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Protein

Copper-transporting ATPase

Gene

copA

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Probably involved in copper export.

Catalytic activityi

ATP + H2O + Cu2+(Side 1) = ADP + phosphate + Cu2+(Side 2).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi12CopperPROSITE-ProRule annotation1
Metal bindingi15CopperPROSITE-ProRule annotation1
Active sitei4354-aspartylphosphate intermediateBy similarity1
Metal bindingi631MagnesiumPROSITE-ProRule annotation1
Metal bindingi635MagnesiumPROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
Biological processCopper transport, Ion transport, Transport
LigandATP-binding, Copper, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciHPY:HP1072-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Copper-transporting ATPase (EC:3.6.3.4)
Gene namesi
Name:copA
Ordered Locus Names:HP_1072
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000429 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 83CytoplasmicSequence analysisAdd BLAST83
Transmembranei84 – 104HelicalSequence analysisAdd BLAST21
Topological domaini105 – 124ExtracellularSequence analysisAdd BLAST20
Transmembranei125 – 144HelicalSequence analysisAdd BLAST20
Topological domaini145 – 151CytoplasmicSequence analysis7
Transmembranei152 – 172HelicalSequence analysisAdd BLAST21
Topological domaini173 – 194ExtracellularSequence analysisAdd BLAST22
Transmembranei195 – 215HelicalSequence analysisAdd BLAST21
Topological domaini216 – 343CytoplasmicSequence analysisAdd BLAST128
Transmembranei344 – 366HelicalSequence analysisAdd BLAST23
Topological domaini367 – 379ExtracellularSequence analysisAdd BLAST13
Transmembranei380 – 397HelicalSequence analysisAdd BLAST18
Topological domaini398 – 685CytoplasmicSequence analysisAdd BLAST288
Transmembranei686 – 705HelicalSequence analysisAdd BLAST20
Topological domaini706 – 716ExtracellularSequence analysisAdd BLAST11
Transmembranei717 – 735HelicalSequence analysisAdd BLAST19
Topological domaini736 – 745CytoplasmicSequence analysis10

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000461701 – 745Copper-transporting ATPaseAdd BLAST745

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP55989

Interactioni

Protein-protein interaction databases

DIPiDIP-3096N
IntActiP55989, 14 interactors
MINTiP55989
STRINGi85962.HP1072

Structurei

3D structure databases

ProteinModelPortaliP55989
SMRiP55989
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 68HMAPROSITE-ProRule annotationAdd BLAST67

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105C59 Bacteria
COG2217 LUCA
KOiK17686
OMAiITVKGGY

Family and domain databases

CDDicd00371 HMA, 1 hit
Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 2 hits
InterProiView protein in InterPro
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR017969 Heavy-metal-associated_CS
IPR006121 HMA_dom
IPR036163 HMA_dom_sf
IPR027256 P-typ_ATPase_IB
IPR001757 P_typ_ATPase
PfamiView protein in Pfam
PF00403 HMA, 1 hit
SUPFAMiSSF55008 SSF55008, 1 hit
SSF56784 SSF56784, 2 hits
SSF81653 SSF81653, 1 hit
SSF81660 SSF81660, 1 hit
SSF81665 SSF81665, 2 hits
TIGRFAMsiTIGR01525 ATPase-IB_hvy, 1 hit
TIGR01494 ATPase_P-type, 1 hit
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit
PS01047 HMA_1, 1 hit
PS50846 HMA_2, 1 hit

Sequencei

Sequence statusi: Complete.

P55989-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKESFYIEGM TCTACSSGIE RSLGRKSFVK KIEVSLLNKS ANIEFDENQT
60 70 80 90 100
NLDEIFKLIE KLGYSPKKAL TKEKKEFFSP NVKLALAVIF TLFVVYLSMG
110 120 130 140 150
AMLSPSLLPE SLLAIDNHSN FLNACLQLIG ALIVMHLGRD FYIQGFKALW
160 170 180 190 200
HRQPNMSSLI AIGTSAALIS SLWQLYLVYT NHYTDQWSYG HYYFESVCVI
210 220 230 240 250
LMFVMVGKRI ENVSKDKALD AMQALMKNAP KTALKMQNNQ QIEVLVDSIV
260 270 280 290 300
VGDILKVLPG SAIAVDGEII EGEGELDESM LSGEALPVYK KVGDKVFSGT
310 320 330 340 350
FNSHTSFLMK ATQNNKNSTL SQIIEMIYNA QSSKAEISRL ADKVSSVFVP
360 370 380 390 400
SVIAISILAF VVWLIIAPKP DFWWNFGIAL EVFVSVLVIS CPCALGLATP
410 420 430 440 450
MSILVANQKA SSLGLFFKDA KSLEKARLVN TIVFDKTGTL TNGKPVVKSV
460 470 480 490 500
HSKIELLELL SLALSIEKSS EHVIAKGIVE YAKEHNAPLK EMSGVKVKTG
510 520 530 540 550
FGISAKTDYQ GTKEIIKVGN SEFFNPINTL EIKENGILVF VGRAISEKED
560 570 580 590 600
ELLGAFVLED LPKKGVKEHI AQIKNLGINT FLLSGDNREN VQKCAFELGI
610 620 630 640 650
DGYISNAKPQ DKLNKIKELK EKGQIVMMVG DGLNDAPSLA MSDVAVVMAK
660 670 680 690 700
GSDVSVQAAD IVSFNNDIKS VYSAIKLSQA TIKNIKENLF WAFCYNSVFI
710 720 730 740
PLACGVLYKA NLMLSPAIAG LAMSLSSVSV VLNSQRLRNF KIKDH
Length:745
Mass (Da):81,853
Last modified:November 1, 1997 - v1
Checksum:i855C10A737C072C9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA Translation: AAD08117.1
PIRiH64653
RefSeqiNP_207863.1, NC_000915.1
WP_000664941.1, NC_018939.1

Genome annotation databases

EnsemblBacteriaiAAD08117; AAD08117; HP_1072
GeneIDi899608
KEGGiheo:C694_05540
hpy:HP1072
PATRICifig|85962.47.peg.1151

Similar proteinsi

Entry informationi

Entry nameiCOPA_HELPY
AccessioniPrimary (citable) accession number: P55989
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: February 28, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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