UniProtKB - P55850 (DSC3_MOUSE)
Desmocollin-3
Dsc3
Functioni
Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms.
GO - Molecular functioni
- calcium ion binding Source: GO_Central
- gamma-catenin binding Source: MGI
GO - Biological processi
- cell-cell adhesion Source: GO_Central
- homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
- in utero embryonic development Source: MGI
- protein stabilization Source: MGI
Keywordsi
Biological process | Cell adhesion |
Ligand | Calcium, Metal-binding |
Enzyme and pathway databases
Reactomei | R-MMU-6805567, Keratinization R-MMU-6809371, Formation of the cornified envelope |
Names & Taxonomyi
Protein namesi | Recommended name: Desmocollin-3 |
Gene namesi | Name:Dsc3 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1194993, Dsc3 |
VEuPathDBi | HostDB:ENSMUSG00000059898 |
Subcellular locationi
Plasma membrane
- Cell membrane Curated; Single-pass type I membrane protein Curated
Other locations
- desmosome By similarity
Extracellular region or secreted
- extracellular region Source: MGI
Plasma Membrane
- plasma membrane Source: MGI
Other locations
- cell junction Source: MGI
- cell-cell junction Source: GO_Central
- cytoplasm Source: MGI
- desmosome Source: MGI
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 136 – 695 | ExtracellularSequence analysisAdd BLAST | 560 | |
Transmembranei | 696 – 716 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 717 – 896 | CytoplasmicSequence analysisAdd BLAST | 180 |
Keywords - Cellular componenti
Cell junction, Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 31 | Sequence analysisAdd BLAST | 31 | |
PropeptideiPRO_0000003877 | 32 – 135 | Sequence analysisAdd BLAST | 104 | |
ChainiPRO_0000003878 | 136 – 896 | Desmocollin-3Add BLAST | 761 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 166 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 392 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 547 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 630 | N-linked (GlcNAc...) (high mannose) asparagine1 Publication | 1 |
Keywords - PTMi
Cleavage on pair of basic residues, GlycoproteinProteomic databases
CPTACi | non-CPTAC-4029 |
PaxDbi | P55850 |
PeptideAtlasi | P55850 |
PRIDEi | P55850 |
ProteomicsDBi | 275405 [P55850-1] 275406 [P55850-2] |
PTM databases
GlyGeni | P55850, 4 sites |
iPTMneti | P55850 |
PhosphoSitePlusi | P55850 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSMUSG00000059898, Expressed in ear and 149 other tissues |
ExpressionAtlasi | P55850, baseline and differential |
Interactioni
GO - Molecular functioni
- gamma-catenin binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 199320, 1 interactor |
STRINGi | 10090.ENSMUSP00000111514 |
Miscellaneous databases
RNActi | P55850, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 136 – 243 | Cadherin 1PROSITE-ProRule annotationAdd BLAST | 108 | |
Domaini | 244 – 355 | Cadherin 2PROSITE-ProRule annotationAdd BLAST | 112 | |
Domaini | 356 – 472 | Cadherin 3PROSITE-ProRule annotationAdd BLAST | 117 | |
Domaini | 473 – 580 | Cadherin 4PROSITE-ProRule annotationAdd BLAST | 108 | |
Domaini | 581 – 691 | Cadherin 5PROSITE-ProRule annotationAdd BLAST | 111 |
Domaini
Keywords - Domaini
Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3594, Eukaryota |
GeneTreei | ENSGT01030000234624 |
InParanoidi | P55850 |
OMAi | TLIMKVQ |
OrthoDBi | 120970at2759 |
PhylomeDBi | P55850 |
TreeFami | TF316817 |
Family and domain databases
