UniProtKB - P55970 (GRPE_HELPY)
Protein
Protein GrpE
Gene
grpE
Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Functioni
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.UniRule annotation
GO - Molecular functioni
- adenyl-nucleotide exchange factor activity Source: GO_Central
- chaperone binding Source: InterPro
- protein homodimerization activity Source: InterPro
- unfolded protein binding Source: GO_Central
GO - Biological processi
- protein folding Source: InterPro
Keywordsi
Molecular function | Chaperone |
Biological process | Stress response |
Enzyme and pathway databases
BioCyci | HPY:HP0110-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Protein GrpEUniRule annotationAlternative name(s): HSP-70 cofactorUniRule annotation |
Gene namesi | Name:grpEUniRule annotation Ordered Locus Names:HP_0110 |
Organismi | Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) |
Taxonomic identifieri | 85962 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter › |
Proteomesi |
|
Subcellular locationi
- Cytoplasm UniRule annotation
GO - Cellular componenti
- cytosol Source: GO_Central
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000113795 | 1 – 189 | Protein GrpEAdd BLAST | 189 |
Proteomic databases
PaxDbi | P55970 |
Interactioni
Subunit structurei
Homodimer.
UniRule annotationGO - Molecular functioni
- chaperone binding Source: InterPro
- protein homodimerization activity Source: InterPro
- unfolded protein binding Source: GO_Central
Protein-protein interaction databases
IntActi | P55970, 1 interactor |
STRINGi | 85962.C694_00545 |
Family & Domainsi
Sequence similaritiesi
Belongs to the GrpE family.UniRule annotation
Phylogenomic databases
eggNOGi | COG0576, Bacteria |
OMAi | YAYEKIA |
Family and domain databases
CDDi | cd00446, GrpE, 1 hit |
Gene3Di | 2.30.22.10, 1 hit 3.90.20.20, 1 hit |
HAMAPi | MF_01151, GrpE, 1 hit |
InterProi | View protein in InterPro IPR000740, GrpE IPR013805, GrpE_coiled_coil IPR009012, GrpE_head |
PANTHERi | PTHR21237, PTHR21237, 1 hit |
Pfami | View protein in Pfam PF01025, GrpE, 1 hit |
PRINTSi | PR00773, GRPEPROTEIN |
SUPFAMi | SSF51064, SSF51064, 1 hit SSF58014, SSF58014, 1 hit |
PROSITEi | View protein in PROSITE PS01071, GRPE, 1 hit |
i Sequence
Sequence statusi: Complete.
P55970-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKDEHNQEHD HLSQKEPEFC EKACKEQQYE EKQEAGEKEG EIKEDFELKY
60 70 80 90 100
KEMHEKYLRV HADFENVKKR LERDKSMALE YAYEKIALDL LPVIDALLGA
110 120 130 140 150
HKSAAEEDKE SALTKGLELT MEKLHEVLAR HGIEGIECLE EFDPHFHNAI
160 170 180
MQVKSEEKEN GKIVQVLQQG YKYKGRVLRP AMVSIAKND
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE000511 Genomic DNA Translation: AAD07179.1 |
PIRi | F64533 |
RefSeqi | NP_206910.1, NC_000915.1 WP_000650844.1, NC_000915.1 |
Genome annotation databases
EnsemblBacteriai | AAD07179; AAD07179; HP_0110 |
KEGGi | hpy:HP0110 |
PATRICi | fig|85962.8.peg.117 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE000511 Genomic DNA Translation: AAD07179.1 |
PIRi | F64533 |
RefSeqi | NP_206910.1, NC_000915.1 WP_000650844.1, NC_000915.1 |
3D structure databases
SMRi | P55970 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | P55970, 1 interactor |
STRINGi | 85962.C694_00545 |
Proteomic databases
PaxDbi | P55970 |
Genome annotation databases
EnsemblBacteriai | AAD07179; AAD07179; HP_0110 |
KEGGi | hpy:HP0110 |
PATRICi | fig|85962.8.peg.117 |
Phylogenomic databases
eggNOGi | COG0576, Bacteria |
OMAi | YAYEKIA |
Enzyme and pathway databases
BioCyci | HPY:HP0110-MONOMER |
Family and domain databases
CDDi | cd00446, GrpE, 1 hit |
Gene3Di | 2.30.22.10, 1 hit 3.90.20.20, 1 hit |
HAMAPi | MF_01151, GrpE, 1 hit |
InterProi | View protein in InterPro IPR000740, GrpE IPR013805, GrpE_coiled_coil IPR009012, GrpE_head |
PANTHERi | PTHR21237, PTHR21237, 1 hit |
Pfami | View protein in Pfam PF01025, GrpE, 1 hit |
PRINTSi | PR00773, GRPEPROTEIN |
SUPFAMi | SSF51064, SSF51064, 1 hit SSF58014, SSF58014, 1 hit |
PROSITEi | View protein in PROSITE PS01071, GRPE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GRPE_HELPY | |
Accessioni | P55970Primary (citable) accession number: P55970 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1997 | |
Last modified: | December 2, 2020 | |
This is version 102 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families