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UniProtKB - P55850 (DSC3_MOUSE)

Entry version 155 (10 Apr 2019)
Sequence version 3 (16 Mar 2016)
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Protein

Desmocollin-3

Gene

Dsc3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion
LigandCalcium, Metal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-6805567 Keratinization
R-MMU-6809371 Formation of the cornified envelope

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Desmocollin-3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Dsc3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1194993 Dsc3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini136 – 695ExtracellularSequence analysisAdd BLAST560
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei696 – 716HelicalSequence analysisAdd BLAST21
Topological domaini717 – 896CytoplasmicSequence analysisAdd BLAST180

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 31Sequence analysisAdd BLAST31
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000000387732 – 135Sequence analysisAdd BLAST104
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000003878136 – 896Desmocollin-3Add BLAST761

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi166N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi392N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi547N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi630N-linked (GlcNAc...) (high mannose) asparagine1 Publication1

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P55850

PeptideAtlas

More...PeptideAtlasi		P55850

PRoteomics IDEntifications database

More...PRIDEi		P55850

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P55850

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P55850

UniCarbKB; an annotated and curated database of glycan structures

More...UniCarbKBi		P55850

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

First expressed at E13.0 in epithelium of whisker pads and external nares, and in most mature vibrissa follicles. 12 hours later, prominently expressed in whiskers and tactile follicles above the eye. At E14.5, also expressed in developing nails and teeth and, at low levels, in ventral and lateral skin. At E15.5, highly expressed in general body epidermis and at E16.5, detected over entire embryo. In the adult, highly expressed in basal layers of stratified cells.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000059898 Expressed in 125 organ(s), highest expression level in ear

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P55850 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		199320, 1 interactor

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000111514

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		P55850

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P55850

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini136 – 243Cadherin 1PROSITE-ProRule annotationAdd BLAST108
Domaini244 – 355Cadherin 2PROSITE-ProRule annotationAdd BLAST112
Domaini356 – 472Cadherin 3PROSITE-ProRule annotationAdd BLAST117
Domaini473 – 580Cadherin 4PROSITE-ProRule annotationAdd BLAST108
Domaini581 – 691Cadherin 5PROSITE-ProRule annotationAdd BLAST111

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Calcium may be bound by the cadherin-like repeats.Curated
Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3594 Eukaryota
ENOG410XQHI LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00950000182765

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000231253

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG102801

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P55850

KEGG Orthology (KO)

More...KOi		K07602

Identification of Orthologs from Complete Genome Data

More...OMAi		NEAPFTR

Database of Orthologous Groups

More...OrthoDBi		120970at2759

TreeFam database of animal gene trees

More...TreeFami		TF316817

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		4.10.900.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR000233 Cadherin_cytoplasmic-dom
IPR014868 Cadherin_pro_dom
IPR027397 Catenin_binding_dom_sf
IPR009122 Desmosomal_cadherin

The PANTHER Classification System

More...PANTHERi		PTHR24025 PTHR24025, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00028 Cadherin, 4 hits
PF01049 Cadherin_C, 1 hit
PF08758 Cadherin_pro, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00205 CADHERIN
PR01818 DESMOCADHERN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00112 CA, 5 hits
SM01055 Cadherin_pro, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49313 SSF49313, 6 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00232 CADHERIN_1, 3 hits
PS50268 CADHERIN_2, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 3A (identifier: P55850-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVVPEFRSPQ CRALCTKLLL TLWVFSFVGE ACKKVTFHVP STLEADKIIG 
        60         70         80         90        100
RVSLKECLSS ADGIMPSDPD FRVLDDGSVY PTRAVVLSDE KRSFTIQLSD 
       110        120        130        140        150
SKMQTQKEIP VILEHKKKVL KKRHTKETVL RRSKRRWAPI PCSMQENSLG 
       160        170        180        190        200
PFPLFLQQVQ SDAAQNYTVF YSISGRGADQ EPLNWFFIER DTGNLYCTRP 
       210        220        230        240        250
VDREEYDVFD LIAYASTADG YSADLPLPLP IKIEDENDNY PLFTEAIYAF 
       260        270        280        290        300
EVPEGSRLGT VVGTVCATDK DEPDTMHTRL KYSILEQTPP SPGLFSVHPD 
       310        320        330        340        350
TGVITTVSHY MDREVVDKYK LIMKVQDMNG QFFGLISTST CIITVQDSND 
       360        370        380        390        400
NAPTFRQNTY ETAVEENTYN VEILRIPVDD KDMINTANWK ANFTILKGNE 
       410        420        430        440        450
NGWFKITTDP VTNEGVLCVV KPLDYEENRQ VTLEIGVNNE APFIKDVANR 
       460        470        480        490        500
IPTMNRAMVT VHVKDQNEGP ECKPPEQYVR IKENSAVGSK INGYKAYDPE 
       510        520        530        540        550
TKNSNGLRYK KLQDPKDWVS IEEVSGLLTI SKTLDREIMA PRNDMYNITV 
       560        570        580        590        600
MAIDQEGKSC TGTLAVNIED VNDNAPEIIQ DYIVICKPKM GYTDISAVDP 
       610        620        630        640        650
DEPIHGPPFQ FNLANTSPEV NRIWTLNQVN DTAARLSYQK TADVQIYNVP 
       660        670        680        690        700
VTVKDRAGQS ATKILRVNLC DCTHPSQCPL RSRSAGITLG KWAILAILLG 
       710        720        730        740        750
IALLFSVLLT LVCGVVTARK GKHFPEDLAQ QNLIISNTEA PGDDRVCSAN 
       760        770        780        790        800
GFTTHTANNS SQGFCGTMGS GMRNGGQETI EMMKGHQTLD SCRVAGHHHT 
       810        820        830        840        850
LDSGRGGHMD TDNCRYTYSE WHSFTQPRLG EKLHVCNQNE DHIPSQDYVL 
       860        870        880        890 
TYNYEGRGSP AGSVGCCSEK QEEEGLDFLN NLEPKFLTLA ETCTKR
Length:896
Mass (Da):100,203
Last modified:March 16, 2016 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDC630F26CD00CB3D
GO
Isoform 3B (identifier: P55850-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     832-839: KLHVCNQN → DSIRGHTG
     840-896: Missing.

