UniProtKB - P55935 (RS9_DROME)
Protein
40S ribosomal protein S9
Gene
RpS9
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
GO - Molecular functioni
- rRNA binding Source: GO_Central
- structural constituent of ribosome Source: FlyBase
GO - Biological processi
- cytoplasmic translation Source: FlyBase
- positive regulation of translational fidelity Source: GO_Central
Keywordsi
Molecular function | Ribonucleoprotein, Ribosomal protein, RNA-binding, rRNA-binding |
Enzyme and pathway databases
Reactomei | R-DME-156827, L13a-mediated translational silencing of Ceruloplasmin expression R-DME-1799339, SRP-dependent cotranslational protein targeting to membrane R-DME-6791226, Major pathway of rRNA processing in the nucleolus and cytosol R-DME-72649, Translation initiation complex formation R-DME-72689, Formation of a pool of free 40S subunits R-DME-72695, Formation of the ternary complex, and subsequently, the 43S complex R-DME-72702, Ribosomal scanning and start codon recognition R-DME-72706, GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-975956, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-DME-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
Names & Taxonomyi
Protein namesi | Recommended name: 40S ribosomal protein S9 |
Gene namesi | Name:RpS9Imported ORF Names:CG3395Imported |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0010408, RpS9 |
Subcellular locationi
Cytosol
- cytosol Source: FlyBase
- cytosolic ribosome Source: FlyBase
- cytosolic small ribosomal subunit Source: GO_Central
Nucleus
- nucleolus Source: FlyBase
Other locations
- cytoplasm Source: FlyBase
- small ribosomal subunit Source: GO_Central
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000132695 | 1 – 195 | 40S ribosomal protein S9Add BLAST | 195 |
Proteomic databases
PaxDbi | P55935 |
PRIDEi | P55935 |
Expressioni
Developmental stagei
Expressed both maternally and zygotically throughout development.1 Publication
Gene expression databases
Bgeei | FBgn0010408, Expressed in embryo and 20 other tissues |
ExpressionAtlasi | P55935, baseline and differential |
Genevisiblei | P55935, DM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 64500, 111 interactors |
IntActi | P55935, 4 interactors |
MINTi | P55935 |
STRINGi | 7227.FBpp0076152 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 109 – 183 | S4 RNA-bindingPROSITE-ProRule annotationAdd BLAST | 75 |
Sequence similaritiesi
Belongs to the universal ribosomal protein uS4 family.Curated
Phylogenomic databases
eggNOGi | KOG3301, Eukaryota |
GeneTreei | ENSGT00550000074829 |
HOGENOMi | CLU_089738_0_0_1 |
InParanoidi | P55935 |
OMAi | THGHIAI |
PhylomeDBi | P55935 |
Family and domain databases
CDDi | cd00165, S4, 1 hit |
Gene3Di | 3.10.290.10, 1 hit |
InterProi | View protein in InterPro IPR022801, Ribosomal_S4/S9 IPR005710, Ribosomal_S4/S9_euk/arc IPR001912, Ribosomal_S4/S9_N IPR018079, Ribosomal_S4_CS IPR002942, S4_RNA-bd IPR036986, S4_RNA-bd_sf |
PANTHERi | PTHR11831, PTHR11831, 1 hit |
Pfami | View protein in Pfam PF00163, Ribosomal_S4, 1 hit PF01479, S4, 1 hit |
SMARTi | View protein in SMART SM01390, Ribosomal_S4, 1 hit SM00363, S4, 1 hit |
TIGRFAMsi | TIGR01018, uS4_arch, 1 hit |
PROSITEi | View protein in PROSITE PS00632, RIBOSOMAL_S4, 1 hit PS50889, S4, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
P55935-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVNGRIPSVF SKTYVTPRRP YEKARLDQEL KIIGEYGLRN KREVWRVKYA
60 70 80 90 100
LAKIRKAARE LLTLDEKDEK RLFQGNALLR RLVRIGVLDE SRMKLDYVLG
110 120 130 140 150
LKIEDFLERR LQTQVFKLGL AKSIHHARVL IRQRHIRVRK QVVNIPSFVV
160 170 180 190
RLDSQKHIDF SLKSPFGGGR PGRVKRKNLK KNQGGGGGAA EEEED
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC6SUW3 | C6SUW3_DROME | 40S ribosomal protein S9 | RpS9 chr3L:9483841..9483937, chr3L:9484246..9484474, Dmel\CG3395, Rp S9, RpL11 | 195 | Annotation score: | ||
Q95RG1 | Q95RG1_DROME | 40S ribosomal protein S9 | RpS9 chr3L:9483841..9483937, chr3L:9484246..9484474, Dmel\CG3395, Rp S9, RpL11 | 137 | Annotation score: |
Sequence cautioni
