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Protein

Metallothionein

Gene
N/A
Organism
Astacus astacus (Noble crayfish) (Astacus fluviatilis)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Metallothioneins have a high content of cysteine residues that bind various heavy metals. Class I MTS in crustacea are involved in the sequestration of elevated levels of heavy-metal ions.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi5Divalent metal cation; cluster B1
Metal bindingi6Divalent metal cation; cluster B1
Metal bindingi10Divalent metal cation; cluster B1
Metal bindingi12Divalent metal cation; cluster B1
Metal bindingi17Divalent metal cation; cluster B1
Metal bindingi21Divalent metal cation; cluster B1
Metal bindingi23Divalent metal cation; cluster B1
Metal bindingi26Divalent metal cation; cluster B1
Metal bindingi28Divalent metal cation; cluster B1
Metal bindingi31Divalent metal cation; cluster A1
Metal bindingi34Divalent metal cation; cluster A1
Metal bindingi38Divalent metal cation; cluster A1
Metal bindingi40Divalent metal cation; cluster A1
Metal bindingi46Divalent metal cation; cluster A1
Metal bindingi50Divalent metal cation; cluster A1
Metal bindingi54Divalent metal cation; cluster A1
Metal bindingi56Divalent metal cation; cluster A1
Metal bindingi57Divalent metal cation; cluster A1

GO - Molecular functioni

Keywordsi

LigandCadmium, Metal-binding, Metal-thiolate cluster

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein
Short name:
MT
OrganismiAstacus astacus (Noble crayfish) (Astacus fluviatilis)
Taxonomic identifieri6715 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaCrustaceaMulticrustaceaMalacostracaEumalacostracaEucaridaDecapodaPleocyemataAstacideaAstacoideaAstacidaeAstacus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001973431 – 58MetallothioneinAdd BLAST58

Expressioni

Inductioni

By cadmium.

Structurei

3D structure databases

ProteinModelPortaliP55951
SMRiP55951
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 29BetaAdd BLAST29
Regioni30 – 58AlphaAdd BLAST29

Sequence similaritiesi

Family and domain databases

InterProiView protein in InterPro
IPR002045 Metalthion_crustacean
IPR017854 Metalthion_dom_sf
PRINTSiPR00858 MTCRUSTACEAN
SUPFAMiSSF57868 SSF57868, 2 hits

Sequencei

Sequence statusi: Complete.

P55951-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPGPCCNDVC ECAAGGCKTG CVCTSCRCSP CDKCTSGCKC PSKEECAKTC

SKPCECCP
Length:58
Mass (Da):5,911
Last modified:November 1, 1997 - v1
Checksum:i576365B3EE5C7122
GO

Mass spectrometryi

Molecular mass is 5910.8 Da from positions 1 - 58. Determined by MALDI. 1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti1Missing in variant isolated in low cadmium concentration. 1

Similar proteinsi

Entry informationi

Entry nameiMT_ASTAS
AccessioniPrimary (citable) accession number: P55951
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: June 20, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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