Show »
Length:839
Mass (Da):93,724
Checksum:i054B1A1BD408F194
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A286YD62A0A286YD62_MOUSE
Desmocollin-3
Dsc3
152Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA72045 differs from that shown. Reason: Frameshift at position 768.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti45A → V in CAA72045 (PubMed:9389456).Curated1
Sequence conflicti435I → T in CAA72045 (PubMed:9389456).Curated1
Sequence conflicti539M → I in CAA72045 (PubMed:9389456).Curated1
Sequence conflicti626L → I in CAA72045 (PubMed:9389456).Curated1
Sequence conflicti694I → Y in CAA72045 (PubMed:9389456).Curated1
Sequence conflicti715V → I in CAA03996 (PubMed:9404003).Curated1
Sequence conflicti730 – 731QQ → HE in CAA72045 (PubMed:9389456).Curated2
Sequence conflicti730 – 731QQ → HE in CAA03996 (PubMed:9404003).Curated2
Sequence conflicti841D → N in CAA72045 (PubMed:9389456).Curated1
Sequence conflicti891E → K in CAA72045 (PubMed:9389456).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_000665832 – 839KLHVCNQN → DSIRGHTG in isoform 3B. Curated8
Alternative sequenceiVSP_000666840 – 896Missing in isoform 3B. CuratedAdd BLAST57

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
Y11169 mRNA Translation: CAA72045.1 Frameshift.
AC105159 Genomic DNA No translation available.
CH466557 Genomic DNA Translation: EDK96937.1
AJ000329 mRNA Translation: CAA03996.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS37744.1 [P55850-1]

NCBI Reference Sequences

More...RefSeqi		NP_001278738.1, NM_001291809.1 [P55850-2]
NP_031908.3, NM_007882.3 [P55850-1]
XP_006525656.1, XM_006525593.3 [P55850-1]

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Mm.89935

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000115848; ENSMUSP00000111514; ENSMUSG00000059898 [P55850-2]
ENSMUST00000225110; ENSMUSP00000153261; ENSMUSG00000059898 [P55850-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		13507

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:13507

UCSC genome browser

More...UCSCi		uc008eea.2 mouse

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y11169 mRNA Translation: CAA72045.1 Frameshift.
AC105159 Genomic DNA No translation available.
CH466557 Genomic DNA Translation: EDK96937.1
AJ000329 mRNA Translation: CAA03996.1
CCDSiCCDS37744.1 [P55850-1]
RefSeqiNP_001278738.1, NM_001291809.1 [P55850-2]
NP_031908.3, NM_007882.3 [P55850-1]
XP_006525656.1, XM_006525593.3 [P55850-1]
UniGeneiMm.89935

3D structure databases

ProteinModelPortaliP55850
SMRiP55850
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199320, 1 interactor
STRINGi10090.ENSMUSP00000111514

PTM databases

iPTMnetiP55850
PhosphoSitePlusiP55850
UniCarbKBiP55850

Proteomic databases

PaxDbiP55850
PeptideAtlasiP55850
PRIDEiP55850

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		13507
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000115848; ENSMUSP00000111514; ENSMUSG00000059898 [P55850-2]
ENSMUST00000225110; ENSMUSP00000153261; ENSMUSG00000059898 [P55850-1]
GeneIDi13507
KEGGimmu:13507
UCSCiuc008eea.2 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		1825
MGIiMGI:1194993 Dsc3

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
GeneTreeiENSGT00950000182765
HOGENOMiHOG000231253
HOVERGENiHBG102801
InParanoidiP55850
KOiK07602
OMAiNEAPFTR
OrthoDBi120970at2759
TreeFamiTF316817

Enzyme and pathway databases

ReactomeiR-MMU-6805567 Keratinization
R-MMU-6809371 Formation of the cornified envelope

Miscellaneous databases

Protein Ontology

More...PROi		PR:P55850

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000059898 Expressed in 125 organ(s), highest expression level in ear
ExpressionAtlasiP55850 baseline and differential

Family and domain databases

Gene3Di4.10.900.10, 1 hit
InterProiView protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR000233 Cadherin_cytoplasmic-dom
IPR014868 Cadherin_pro_dom
IPR027397 Catenin_binding_dom_sf
IPR009122 Desmosomal_cadherin
PANTHERiPTHR24025 PTHR24025, 1 hit
PfamiView protein in Pfam
PF00028 Cadherin, 4 hits
PF01049 Cadherin_C, 1 hit
PF08758 Cadherin_pro, 1 hit
PRINTSiPR00205 CADHERIN
PR01818 DESMOCADHERN
SMARTiView protein in SMART
SM00112 CA, 5 hits
SM01055 Cadherin_pro, 1 hit
SUPFAMiSSF49313 SSF49313, 6 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 3 hits
PS50268 CADHERIN_2, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDSC3_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P55850
Secondary accession number(s): G5E8S6, O55110, O55122
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: March 16, 2016
Last modified: April 10, 2019
This is version 155 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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