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Protein

Metallothionein

Gene
N/A
Organism
Carcinus maenas (Common shore crab) (Green crab)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Metallothioneins have a high content of cysteine residues that bind various heavy metals. Class I MTS in marine crustacea are involved in the sequestration of elevated levels of heavy-metal ions.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi5Divalent metal cation; cluster B1
Metal bindingi6Divalent metal cation; cluster B1
Metal bindingi10Divalent metal cation; cluster B1
Metal bindingi12Divalent metal cation; cluster B1
Metal bindingi17Divalent metal cation; cluster B1
Metal bindingi21Divalent metal cation; cluster B1
Metal bindingi23Divalent metal cation; cluster B1
Metal bindingi26Divalent metal cation; cluster B1
Metal bindingi28Divalent metal cation; cluster B1
Metal bindingi31Divalent metal cation; cluster A1
Metal bindingi34Divalent metal cation; cluster A1
Metal bindingi38Divalent metal cation; cluster A1
Metal bindingi40Divalent metal cation; cluster A1
Metal bindingi46Divalent metal cation; cluster A1
Metal bindingi50Divalent metal cation; cluster A1
Metal bindingi54Divalent metal cation; cluster A1
Metal bindingi56Divalent metal cation; cluster A1
Metal bindingi57Divalent metal cation; cluster A1

GO - Molecular functioni

Keywordsi

LigandCadmium, Metal-binding, Metal-thiolate cluster

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein
Short name:
MT
OrganismiCarcinus maenas (Common shore crab) (Green crab)
Taxonomic identifieri6759 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaCrustaceaMulticrustaceaMalacostracaEumalacostracaEucaridaDecapodaPleocyemataBrachyuraEubrachyuraPortunoideaCarcinidaeCarcinus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001973391 – 58MetallothioneinAdd BLAST58

Expressioni

Inductioni

By cadmium.

Structurei

3D structure databases

ProteinModelPortaliP55948
SMRiP55948
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 29BetaAdd BLAST29
Regioni30 – 58AlphaAdd BLAST29

Sequence similaritiesi

Family and domain databases

InterProiView protein in InterPro
IPR002045 Metalthion_crustacean
IPR017854 Metalthion_dom_sf
PRINTSiPR00858 MTCRUSTACEAN
SUPFAMiSSF57868 SSF57868, 2 hits

Sequencei

Sequence statusi: Complete.

P55948-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPDPCCIDKC ECKEGGCKAG CKCTSCRCTP CEKCSSGCKC TTKEDCCKTC

TKPCSCCP
Length:58
Mass (Da):6,133
Last modified:November 1, 1997 - v1
Checksum:i0167CDA2E9C9731D
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti1Missing in variant isolated in low cadmium concentration. 1

Sequence databases

PIRiS43367

Similar proteinsi

Cross-referencesi

Sequence databases

PIRiS43367

3D structure databases

ProteinModelPortaliP55948
SMRiP55948
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiView protein in InterPro
IPR002045 Metalthion_crustacean
IPR017854 Metalthion_dom_sf
PRINTSiPR00858 MTCRUSTACEAN
SUPFAMiSSF57868 SSF57868, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiMT_CARMA
AccessioniPrimary (citable) accession number: P55948
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: June 20, 2018
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Metallothioneins
    Classification of metallothioneins and list of entries
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Main funding by: National Institutes of Health

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