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Entry version 173 (02 Dec 2020)
Sequence version 3 (30 Nov 2010)
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Protein

Putative tyrosine-protein phosphatase TPTE

Gene

TPTE

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Could be involved in signal transduction.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei338Sequence analysis1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protein phosphatase

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
P56180

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1660514, Synthesis of PIPs at the Golgi membrane

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Putative tyrosine-protein phosphatase TPTE (EC:3.1.3.48)
Alternative name(s):
Cancer/testis antigen 44
Short name:
CT44
Transmembrane phosphatase with tensin homology
Tumor antigen BJ-HCC-5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TPTE
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 21

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...
EuPathDBi
HostDB:ENSG00000274391.4

Human Gene Nomenclature Database

More...
HGNCi
HGNC:12023, TPTE

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604336, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P56180

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei91 – 111HelicalSequence analysisAdd BLAST21
Transmembranei128 – 148HelicalSequence analysisAdd BLAST21
Transmembranei164 – 184HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
7179

Open Targets

More...
OpenTargetsi
ENSG00000274391

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36702

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P56180, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TPTE

Domain mapping of disease mutations (DMDM)

More...
DMDMi
313104272

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002159071 – 551Putative tyrosine-protein phosphatase TPTEAdd BLAST551

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P56180

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P56180

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P56180

PeptideAtlas

More...
PeptideAtlasi
P56180

PRoteomics IDEntifications database

More...
PRIDEi
P56180

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
56895 [P56180-1]
56896 [P56180-2]
56897 [P56180-3]
56898 [P56180-4]

PTM databases

DEPOD human dephosphorylation database

More...
DEPODi
TPTE

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P56180

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P56180

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Exclusively expressed in testis.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000274391, Expressed in right testis and 23 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P56180, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P56180, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000274391, Tissue enriched (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
113031, 127 interactors

Protein interaction database and analysis system

More...
IntActi
P56180, 60 interactors

Molecular INTeraction database

More...
MINTi
P56180

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000484403

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P56180, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P56180

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini228 – 404Phosphatase tensin-typePROSITE-ProRule annotationAdd BLAST177
Domaini411 – 540C2 tensin-typePROSITE-ProRule annotationAdd BLAST130

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2283, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154335

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_020105_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P56180

Identification of Orthologs from Complete Genome Data

More...
OMAi
NEAVSTH

Database of Orthologous Groups

More...
OrthoDBi
639380at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P56180

TreeFam database of animal gene trees

More...
TreeFami
TF354329

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.120.350, 1 hit
3.90.190.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000340, Dual-sp_phosphatase_cat-dom
IPR029021, Prot-tyrosine_phosphatase-like
IPR014020, Tensin_C2-dom
IPR029023, Tensin_phosphatase
IPR016130, Tyr_Pase_AS
IPR027359, Volt_channel_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00782, DSPc, 1 hit
PF10409, PTEN_C2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01326, PTEN_C2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52799, SSF52799, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51182, C2_TENSIN, 1 hit
PS51181, PPASE_TENSIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P56180-1) [UniParc]FASTAAdd to basket
Also known as: Alpha

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNESPDPTDL AGVIIELGPN DSPQTSEFKG ATEEAPAKES PHTSEFKGAA
60 70 80 90 100
RVSPISESVL ARLSKFEVED AENVASYDSK IKKIVHSIVS SFAFGLFGVF
110 120 130 140 150
LVLLDVTLIL ADLIFTDSKL YIPLEYRSIS LAIALFFLMD VLLRVFVERR
160 170 180 190 200
QQYFSDLFNI LDTAIIVILL LVDVVYIFFD IKLLRNIPRW THLLRLLRLI
210 220 230 240 250
ILLRIFHLFH QKRQLEKLIR RRVSENKRRY TRDGFDLDLT YVTERIIAMS
260 270 280 290 300
FPSSGRQSFY RNPIKEVVRF LDKKHRNHYR VYNLCSERAY DPKHFHNRVV
310 320 330 340 350
RIMIDDHNVP TLHQMVVFTK EVNEWMAQDL ENIVAIHCKG GTDRTGTMVC
360 370 380 390 400
AFLIASEICS TAKESLYYFG ERRTDKTHSE KFQGVKTPSQ KRYVAYFAQV
410 420 430 440 450
KHLYNWNLPP RRILFIKHFI IYSIPRYVRD LKIQIEMEKK VVFSTISLGK
460 470 480 490 500
CSVLDNITTD KILIDVFDGL PLYDDVKVQF FYSNLPTYYD NCSFYFWLHT
510 520 530 540 550
SFIENNRLYL PKNELDNLHK QKARRIYPSD FAVEILFGEK MTSSDVVAGS

