Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Putative tyrosine-protein phosphatase TPTE

Gene

TPTE

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Could be involved in signal transduction.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei338Sequence analysis1

GO - Molecular functioni

GO - Biological processi

  • protein dephosphorylation Source: ProtInc
  • signal transduction Source: ProtInc

Keywordsi

Molecular functionHydrolase, Protein phosphatase

Enzyme and pathway databases

ReactomeiR-HSA-1660514 Synthesis of PIPs at the Golgi membrane

Names & Taxonomyi

Protein namesi
Recommended name:
Putative tyrosine-protein phosphatase TPTE (EC:3.1.3.48)
Alternative name(s):
Cancer/testis antigen 44
Short name:
CT44
Transmembrane phosphatase with tensin homology
Tumor antigen BJ-HCC-5
Gene namesi
Name:TPTE
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

EuPathDBiHostDB:ENSG00000274391.4
HGNCiHGNC:12023 TPTE
MIMi604336 gene
neXtProtiNX_P56180

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei91 – 111HelicalSequence analysisAdd BLAST21
Transmembranei128 – 148HelicalSequence analysisAdd BLAST21
Transmembranei164 – 184HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi7179
OpenTargetsiENSG00000274391
PharmGKBiPA36702

Polymorphism and mutation databases

BioMutaiTPTE
DMDMi313104272

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002159071 – 551Putative tyrosine-protein phosphatase TPTEAdd BLAST551

Proteomic databases

PaxDbiP56180
PeptideAtlasiP56180
PRIDEiP56180
ProteomicsDBi56895
56896 [P56180-2]
56897 [P56180-3]
56898 [P56180-4]

PTM databases

DEPODiP56180
iPTMnetiP56180
PhosphoSitePlusiP56180

Expressioni

Tissue specificityi

Exclusively expressed in testis.1 Publication

Gene expression databases

BgeeiENSG00000274391
CleanExiHS_TPTE
ExpressionAtlasiP56180 baseline and differential
GenevisibleiP56180 HS

Organism-specific databases

HPAiHPA049690
HPA068342

Interactioni

Protein-protein interaction databases

BioGridi113031, 62 interactors
IntActiP56180, 51 interactors
STRINGi9606.ENSP00000355208

Structurei

3D structure databases

ProteinModelPortaliP56180
SMRiP56180
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini228 – 404Phosphatase tensin-typePROSITE-ProRule annotationAdd BLAST177
Domaini411 – 540C2 tensin-typePROSITE-ProRule annotationAdd BLAST130

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2283 Eukaryota
COG2453 LUCA
GeneTreeiENSGT00760000119113
HOVERGENiHBG084209
InParanoidiP56180
KOiK18079
OMAiAHYNANE
OrthoDBiEOG091G09VG
PhylomeDBiP56180
TreeFamiTF354329

Family and domain databases

Gene3Di1.20.120.350, 1 hit
3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR000340 Dual-sp_phosphatase_cat-dom
IPR029021 Prot-tyrosine_phosphatase-like
IPR014020 Tensin_C2-dom
IPR029023 Tensin_phosphatase
IPR016130 Tyr_Pase_AS
IPR027359 Volt_channel_dom_sf
PfamiView protein in Pfam
PF00782 DSPc, 1 hit
PF10409 PTEN_C2, 1 hit
SMARTiView protein in SMART
SM01326 PTEN_C2, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS51182 C2_TENSIN, 1 hit
PS51181 PPASE_TENSIN, 1 hit

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P56180-1) [UniParc]FASTAAdd to basket
Also known as: Alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNESPDPTDL AGVIIELGPN DSPQTSEFKG ATEEAPAKES PHTSEFKGAA
60 70 80 90 100
RVSPISESVL ARLSKFEVED AENVASYDSK IKKIVHSIVS SFAFGLFGVF
110 120 130 140 150
LVLLDVTLIL ADLIFTDSKL YIPLEYRSIS LAIALFFLMD VLLRVFVERR
160 170 180 190 200
QQYFSDLFNI LDTAIIVILL LVDVVYIFFD IKLLRNIPRW THLLRLLRLI
210 220 230 240 250
ILLRIFHLFH QKRQLEKLIR RRVSENKRRY TRDGFDLDLT YVTERIIAMS
260 270 280 290 300
FPSSGRQSFY RNPIKEVVRF LDKKHRNHYR VYNLCSERAY DPKHFHNRVV
310 320 330 340 350
RIMIDDHNVP TLHQMVVFTK EVNEWMAQDL ENIVAIHCKG GTDRTGTMVC
360 370 380 390 400
AFLIASEICS TAKESLYYFG ERRTDKTHSE KFQGVKTPSQ KRYVAYFAQV
410 420 430 440 450
KHLYNWNLPP RRILFIKHFI IYSIPRYVRD LKIQIEMEKK VVFSTISLGK
460 470 480 490 500
CSVLDNITTD KILIDVFDGL PLYDDVKVQF FYSNLPTYYD NCSFYFWLHT
510 520 530 540 550
SFIENNRLYL PKNELDNLHK QKARRIYPSD FAVEILFGEK MTSSDVVAGS

