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Protein

Vacuolating cytotoxin autotransporter

Gene

vacA

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Induces vacuolation of eukaryotic cells. Causes ulceration and gastric lesions.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionToxin

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

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BioCyci
HPY:HP0887-MONOMER

Protein family/group databases

Transport Classification Database

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TCDBi
1.C.9.1.1 the vacuolating cytotoxin (vaca) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Vacuolating cytotoxin autotransporter
Cleaved into the following 2 chains:
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:vacA
Ordered Locus Names:HP_0887
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri85962 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000429 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Vacuolating cytotoxin translocator :

GO - Cellular componenti

Keywords - Cellular componenti

Cell outer membrane, Membrane, Periplasm, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000022652? – 1290Vacuolating cytotoxin translocatorSequence analysis
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 33Sequence analysisAdd BLAST33
ChainiPRO_000038758634 – 1290Vacuolating cytotoxin autotransporterAdd BLAST1257
ChainiPRO_000002265134 – ?Vacuolating cytotoxin

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P55981

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Database of interacting proteins

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DIPi
DIP-3244N

Protein interaction database and analysis system

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IntActi
P55981, 15 interactors

Molecular INTeraction database

More...
MINTi
P55981

STRING: functional protein association networks

More...
STRINGi
85962.HP0887

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P55981

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P55981

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1018 – 1290AutotransporterPROSITE-ProRule annotationAdd BLAST273

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The signal peptide, cleaved at the inner membrane, guides the autotransporter protein to the periplasmic space. Then, insertion of the C-terminal translocator domain in the outer membrane forms a hydrophilic pore for the translocation of the passenger domain to the bacterial cell surface, with subsequent cleavage (By similarity).By similarity

Keywords - Domaini

Signal, Transmembrane, Transmembrane beta strand

Phylogenomic databases

KEGG Orthology (KO)

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KOi
K11028

Identification of Orthologs from Complete Genome Data

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OMAi
WQSAGLN

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.40.128.130, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR005546 Autotransporte_beta
IPR036709 Autotransporte_beta_dom_sf
IPR003842 Vacuolating_cytotoxin

