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Entry version 163 (08 May 2019)
Sequence version 3 (30 Nov 2010)
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Protein

Putative tyrosine-protein phosphatase TPTE

Gene

TPTE

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Could be involved in signal transduction.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei338Sequence analysis1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protein phosphatase

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1660514 Synthesis of PIPs at the Golgi membrane

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Putative tyrosine-protein phosphatase TPTE (EC:3.1.3.48)
Alternative name(s):
Cancer/testis antigen 44
Short name:
CT44
Transmembrane phosphatase with tensin homology
Tumor antigen BJ-HCC-5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TPTE
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 21

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:12023 TPTE

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604336 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P56180

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei91 – 111HelicalSequence analysisAdd BLAST21
Transmembranei128 – 148HelicalSequence analysisAdd BLAST21
Transmembranei164 – 184HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
7179

Open Targets

More...
OpenTargetsi
ENSG00000274391

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36702

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TPTE

Domain mapping of disease mutations (DMDM)

More...
DMDMi
313104272

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002159071 – 551Putative tyrosine-protein phosphatase TPTEAdd BLAST551

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P56180

PeptideAtlas

More...
PeptideAtlasi
P56180

PRoteomics IDEntifications database

More...
PRIDEi
P56180

ProteomicsDB human proteome resource

More...
ProteomicsDBi
56895
56896 [P56180-2]
56897 [P56180-3]
56898 [P56180-4]

PTM databases

DEPOD human dephosphorylation database

More...
DEPODi
P56180

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P56180

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P56180

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Exclusively expressed in testis.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000274391 Expressed in 16 organ(s), highest expression level in right testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P56180 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P56180 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA049690
HPA068342

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
113031, 104 interactors

Protein interaction database and analysis system

More...
IntActi
P56180, 52 interactors

Molecular INTeraction database

More...
MINTi
P56180

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000484403

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P56180

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini228 – 404Phosphatase tensin-typePROSITE-ProRule annotationAdd BLAST177
Domaini411 – 540C2 tensin-typePROSITE-ProRule annotationAdd BLAST130

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2283 Eukaryota
COG2453 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154335

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P56180

KEGG Orthology (KO)

More...
KOi
K18079

Identification of Orthologs from Complete Genome Data

More...
OMAi
AHYNANE

Database of Orthologous Groups

More...
OrthoDBi
639380at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P56180

TreeFam database of animal gene trees

More...
TreeFami
TF354329

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.120.350, 1 hit
3.90.190.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000340 Dual-sp_phosphatase_cat-dom
IPR029021 Prot-tyrosine_phosphatase-like
IPR014020 Tensin_C2-dom
IPR029023 Tensin_phosphatase
IPR016130 Tyr_Pase_AS
IPR027359 Volt_channel_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00782 DSPc, 1 hit
PF10409 PTEN_C2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01326 PTEN_C2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52799 SSF52799, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51182 C2_TENSIN, 1 hit
PS51181 PPASE_TENSIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P56180-1) [UniParc]FASTAAdd to basket
Also known as: Alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNESPDPTDL AGVIIELGPN DSPQTSEFKG ATEEAPAKES PHTSEFKGAA
60 70 80 90 100
RVSPISESVL ARLSKFEVED AENVASYDSK IKKIVHSIVS SFAFGLFGVF
110 120 130 140 150
LVLLDVTLIL ADLIFTDSKL YIPLEYRSIS LAIALFFLMD VLLRVFVERR
160 170 180 190 200
QQYFSDLFNI LDTAIIVILL LVDVVYIFFD IKLLRNIPRW THLLRLLRLI
210 220 230 240 250
ILLRIFHLFH QKRQLEKLIR RRVSENKRRY TRDGFDLDLT YVTERIIAMS
260 270 280 290 300
FPSSGRQSFY RNPIKEVVRF LDKKHRNHYR VYNLCSERAY DPKHFHNRVV
310 320 330 340 350
RIMIDDHNVP TLHQMVVFTK EVNEWMAQDL ENIVAIHCKG GTDRTGTMVC
360 370 380 390 400
AFLIASEICS TAKESLYYFG ERRTDKTHSE KFQGVKTPSQ KRYVAYFAQV
410 420 430 440 450
KHLYNWNLPP RRILFIKHFI IYSIPRYVRD LKIQIEMEKK VVFSTISLGK
460 470 480 490 500
CSVLDNITTD KILIDVFDGL PLYDDVKVQF FYSNLPTYYD NCSFYFWLHT
510 520 530 540 550
SFIENNRLYL PKNELDNLHK QKARRIYPSD FAVEILFGEK MTSSDVVAGS

