UniProtKB - P56079 (CDS_DROME)
Phosphatidate cytidylyltransferase, photoreceptor-specific
Cds
Functioni
Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an important precursor for the synthesis of phosphatidylinositol (PtdIns) and phosphatidylglycerol (PG) (PubMed:7816135, PubMed:24603715).
Required for the regeneration of the signaling molecule phosphatidylinositol 4,5-bisphosphate (PtdInsP2) from PA and maintenance of its steady supply during signaling thus playing an essential role during phospholipase C-mediated transduction (PubMed:7816135).
In the salivary glands and possibly other adipose tissues, function is essential for regulating cell growth and neutral lipid storage by coordinating PtdIns metabolism and insulin pathway activity (PubMed:24603715).
Acts by positively regulating activity of the insulin pathway through synthesis of PtdIns, and in turn the insulin pathway up-regulates the synthesis of CdsA (PubMed:24603715).
This CdsA-insulin positive feedback loop may be one of the mechanisms for coordinating cell growth and fat storage; switching to fat storage when cells reach homeostasis or converting from growth to fat storage under nutrient-poor conditions (PubMed:24603715).
Required for spermatid individualization by regulating lipid compositions and lipid-mediated signaling during spermatogenesis (PubMed:26791243).
3 PublicationsCatalytic activityi
- a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H+ = a CDP-1,2-diacyl-sn-glycerol + diphosphate2 Publications1 PublicationEC:2.7.7.412 Publications1 Publication
: CDP-diacylglycerol biosynthesis Pathwayi
This protein is involved in step 3 of the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate.2 Publications1 Publication This subpathway is part of the pathway CDP-diacylglycerol biosynthesis, which is itself part of Phospholipid metabolism.View all proteins of this organism that are known to be involved in the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate, the pathway CDP-diacylglycerol biosynthesis and in Phospholipid metabolism.
GO - Molecular functioni
- phosphatidate cytidylyltransferase activity Source: FlyBase
GO - Biological processi
- CDP-diacylglycerol biosynthetic process Source: FlyBase
- lipid biosynthetic process Source: FlyBase
- negative regulation of triglyceride biosynthetic process Source: FlyBase
- phototransduction Source: FlyBase
- positive regulation of phosphatidylinositol biosynthetic process Source: FlyBase
- regulation of lipid storage Source: FlyBase
- rhodopsin mediated signaling pathway Source: FlyBase
- sperm individualization Source: FlyBase
- terminal branching, open tracheal system Source: FlyBase
- thermotaxis Source: FlyBase
- visual perception Source: UniProtKB-KW
Keywordsi
Molecular function | Nucleotidyltransferase, Transferase |
Biological process | Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism, Sensory transduction, Vision |
Enzyme and pathway databases
BRENDAi | 2.7.7.41, 1994 |
Reactomei | R-DME-1483148, Synthesis of PG R-DME-1483226, Synthesis of PI |
UniPathwayi | UPA00557;UER00614 |
Names & Taxonomyi
Protein namesi | Recommended name: Phosphatidate cytidylyltransferase, photoreceptor-specific (EC:2.7.7.412 Publications1 Publication)Alternative name(s): CDP-DAG synthase1 Publication CDP-DG synthase CDP-diacylglycerol synthaseImported Short name: CDS CDP-diglyceride pyrophosphorylase CDP-diglyceride synthase CTP:phosphatidate cytidylyltransferase |
Gene namesi | ORF Names:CG7962Imported |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0010350, Cds |
VEuPathDBi | VectorBase:FBgn0010350 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane 1 Publication; Multi-pass membrane protein Curated
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: GO_Central
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 88 – 108 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 147 – 167 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 180 – 200 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 203 – 223 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 227 – 247 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 276 – 296 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 350 – 370 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Endoplasmic reticulum, MembranePathology & Biotechi
Disruption phenotypei
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000090720 | 1 – 447 | Phosphatidate cytidylyltransferase, photoreceptor-specificAdd BLAST | 447 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 30 | Phosphoserine1 Publication | 1 | |
Modified residuei | 34 | Phosphoserine1 Publication | 1 | |
