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Protein

Small ubiquitin-related modifier 1

Gene

SUMO1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Required for the massive protein sumoylation in the nucleus induced by heat shock and controlled by SIZ1. Involved in the regulation of the heat stress transcription factor HSFA2 in acquired thermotolerance.3 Publications

Miscellaneous

Stress conditions rapidly and substantially elevates the amount of SUMO1 and SUMO2 conjugates with a concomitant reduction in the amount of free SUMO proteins. The SUMO conjugation system plays an important function in stress protection and/or repair.

GO - Molecular functioni

  • protein tag Source: TAIR

GO - Biological processi

  • heat acclimation Source: UniProtKB
  • negative regulation of DNA-binding transcription factor activity Source: UniProtKB
  • protein sumoylation Source: TAIR
  • response to heat Source: TAIR

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-ATH-3065676 SUMO is conjugated to E1 (UBA2:SAE1)
R-ATH-3065678 SUMO is transferred from E1 to E2 (UBE2I, UBC9)
R-ATH-3065679 SUMO is proteolytically processed
R-ATH-3108214 SUMOylation of DNA damage response and repair proteins
R-ATH-3899300 SUMOylation of transcription cofactors
R-ATH-4085377 SUMOylation of SUMOylation proteins
R-ATH-4551638 SUMOylation of chromatin organization proteins
R-ATH-4570464 SUMOylation of RNA binding proteins
R-ATH-4615885 SUMOylation of DNA replication proteins
R-ATH-4655427 SUMOylation of DNA methylation proteins
R-ATH-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-ATH-5696395 Formation of Incision Complex in GG-NER

Names & Taxonomyi

Protein namesi
Recommended name:
Small ubiquitin-related modifier 1
Short name:
AtSUMO1
Alternative name(s):
Ubiquitin-like protein SMT3
Gene namesi
Name:SUMO1
Synonyms:SMT3, SUM1
Ordered Locus Names:At4g26840
ORF Names:F10M23.180
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

AraportiAT4G26840
TAIRilocus:2116332 AT4G26840

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

No visible phenotype.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001148911 – 100Small ubiquitin-related modifier 1Add BLAST100

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki93Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)

Keywords - PTMi

Isopeptide bond

Proteomic databases

PaxDbiP55852
PRIDEiP55852

Expressioni

Gene expression databases

ExpressionAtlasiP55852 baseline and differential
GenevisibleiP55852 AT

Interactioni

Subunit structurei

Interacts with SAE2, SCE1, SIZ1 and MMS21 (By similarity). Interacts with HSFA2. Covalently attached to ABI5, FLD, GTE3, HSFA2 and ICE1.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ABI5Q9SJN02EBI-15763381,EBI-1778690

Protein-protein interaction databases

BioGridi14078, 142 interactors
DIPiDIP-48780N
IntActiP55852, 1 interactor
STRINGi3702.AT4G26840.1

Structurei

3D structure databases

ProteinModelPortaliP55852
SMRiP55852
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 93Ubiquitin-likePROSITE-ProRule annotationAdd BLAST78

Sequence similaritiesi

Belongs to the ubiquitin family. SUMO subfamily.Curated

Phylogenomic databases

eggNOGiKOG1769 Eukaryota
COG5227 LUCA
HOGENOMiHOG000207495
InParanoidiP55852
KOiK12160
OMAiMSANQEE
OrthoDBiEOG09360VZQ
PhylomeDBiP55852

Family and domain databases

CDDicd01763 Sumo, 1 hit
InterProiView protein in InterPro
IPR022617 Rad60/SUMO-like_dom
IPR033950 Sumo
IPR029071 Ubiquitin-like_domsf
IPR000626 Ubiquitin_dom
PfamiView protein in Pfam
PF11976 Rad60-SLD, 1 hit
SMARTiView protein in SMART
SM00213 UBQ, 1 hit
SUPFAMiSSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50053 UBIQUITIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

P55852-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSANQEEDKK PGDGGAHINL KVKGQDGNEV FFRIKRSTQL KKLMNAYCDR
60 70 80 90 100
QSVDMNSIAF LFDGRRLRAE QTPDELDMED GDEIDAMLHQ TGGSGGGATA
Length:100
Mass (Da):10,976
Last modified:June 20, 2002 - v2
Checksum:i6F1E8721E7734A4A
GO

