copA

Functionⁱ

Probably involved in copper export.

Catalytic activityⁱ

ATP + H₂O + Cu²⁺(Side 1) = ADP + phosphate + Cu²⁺(Side 2).

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	12	CopperPROSITE-ProRule annotation	1
Metal bindingⁱ	15	CopperPROSITE-ProRule annotation	1
Active siteⁱ	435	4-aspartylphosphate intermediateBy similarity	1
Metal bindingⁱ	631	MagnesiumPROSITE-ProRule annotation	1
Metal bindingⁱ	635	MagnesiumPROSITE-ProRule annotation	1

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
copper-exporting ATPase activity Source: UniProtKB-EC
copper-transporting ATPase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
metal ion binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase
Biological process	Copper transport, Ion transport, Transport
Ligand	ATP-binding, Copper, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCycⁱ	HPY:HP1072-MONOMER

BioCycⁱ

HPY:HP1072-MONOMER

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Copper-transporting ATPase (EC:3.6.3.4)
Gene namesⁱ	Name:copA Ordered Locus Names:HP_1072
Organismⁱ	Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifierⁱ	85962 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Proteobacteria › delta/epsilon subdivisions › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter › Helicobacter pylori
Proteomesⁱ	UP000000429 Componentⁱ: Chromosome

Subcellular locationⁱ

Cell membrane ; Multi-pass membrane protein

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 83	CytoplasmicSequence analysisAdd BLAST	83
Transmembraneⁱ	84 – 104	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	105 – 124	ExtracellularSequence analysisAdd BLAST	20
Transmembraneⁱ	125 – 144	HelicalSequence analysisAdd BLAST	20
Topological domainⁱ	145 – 151	CytoplasmicSequence analysis	7
Transmembraneⁱ	152 – 172	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	173 – 194	ExtracellularSequence analysisAdd BLAST	22
Transmembraneⁱ	195 – 215	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	216 – 343	CytoplasmicSequence analysisAdd BLAST	128
Transmembraneⁱ	344 – 366	HelicalSequence analysisAdd BLAST	23
Topological domainⁱ	367 – 379	ExtracellularSequence analysisAdd BLAST	13
Transmembraneⁱ	380 – 397	HelicalSequence analysisAdd BLAST	18
Topological domainⁱ	398 – 685	CytoplasmicSequence analysisAdd BLAST	288
Transmembraneⁱ	686 – 705	HelicalSequence analysisAdd BLAST	20
Topological domainⁱ	706 – 716	ExtracellularSequence analysisAdd BLAST	11
Transmembraneⁱ	717 – 735	HelicalSequence analysisAdd BLAST	19
Topological domainⁱ	736 – 745	CytoplasmicSequence analysis	10

GO - Cellular componentⁱ

integral component of membrane Source: UniProtKB-KW
plasma membrane Source: UniProtKB-SubCell

View the complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

Cell membrane, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000046170	1 – 745	Copper-transporting ATPaseAdd BLAST		745

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

PaxDbⁱ	P55989

PaxDbⁱ

P55989

Interactionⁱ

Protein-protein interaction databases

Database of interacting proteins More...DIPⁱ	DIP-3096N
IntActⁱ	P55989, 14 interactors
Molecular INTeraction database More...MINTⁱ	P55989
STRINGⁱ	85962.HP1072

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P55989
SMRⁱ	P55989
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	2 – 68	HMAPROSITE-ProRule annotationAdd BLAST		67

Sequence similaritiesⁱ

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily. [View classification]Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG4105C59 Bacteria COG2217 LUCA
KEGG Orthology (KO) More...KOⁱ	K17686
OMAⁱ	ITVKGGY