D
Length:551
Mass (Da):64,322
Last modified:November 30, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i48C2F28BEAA0DDA6
GO
Isoform 2 (identifier: P56180-2) [UniParc]FASTAAdd to basket
Also known as: Beta

The sequence of this isoform differs from the canonical sequence as follows:
     41-58: Missing.

Show »
Length:533
Mass (Da):62,440
Checksum:iAE2268E2EAABE825
GO
Isoform 3 (identifier: P56180-3) [UniParc]FASTAAdd to basket
Also known as: Gamma

The sequence of this isoform differs from the canonical sequence as follows:
     41-78: Missing.

Show »
Length:513
Mass (Da):60,203
Checksum:i7F1EE9541DA13348
GO
Isoform 4 (identifier: P56180-4) [UniParc]FASTAAdd to basket
Also known as: Delta

The sequence of this isoform differs from the canonical sequence as follows:
     1-138: Missing.

Show »
Length:413
Mass (Da):49,344
Checksum:iA32CAAF888C73104
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X1C4A0A087X1C4_HUMAN
Putative tyrosine-protein phosphata...
TPTE
140Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_036516144R → Q in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs144333919Ensembl.1
Natural variantiVAR_057347195R → Q. Corresponds to variant dbSNP:rs1810856Ensembl.1
Natural variantiVAR_065097386K → E5 PublicationsCorresponds to variant dbSNP:rs212146Ensembl.1
Natural variantiVAR_025400470L → P3 PublicationsCorresponds to variant dbSNP:rs150482Ensembl.1
Natural variantiVAR_061895482Y → S. Corresponds to variant dbSNP:rs9996Ensembl.1
Natural variantiVAR_057348549G → E. Corresponds to variant dbSNP:rs169758Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0173191 – 138Missing in isoform 4. 1 PublicationAdd BLAST138
Alternative sequenceiVSP_01732041 – 78Missing in isoform 3. 1 PublicationAdd BLAST38
Alternative sequenceiVSP_01732141 – 58Missing in isoform 2. 3 PublicationsAdd BLAST18

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF007118 mRNA Translation: AAC34574.1
AY219886 mRNA Translation: AAP45143.1
AY219887 mRNA Translation: AAP45144.1
AY219888 mRNA Translation: AAP45145.1
AF495908 mRNA Translation: AAQ06674.1
AK314285 mRNA Translation: BAG36944.1
AF254982 Genomic DNA No translation available.
AF254983 Genomic DNA No translation available.
AL078471 Genomic DNA No translation available.
AL163201 Genomic DNA Translation: CAB90528.1
BC028719 mRNA Translation: AAH28719.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS74771.1 [P56180-1]
CCDS74772.1 [P56180-2]
CCDS74773.1 [P56180-3]
CCDS77617.1 [P56180-4]

NCBI Reference Sequences

More...
RefSeqi
NP_001277153.1, NM_001290224.1
NP_954868.1, NM_199259.3
NP_954869.1, NM_199260.3
NP_954870.2, NM_199261.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000427445; ENSP00000482488; ENSG00000274391 [P56180-3]
ENST00000612746; ENSP00000483087; ENSG00000274391 [P56180-4]
ENST00000618007; ENSP00000484403; ENSG00000274391 [P56180-1]
ENST00000622113; ENSP00000482040; ENSG00000274391 [P56180-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
7179

