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UniProtKB - P55989 (COPA_HELPY)
Protein
Copper-transporting ATPase
Gene
copA
Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Functioni
Probably involved in copper export.
Catalytic activityi
- EC:7.2.2.9
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 12 | CopperPROSITE-ProRule annotation | 1 | |
Metal bindingi | 15 | CopperPROSITE-ProRule annotation | 1 | |
Active sitei | 435 | 4-aspartylphosphate intermediateBy similarity | 1 | |
Metal bindingi | 631 | MagnesiumPROSITE-ProRule annotation | 1 | |
Metal bindingi | 635 | MagnesiumPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- copper ion binding Source: GO_Central
- P-type divalent copper transporter activity Source: GO_Central
GO - Biological processi
- copper ion homeostasis Source: GO_Central
Keywordsi
Molecular function | Translocase |
Biological process | Copper transport, Ion transport, Transport |
Ligand | ATP-binding, Copper, Magnesium, Metal-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:copA Ordered Locus Names:HP_1072 |
Organismi | Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) |
Taxonomic identifieri | 85962 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
- membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 83 | CytoplasmicSequence analysisAdd BLAST | 83 | |
Transmembranei | 84 – 104 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 105 – 124 | ExtracellularSequence analysisAdd BLAST | 20 | |
Transmembranei | 125 – 144 | HelicalSequence analysisAdd BLAST | 20 | |
Topological domaini | 145 – 151 | CytoplasmicSequence analysis | 7 | |
Transmembranei | 152 – 172 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 173 – 194 | ExtracellularSequence analysisAdd BLAST | 22 | |
Transmembranei | 195 – 215 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 216 – 343 | CytoplasmicSequence analysisAdd BLAST | 128 | |
Transmembranei | 344 – 366 | HelicalSequence analysisAdd BLAST | 23 | |
Topological domaini | 367 – 379 | ExtracellularSequence analysisAdd BLAST | 13 | |
Transmembranei | 380 – 397 | HelicalSequence analysisAdd BLAST | 18 | |
Topological domaini | 398 – 685 | CytoplasmicSequence analysisAdd BLAST | 288 | |
Transmembranei | 686 – 705 | HelicalSequence analysisAdd BLAST | 20 | |
Topological domaini | 706 – 716 | ExtracellularSequence analysisAdd BLAST | 11 | |
Transmembranei | 717 – 735 | HelicalSequence analysisAdd BLAST | 19 | |
Topological domaini | 736 – 745 | CytoplasmicSequence analysis | 10 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000046170 | 1 – 745 | Copper-transporting ATPaseAdd BLAST | 745 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | P55989 |
Interactioni
Protein-protein interaction databases
DIPi | DIP-3096N |
IntActi | P55989, 14 interactors |
MINTi | P55989 |
STRINGi | 85962.C694_05540 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 2 – 68 | HMAPROSITE-ProRule annotationAdd BLAST | 67 |
Sequence similaritiesi
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG2217, Bacteria |
OMAi | ACGMNMV |
PhylomeDBi | P55989 |
Family and domain databases
CDDi | cd00371, HMA, 1 hit |
Gene3Di | 3.40.1110.10, 1 hit 3.40.50.1000, 1 hit |
InterProi | View protein in InterPro IPR023299, ATPase_P-typ_cyto_dom_N IPR018303, ATPase_P-typ_P_site IPR023298, ATPase_P-typ_TM_dom_sf IPR008250, ATPase_P-typ_transduc_dom_A_sf IPR036412, HAD-like_sf IPR023214, HAD_sf IPR017969, Heavy-metal-associated_CS IPR006121, HMA_dom IPR036163, HMA_dom_sf IPR027256, P-typ_ATPase_IB IPR001757, P_typ_ATPase IPR044492, P_typ_ATPase_HD_dom |
Pfami | View protein in Pfam PF00403, HMA, 1 hit |
SFLDi | SFLDF00027, p-type_atpase, 1 hit |