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00371 HMA, 1 hit
Gene3Dⁱ	3.40.1110.10, 1 hit 3.40.50.1000, 1 hit
InterProⁱ	View protein in InterPro IPR023299 ATPase_P-typ_cyto_dom_N IPR018303 ATPase_P-typ_P_site IPR023298 ATPase_P-typ_TM_dom_sf IPR008250 ATPase_P-typ_transduc_dom_A_sf IPR036412 HAD-like_sf IPR023214 HAD_sf IPR017969 Heavy-metal-associated_CS IPR006121 HMA_dom IPR036163 HMA_dom_sf IPR027256 P-typ_ATPase_IB IPR001757 P_typ_ATPase
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00403 HMA, 1 hit
SUPFAMⁱ	SSF55008 SSF55008, 1 hit SSF56784 SSF56784, 1 hit SSF81653 SSF81653, 1 hit SSF81660 SSF81660, 1 hit SSF81665 SSF81665, 1 hit
TIGRFAMsⁱ	TIGR01525 ATPase-IB_hvy, 1 hit TIGR01494 ATPase_P-type, 1 hit
PROSITEⁱ	View protein in PROSITE PS00154 ATPASE_E1_E2, 1 hit PS01047 HMA_1, 1 hit PS50846 HMA_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P55989-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MKESFYIEGM TCTACSSGIE RSLGRKSFVK KIEVSLLNKS ANIEFDENQT 
        60         70         80         90        100
NLDEIFKLIE KLGYSPKKAL TKEKKEFFSP NVKLALAVIF TLFVVYLSMG 
       110        120        130        140        150
AMLSPSLLPE SLLAIDNHSN FLNACLQLIG ALIVMHLGRD FYIQGFKALW 
       160        170        180        190        200
HRQPNMSSLI AIGTSAALIS SLWQLYLVYT NHYTDQWSYG HYYFESVCVI 
       210        220        230        240        250
LMFVMVGKRI ENVSKDKALD AMQALMKNAP KTALKMQNNQ QIEVLVDSIV 
       260        270        280        290        300
VGDILKVLPG SAIAVDGEII EGEGELDESM LSGEALPVYK KVGDKVFSGT 
       310        320        330        340        350
FNSHTSFLMK ATQNNKNSTL SQIIEMIYNA QSSKAEISRL ADKVSSVFVP 
       360        370        380        390        400
SVIAISILAF VVWLIIAPKP DFWWNFGIAL EVFVSVLVIS CPCALGLATP 
       410        420        430        440        450
MSILVANQKA SSLGLFFKDA KSLEKARLVN TIVFDKTGTL TNGKPVVKSV 
       460        470        480        490        500
HSKIELLELL SLALSIEKSS EHVIAKGIVE YAKEHNAPLK EMSGVKVKTG 
       510        520        530        540        550
FGISAKTDYQ GTKEIIKVGN SEFFNPINTL EIKENGILVF VGRAISEKED 
       560        570        580        590        600
ELLGAFVLED LPKKGVKEHI AQIKNLGINT FLLSGDNREN VQKCAFELGI 
       610        620        630        640        650
DGYISNAKPQ DKLNKIKELK EKGQIVMMVG DGLNDAPSLA MSDVAVVMAK 
       660        670        680        690        700
GSDVSVQAAD IVSFNNDIKS VYSAIKLSQA TIKNIKENLF WAFCYNSVFI 
       710        720        730        740 
PLACGVLYKA NLMLSPAIAG LAMSLSSVSV VLNSQRLRNF KIKDH

Length:745

Mass (Da):81,853

Last modified:November 1, 1997 - v1

Checksum:ⁱ855C10A737C072C9

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AE000511 Genomic DNA Translation: AAD08117.1
PIRⁱ	H64653
NCBI Reference Sequences More...RefSeqⁱ	NP_207863.1, NC_000915.1 WP_000664941.1, NC_018939.1

Genome annotation databases

EnsemblBacteriaⁱ	AAD08117; AAD08117; HP_1072
GeneIDⁱ	899608
KEGGⁱ	heo:C694_05540 hpy:HP1072
PATRICⁱ	fig\|85962.47.peg.1151