D
Length:551
Mass (Da):64,322
Last modified:November 30, 2010 - v3
Checksum:i48C2F28BEAA0DDA6
GO
Isoform 2 (identifier: P56180-2) [UniParc]FASTAAdd to basket
Also known as: Beta

The sequence of this isoform differs from the canonical sequence as follows:
     41-58: Missing.

Show »
Length:533
Mass (Da):62,440
Checksum:iAE2268E2EAABE825
GO
Isoform 3 (identifier: P56180-3) [UniParc]FASTAAdd to basket
Also known as: Gamma

The sequence of this isoform differs from the canonical sequence as follows:
     41-78: Missing.

Show »
Length:513
Mass (Da):60,203
Checksum:i7F1EE9541DA13348
GO
Isoform 4 (identifier: P56180-4) [UniParc]FASTAAdd to basket
Also known as: Delta

The sequence of this isoform differs from the canonical sequence as follows:
     1-138: Missing.

Show »
Length:413
Mass (Da):49,344
Checksum:iA32CAAF888C73104
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_036516144R → Q in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs144333919Ensembl.1
Natural variantiVAR_057347195R → Q. Corresponds to variant dbSNP:rs1810856Ensembl.1
Natural variantiVAR_065097386K → E5 PublicationsCorresponds to variant dbSNP:rs212146Ensembl.1
Natural variantiVAR_025400470L → P3 PublicationsCorresponds to variant dbSNP:rs150482Ensembl.1
Natural variantiVAR_061895482Y → S. Corresponds to variant dbSNP:rs9996Ensembl.1
Natural variantiVAR_057348549G → E. Corresponds to variant dbSNP:rs169758Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0173191 – 138Missing in isoform 4. 1 PublicationAdd BLAST138
Alternative sequenceiVSP_01732041 – 78Missing in isoform 3. 1 PublicationAdd BLAST38
Alternative sequenceiVSP_01732141 – 58Missing in isoform 2. 3 PublicationsAdd BLAST18

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF007118 mRNA Translation: AAC34574.1
AY219886 mRNA Translation: AAP45143.1
AY219887 mRNA Translation: AAP45144.1
AY219888 mRNA Translation: AAP45145.1
AF495908 mRNA Translation: AAQ06674.1
AK314285 mRNA Translation: BAG36944.1
AF254982 Genomic DNA No translation available.
AF254983 Genomic DNA No translation available.
AL078471 Genomic DNA No translation available.
AL163201 Genomic DNA Translation: CAB90528.1
BC028719 mRNA Translation: AAH28719.1
CCDSiCCDS74771.1 [P56180-1]
CCDS74772.1 [P56180-2]
CCDS74773.1 [P56180-3]
CCDS77617.1 [P56180-4]
RefSeqiNP_001277153.1, NM_001290224.1
NP_954868.1, NM_199259.3
NP_954869.1, NM_199260.3
NP_954870.2, NM_199261.3
UniGeneiHs.122986

Genome annotation databases

EnsembliENST00000427445; ENSP00000482488; ENSG00000274391 [P56180-3]
ENST00000612746; ENSP00000483087; ENSG00000274391 [P56180-4]
ENST00000618007; ENSP00000484403; ENSG00000274391 [P56180-1]
ENST00000622113; ENSP00000482040; ENSG00000274391 [P56180-2]
GeneIDi7179
KEGGihsa:7179
UCSCiuc002yip.2 human [P56180-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTPTE_HUMAN
AccessioniPrimary (citable) accession number: P56180
Secondary accession number(s): B2RAP7
, C9J6D6, C9JKK8, Q6XPS4, Q6XPS5, Q71JA8, Q8NCS8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 30, 2010
Last modified: June 20, 2018
This is version 157 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health