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Protein

Mitochondrial uncoupling protein 2

Gene

UCP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Enzyme and pathway databases

ReactomeiR-HSA-167826 The fatty acid cycling model
R-HSA-167827 The proton buffering model

Protein family/group databases

TCDBi2.A.29.3.4 the mitochondrial carrier (mc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial uncoupling protein 2
Short name:
UCP 2
Alternative name(s):
Solute carrier family 25 member 8
UCPH
Gene namesi
Name:UCP2
Synonyms:SLC25A8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000175567.8
HGNCiHGNC:12518 UCP2
MIMi601693 gene
neXtProtiNX_P55851

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 10Mitochondrial matrixSequence analysis10
Transmembranei11 – 32Helical; Name=1Sequence analysisAdd BLAST22
Topological domaini33 – 77Mitochondrial intermembraneSequence analysisAdd BLAST45
Transmembranei78 – 100Helical; Name=2Sequence analysisAdd BLAST23
Topological domaini101 – 119Mitochondrial matrixSequence analysisAdd BLAST19
Transmembranei120 – 136Helical; Name=3Sequence analysisAdd BLAST17
Topological domaini137 – 180Mitochondrial intermembraneSequence analysisAdd BLAST44
Transmembranei181 – 197Helical; Name=4Sequence analysisAdd BLAST17
Topological domaini198 – 214Mitochondrial matrixSequence analysisAdd BLAST17
Transmembranei215 – 234Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini235 – 268Mitochondrial intermembraneSequence analysisAdd BLAST34
Transmembranei269 – 291Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini292 – 309Mitochondrial matrixSequence analysisAdd BLAST18

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi7351
GeneReviewsiUCP2
MalaCardsiUCP2
MIMi607447 phenotype
OpenTargetsiENSG00000175567
Orphaneti276556 Hyperinsulinism due to UCP2 deficiency
PharmGKBiPA37165

Polymorphism and mutation databases

BioMutaiUCP2
DMDMi2497981

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000906641 – 309Mitochondrial uncoupling protein 2Add BLAST309

Proteomic databases

PaxDbiP55851
PeptideAtlasiP55851
PRIDEiP55851
ProteomicsDBi56873

PTM databases

iPTMnetiP55851
PhosphoSitePlusiP55851

Expressioni

Tissue specificityi

Widely expressed in adult human tissues, including tissues rich in macrophages. Most expressed in white adipose tissue and skeletal muscle.

Gene expression databases

BgeeiENSG00000175567 Expressed in 230 organ(s), highest expression level in oviduct epithelium
CleanExiHS_UCP2
ExpressionAtlasiP55851 baseline and differential
GenevisibleiP55851 HS

Organism-specific databases

HPAiCAB025583
HPA075202

Interactioni

Subunit structurei

Acts as a dimer forming a proton channel.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
KRTAP10-7P604093EBI-2842077,EBI-10172290

Protein-protein interaction databases

BioGridi113198, 21 interactors
IntActiP55851, 2 interactors
STRINGi9606.ENSP00000312029

Structurei

3D structure databases

ProteinModelPortaliP55851
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati11 – 106Solcar 1Add BLAST96
Repeati114 – 203Solcar 2Add BLAST90
Repeati212 – 297Solcar 3Add BLAST86

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni276 – 298Purine nucleotide bindingBy similarityAdd BLAST23

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0753 Eukaryota
ENOG410XRV1 LUCA
GeneTreeiENSGT00760000119170
HOGENOMiHOG000165140
HOVERGENiHBG009528
InParanoidiP55851
KOiK15103
OMAiSEHAGIG
OrthoDBiEOG091G0BQ7
PhylomeDBiP55851
TreeFamiTF323211

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR002030 Mit_uncoupling_UCP-like
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
PRINTSiPR00784 MTUNCOUPLING
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

P55851-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVGFKATDVP PTATVKFLGA GTAACIADLI TFPLDTAKVR LQIQGESQGP
60 70 80 90 100
VRATASAQYR GVMGTILTMV RTEGPRSLYN GLVAGLQRQM SFASVRIGLY
110 120 130 140 150
DSVKQFYTKG SEHASIGSRL LAGSTTGALA VAVAQPTDVV KVRFQAQARA
160 170 180 190 200
GGGRRYQSTV NAYKTIAREE GFRGLWKGTS PNVARNAIVN CAELVTYDLI
210 220 230 240 250
KDALLKANLM TDDLPCHFTS AFGAGFCTTV IASPVDVVKT RYMNSALGQY
260 270 280 290 300
SSAGHCALTM LQKEGPRAFY KGFMPSFLRL GSWNVVMFVT YEQLKRALMA

ACTSREAPF
Length:309
Mass (Da):33,229
Last modified:November 1, 1997 - v1
Checksum:i2E1741391621E3D9
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YFR8H0YFR8_HUMAN
Mitochondrial uncoupling protein 2
UCP2
282Annotation score:
F5GX45F5GX45_HUMAN
Mitochondrial uncoupling protein 2
UCP2
225Annotation score:
H0YFQ0H0YFQ0_HUMAN
Mitochondrial uncoupling protein 2
UCP2
129Annotation score:
F5H312F5H312_HUMAN
Mitochondrial uncoupling protein 2
UCP2
32Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti219T → I in AAB48411 (PubMed:9054939).Curated1

