLi | CHEMBL2363065 |
DrugBanki | DB00157, NADH DB09270, Ubidecarenone |
DrugCentrali | P56181 |
PTM databases
iPTMneti | P56181 |
PhosphoSitePlusi | P56181 |
Genetic variation databases
BioMutai | NDUFV3 |
Proteomic databases
EPDi | P56181 |
jPOSTi | P56181 |
MassIVEi | P56181 |
MaxQBi | P56181 |
PaxDbi | P56181 |
PeptideAtlasi | P56181 |
PRIDEi | P56181 |
ProteomicsDBi | 56899 [P56181-1] 56900 [P56181-2] |
TopDownProteomicsi | P56181-1 [P56181-1] |
Protocols and materials databases
Antibodypediai | 9794, 150 antibodies |
DNASUi | 4731 |
Genome annotation databases
Ensembli | ENST00000340344; ENSP00000342895; ENSG00000160194 [P56181-1] ENST00000354250; ENSP00000346196; ENSG00000160194 [P56181-2] |
GeneIDi | 4731 |
KEGGi | hsa:4731 |
UCSCi | uc002zcm.4, human [P56181-1] |
Organism-specific databases
CTDi | 4731 |
DisGeNETi | 4731 |
GeneCardsi | NDUFV3 |
HGNCi | HGNC:7719, NDUFV3 |
HPAi | ENSG00000160194, Tissue enhanced (skeletal) |
MIMi | 602184, gene |
neXtProti | NX_P56181 |
OpenTargetsi | ENSG00000160194 |
PharmGKBi | PA31529 |
VEuPathDBi | HostDB:ENSG00000160194.17 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S46A, Eukaryota |
GeneTreei | ENSGT00390000012196 |
HOGENOMi | CLU_045834_0_0_1 |
InParanoidi | P56181 |
OMAi | YPEKPRQ |
OrthoDBi | 1132013at2759 |
PhylomeDBi | P56181 |
TreeFami | TF338771 |
Enzyme and pathway databases
BioCyci | MetaCyc:HS08459-MONOMER |
PathwayCommonsi | P56181 |
Reactomei | R-HSA-611105, Respiratory electron transport R-HSA-6799198, Complex I biogenesis |
SIGNORi | P56181 |
Miscellaneous databases
BioGRID-ORCSi | 4731, 2 hits in 1000 CRISPR screens |
ChiTaRSi | NDUFV3, human |
GeneWikii | NDUFV3 |
GenomeRNAii | 4731 |
Pharosi | P56181, Tclin |
PROi | PR:P56181 |
RNActi | P56181, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000160194, Expressed in quadriceps femoris and 216 other tissues |
Genevisiblei | P56181, HS |
Family and domain databases
InterProi | View protein in InterPro IPR026193, NDUFV3 |
PANTHERi | PTHR17117, PTHR17117, 2 hits |
Pfami | View protein in Pfam PF15880, NDUFV3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NDUV3_HUMAN | |
Accessioni | P56181Primary (citable) accession number: P56181 Secondary accession number(s): A8K0M1 Q9HCR5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | April 16, 2002 | |
Last modified: | April 7, 2021 | |
This is version 165 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 21
Human chromosome 21: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families