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Protein

Golgin subfamily A member 3

Gene

Golga3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays an important role in spermatogenesis and/or testis development. Probably identical with the serologically detectable male antigen (SDM). Probably involved in maintaining Golgi structure.1 Publication

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Golgin subfamily A member 3
Alternative name(s):
Golgin-160
Male-enhanced antigen 2
Short name:
MEA-2
Gene namesi
Name:Golga3
Synonyms:Mea2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:96958 Golga3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001900581 – 1487Golgin subfamily A member 3Add BLAST1487

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei18PhosphoserineBy similarity1
Modified residuei60PhosphoserineCombined sources1
Modified residuei270PhosphoserineBy similarity1
Modified residuei381PhosphoserineBy similarity1
Modified residuei385PhosphoserineBy similarity1
Modified residuei461PhosphoserineBy similarity1
Modified residuei979PhosphoserineCombined sources1
Modified residuei1387PhosphoserineBy similarity1
Modified residuei1479PhosphoserineCombined sources1

Post-translational modificationi

Cleaved by caspases in apoptotic cells.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP55937
PeptideAtlasiP55937
PRIDEiP55937

PTM databases

iPTMnetiP55937
PhosphoSitePlusiP55937

Expressioni

Tissue specificityi

Highly expressed in testis. Transcripts can be found in spermatids during spermatogenesis. No expression in Leydig cells, spermatogonia or spermatocytes. Detected at low levels in all tissues.

Gene expression databases

CleanExiMM_GOLGA3

Interactioni

Subunit structurei

Homodimer. Interacts with GOLGA7. Interacts with GOPC (By similarity).By similarity

Protein-protein interaction databases

BioGridi234694, 4 interactors
IntActiP55937, 4 interactors
STRINGi10090.ENSMUSP00000108131

Structurei

3D structure databases

ProteinModelPortaliP55937
SMRiP55937
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni121 – 141Interaction with GOPCBy similarityAdd BLAST21
Regioni172 – 257Golgi-targeting domainBy similarityAdd BLAST86

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili358 – 1454Sequence analysisAdd BLAST1097

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi238 – 321Ser-richAdd BLAST84
Compositional biasi363 – 366Poly-Ala4
Compositional biasi534 – 734Gln-richAdd BLAST201
Compositional biasi1228 – 1366Gln-richAdd BLAST139

Domaini

Extended rod-like protein with coiled-coil domains.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IFW4 Eukaryota
ENOG410YGSW LUCA
HOGENOMiHOG000112752
HOVERGENiHBG051753
InParanoidiP55937
PhylomeDBiP55937

Family and domain databases

InterProiView protein in InterPro
IPR033288 Golga3
PANTHERiPTHR18902:SF26 PTHR18902:SF26, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 2 (identifier: P55937-2) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDGASAKQDG LWESKSSSDV SSCPEASLET VGSLARLPDQ QDTAQDASVE
60 70 80 90 100
VNRGFKEEGS PDRSSQVAIC QNGQIPDLQL SLDPTTSPVG PDASTGVDGF
110 120 130 140 150
HDNLRNSQGT SAEGSVRKEA LQSLRLSLPM QETQLCSTAS SLPLEKEEQV
160 170 180 190 200
RLQARKRLEE QLMQYRVKRH RERSSQPATK MKLFSTLDPE LMLNPENLPR
210 220 230 240 250
ASTVAVTKEY SFLRTSVPRG PKVGSLGLLA HSKEKKNSKS SKIRSLADYR
260 270 280 290 300
TEDPSDSGGL GSTADAVGSS LKQSRSSTSV VSEVSPSSET DNRVESASMT
310 320 330 340 350
GDSVSEADGN ESDSSSHSSL SARGACGVLG NVGMPGTAYM VDGQEISAEA
360 370 380 390 400
LGQFPSIKDV LQAAAAQHQD QNQEANGEVR SRRDSICSSV SMESSLAEPQ
410 420 430 440 450
DELLQILKDK RRLEGQVEAL SLEASQALQE KAELQAQLAA LSTRLQAQVE
460 470 480 490 500
HSHSSQQKQD SLSSEVDTLK QSCWDLGRAM TDLQSMLEAK NASLASSNND
510 520 530 540 550
LQVAEEQYQR LMAKVEDMQR NILSKDNTVH DLRQQMTALQ SQLQQVQLER
560 570 580 590 600
TTLTSKLQAS QAEITSLQHA RQWYQQQLTL AQEARVRLQG EMAHIQVGQM
610 620 630 640 650
TQAGLLEHLK LENVSLSHQL TETQHRSIKE KERIAVQLQS IEADMLDQEA
660 670 680 690 700
AFVQIREAKT MVEEDLQRRL EEFEGEREQL QKVADAAASL EQQLEQVKLT
710 720 730 740 750
LFQRDQQLAA LQQEHLDVIK QLTSTQEALQ AKGQSLDDLH TRYDELQARL
760 770 780 790 800
EELQREADSR EDAIHFLQNE KIVLEVALQS AKSDKEELDR GARRLEEDTE
810 820 830 840 850
ETSGLLEQLR QDLAVKSNQV EHLQQETATL RKQMQKVKEQ FVQQKVMVEA
860 870 880 890 900
YRRDATSKDQ LINELKATKK RLDSEMKELR QELIKLQGEK KTVEVEHSRL
910 920 930 940 950
QKDMSLVHQQ MAELEGHLQS VQKERDEMEI HLQSLKFDKE QMIALTEANE
960 970 980 990 1000
TLKKQIEELQ QEAKKAITEQ KQKMKRLGSD LTSAQKEMKT KHKAYENAVS
1010 1020 1030 1040 1050
ILSRRLQEAL ASKEATDAEL NQLRAQSTGG SSDPVLHEKI RALEVELQNV
1060 1070 1080 1090 1100
GQSKILLEKE LQEVITMTSQ ELEESREKVL ELEDELQESR GFRRKIKRLE
1110 1120 1130 1140 1150
ESNKKLALEL EHERGKLTGL GQSNAALREH NSILETALAK READLVQLNL
1160 1170 1180 1190 1200
QVQAVLQRKE EEDRQMKQLV QALQVSLEKE KMEVNSLKEQ MAAARIEAGH
1210 1220 1230 1240 1250
NRRHFKAATL ELSEVKKELQ AKEHLVQTLQ AEVDELQIQD GKHSQEIAQF
1260 1270 1280 1290 1300
QTELAEARTQ LQLLQKKLDE QMSQQPTGSQ EMEDLKWELD QKEREIQSLK
1310 1320 1330 1340 1350
QQLDLTEQQG KKELEGTQQT LQTIKSELEM VQEDLSETQK DKFMLQAKVS
1360 1370 1380 1390 1400
ELKNNMKTLL QQNQQLKLDL RRGAAKKKEP KGESNSSSPA TPIKIPDCPV
1410 1420 1430 1440 1450
PASLLEELLR PPPAVSKEPL KNLNNCLQQL KQEMDSLQRQ MEEHTITVHE
1460 1470 1480
SLSSWAQVEA APAEHAHPRG DTKLHNQNSV PRDGLGQ
Note: No experimental confirmation available.
Length:1,487
Mass (Da):167,220
Last modified:November 8, 2005 - v3
Checksum:i831303DC90754F0B
GO
Isoform 1 (identifier: P55937-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     97-136: Missing.