D
Length:551
Mass (Da):64,322
Last modified:November 30, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i48C2F28BEAA0DDA6
GO
Isoform 2 (identifier: P56180-2) [UniParc]FASTAAdd to basket
Also known as: Beta

The sequence of this isoform differs from the canonical sequence as follows:
     41-58: Missing.

Show »
Length:533
Mass (Da):62,440
Checksum:iAE2268E2EAABE825
GO
Isoform 3 (identifier: P56180-3) [UniParc]FASTAAdd to basket
Also known as: Gamma

The sequence of this isoform differs from the canonical sequence as follows:
     41-78: Missing.

Show »
Length:513
Mass (Da):60,203
Checksum:i7F1EE9541DA13348
GO
Isoform 4 (identifier: P56180-4) [UniParc]FASTAAdd to basket
Also known as: Delta

The sequence of this isoform differs from the canonical sequence as follows:
     1-138: Missing.

Show »
Length:413
Mass (Da):49,344
Checksum:iA32CAAF888C73104
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X1C4A0A087X1C4_HUMAN
Putative tyrosine-protein phosphata...
TPTE
140Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_036516144R → Q in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs144333919Ensembl.1
Natural variantiVAR_057347195R → Q. Corresponds to variant dbSNP:rs1810856Ensembl.1
Natural variantiVAR_065097386K → E5 PublicationsCorresponds to variant dbSNP:rs212146Ensembl.1
Natural variantiVAR_025400470L → P3 PublicationsCorresponds to variant dbSNP:rs150482Ensembl.1
Natural variantiVAR_061895482Y → S. Corresponds to variant dbSNP:rs9996Ensembl.1
Natural variantiVAR_057348549G → E. Corresponds to variant dbSNP:rs169758Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0173191 – 138Missing in isoform 4. 1 PublicationAdd BLAST138
Alternative sequenceiVSP_01732041 – 78Missing in isoform 3. 1 PublicationAdd BLAST38
Alternative sequenceiVSP_01732141 – 58Missing in isoform 2. 3 PublicationsAdd BLAST18

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF007118 mRNA Translation: AAC34574.1
AY219886 mRNA Translation: AAP45143.1
AY219887 mRNA Translation: AAP45144.1
AY219888 mRNA Translation: AAP45145.1
AF495908 mRNA Translation: AAQ06674.1
AK314285 mRNA Translation: BAG36944.1
AF254982 Genomic DNA No translation available.
AF254983 Genomic DNA No translation available.
AL078471 Genomic DNA No translation available.
AL163201 Genomic DNA Translation: CAB90528.1
BC028719 mRNA Translation: AAH28719.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS74771.1 [P56180-1]
CCDS74772.1 [P56180-2]
CCDS74773.1 [P56180-3]
CCDS77617.1 [P56180-4]

NCBI Reference Sequences

More...
RefSeqi
NP_001277153.1, NM_001290224.1 [P56180-4]
NP_954868.1, NM_199259.3 [P56180-2]
NP_954869.1, NM_199260.3 [P56180-3]
NP_954870.2, NM_199261.3 [P56180-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000427445; ENSP00000482488; ENSG00000274391 [P56180-3]
ENST00000612746; ENSP00000483087; ENSG00000274391 [P56180-4]
ENST00000618007; ENSP00000484403; ENSG00000274391 [P56180-1]
ENST00000622113; ENSP00000482040; ENSG00000274391 [P56180-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
7179