The sequence CAB41492 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 57 | A → V in CAB41492 (PubMed:8400363).Curated | 1 | |
Sequence conflicti | 69 | E → A in CAB41492 (PubMed:8400363).Curated | 1 | |
Sequence conflicti | 76 – 79 | NALL → KSLV in CAB41492 (PubMed:8400363).Curated | 4 | |
Sequence conflicti | 104 | E → Q in CAB41492 (PubMed:8400363).Curated | 1 | |
Sequence conflicti | 138 | V → A in CAB41492 (PubMed:8400363).Curated | 1 | |
Sequence conflicti | 164 | S → M in CAB41492 (PubMed:8400363).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X69677 mRNA Translation: CAB41492.1 Frameshift. AE014296 Genomic DNA Translation: AAF50249.1 AE014296 Genomic DNA Translation: AAN11946.1 |
RefSeqi | NP_001287008.1, NM_001300079.1 NP_524004.2, NM_079280.4 NP_729506.1, NM_168350.2 |
Genome annotation databases
EnsemblMetazoai | FBtr0076423; FBpp0076152; FBgn0010408 FBtr0076425; FBpp0076154; FBgn0010408 FBtr0342577; FBpp0309532; FBgn0010408 |
GeneIDi | 39108 |
KEGGi | dme:Dmel_CG3395 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X69677 mRNA Translation: CAB41492.1 Frameshift. AE014296 Genomic DNA Translation: AAF50249.1 AE014296 Genomic DNA Translation: AAN11946.1 |
RefSeqi | NP_001287008.1, NM_001300079.1 NP_524004.2, NM_079280.4 NP_729506.1, NM_168350.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4V6W | electron microscopy | 6.00 | AJ | 1-195 | [»] | |
SMRi | P55935 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 64500, 111 interactors |
IntActi | P55935, 4 interactors |
MINTi | P55935 |
STRINGi | 7227.FBpp0076152 |
Proteomic databases
PaxDbi | P55935 |
PRIDEi | P55935 |
Genome annotation databases
EnsemblMetazoai | FBtr0076423; FBpp0076152; FBgn0010408 FBtr0076425; FBpp0076154; FBgn0010408 FBtr0342577; FBpp0309532; FBgn0010408 |
GeneIDi | 39108 |
KEGGi | dme:Dmel_CG3395 |
Organism-specific databases
CTDi | 6203 |
FlyBasei | FBgn0010408, RpS9 |
Phylogenomic databases
eggNOGi | KOG3301, Eukaryota |
GeneTreei | ENSGT00550000074829 |
HOGENOMi | CLU_089738_0_0_1 |
InParanoidi | P55935 |
OMAi | THGHIAI |
PhylomeDBi | P55935 |
Enzyme and pathway databases
Reactomei | R-DME-156827, L13a-mediated translational silencing of Ceruloplasmin expression R-DME-1799339, SRP-dependent cotranslational protein targeting to membrane R-DME-6791226, Major pathway of rRNA processing in the nucleolus and cytosol R-DME-72649, Translation initiation complex formation R-DME-72689, Formation of a pool of free 40S subunits R-DME-72695, Formation of the ternary complex, and subsequently, the 43S complex R-DME-72702, Ribosomal scanning and start codon recognition R-DME-72706, GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-975956, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-DME-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
Miscellaneous databases
BioGRID-ORCSi | 39108, 1 hit in 1 CRISPR screen |
ChiTaRSi | RpS9, fly |
GenomeRNAii | 39108 |
PROi | PR:P55935 |
Gene expression databases
Bgeei | FBgn0010408, Expressed in embryo and 20 other tissues |
ExpressionAtlasi | P55935, baseline and differential |
Genevisiblei | P55935, DM |
Family and domain databases
CDDi | cd00165, S4, 1 hit |
Gene3Di | 3.10.290.10, 1 hit |
InterProi | View protein in InterPro IPR022801, Ribosomal_S4/S9 IPR005710, Ribosomal_S4/S9_euk/arc IPR001912, Ribosomal_S4/S9_N IPR018079, Ribosomal_S4_CS IPR002942, S4_RNA-bd IPR036986, S4_RNA-bd_sf |
PANTHERi | PTHR11831, PTHR11831, 1 hit |
Pfami | View protein in Pfam PF00163, Ribosomal_S4, 1 hit PF01479, S4, 1 hit |
SMARTi | View protein in SMART SM01390, Ribosomal_S4, 1 hit SM00363, S4, 1 hit |
TIGRFAMsi | TIGR01018, uS4_arch, 1 hit |
PROSITEi | View protein in PROSITE PS00632, RIBOSOMAL_S4, 1 hit PS50889, S4, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RS9_DROME | |
Accessioni | P55935Primary (citable) accession number: P55935 Secondary accession number(s): A4V1R4 Q9XZU5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | March 1, 2005 | |
Last modified: | December 2, 2020 | |
This is version 145 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Ribosomal proteins
Ribosomal proteins families and list of entries