Show »
Length:1,447
Mass (Da):162,821
Checksum:i8BB68F2D142F8A9B
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9QP99E9QP99_MOUSE
Golgin subfamily A member 3
Golga3
1,487Annotation score:
A0A0R4J1H6A0A0R4J1H6_MOUSE
Golgin subfamily A member 3
Golga3
1,447Annotation score:
D3Z0Q8D3Z0Q8_MOUSE
Golgin subfamily A member 3
Golga3
121Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti30T → I in AAH53002 (PubMed:15489334).Curated1
Sequence conflicti477G → E in AAH53002 (PubMed:15489334).Curated1
Sequence conflicti592M → T in BAA86889 (PubMed:11835574).Curated1
Sequence conflicti592M → T in BAA86890 (PubMed:11835574).Curated1
Sequence conflicti843Q → L in BAA86889 (PubMed:11835574).Curated1
Sequence conflicti843Q → L in BAA86890 (PubMed:11835574).Curated1
Sequence conflicti982T → S in AAH53002 (PubMed:15489334).Curated1
Sequence conflicti1015A → S in AAH43452 (PubMed:15489334).Curated1
Sequence conflicti1466A → P in BAC27949 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01607197 – 136Missing in isoform 1. 2 PublicationsAdd BLAST40

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D78270 mRNA Translation: BAA19612.2
AB029537 Genomic DNA Translation: BAA86889.2
AB029537 Genomic DNA Translation: BAA86890.2
BC043452 mRNA Translation: AAH43452.1
BC053002 mRNA Translation: AAH53002.1
AK032610 mRNA Translation: BAC27949.1
CCDSiCCDS39209.1 [P55937-1]
CCDS84928.1 [P55937-2]
PIRiT42722
RefSeqiNP_032172.3, NM_008146.3
UniGeneiMm.393008
Mm.9392

Genome annotation databases

GeneIDi269682
KEGGimmu:269682

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D78270 mRNA Translation: BAA19612.2
AB029537 Genomic DNA Translation: BAA86889.2
AB029537 Genomic DNA Translation: BAA86890.2
BC043452 mRNA Translation: AAH43452.1
BC053002 mRNA Translation: AAH53002.1
AK032610 mRNA Translation: BAC27949.1
CCDSiCCDS39209.1 [P55937-1]
CCDS84928.1 [P55937-2]
PIRiT42722
RefSeqiNP_032172.3, NM_008146.3
UniGeneiMm.393008
Mm.9392

3D structure databases

ProteinModelPortaliP55937
SMRiP55937
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi234694, 4 interactors
IntActiP55937, 4 interactors
STRINGi10090.ENSMUSP00000108131

PTM databases

iPTMnetiP55937
PhosphoSitePlusiP55937

Proteomic databases

PaxDbiP55937
PeptideAtlasiP55937
PRIDEiP55937

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi269682
KEGGimmu:269682

Organism-specific databases

CTDi2802
MGIiMGI:96958 Golga3

Phylogenomic databases

eggNOGiENOG410IFW4 Eukaryota
ENOG410YGSW LUCA
HOGENOMiHOG000112752
HOVERGENiHBG051753
InParanoidiP55937
PhylomeDBiP55937

Miscellaneous databases

PROiPR:P55937
SOURCEiSearch...

Gene expression databases

CleanExiMM_GOLGA3

Family and domain databases

InterProiView protein in InterPro
IPR033288 Golga3
PANTHERiPTHR18902:SF26 PTHR18902:SF26, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGOGA3_MOUSE
AccessioniPrimary (citable) accession number: P55937
Secondary accession number(s): Q80VF5
, Q8CCK4, Q9QYT2, Q9QYT3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 8, 2005
Last modified: September 12, 2018
This is version 136 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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