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:7179

UCSC genome browser

More...
UCSCi
uc002yip.2, human [P56180-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF007118 mRNA Translation: AAC34574.1
AY219886 mRNA Translation: AAP45143.1
AY219887 mRNA Translation: AAP45144.1
AY219888 mRNA Translation: AAP45145.1
AF495908 mRNA Translation: AAQ06674.1
AK314285 mRNA Translation: BAG36944.1
AF254982 Genomic DNA No translation available.
AF254983 Genomic DNA No translation available.
AL078471 Genomic DNA No translation available.
AL163201 Genomic DNA Translation: CAB90528.1
BC028719 mRNA Translation: AAH28719.1
CCDSiCCDS74771.1 [P56180-1]
CCDS74772.1 [P56180-2]
CCDS74773.1 [P56180-3]
CCDS77617.1 [P56180-4]
RefSeqiNP_001277153.1, NM_001290224.1 [P56180-4]
NP_954868.1, NM_199259.3 [P56180-2]
NP_954869.1, NM_199260.3 [P56180-3]
NP_954870.2, NM_199261.3 [P56180-1]

3D structure databases

SMRiP56180
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi113031, 127 interactors
IntActiP56180, 60 interactors
MINTiP56180
STRINGi9606.ENSP00000484403

PTM databases

DEPODiTPTE
iPTMnetiP56180
PhosphoSitePlusiP56180

Polymorphism and mutation databases

BioMutaiTPTE
DMDMi313104272

Proteomic databases

jPOSTiP56180
MassIVEiP56180
PaxDbiP56180
PeptideAtlasiP56180
PRIDEiP56180
ProteomicsDBi56895 [P56180-1]
56896 [P56180-2]
56897 [P56180-3]
56898 [P56180-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
73437, 295 antibodies

The DNASU plasmid repository

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DNASUi
7179

Genome annotation databases

EnsembliENST00000427445; ENSP00000482488; ENSG00000274391 [P56180-3]
ENST00000612746; ENSP00000483087; ENSG00000274391 [P56180-4]
ENST00000618007; ENSP00000484403; ENSG00000274391 [P56180-1]
ENST00000622113; ENSP00000482040; ENSG00000274391 [P56180-2]
GeneIDi7179
KEGGihsa:7179
UCSCiuc002yip.2, human [P56180-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
7179
DisGeNETi7179
EuPathDBiHostDB:ENSG00000274391.4

GeneCards: human genes, protein and diseases

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GeneCardsi
TPTE
HGNCiHGNC:12023, TPTE
HPAiENSG00000274391, Tissue enriched (testis)
MIMi604336, gene
neXtProtiNX_P56180
OpenTargetsiENSG00000274391
PharmGKBiPA36702

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG2283, Eukaryota
GeneTreeiENSGT00940000154335
HOGENOMiCLU_020105_3_0_1
InParanoidiP56180
OMAiNEAVSTH
OrthoDBi639380at2759
PhylomeDBiP56180
TreeFamiTF354329

Enzyme and pathway databases

PathwayCommonsiP56180
ReactomeiR-HSA-1660514, Synthesis of PIPs at the Golgi membrane

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
7179, 20 hits in 817 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TPTE, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
TPTE

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
7179
PharosiP56180, Tbio

Protein Ontology

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PROi
PR:P56180
RNActiP56180, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000274391, Expressed in right testis and 23 other tissues
ExpressionAtlasiP56180, baseline and differential
GenevisibleiP56180, HS

Family and domain databases

Gene3Di1.20.120.350, 1 hit
3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR000340, Dual-sp_phosphatase_cat-dom
IPR029021, Prot-tyrosine_phosphatase-like
IPR014020, Tensin_C2-dom
IPR029023, Tensin_phosphatase
IPR016130, Tyr_Pase_AS
IPR027359, Volt_channel_dom_sf
PfamiView protein in Pfam
PF00782, DSPc, 1 hit
PF10409, PTEN_C2, 1 hit
SMARTiView protein in SMART
SM01326, PTEN_C2, 1 hit
SUPFAMiSSF52799, SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS51182, C2_TENSIN, 1 hit
PS51181, PPASE_TENSIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTPTE_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P56180
Secondary accession number(s): B2RAP7
, C9J6D6, C9JKK8, Q6XPS4, Q6XPS5, Q71JA8, Q8NCS8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 30, 2010
Last modified: December 2, 2020
This is version 173 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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