Modified residuei | 35 | Phosphoserine1 Publication | 1 | |
Modified residuei | 40 | Phosphoserine1 Publication | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | P56079 |
PRIDEi | P56079 |
PTM databases
iPTMneti | P56079 |
Expressioni
Tissue specificityi
Developmental stagei
Gene expression databases
Bgeei | FBgn0010350, Expressed in brain and 19 other tissues |
ExpressionAtlasi | P56079, baseline and differential |
Genevisiblei | P56079, DM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 68739, 20 interactors |
DIPi | DIP-23447N |
IntActi | P56079, 3 interactors |
STRINGi | 7227.FBpp0076411 |
Structurei
3D structure databases
AlphaFoldDBi | P56079 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 49 | DisorderedSequence analysisAdd BLAST | 49 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 15 | Basic and acidic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 30 – 49 | Basic and acidic residuesSequence analysisAdd BLAST | 20 |
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1440, Eukaryota |
HOGENOMi | CLU_023471_0_1_1 |
InParanoidi | P56079 |
OMAi | FIMNNIF |
OrthoDBi | 1072976at2759 |
PhylomeDBi | P56079 |
Family and domain databases
InterProi | View protein in InterPro IPR000374, PC_trans IPR016720, PC_Trfase_euk |
PANTHERi | PTHR13773, PTHR13773, 1 hit |
PIRSFi | PIRSF018269, PC_trans_euk, 1 hit |
PROSITEi | View protein in PROSITE PS01315, CDS, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MAEVRRRKGE DEPLEDTAIS GSDAANKRNS AADSSDHVDS EEEKIPEEKF
60 70 80 90 100
VDELAKNLPQ GTDKTPEILD SALKDLPDRW KNWVIRGIFT WIMICGFALI
110 120 130 140 150
IYGGPLALMI TTLLVQVKCF QEIISIGYQV YRIHGLPWFR SLSWYFLLTS
160 170 180 190 200
NYFFYGENLV DYFGVVINRV EYLKFLVTYH RFLSFALYII GFVWFVLSLV
210 220 230 240 250
KKYYIKQFSL FAWTHVSLLI VVTQSYLIIQ NIFEGLIWFI VPVSMIVCND
260 270 280 290 300
VMAYVFGFFF GRTPLIKLSP KKTWEGFIGG GFATVLFGIL FSYVLCNYQY
310 320 330 340 350
FICPIQYSEE QGRMTMSCVP SYLFTPQEYS LKLFGIGKTL NLYPFIWHSI
360 370 380 390 400
SLSLFSSIIG PFGGFFASGF KRAFKIKDFG DMIPGHGGIM DRFDCQFLMA
410 420 430 440
TFVNVYISSF IRTPSPAKLL TQIYNLKPDQ QYQIYQSLKD NLGDMLT
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketX2JC55 | X2JC55_DROME | Phosphatidate cytidylyltransferase | Cds CDS, cds, CdsA, cdsA, Dmel\CG7962 | 447 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 444 | D → H no nucleotide entry (PubMed:7816135).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014296 Genomic DNA Translation: AAF50483.1 |
RefSeqi | NP_001286976.1, NM_001300047.1 NP_524661.1, NM_079922.4 |
Genome annotation databases
EnsemblMetazoai | FBtr0076688; FBpp0076411; FBgn0010350 FBtr0346546; FBpp0312164; FBgn0010350 |
GeneIDi | 43950 |
KEGGi | dme:Dmel_CG7962 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014296 Genomic DNA Translation: AAF50483.1 |
RefSeqi | NP_001286976.1, NM_001300047.1 NP_524661.1, NM_079922.4 |
3D structure databases
AlphaFoldDBi | P56079 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 68739, 20 interactors |
DIPi | DIP-23447N |
IntActi | P56079, 3 interactors |
STRINGi | 7227.FBpp0076411 |
PTM databases
iPTMneti | P56079 |
Proteomic databases
PaxDbi | P56079 |
PRIDEi | P56079 |
Genome annotation databases
EnsemblMetazoai | FBtr0076688; FBpp0076411; FBgn0010350 FBtr0346546; FBpp0312164; FBgn0010350 |
GeneIDi | 43950 |
KEGGi | dme:Dmel_CG7962 |
Organism-specific databases
CTDi | 43950 |
FlyBasei | FBgn0010350, Cds |
VEuPathDBi | VectorBase:FBgn0010350 |
Phylogenomic databases
eggNOGi | KOG1440, Eukaryota |
HOGENOMi | CLU_023471_0_1_1 |
InParanoidi | P56079 |
OMAi | FIMNNIF |
OrthoDBi | 1072976at2759 |
PhylomeDBi | P56079 |
Enzyme and pathway databases
UniPathwayi | UPA00557;UER00614 |
BRENDAi | 2.7.7.41, 1994 |
Reactomei | R-DME-1483148, Synthesis of PG R-DME-1483226, Synthesis of PI |
Miscellaneous databases
BioGRID-ORCSi | 43950, 0 hits in 3 CRISPR screens |
ChiTaRSi | CdsA, fly |
GenomeRNAii | 43950 |
PROi | PR:P56079 |
Gene expression databases
Bgeei | FBgn0010350, Expressed in brain and 19 other tissues |
ExpressionAtlasi | P56079, baseline and differential |
Genevisiblei | P56079, DM |
Family and domain databases
InterProi | View protein in InterPro IPR000374, PC_trans IPR016720, PC_Trfase_euk |
PANTHERi | PTHR13773, PTHR13773, 1 hit |
PIRSFi | PIRSF018269, PC_trans_euk, 1 hit |
PROSITEi | View protein in PROSITE PS01315, CDS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CDS_DROME | |
Accessioni | P56079Primary (citable) accession number: P56079 Secondary accession number(s): Q9VSE0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | December 1, 2000 | |
Last modified: | May 25, 2022 | |
This is version 166 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families