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03797 Autotransporter, 1 hit
PF02691 VacA, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01656 VACCYTOTOXIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00869 Autotransporter, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF103515 SSF103515, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51208 AUTOTRANSPORTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P55981-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEIQQTHRKI NRPLVSLALV GALVSITPQQ SHAAFFTTVI IPAIVGGIAT
60 70 80 90 100
GAAVGTVSGL LGWGLKQAEE ANKTPDKPDK VWRIQAGKGF NEFPNKEYDL
110 120 130 140 150
YRSLLSSKID GGWDWGNAAT HYWVKGGQWN KLEVDMKDAV GTYNLSGLRN
160 170 180 190 200
FTGGDLDVNM QKATLRLGQF NGNSFTSYKD SADRTTRVDF NAKNILIDNF
210 220 230 240 250
LEINNRVGSG AGRKASSTVL TLQASEGITS SKNAEISLYD GATLNLASNS
260 270 280 290 300
VKLMGNVWMG RLQYVGAYLA PSYSTINTSK VTGEVNFNHL TVGDHNAAQA
310 320 330 340 350
GIIASNKTHI GTLDLWQSAG LNIIAPPEGG YKDKPKDKPS NTTQNNANNN
360 370 380 390 400
QQNSAQNNSN TQVINPPNSA QKTEIQPTQV IDGPFAGGKD TVVNIDRINT
410 420 430 440 450
NADGTIKVGG YKASLTTNAA HLHIGKGGIN LSNQASGRTL LVENLTGNIT
460 470 480 490 500
VDGPLRVNNQ VGGYALAGSS ANFEFKAGTD TKNGTATFNN DISLGRFVNL
510 520 530 540 550
KVDAHTANFK GIDTGNGGFN TLDFSGVTGK VNINKLITAS TNVAVKNFNI
560 570 580 590 600
NELVVKTNGV SVGEYTHFSE DIGSQSRINT VRLETGTRSI FSGGVKFKSG
610 620 630 640 650
EKLVIDEFYY SPWNYFDARN IKNVEITRKF ASSTPENPWG TSKLMFNNLT
660 670 680 690 700
LGQNAVMDYS QFSNLTIQGD FINNQGTINY LVRGGQVATL NVGNAAAMFF
710 720 730 740 750
SNNVDSATGF YQPLMKINSA QDLIKNKEHV LLKAKIIGYG NVSLGTNSIS
760 770 780 790 800
NVNLIEQFKE RLALYNNNNR MDICVVRNTD DIKACGTAIG NQSMVNNPDN
810 820 830 840 850
YKYLIGKAWK NIGISKTANG SKISVYYLGN STPTEKGGNT TNLPTNTTSN
860 870 880 890 900
VRSANNALAQ NAPFAQPSAT PNLVAINQHD FGTIESVFEL ANRSKDIDTL
910 920 930 940 950
YANSGAQGRD LLQTLLIDSH DAGYARQMID NTSTGEITKQ LNAATTTLNN
960 970 980 990 1000
IASLEHKTSS LQTLSLSNAM ILNSRLVNLS RRHTNNIDSF AQRLQALKDQ
1010 1020 1030 1040 1050
KFASLESAAE VLYQFAPKYE KPTNVWANAI GGTSLNNGGN ASLYGTSAGV
1060 1070 1080 1090 1100
DAYLNGEVEA IVGGFGSYGY SSFNNQANSL NSGANNTNFG VYSRIFANQH
1110 1120 1130 1140 1150
EFDFEAQGAL GSDQSSLNFK SALLRDLNQS YNYLAYSAAT RASYGYDFAF
1160 1170 1180 1190 1200
FRNALVLKPS VGVSYNHLGS TNFKSNSNQV ALKNGSSSQH LFNASANVEA
1210 1220 1230 1240 1250
RYYYGDTSYF YMNAGVLQEF ANFGSSNAVS LNTFKVNAAH NPLSTHARVM
1260 1270 1280 1290
MGGELKLAKE VFLNLGFVYL HNLISNIGHF ASNLGMRYSF
Length:1,290
Mass (Da):139,312
Last modified:November 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF48B23513447A1AC
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AE000511 Genomic DNA Translation: AAD07935.1

Protein sequence database of the Protein Information Resource

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PIRi
G64630

NCBI Reference Sequences

More...
RefSeqi
NP_207680.1, NC_000915.1
WP_000405496.1, NC_000915.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAD07935; AAD07935; HP_0887

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
899415

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hpy:HP0887

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|85962.8.peg.919

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA Translation: AAD07935.1
PIRiG64630
RefSeqiNP_207680.1, NC_000915.1
WP_000405496.1, NC_000915.1

3D structure databases

ProteinModelPortaliP55981
SMRiP55981
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-3244N
IntActiP55981, 15 interactors
MINTiP55981
STRINGi85962.HP0887

Protein family/group databases

TCDBi1.C.9.1.1 the vacuolating cytotoxin (vaca) family

Proteomic databases

PaxDbiP55981

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD07935; AAD07935; HP_0887
GeneIDi899415
KEGGihpy:HP0887
PATRICifig|85962.8.peg.919

Phylogenomic databases

KOiK11028
OMAiWQSAGLN

Enzyme and pathway databases

BioCyciHPY:HP0887-MONOMER

Family and domain databases

Gene3Di2.40.128.130, 1 hit
InterProiView protein in InterPro
IPR005546 Autotransporte_beta
IPR036709 Autotransporte_beta_dom_sf
IPR003842 Vacuolating_cytotoxin
PfamiView protein in Pfam
PF03797 Autotransporter, 1 hit
PF02691 VacA, 1 hit
PRINTSiPR01656 VACCYTOTOXIN
SMARTiView protein in SMART
SM00869 Autotransporter, 1 hit
SUPFAMiSSF103515 SSF103515, 1 hit
PROSITEiView protein in PROSITE
PS51208 AUTOTRANSPORTER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiVACA_HELPY
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P55981
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 10, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
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