Polymorphismi

Genetic variations in UCP2 define the body mass index quantitative trait locus 4 (BMIQ4) [MIMi:607447]. A common polymorphism in the promoter of UCP2 has been shown to be associated with a decreased risk of obesity in middle-aged individuals.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01612955A → V4 PublicationsCorresponds to variant dbSNP:rs660339EnsemblClinVar.1
Natural variantiVAR_02399876R → Q1 PublicationCorresponds to variant dbSNP:rs45541732EnsemblClinVar.1
Natural variantiVAR_023999154R → Q1 PublicationCorresponds to variant dbSNP:rs45486692Ensembl.1
Natural variantiVAR_024000268A → G1 PublicationCorresponds to variant dbSNP:rs45490393EnsemblClinVar.1
Natural variantiVAR_024001282S → C1 PublicationCorresponds to variant dbSNP:rs45596837Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82819 mRNA Translation: AAC51336.1
U76367 mRNA Translation: AAB48411.1
U94592 mRNA Translation: AAB53091.1
AJ223477, AJ223478, AJ223479 Genomic DNA Translation: CAA11402.1
AF019409 Genomic DNA Translation: AAC39690.1
AF096289 Genomic DNA Translation: AAD21151.1
AK222540 mRNA Translation: BAD96260.1
AK222557 mRNA Translation: BAD96277.1
DQ087219 Genomic DNA Translation: AAY68217.1
BC011737 mRNA Translation: AAH11737.1
CCDSiCCDS8228.1
RefSeqiNP_003346.2, NM_003355.2
UniGeneiHs.80658

Genome annotation databases

EnsembliENST00000310473; ENSP00000312029; ENSG00000175567
GeneIDi7351
KEGGihsa:7351
UCSCiuc001oup.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82819 mRNA Translation: AAC51336.1
U76367 mRNA Translation: AAB48411.1
U94592 mRNA Translation: AAB53091.1
AJ223477, AJ223478, AJ223479 Genomic DNA Translation: CAA11402.1
AF019409 Genomic DNA Translation: AAC39690.1
AF096289 Genomic DNA Translation: AAD21151.1
AK222540 mRNA Translation: BAD96260.1
AK222557 mRNA Translation: BAD96277.1
DQ087219 Genomic DNA Translation: AAY68217.1
BC011737 mRNA Translation: AAH11737.1
CCDSiCCDS8228.1
RefSeqiNP_003346.2, NM_003355.2
UniGeneiHs.80658

3D structure databases

ProteinModelPortaliP55851
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113198, 21 interactors
IntActiP55851, 2 interactors
STRINGi9606.ENSP00000312029

Protein family/group databases

TCDBi2.A.29.3.4 the mitochondrial carrier (mc) family

PTM databases

iPTMnetiP55851
PhosphoSitePlusiP55851

Polymorphism and mutation databases

BioMutaiUCP2
DMDMi2497981

Proteomic databases

PaxDbiP55851
PeptideAtlasiP55851
PRIDEiP55851
ProteomicsDBi56873

Protocols and materials databases

DNASUi7351
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000310473; ENSP00000312029; ENSG00000175567
GeneIDi7351
KEGGihsa:7351
UCSCiuc001oup.2 human

Organism-specific databases

CTDi7351
DisGeNETi7351
EuPathDBiHostDB:ENSG00000175567.8
GeneCardsiUCP2
GeneReviewsiUCP2
H-InvDBiHIX0095887
HGNCiHGNC:12518 UCP2
HPAiCAB025583
HPA075202
MalaCardsiUCP2
MIMi601693 gene
607447 phenotype
neXtProtiNX_P55851
OpenTargetsiENSG00000175567
Orphaneti276556 Hyperinsulinism due to UCP2 deficiency
PharmGKBiPA37165
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0753 Eukaryota
ENOG410XRV1 LUCA
GeneTreeiENSGT00760000119170
HOGENOMiHOG000165140
HOVERGENiHBG009528
InParanoidiP55851
KOiK15103
OMAiSEHAGIG
OrthoDBiEOG091G0BQ7
PhylomeDBiP55851
TreeFamiTF323211

Enzyme and pathway databases

ReactomeiR-HSA-167826 The fatty acid cycling model
R-HSA-167827 The proton buffering model

Miscellaneous databases

ChiTaRSiUCP2 human
GeneWikiiUCP2
GenomeRNAii7351
PROiPR:P55851
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000175567 Expressed in 230 organ(s), highest expression level in oviduct epithelium
CleanExiHS_UCP2
ExpressionAtlasiP55851 baseline and differential
GenevisibleiP55851 HS

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR002030 Mit_uncoupling_UCP-like
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
PRINTSiPR00784 MTUNCOUPLING
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiUCP2_HUMAN
AccessioniPrimary (citable) accession number: P55851
Secondary accession number(s): Q4PJH8, Q53HM3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: September 12, 2018
This is version 157 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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