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Protein

T-related protein

Gene

byn

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Required for the specification of the hindgut and anal pads.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi96 – 264T-boxPROSITE-ProRule annotationAdd BLAST169

GO - Molecular functioni

  • DNA binding Source: FlyBase
  • protein homodimerization activity Source: FlyBase
  • RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: FlyBase

GO - Biological processi

  • cell fate determination Source: FlyBase
  • hindgut morphogenesis Source: FlyBase
  • Malpighian tubule morphogenesis Source: FlyBase
  • mesoderm migration involved in gastrulation Source: FlyBase
  • midgut development Source: FlyBase
  • pole cell migration Source: FlyBase
  • positive regulation of transcription by RNA polymerase II Source: FlyBase
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
T-related protein
Short name:
Trp
Alternative name(s):
Protein brachyenteron
Gene namesi
Name:byn
Synonyms:trg
ORF Names:CG7260
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0011723 byn

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001844671 – 697T-related proteinAdd BLAST697

Proteomic databases

PaxDbiP55965
PRIDEiP55965

Expressioni

Developmental stagei

First expressed at the beginning of nuclear cycle 14 in the posterior terminal region. As cellularization proceeds, expression becomes confined to a ring area encompassing the primordium of the hindgut and anal pads. Expression is maintained in this region until the end of embryogenesis.1 Publication

Gene expression databases

BgeeiFBgn0011723
ExpressionAtlasiP55965 baseline and differential
GenevisibleiP55965 DM

Interactioni

GO - Molecular functioni

  • protein homodimerization activity Source: FlyBase

Protein-protein interaction databases

BioGridi64710, 4 interactors
STRINGi7227.FBpp0304380

Structurei

3D structure databases

ProteinModelPortaliP55965
SMRiP55965
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi22 – 34Poly-GlyAdd BLAST13
Compositional biasi291 – 298Poly-Ala8
Compositional biasi395 – 402Poly-Ser8
Compositional biasi582 – 585Poly-Ala4

Phylogenomic databases

eggNOGiKOG3585 Eukaryota
ENOG410XSTS LUCA
GeneTreeiENSGT00900000140847
InParanoidiP55965
KOiK10172
OrthoDBiEOG091G05OC

Family and domain databases

CDDicd00182 TBOX, 1 hit
Gene3Di2.60.40.820, 1 hit
InterProiView protein in InterPro
IPR008967 p53-like_TF_DNA-bd
IPR036960 T-box_sf
IPR002070 TF_Brachyury
IPR001699 TF_T-box
IPR018186 TF_T-box_CS
PANTHERiPTHR11267 PTHR11267, 1 hit
PfamiView protein in Pfam
PF00907 T-box, 1 hit
PRINTSiPR00938 BRACHYURY
PR00937 TBOX
SMARTiView protein in SMART
SM00425 TBOX, 1 hit
SUPFAMiSSF49417 SSF49417, 1 hit
PROSITEiView protein in PROSITE
PS01283 TBOX_1, 1 hit
PS01264 TBOX_2, 1 hit
PS50252 TBOX_3, 1 hit

Sequencei

Sequence statusi: Complete.

P55965-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTSHILSAV DPTTGLSGNV SGGGGGGGAG GGAGSGSPQH VTHNGHGHGH
60 70 80 90 100
GLGGVAAVSG GGASVSGNGG HRVVGGAGSP NELDRNLRIS LDDRELWLRF
110 120 130 140 150
QNLTNEMIVT KNGRRMFPVV KISASGLDPA AMYTVLLEFV QIDSHRWKYV
160 170 180 190 200
NGEWVPGGKA EVPPSNPIYV HPESPNFGAH WMKEPISFAK VKLTNKTNGN
210 220 230 240 250
GQIMLNSLHK YEPRVHLVRV GSEQRHVVTY PFPETQFIAV TAYQNEEVTS
260 270 280 290 300
LKIKYNPFAK AFLDAKERPD TLYPHDTHYG WLIPPPTHYT AAAAAVAAPP
310 320 330 340 350
PLSIAQSHGL VASCPSVSSA ESVGPSSGGS CDRYGRSLSS RSVAPTRTTP
360 370 380 390 400
YSRPRVVSGS GSNGSAGNAS STSPQPPSAP QTPTSLHSTS TGSVSTSVSS
410 420 430 440 450
SSGGGIGSAP STGCFSSSYA QSGFMSVDAS PTASVFSYPS SWQSNGNYWN
460 470 480 490 500
ATSVPGPMPM NVCSGRNISS HNSPSPTNGS PSYTTSSPSY TIHHLTPHSH
510 520 530 540 550
QYNMAQTDIY GTGVGVGGGA GTTGSPQAAY GAAAHQVYHP TPTSPTHQLY
560 570 580 590 600
TNAVLNAPSA LSYSASGWHN GSGAEYGLYQ NAAAAYYQPE YIPLEIGYAT
610 620 630 640 650
HPLEPVDVSK TLDDPQAAMY KPSDEQGSVI TLECASSSLK SSHDIKIESS
660 670 680 690
SLEHAGERGT VGGGAAVVSV PTAVVNGAPA VAADTWTPLT PPQSTLQ
Length:697
Mass (Da):72,117
Last modified:August 14, 2001 - v2
Checksum:iC30FD62E20F936D5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti321E → G in AAB32396 (PubMed:7958884).Curated1
Sequence conflicti426S → P in AAB32396 (PubMed:7958884).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S74163 mRNA Translation: AAB32396.2
AE014296 Genomic DNA Translation: AAF49989.2
PIRiA55160
RefSeqiNP_524031.2, NM_079307.2
UniGeneiDm.27127

Genome annotation databases

EnsemblMetazoaiFBtr0332070; FBpp0304380; FBgn0011723
GeneIDi39349
KEGGidme:Dmel_CG7260

Similar proteinsi

Entry informationi

Entry nameiBYN_DROME
AccessioniPrimary (citable) accession number: P55965
Secondary accession number(s): Q9VTQ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: August 14, 2001
Last modified: May 23, 2018
This is version 148 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase

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