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Protein

Mitochondrial uncoupling protein 3

Gene

UCP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation. As a result, energy is dissipated in the form of heat. May play a role in the modulation of tissue respiratory control. Participates in thermogenesis and energy balance.

GO - Molecular functioni

  • oxidative phosphorylation uncoupler activity Source: GO_Central
  • transporter activity Source: ProtInc

GO - Biological processi

Keywordsi

Biological processTransport

Enzyme and pathway databases

ReactomeiR-HSA-167826 The fatty acid cycling model
R-HSA-167827 The proton buffering model
SIGNORiP55916

Protein family/group databases

TCDBi2.A.29.3.5 the mitochondrial carrier (mc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial uncoupling protein 3
Short name:
UCP 3
Alternative name(s):
Solute carrier family 25 member 9
Gene namesi
Name:UCP3
Synonyms:SLC25A9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000175564.12
HGNCiHGNC:12519 UCP3
MIMi602044 gene
neXtProtiNX_P55916

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei11 – 32Helical; Name=1Sequence analysisAdd BLAST22
Transmembranei77 – 99Helical; Name=2Sequence analysisAdd BLAST23
Transmembranei120 – 136Helical; Name=3Sequence analysisAdd BLAST17
Transmembranei184 – 200Helical; Name=4Sequence analysisAdd BLAST17
Transmembranei218 – 237Helical; Name=5Sequence analysisAdd BLAST20
Transmembranei272 – 294Helical; Name=6Sequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Involvement in diseasei

Obesity (OBESITY)2 Publications
The gene represented in this entry may be involved in disease pathogenesis.
Disease descriptionA condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.
See also OMIM:601665

Keywords - Diseasei

Diabetes mellitus, Disease mutation, Obesity

Organism-specific databases

DisGeNETi7352
MalaCardsiUCP3
MIMi601665 phenotype
OpenTargetsiENSG00000175564
PharmGKBiPA37166

Polymorphism and mutation databases

BioMutaiUCP3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000906721 – 312Mitochondrial uncoupling protein 3Add BLAST312

Proteomic databases

EPDiP55916
PaxDbiP55916
PRIDEiP55916
ProteomicsDBi56879
56880 [P55916-2]
56881 [P55916-3]

PTM databases

iPTMnetiP55916
PhosphoSitePlusiP55916

Expressioni

Tissue specificityi

Only in skeletal muscle and heart. Is more expressed in glycolytic than in oxidative skeletal muscles.1 Publication

Gene expression databases

BgeeiENSG00000175564
CleanExiHS_UCP3
ExpressionAtlasiP55916 baseline and differential
GenevisibleiP55916 HS

Organism-specific databases

HPAiCAB010771
HPA072225

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
NSP034952EBI-9116865,EBI-2548993From Influenza A virus (strain A/Udorn/307/1972 H3N2).

Protein-protein interaction databases

BioGridi113199, 3 interactors
IntActiP55916, 1 interactor
MINTiP55916
STRINGi9606.ENSP00000323740

Structurei

3D structure databases

ProteinModelPortaliP55916
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati11 – 105Solcar 1Add BLAST95
Repeati114 – 206Solcar 2Add BLAST93
Repeati215 – 300Solcar 3Add BLAST86

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni279 – 301Purine nucleotide bindingBy similarityAdd BLAST23

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0753 Eukaryota
ENOG410XRV1 LUCA
GeneTreeiENSGT00760000119170
HOGENOMiHOG000165140
HOVERGENiHBG009528
InParanoidiP55916
KOiK15103
OMAiLRQWEGQ
OrthoDBiEOG091G0BQ7
PhylomeDBiP55916
TreeFamiTF323211

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR002030 Mit_uncoupling_UCP-like
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
PRINTSiPR00784 MTUNCOUPLING
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform UCP3L (identifier: P55916-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVGLKPSDVP PTMAVKFLGA GTAACFADLV TFPLDTAKVR LQIQGENQAV
60 70 80 90 100
QTARLVQYRG VLGTILTMVR TEGPCSPYNG LVAGLQRQMS FASIRIGLYD
110 120 130 140 150
SVKQVYTPKG ADNSSLTTRI LAGCTTGAMA VTCAQPTDVV KVRFQASIHL
160 170 180 190 200
GPSRSDRKYS GTMDAYRTIA REEGVRGLWK GTLPNIMRNA IVNCAEVVTY
210 220 230 240 250
DILKEKLLDY HLLTDNFPCH FVSAFGAGFC ATVVASPVDV VKTRYMNSPP
260 270 280 290 300
GQYFSPLDCM IKMVAQEGPT AFYKGFTPSF LRLGSWNVVM FVTYEQLKRA
310
LMKVQMLRES PF
Length:312
Mass (Da):34,216
Last modified:November 1, 1997 - v1
Checksum:iD0E04A8DB352B17C
GO
Isoform UCP3S (identifier: P55916-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     276-312: Missing.

Show »
Length:275
Mass (Da):29,783
Checksum:i4E0FDF29E06A8AD9
GO
Isoform 3 (identifier: P55916-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     114-216: Missing.

Show »
Length:209
Mass (Da):22,874
Checksum:i4DC46DECA9A50E17
GO

Sequence cautioni

The sequence AAC51785 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti193 – 194NC → KS in AAC18822 (PubMed:9498661).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0501369V → M. Corresponds to variant dbSNP:rs8179180Ensembl.1
Natural variantiVAR_00440770R → W in severe obesity with type 2 diabetes. 1 PublicationCorresponds to variant dbSNP:rs17848368EnsemblClinVar.1
Natural variantiVAR_004408102V → I in obesity. 1 PublicationCorresponds to variant dbSNP:rs2229707EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_003270114 – 216Missing in isoform 3. 1 PublicationAdd BLAST103
Alternative sequenceiVSP_003271276 – 312Missing in isoform UCP3S. CuratedAdd BLAST37

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U84763 mRNA Translation: AAC51367.1
U82818 mRNA Translation: AAC51356.1
AF001787 mRNA Translation: AAC51369.1
AF011449 mRNA Translation: AAC51767.1
AF012202
, AF012197, AF012198, AF012199, AF012200, AF012201 Genomic DNA Translation: AAC51785.1 Different initiation.
AF026958, AF026956, AF026957 Genomic DNA Translation: AAC18822.1
AF050113 Genomic DNA Translation: AAG02284.1
BC008392 mRNA Translation: AAH08392.1
CCDSiCCDS44677.1 [P55916-2]
CCDS8229.1 [P55916-1]
PIRiJC5522
RefSeqiNP_003347.1, NM_003356.3 [P55916-1]
NP_073714.1, NM_022803.2 [P55916-2]
UniGeneiHs.101337
Hs.621879

Genome annotation databases

EnsembliENST00000314032; ENSP00000323740; ENSG00000175564 [P55916-1]
ENST00000426995; ENSP00000392143; ENSG00000175564 [P55916-2]
GeneIDi7352
KEGGihsa:7352
UCSCiuc001our.4 human [P55916-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiUCP3_HUMAN
AccessioniPrimary (citable) accession number: P55916
Secondary accession number(s): O60475, Q96HL3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: June 20, 2018
This is version 158 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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