SUPFAMi | SSF55008, SSF55008, 1 hit SSF56784, SSF56784, 1 hit SSF81653, SSF81653, 1 hit SSF81660, SSF81660, 1 hit SSF81665, SSF81665, 1 hit |
TIGRFAMsi | TIGR01525, ATPase-IB_hvy, 1 hit TIGR01494, ATPase_P-type, 1 hit |
PROSITEi | View protein in PROSITE PS00154, ATPASE_E1_E2, 1 hit PS01047, HMA_1, 1 hit PS50846, HMA_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P55989-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKESFYIEGM TCTACSSGIE RSLGRKSFVK KIEVSLLNKS ANIEFDENQT
60 70 80 90 100
NLDEIFKLIE KLGYSPKKAL TKEKKEFFSP NVKLALAVIF TLFVVYLSMG
110 120 130 140 150
AMLSPSLLPE SLLAIDNHSN FLNACLQLIG ALIVMHLGRD FYIQGFKALW
160 170 180 190 200
HRQPNMSSLI AIGTSAALIS SLWQLYLVYT NHYTDQWSYG HYYFESVCVI
210 220 230 240 250
LMFVMVGKRI ENVSKDKALD AMQALMKNAP KTALKMQNNQ QIEVLVDSIV
260 270 280 290 300
VGDILKVLPG SAIAVDGEII EGEGELDESM LSGEALPVYK KVGDKVFSGT
310 320 330 340 350
FNSHTSFLMK ATQNNKNSTL SQIIEMIYNA QSSKAEISRL ADKVSSVFVP
360 370 380 390 400
SVIAISILAF VVWLIIAPKP DFWWNFGIAL EVFVSVLVIS CPCALGLATP
410 420 430 440 450
MSILVANQKA SSLGLFFKDA KSLEKARLVN TIVFDKTGTL TNGKPVVKSV
460 470 480 490 500
HSKIELLELL SLALSIEKSS EHVIAKGIVE YAKEHNAPLK EMSGVKVKTG
510 520 530 540 550
FGISAKTDYQ GTKEIIKVGN SEFFNPINTL EIKENGILVF VGRAISEKED
560 570 580 590 600
ELLGAFVLED LPKKGVKEHI AQIKNLGINT FLLSGDNREN VQKCAFELGI
610 620 630 640 650
DGYISNAKPQ DKLNKIKELK EKGQIVMMVG DGLNDAPSLA MSDVAVVMAK
660 670 680 690 700
GSDVSVQAAD IVSFNNDIKS VYSAIKLSQA TIKNIKENLF WAFCYNSVFI
710 720 730 740
PLACGVLYKA NLMLSPAIAG LAMSLSSVSV VLNSQRLRNF KIKDH
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE000511 Genomic DNA Translation: AAD08117.1 |
PIRi | H64653 |
RefSeqi | NP_207863.1, NC_000915.1 WP_000664941.1, NC_018939.1 |
Genome annotation databases
EnsemblBacteriai | AAD08117; AAD08117; HP_1072 |
KEGGi | hpy:HP_1072 |
PATRICi | fig|85962.47.peg.1151 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE000511 Genomic DNA Translation: AAD08117.1 |
PIRi | H64653 |
RefSeqi | NP_207863.1, NC_000915.1 WP_000664941.1, NC_018939.1 |
3D structure databases
SMRi | P55989 |
ModBasei | Search... |
Protein-protein interaction databases
DIPi | DIP-3096N |
IntActi | P55989, 14 interactors |
MINTi | P55989 |
STRINGi | 85962.C694_05540 |
Proteomic databases
PaxDbi | P55989 |
Genome annotation databases
EnsemblBacteriai | AAD08117; AAD08117; HP_1072 |
KEGGi | hpy:HP_1072 |
PATRICi | fig|85962.47.peg.1151 |
Phylogenomic databases
eggNOGi | COG2217, Bacteria |
OMAi | ACGMNMV |
PhylomeDBi | P55989 |
Family and domain databases
CDDi | cd00371, HMA, 1 hit |
Gene3Di | 3.40.1110.10, 1 hit 3.40.50.1000, 1 hit |
InterProi | View protein in InterPro IPR023299, ATPase_P-typ_cyto_dom_N IPR018303, ATPase_P-typ_P_site IPR023298, ATPase_P-typ_TM_dom_sf IPR008250, ATPase_P-typ_transduc_dom_A_sf IPR036412, HAD-like_sf IPR023214, HAD_sf IPR017969, Heavy-metal-associated_CS IPR006121, HMA_dom IPR036163, HMA_dom_sf IPR027256, P-typ_ATPase_IB IPR001757, P_typ_ATPase IPR044492, P_typ_ATPase_HD_dom |
Pfami | View protein in Pfam PF00403, HMA, 1 hit |
SFLDi | SFLDF00027, p-type_atpase, 1 hit |
SUPFAMi | SSF55008, SSF55008, 1 hit SSF56784, SSF56784, 1 hit SSF81653, SSF81653, 1 hit SSF81660, SSF81660, 1 hit SSF81665, SSF81665, 1 hit |
TIGRFAMsi | TIGR01525, ATPase-IB_hvy, 1 hit TIGR01494, ATPase_P-type, 1 hit |
PROSITEi | View protein in PROSITE PS00154, ATPASE_E1_E2, 1 hit PS01047, HMA_1, 1 hit PS50846, HMA_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | COPA_HELPY | |
Accessioni | P55989Primary (citable) accession number: P55989 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1997 | |
Last modified: | February 23, 2022 | |
This is version 147 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families