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:7179

UCSC genome browser

More...
UCSCi
uc002yip.2 human [P56180-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF007118 mRNA Translation: AAC34574.1
AY219886 mRNA Translation: AAP45143.1
AY219887 mRNA Translation: AAP45144.1
AY219888 mRNA Translation: AAP45145.1
AF495908 mRNA Translation: AAQ06674.1
AK314285 mRNA Translation: BAG36944.1
AF254982 Genomic DNA No translation available.
AF254983 Genomic DNA No translation available.
AL078471 Genomic DNA No translation available.
AL163201 Genomic DNA Translation: CAB90528.1
BC028719 mRNA Translation: AAH28719.1
CCDSiCCDS74771.1 [P56180-1]
CCDS74772.1 [P56180-2]
CCDS74773.1 [P56180-3]
CCDS77617.1 [P56180-4]
RefSeqiNP_001277153.1, NM_001290224.1
NP_954868.1, NM_199259.3
NP_954869.1, NM_199260.3
NP_954870.2, NM_199261.3

3D structure databases

SMRiP56180
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113031, 104 interactors
IntActiP56180, 52 interactors
MINTiP56180
STRINGi9606.ENSP00000484403

PTM databases

DEPODiP56180
iPTMnetiP56180
PhosphoSitePlusiP56180

Polymorphism and mutation databases

BioMutaiTPTE
DMDMi313104272

Proteomic databases

PaxDbiP56180
PeptideAtlasiP56180
PRIDEiP56180
ProteomicsDBi56895
56896 [P56180-2]
56897 [P56180-3]
56898 [P56180-4]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
7179
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000427445; ENSP00000482488; ENSG00000274391 [P56180-3]
ENST00000612746; ENSP00000483087; ENSG00000274391 [P56180-4]
ENST00000618007; ENSP00000484403; ENSG00000274391 [P56180-1]
ENST00000622113; ENSP00000482040; ENSG00000274391 [P56180-2]
GeneIDi7179
KEGGihsa:7179
UCSCiuc002yip.2 human [P56180-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7179
DisGeNETi7179

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TPTE
HGNCiHGNC:12023 TPTE
HPAiHPA049690
HPA068342
MIMi604336 gene
neXtProtiNX_P56180
OpenTargetsiENSG00000274391
PharmGKBiPA36702

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2283 Eukaryota
COG2453 LUCA
GeneTreeiENSGT00940000154335
InParanoidiP56180
KOiK18079
OMAiAHYNANE
OrthoDBi639380at2759
PhylomeDBiP56180
TreeFamiTF354329

Enzyme and pathway databases

ReactomeiR-HSA-1660514 Synthesis of PIPs at the Golgi membrane

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
TPTE

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
7179

Protein Ontology

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PROi
PR:P56180

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000274391 Expressed in 16 organ(s), highest expression level in right testis
ExpressionAtlasiP56180 baseline and differential
GenevisibleiP56180 HS

Family and domain databases

Gene3Di1.20.120.350, 1 hit
3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR000340 Dual-sp_phosphatase_cat-dom
IPR029021 Prot-tyrosine_phosphatase-like
IPR014020 Tensin_C2-dom
IPR029023 Tensin_phosphatase
IPR016130 Tyr_Pase_AS
IPR027359 Volt_channel_dom_sf
PfamiView protein in Pfam
PF00782 DSPc, 1 hit
PF10409 PTEN_C2, 1 hit
SMARTiView protein in SMART
SM01326 PTEN_C2, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS51182 C2_TENSIN, 1 hit
PS51181 PPASE_TENSIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTPTE_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P56180
Secondary accession number(s): B2RAP7
, C9J6D6, C9JKK8, Q6XPS4, Q6XPS5, Q71JA8, Q8NCS8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 30, 2010
Last modified: May 8, 2019
This is version 163 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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