Protein	Similar proteins		Species	Score	Length	Source
P55989	Copper-transporting ATPase		HELPX		745	UniRef100_P55989
Copper-transporting ATPase		Helicobacter pylori SS1		745
UPI0007E9A823		HELPX		647

Protein	Similar proteins		Species	Score	Length	Source
P55989	Copper-transporting ATPase		HELPX		741	UniRef90_Q59467
Copper-transporting ATPase		HELPJ		745
Uncharacterized protein (Fragment)		Helicobacter pylori PZ5004		105
Copper-transporting ATPase		Helicobacter pylori SS1		745
Copper-transporting ATPase		HELPH		745
+669

Protein	Similar proteins		Species	Score	Length	Source
P55989	Copper-transporting ATPase		HELPX		741	UniRef50_Q59467
Copper-transporting ATPase		HELPJ		745
Copper-transporting ATPase		HELPG		745
Copper-transporting ATPase		HELPM		745
Copper-translocating P-type ATPase		Helicobacter pylori NQ4099		745
+694

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AE000511 Genomic DNA Translation: AAD08117.1
PIRⁱ	H64653
RefSeqⁱ	NP_207863.1, NC_000915.1 WP_000664941.1, NC_018939.1

3D structure databases

ProteinModelPortalⁱ	P55989
SMRⁱ	P55989
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

DIPⁱ	DIP-3096N
IntActⁱ	P55989, 14 interactors
MINTⁱ	P55989
STRINGⁱ	85962.HP1072

Proteomic databases

PaxDbⁱ	P55989

PaxDbⁱ

P55989

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	AAD08117; AAD08117; HP_1072
GeneIDⁱ	899608
KEGGⁱ	heo:C694_05540 hpy:HP1072
PATRICⁱ	fig\|85962.47.peg.1151

Phylogenomic databases

eggNOGⁱ	ENOG4105C59 Bacteria COG2217 LUCA
KOⁱ	K17686
OMAⁱ	ITVKGGY

Enzyme and pathway databases

BioCycⁱ	HPY:HP1072-MONOMER

BioCycⁱ

HPY:HP1072-MONOMER

Family and domain databases

CDDⁱ	cd00371 HMA, 1 hit
Gene3Dⁱ	3.40.1110.10, 1 hit 3.40.50.1000, 1 hit
InterProⁱ	View protein in InterPro IPR023299 ATPase_P-typ_cyto_dom_N IPR018303 ATPase_P-typ_P_site IPR023298 ATPase_P-typ_TM_dom_sf IPR008250 ATPase_P-typ_transduc_dom_A_sf IPR036412 HAD-like_sf IPR023214 HAD_sf IPR017969 Heavy-metal-associated_CS IPR006121 HMA_dom IPR036163 HMA_dom_sf IPR027256 P-typ_ATPase_IB IPR001757 P_typ_ATPase
Pfamⁱ	View protein in Pfam PF00403 HMA, 1 hit
SUPFAMⁱ	SSF55008 SSF55008, 1 hit SSF56784 SSF56784, 1 hit SSF81653 SSF81653, 1 hit SSF81660 SSF81660, 1 hit SSF81665 SSF81665, 1 hit
TIGRFAMsⁱ	TIGR01525 ATPase-IB_hvy, 1 hit TIGR01494 ATPase_P-type, 1 hit
PROSITEⁱ	View protein in PROSITE PS00154 ATPASE_E1_E2, 1 hit PS01047 HMA_1, 1 hit PS50846 HMA_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	COPA_HELPY
Accessionⁱ	P55989Primary (citable) accession number: P55989
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	November 1, 1997
	Last modified:	November 7, 2018
	This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

UniProtKB

UniParc

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Proteomes

Annotation systems

Supporting data

UniProtKB - P55989 (COPA_HELPY)

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Copper-transporting ATPase

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

GO - Cellular componenti

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Keywords - PTMi

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