Gene3Di | 4.10.900.10, 1 hit |
InterProi | View protein in InterPro IPR002126, Cadherin-like_dom IPR015919, Cadherin-like_sf IPR020894, Cadherin_CS IPR000233, Cadherin_cytoplasmic-dom IPR014868, Cadherin_pro_dom IPR027397, Catenin-bd_sf IPR009122, Desmosomal_cadherin |
Pfami | View protein in Pfam PF00028, Cadherin, 4 hits PF01049, Cadherin_C, 1 hit PF08758, Cadherin_pro, 1 hit |
PRINTSi | PR00205, CADHERIN PR01818, DESMOCADHERN |
SMARTi | View protein in SMART SM00112, CA, 5 hits SM01055, Cadherin_pro, 1 hit |
SUPFAMi | SSF49313, SSF49313, 6 hits |
PROSITEi | View protein in PROSITE PS00232, CADHERIN_1, 3 hits PS50268, CADHERIN_2, 5 hits |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MVVPEFRSPQ CRALCTKLLL TLWVFSFVGE ACKKVTFHVP STLEADKIIG
60 70 80 90 100
RVSLKECLSS ADGIMPSDPD FRVLDDGSVY PTRAVVLSDE KRSFTIQLSD
110 120 130 140 150
SKMQTQKEIP VILEHKKKVL KKRHTKETVL RRSKRRWAPI PCSMQENSLG
160 170 180 190 200
PFPLFLQQVQ SDAAQNYTVF YSISGRGADQ EPLNWFFIER DTGNLYCTRP
210 220 230 240 250
VDREEYDVFD LIAYASTADG YSADLPLPLP IKIEDENDNY PLFTEAIYAF
260 270 280 290 300
EVPEGSRLGT VVGTVCATDK DEPDTMHTRL KYSILEQTPP SPGLFSVHPD
310 320 330 340 350
TGVITTVSHY MDREVVDKYK LIMKVQDMNG QFFGLISTST CIITVQDSND
360 370 380 390 400
NAPTFRQNTY ETAVEENTYN VEILRIPVDD KDMINTANWK ANFTILKGNE
410 420 430 440 450
NGWFKITTDP VTNEGVLCVV KPLDYEENRQ VTLEIGVNNE APFIKDVANR
460 470 480 490 500
IPTMNRAMVT VHVKDQNEGP ECKPPEQYVR IKENSAVGSK INGYKAYDPE
510 520 530 540 550
TKNSNGLRYK KLQDPKDWVS IEEVSGLLTI SKTLDREIMA PRNDMYNITV
560 570 580 590 600
MAIDQEGKSC TGTLAVNIED VNDNAPEIIQ DYIVICKPKM GYTDISAVDP
610 620 630 640 650
DEPIHGPPFQ FNLANTSPEV NRIWTLNQVN DTAARLSYQK TADVQIYNVP
660 670 680 690 700
VTVKDRAGQS ATKILRVNLC DCTHPSQCPL RSRSAGITLG KWAILAILLG
710 720 730 740 750
IALLFSVLLT LVCGVVTARK GKHFPEDLAQ QNLIISNTEA PGDDRVCSAN
760 770 780 790 800
GFTTHTANNS SQGFCGTMGS GMRNGGQETI EMMKGHQTLD SCRVAGHHHT
810 820 830 840 850
LDSGRGGHMD TDNCRYTYSE WHSFTQPRLG EKLHVCNQNE DHIPSQDYVL
860 870 880 890
TYNYEGRGSP AGSVGCCSEK QEEEGLDFLN NLEPKFLTLA ETCTKR
The sequence of this isoform differs from the canonical sequence as follows:
832-839: KLHVCNQN → DSIRGHTG
840-896: Missing.
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A286YD62 | A0A286YD62_MOUSE | Desmocollin-3 | Dsc3 | 152 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 45 | A → V in CAA72045 (PubMed:9389456).Curated | 1 | |
Sequence conflicti | 435 | I → T in CAA72045 (PubMed:9389456).Curated | 1 | |
Sequence conflicti | 539 | M → I in CAA72045 (PubMed:9389456).Curated | 1 | |
Sequence conflicti | 626 | L → I in CAA72045 (PubMed:9389456).Curated | 1 | |
Sequence conflicti | 694 | I → Y in CAA72045 (PubMed:9389456).Curated | 1 | |
Sequence conflicti | 715 | V → I in CAA03996 (PubMed:9404003).Curated | 1 | |
Sequence conflicti | 730 – 731 | QQ → HE in CAA72045 (PubMed:9389456).Curated | 2 | |
Sequence conflicti | 730 – 731 | QQ → HE in CAA03996 (PubMed:9404003).Curated | 2 | |
Sequence conflicti | 841 | D → N in CAA72045 (PubMed:9389456).Curated | 1 | |
Sequence conflicti | 891 | E → K in CAA72045 (PubMed:9389456).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_000665 | 832 – 839 | KLHVCNQN → DSIRGHTG in isoform 3B. Curated | 8 | |
Alternative sequenceiVSP_000666 | 840 – 896 | Missing in isoform 3B. CuratedAdd BLAST | 57 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y11169 mRNA Translation: CAA72045.1 Frameshift. AC105159 Genomic DNA No translation available. CH466557 Genomic DNA Translation: EDK96937.1 AJ000329 mRNA Translation: CAA03996.1 |
