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Entry version 168 (08 May 2019)
Sequence version 2 (23 Jan 2002)
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Protein

GDNF family receptor alpha-1

Gene

GFRA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-419037 NCAM1 interactions
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-8853659 RET signaling

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P56159

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P56159

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
GDNF family receptor alpha-1
Short name:
GDNF receptor alpha-1
Short name:
GDNFR-alpha-1
Short name:
GFR-alpha-1
Alternative name(s):
RET ligand 1
TGF-beta-related neurotrophic factor receptor 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GFRA1
Synonyms:GDNFRA, RETL1, TRNR1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:4243 GFRA1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
601496 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P56159

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
2674

Open Targets

More...
OpenTargetsi
ENSG00000151892

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA28653

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3833481

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
1743

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GFRA1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
20141405

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 24Sequence analysisAdd BLAST24
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001077725 – 429GDNF family receptor alpha-1Add BLAST405
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_0000010778430 – 465Removed in mature formSequence analysisAdd BLAST36

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi29 ↔ 87By similarity
Disulfide bondi36 ↔ 42By similarity
Disulfide bondi52 ↔ 72By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi59N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi89 ↔ 99By similarity
Disulfide bondi154 ↔ 214By similarity
Disulfide bondi161 ↔ 167By similarity
Disulfide bondi178 ↔ 192By similarity
Disulfide bondi187 ↔ 233By similarity
Disulfide bondi216 ↔ 221By similarity
Disulfide bondi243 ↔ 313By similarity
Disulfide bondi250 ↔ 256By similarity
Disulfide bondi267 ↔ 285By similarity
Disulfide bondi277 ↔ 337By similarity
Disulfide bondi315 ↔ 325By similarity
Glycosylationi347N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi406N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi429GPI-anchor amidated serineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P56159

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P56159

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P56159

PeptideAtlas

More...
PeptideAtlasi
P56159

PRoteomics IDEntifications database

More...
PRIDEi
P56159

ProteomicsDB human proteome resource

More...
ProteomicsDBi
56888
56889 [P56159-2]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1265

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P56159

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P56159

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000151892 Expressed in 183 organ(s), highest expression level in female gonad

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P56159 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA043829

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

2 molecules of GDNFR-alpha are thought to form a complex with the disulfide-linked GDNF dimer and with 2 molecules of RET.By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
108942, 6 interactors

Database of interacting proteins

More...
DIPi
DIP-59052N

Protein interaction database and analysis system

More...
IntActi
P56159, 3 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000347591

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P56159

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati25 – 1131Add BLAST89
Repeati150 – 2382Add BLAST89
Repeati239 – 3423Add BLAST104

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi362 – 369Poly-Thr8

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GDNFR family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IU4F Eukaryota
ENOG410XPTA LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000155560

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000008695

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P56159

KEGG Orthology (KO)

More...
KOi
K19895

Identification of Orthologs from Complete Genome Data

More...
OMAi
VPKGNNC

Database of Orthologous Groups

More...
OrthoDBi
850255at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P56159

TreeFam database of animal gene trees

More...
TreeFami
TF331647

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016017 GDNF/GAS1
IPR037193 GDNF_alpha
IPR003438 GDNF_rcpt
IPR003503 GDNF_rcpt_A1
IPR017372 Glial_neurotroph_fac_rcpt_a1/2

The PANTHER Classification System

More...
PANTHERi
PTHR10269 PTHR10269, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02351 GDNF, 3 hits

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF038071 GDNF_family_receptor_alpha, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01317 GDNFRALPHA1
PR01316 GDNFRECEPTOR

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00907 GDNF, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF110035 SSF110035, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P56159-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFLATLYFAL PLLDLLLSAE VSGGDRLDCV KASDQCLKEQ SCSTKYRTLR
60 70 80 90 100
QCVAGKETNF SLASGLEAKD ECRSAMEALK QKSLYNCRCK RGMKKEKNCL
110 120 130 140 150
RIYWSMYQSL QGNDLLEDSP YEPVNSRLSD IFRVVPFISD VFQQVEHIPK
160 170 180 190 200
GNNCLDAAKA CNLDDICKKY RSAYITPCTT SVSNDVCNRR KCHKALRQFF
210 220 230 240 250
DKVPAKHSYG MLFCSCRDIA CTERRRQTIV PVCSYEEREK PNCLNLQDSC
260 270 280 290 300
KTNYICRSRL ADFFTNCQPE SRSVSSCLKE NYADCLLAYS GLIGTVMTPN
310 320 330 340 350
YIDSSSLSVA PWCDCSNSGN DLEECLKFLN FFKDNTCLKN AIQAFGNGSD
360 370 380 390 400
VTVWQPAFPV QTTTATTTTA LRVKNKPLGP AGSENEIPTH VLPPCANLQA
410 420 430 440 450
QKLKSNVSGN THLCISNGNY EKEGLGASSH ITTKSMAAPP SCGLSPLLVL
460
VVTALSTLLS LTETS
Length:465
Mass (Da):51,456
Last modified:January 23, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i91A550D06A6777BD
GO
Isoform 2 (identifier: P56159-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     140-144: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:460
Mass (Da):50,838
Checksum:iF5620DE4F2E122AA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti245Missing no nucleotide entry (PubMed:8674117).Curated1
Sequence conflicti358F → P no nucleotide entry (PubMed:8674117).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01248885Y → N1 PublicationCorresponds to variant dbSNP:rs8192662Ensembl.1
Natural variantiVAR_012489366T → A2 PublicationsCorresponds to variant dbSNP:rs2072276Ensembl.1
Natural variantiVAR_018261371L → R May be involved in congenital central hypoventilation syndrome. 1 PublicationCorresponds to variant dbSNP:rs924541616Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_001660140 – 144Missing in isoform 2. 4 Publications5

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U97144 mRNA Translation: AAC51646.1
AF038420
, AF038411, AF038412, AF038413, AF038414, AF038415, AF038416, AF038417, AF038418, AF038419 Genomic DNA Translation: AAC39693.1
AF038421 mRNA Translation: AAC39692.1
AF042080 mRNA Translation: AAB97371.1
AF058999
, AF058990, AF058991, AF058992, AF058993, AF058994, AF058995, AF058996, AF058997, AF058998 Genomic DNA Translation: AAC14431.1
U95847 mRNA Translation: AAB71811.1
AK292886 mRNA Translation: BAF85575.1
CH471066 Genomic DNA Translation: EAW49458.1
BC014962 mRNA Translation: AAH14962.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS44481.1 [P56159-1]
CCDS7593.1 [P56159-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001138925.1, NM_001145453.2 [P56159-2]
NP_001335025.1, NM_001348096.1 [P56159-2]
NP_001335026.1, NM_001348097.1
NP_001335027.1, NM_001348098.1 [P56159-1]
NP_005255.1, NM_005264.5 [P56159-1]
NP_665736.1, NM_145793.4 [P56159-2]
XP_011537936.1, XM_011539634.1 [P56159-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000355422; ENSP00000347591; ENSG00000151892 [P56159-1]
ENST00000369234; ENSP00000358237; ENSG00000151892 [P56159-1]
ENST00000369236; ENSP00000358239; ENSG00000151892 [P56159-2]
ENST00000439649; ENSP00000393725; ENSG00000151892 [P56159-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2674

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:2674

UCSC genome browser

More...
UCSCi
uc001lci.4 human [P56159-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U97144 mRNA Translation: AAC51646.1
AF038420
, AF038411, AF038412, AF038413, AF038414, AF038415, AF038416, AF038417, AF038418, AF038419 Genomic DNA Translation: AAC39693.1
AF038421 mRNA Translation: AAC39692.1
AF042080 mRNA Translation: AAB97371.1
AF058999
, AF058990, AF058991, AF058992, AF058993, AF058994, AF058995, AF058996, AF058997, AF058998 Genomic DNA Translation: AAC14431.1
U95847 mRNA Translation: AAB71811.1
AK292886 mRNA Translation: BAF85575.1
CH471066 Genomic DNA Translation: EAW49458.1
BC014962 mRNA Translation: AAH14962.1
CCDSiCCDS44481.1 [P56159-1]
CCDS7593.1 [P56159-2]
RefSeqiNP_001138925.1, NM_001145453.2 [P56159-2]
NP_001335025.1, NM_001348096.1 [P56159-2]
NP_001335026.1, NM_001348097.1
NP_001335027.1, NM_001348098.1 [P56159-1]
NP_005255.1, NM_005264.5 [P56159-1]
NP_665736.1, NM_145793.4 [P56159-2]
XP_011537936.1, XM_011539634.1 [P56159-1]

3D structure databases

SMRiP56159
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108942, 6 interactors
DIPiDIP-59052N
IntActiP56159, 3 interactors
STRINGi9606.ENSP00000347591

Chemistry databases

ChEMBLiCHEMBL3833481
GuidetoPHARMACOLOGYi1743

PTM databases

GlyConnecti1265
iPTMnetiP56159
PhosphoSitePlusiP56159

Polymorphism and mutation databases

BioMutaiGFRA1
DMDMi20141405

Proteomic databases

jPOSTiP56159
MaxQBiP56159
PaxDbiP56159
PeptideAtlasiP56159
PRIDEiP56159
ProteomicsDBi56888
56889 [P56159-2]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
2674
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355422; ENSP00000347591; ENSG00000151892 [P56159-1]
ENST00000369234; ENSP00000358237; ENSG00000151892 [P56159-1]
ENST00000369236; ENSP00000358239; ENSG00000151892 [P56159-2]
ENST00000439649; ENSP00000393725; ENSG00000151892 [P56159-2]
GeneIDi2674
KEGGihsa:2674
UCSCiuc001lci.4 human [P56159-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
2674
DisGeNETi2674

GeneCards: human genes, protein and diseases

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GeneCardsi
GFRA1
HGNCiHGNC:4243 GFRA1
HPAiHPA043829
MIMi601496 gene
neXtProtiNX_P56159
OpenTargetsiENSG00000151892
PharmGKBiPA28653

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IU4F Eukaryota
ENOG410XPTA LUCA
GeneTreeiENSGT00940000155560
HOGENOMiHOG000008695
InParanoidiP56159
KOiK19895
OMAiVPKGNNC
OrthoDBi850255at2759
PhylomeDBiP56159
TreeFamiTF331647

Enzyme and pathway databases

ReactomeiR-HSA-419037 NCAM1 interactions
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-8853659 RET signaling
SignaLinkiP56159
SIGNORiP56159

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
GFRA1 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
GDNF_family_receptor_alpha_1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
2674

Protein Ontology

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PROi
PR:P56159

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000151892 Expressed in 183 organ(s), highest expression level in female gonad
GenevisibleiP56159 HS

Family and domain databases

InterProiView protein in InterPro
IPR016017 GDNF/GAS1
IPR037193 GDNF_alpha
IPR003438 GDNF_rcpt
IPR003503 GDNF_rcpt_A1
IPR017372 Glial_neurotroph_fac_rcpt_a1/2
PANTHERiPTHR10269 PTHR10269, 1 hit
PfamiView protein in Pfam
PF02351 GDNF, 3 hits
PIRSFiPIRSF038071 GDNF_family_receptor_alpha, 1 hit
PRINTSiPR01317 GDNFRALPHA1
PR01316 GDNFRECEPTOR
SMARTiView protein in SMART
SM00907 GDNF, 3 hits
SUPFAMiSSF110035 SSF110035, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGFRA1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P56159
Secondary accession number(s): A8KA21, O15507, O43912
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2002
Last modified: May 8, 2019
This is version 168 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
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