Sequence cautioni

The sequence CAA67923 differs from that shown. Sequencing errors.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99609 mRNA Translation: CAA67923.1 Sequence problems.
AF510519 mRNA Translation: AAN03845.1
AL035440 Genomic DNA Translation: CAB36530.1
AL161565 Genomic DNA Translation: CAB79539.1
CP002687 Genomic DNA Translation: AEE85259.1
AY072368 mRNA Translation: AAL62360.1
BT008437 mRNA Translation: AAP37796.1
AY086914 mRNA Translation: AAM64478.1
PIRiT04807
RefSeqiNP_194414.1, NM_118818.4
UniGeneiAt.185

Genome annotation databases

EnsemblPlantsiAT4G26840.1; AT4G26840.1; AT4G26840
GeneIDi828791
GrameneiAT4G26840.1; AT4G26840.1; AT4G26840
KEGGiath:AT4G26840

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99609 mRNA Translation: CAA67923.1 Sequence problems.
AF510519 mRNA Translation: AAN03845.1
AL035440 Genomic DNA Translation: CAB36530.1
AL161565 Genomic DNA Translation: CAB79539.1
CP002687 Genomic DNA Translation: AEE85259.1
AY072368 mRNA Translation: AAL62360.1
BT008437 mRNA Translation: AAP37796.1
AY086914 mRNA Translation: AAM64478.1
PIRiT04807
RefSeqiNP_194414.1, NM_118818.4
UniGeneiAt.185

3D structure databases

ProteinModelPortaliP55852
SMRiP55852
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi14078, 142 interactors
DIPiDIP-48780N
IntActiP55852, 1 interactor
STRINGi3702.AT4G26840.1

Proteomic databases

PaxDbiP55852
PRIDEiP55852

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT4G26840.1; AT4G26840.1; AT4G26840
GeneIDi828791
GrameneiAT4G26840.1; AT4G26840.1; AT4G26840
KEGGiath:AT4G26840

Organism-specific databases

AraportiAT4G26840
TAIRilocus:2116332 AT4G26840

Phylogenomic databases

eggNOGiKOG1769 Eukaryota
COG5227 LUCA
HOGENOMiHOG000207495
InParanoidiP55852
KOiK12160
OMAiMSANQEE
OrthoDBiEOG09360VZQ
PhylomeDBiP55852

Enzyme and pathway databases

ReactomeiR-ATH-3065676 SUMO is conjugated to E1 (UBA2:SAE1)
R-ATH-3065678 SUMO is transferred from E1 to E2 (UBE2I, UBC9)
R-ATH-3065679 SUMO is proteolytically processed
R-ATH-3108214 SUMOylation of DNA damage response and repair proteins
R-ATH-3899300 SUMOylation of transcription cofactors
R-ATH-4085377 SUMOylation of SUMOylation proteins
R-ATH-4551638 SUMOylation of chromatin organization proteins
R-ATH-4570464 SUMOylation of RNA binding proteins
R-ATH-4615885 SUMOylation of DNA replication proteins
R-ATH-4655427 SUMOylation of DNA methylation proteins
R-ATH-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-ATH-5696395 Formation of Incision Complex in GG-NER

Miscellaneous databases

PROiPR:P55852

Gene expression databases

ExpressionAtlasiP55852 baseline and differential
GenevisibleiP55852 AT

Family and domain databases

CDDicd01763 Sumo, 1 hit
InterProiView protein in InterPro
IPR022617 Rad60/SUMO-like_dom
IPR033950 Sumo
IPR029071 Ubiquitin-like_domsf
IPR000626 Ubiquitin_dom
PfamiView protein in Pfam
PF11976 Rad60-SLD, 1 hit
SMARTiView protein in SMART
SM00213 UBQ, 1 hit
SUPFAMiSSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50053 UBIQUITIN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSUMO1_ARATH
AccessioniPrimary (citable) accession number: P55852
Secondary accession number(s): Q547B9, Q9SZ24
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: June 20, 2002
Last modified: November 7, 2018
This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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Main funding by: National Institutes of Health

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