CCDSi | CCDS37744.1 [P55850-1] CCDS89197.1 [P55850-2] |
RefSeqi | NP_001278738.1, NM_001291809.1 [P55850-2] NP_031908.3, NM_007882.3 [P55850-1] XP_006525656.1, XM_006525593.3 [P55850-1] |
Genome annotation databases
Ensembli | ENSMUST00000115848; ENSMUSP00000111514; ENSMUSG00000059898 [P55850-2] ENSMUST00000225110; ENSMUSP00000153261; ENSMUSG00000059898 [P55850-1] |
GeneIDi | 13507 |
KEGGi | mmu:13507 |
UCSCi | uc008eea.2, mouse |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y11169 mRNA Translation: CAA72045.1 Frameshift. AC105159 Genomic DNA No translation available. CH466557 Genomic DNA Translation: EDK96937.1 AJ000329 mRNA Translation: CAA03996.1 |
CCDSi | CCDS37744.1 [P55850-1] CCDS89197.1 [P55850-2] |
RefSeqi | NP_001278738.1, NM_001291809.1 [P55850-2] NP_031908.3, NM_007882.3 [P55850-1] XP_006525656.1, XM_006525593.3 [P55850-1] |
3D structure databases
SMRi | P55850 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 199320, 1 interactor |
STRINGi | 10090.ENSMUSP00000111514 |
PTM databases
GlyGeni | P55850, 4 sites |
iPTMneti | P55850 |
PhosphoSitePlusi | P55850 |
Proteomic databases
CPTACi | non-CPTAC-4029 |
PaxDbi | P55850 |
PeptideAtlasi | P55850 |
PRIDEi | P55850 |
ProteomicsDBi | 275405 [P55850-1] 275406 [P55850-2] |
Protocols and materials databases
Antibodypediai | 7988, 237 antibodies from 33 providers |
DNASUi | 13507 |
Genome annotation databases
Ensembli | ENSMUST00000115848; ENSMUSP00000111514; ENSMUSG00000059898 [P55850-2] ENSMUST00000225110; ENSMUSP00000153261; ENSMUSG00000059898 [P55850-1] |
GeneIDi | 13507 |
KEGGi | mmu:13507 |
UCSCi | uc008eea.2, mouse |
Organism-specific databases
CTDi | 1825 |
MGIi | MGI:1194993, Dsc3 |
VEuPathDBi | HostDB:ENSMUSG00000059898 |
Phylogenomic databases
eggNOGi | KOG3594, Eukaryota |
GeneTreei | ENSGT01030000234624 |
InParanoidi | P55850 |
OMAi | TLIMKVQ |
OrthoDBi | 120970at2759 |
PhylomeDBi | P55850 |
TreeFami | TF316817 |
Enzyme and pathway databases
Reactomei | R-MMU-6805567, Keratinization R-MMU-6809371, Formation of the cornified envelope |
Miscellaneous databases
BioGRID-ORCSi | 13507, 1 hit in 63 CRISPR screens |
PROi | PR:P55850 |
RNActi | P55850, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000059898, Expressed in ear and 149 other tissues |
ExpressionAtlasi | P55850, baseline and differential |
Family and domain databases
Gene3Di | 4.10.900.10, 1 hit |
InterProi | View protein in InterPro IPR002126, Cadherin-like_dom IPR015919, Cadherin-like_sf IPR020894, Cadherin_CS IPR000233, Cadherin_cytoplasmic-dom IPR014868, Cadherin_pro_dom IPR027397, Catenin-bd_sf IPR009122, Desmosomal_cadherin |
Pfami | View protein in Pfam PF00028, Cadherin, 4 hits PF01049, Cadherin_C, 1 hit PF08758, Cadherin_pro, 1 hit |
PRINTSi | PR00205, CADHERIN PR01818, DESMOCADHERN |
SMARTi | View protein in SMART SM00112, CA, 5 hits SM01055, Cadherin_pro, 1 hit |
SUPFAMi | SSF49313, SSF49313, 6 hits |
PROSITEi | View protein in PROSITE PS00232, CADHERIN_1, 3 hits PS50268, CADHERIN_2, 5 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | DSC3_MOUSE | |
Accessioni | P55850Primary (citable) accession number: P55850 Secondary accession number(s): G5E8S6, O55110, O55122 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | March 16, 2016 | |
Last modified: | February 23, 2022 | |
This is version 171 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot