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Protein

Metallothionein-1B

Gene
N/A
Organism
Callinectes sapidus (Blue crab)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds six divalent metal ions. Known to bind copper and cadmium.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi5Divalent metal cation; cluster B1
Metal bindingi6Divalent metal cation; cluster B1
Metal bindingi10Divalent metal cation; cluster B1
Metal bindingi12Divalent metal cation; cluster B1
Metal bindingi17Divalent metal cation; cluster B1
Metal bindingi21Divalent metal cation; cluster B1
Metal bindingi23Divalent metal cation; cluster B1
Metal bindingi26Divalent metal cation; cluster B1
Metal bindingi28Divalent metal cation; cluster B1
Metal bindingi31Divalent metal cation; cluster A1
Metal bindingi34Divalent metal cation; cluster A1
Metal bindingi38Divalent metal cation; cluster A1
Metal bindingi40Divalent metal cation; cluster A1
Metal bindingi46Divalent metal cation; cluster A1
Metal bindingi50Divalent metal cation; cluster A1
Metal bindingi54Divalent metal cation; cluster A1
Metal bindingi56Divalent metal cation; cluster A1
Metal bindingi57Divalent metal cation; cluster A1

GO - Molecular functioni

Keywordsi

LigandCadmium, Copper, Metal-binding, Metal-thiolate cluster

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein-1B
Short name:
MT-1B
Alternative name(s):
Metallothionein-IB
Short name:
MT-IB
Cleaved into the following chain:
Metallothionein-1A
Short name:
MT-1A
Alternative name(s):
Metallothionein-IA
Short name:
MT-IA
OrganismiCallinectes sapidus (Blue crab)
Taxonomic identifieri6763 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaCrustaceaMulticrustaceaMalacostracaEumalacostracaEucaridaDecapodaPleocyemataBrachyuraEubrachyuraPortunoideaPortunidaeCallinectes

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000417541 – 59Metallothionein-1BAdd BLAST59
ChainiPRO_00000417552 – 59Metallothionein-1AAdd BLAST58

Structurei

Secondary structure

159
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP55949
SMRiP55949
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP55949

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 29BetaAdd BLAST29
Regioni30 – 59AlphaAdd BLAST30

Sequence similaritiesi

Family and domain databases

InterProiView protein in InterPro
IPR002045 Metalthion_crustacean
IPR017854 Metalthion_dom_sf
PRINTSiPR00858 MTCRUSTACEAN
SUPFAMiSSF57868 SSF57868, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55949-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPGPCCNDKC VCQEGGCKAG CQCTSCRCSP CQKCTSGCKC ATKEECSKTC

TKPCSCCPK
Length:59
Mass (Da):6,141
Last modified:November 1, 1997 - v1
Checksum:i4398B0A9D1A96D34
GO

Sequence databases

PIRiS59072

Similar proteinsi

Cross-referencesi

Sequence databases

PIRiS59072

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DMCNMR-A29-59[»]
1DMDNMR-A29-59[»]
1DMENMR-A2-29[»]
1DMFNMR-A2-29[»]
ProteinModelPortaliP55949
SMRiP55949
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP55949

Family and domain databases

InterProiView protein in InterPro
IPR002045 Metalthion_crustacean
IPR017854 Metalthion_dom_sf
PRINTSiPR00858 MTCRUSTACEAN
SUPFAMiSSF57868 SSF57868, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiMT1_CALSI
AccessioniPrimary (citable) accession number: P55949
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: June 20, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Metallothioneins
    Classification of metallothioneins and list of entries
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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