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Protein

SH3 domain-binding glutamic acid-rich protein

Gene

SH3BGR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Caution

It is uncertain whether Met-1 or Met-64 is the initiator.Curated

GO - Molecular functioni

  • SH3/SH2 adaptor activity Source: ProtInc
  • SH3 domain binding Source: UniProtKB-KW

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
SH3 domain-binding glutamic acid-rich protein
Short name:
SH3BGR protein
Alternative name(s):
21-glutamic acid-rich protein
Short name:
21-GARP
Gene namesi
Name:SH3BGR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

EuPathDBiHostDB:ENSG00000185437.13
HGNCiHGNC:10822 SH3BGR
MIMi602230 gene
neXtProtiNX_P55822

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi6450
OpenTargetsiENSG00000185437
PharmGKBiPA35730

Polymorphism and mutation databases

BioMutaiSH3BGR
DMDMi215274184

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002207431 – 239SH3 domain-binding glutamic acid-rich proteinAdd BLAST239

Proteomic databases

EPDiP55822
MaxQBiP55822
PaxDbiP55822
PeptideAtlasiP55822
PRIDEiP55822
ProteomicsDBi56872

PTM databases

iPTMnetiP55822
PhosphoSitePlusiP55822

Expressioni

Tissue specificityi

Expressed in heart and skeletal muscle.

Gene expression databases

BgeeiENSG00000185437 Expressed in 209 organ(s), highest expression level in vastus lateralis
CleanExiHS_SH3BGR
ExpressionAtlasiP55822 baseline and differential
GenevisibleiP55822 HS

Organism-specific databases

HPAiCAB003685
HPA030690

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112348, 6 interactors
IntActiP55822, 2 interactors
STRINGi9606.ENSP00000332513

Structurei

3D structure databases

ProteinModelPortaliP55822
SMRiP55822
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi124 – 130SH3-bindingSequence analysis7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi170 – 239Glu-rich (acidic)Add BLAST70

Sequence similaritiesi

Belongs to the SH3BGR family.Curated

Keywords - Domaini

SH3-binding

Phylogenomic databases

eggNOGiKOG4023 Eukaryota
ENOG4111N7M LUCA
GeneTreeiENSGT00440000039098
HOGENOMiHOG000037924
HOVERGENiHBG054781
InParanoidiP55822
OMAiCNEDNRM
OrthoDBiEOG091G10PC
PhylomeDBiP55822
TreeFamiTF105574

Family and domain databases

CDDicd03030 GRX_SH3BGR, 1 hit
InterProiView protein in InterPro
IPR006993 Glut_rich_SH3-bd
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF04908 SH3BGR, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P55822-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPLLLLGETE PLKLERDCRS PVDPWAAASP DLALACLCHC QDLSSGAFPD
60 70 80 90 100
RGVLGGVLFP TVEMVIKVFV ATSSGSIAIR KKQQEVVGFL EANKIDFKEL
110 120 130 140 150
DIAGDEDNRR WMRENVPGEK KPQNGIPLPP QIFNEEQYCG DFDSFFSAKE
160 170 180 190 200
ENIIYSFLGL APPPDSKGSE KAEEGGETEA QKEGSEDVGN LPEAQEKNEE
210 220 230
EGETATEETE EIAMEGAEGE AEEEEETAEG EEPGEDEDS
Length:239
Mass (Da):26,086
Last modified:November 25, 2008 - v3
Checksum:iBA57B1C8034D6BBC
GO
Isoform 2 (identifier: P55822-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-111: Missing.

Note: No experimental confirmation available.
Show »
Length:128
Mass (Da):13,976
Checksum:i1E2E0AADFFAC0B28
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JJT2C9JJT2_HUMAN
SH3 domain-binding glutamic acid-ri...
SH3BGR
97Annotation score:
H7C2G0H7C2G0_HUMAN
SH3 domain-binding glutamic acid-ri...
SH3BGR
137Annotation score:
H7C3V3H7C3V3_HUMAN
SH3 domain-binding glutamic acid-ri...
SH3BGR
81Annotation score:
C9JX40C9JX40_HUMAN
SH3 domain-binding glutamic acid-ri...
SH3BGR
106Annotation score:
H7C1Y8H7C1Y8_HUMAN
SH3 domain-binding glutamic acid-ri...
SH3BGR
54Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti232E → EE in BM474020 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05718223D → E1 PublicationCorresponds to variant dbSNP:rs11575939Ensembl.1
Natural variantiVAR_05718350D → N2 PublicationsCorresponds to variant dbSNP:rs6517549Ensembl.1
Natural variantiVAR_028233188V → A1 PublicationCorresponds to variant dbSNP:rs9974333Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0457881 – 111Missing in isoform 2. 1 PublicationAdd BLAST111

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X93498 mRNA Translation: CAB57259.1
AL163279 Genomic DNA Translation: CAB90456.1
AL163280 Genomic DNA Translation: CAB90445.1
AF121781 Genomic DNA Translation: AAD12067.1
AF121897 Genomic DNA No translation available.
CH471079 Genomic DNA Translation: EAX09638.1
CH471079 Genomic DNA Translation: EAX09639.1
CH471079 Genomic DNA Translation: EAX09640.1
BC006371 mRNA Translation: AAH06371.1
BM474020 mRNA No translation available.
CCDSiCCDS13666.1 [P55822-1]
CCDS33560.1 [P55822-2]
RefSeqiNP_001001713.1, NM_001001713.1 [P55822-2]
NP_001304671.1, NM_001317742.1 [P55822-2]
NP_031367.1, NM_007341.2
UniGeneiHs.473847

Genome annotation databases

EnsembliENST00000333634; ENSP00000332513; ENSG00000185437 [P55822-1]
ENST00000380631; ENSP00000370005; ENSG00000185437 [P55822-2]
ENST00000380634; ENSP00000370008; ENSG00000185437 [P55822-2]
ENST00000380637; ENSP00000370011; ENSG00000185437 [P55822-2]
GeneIDi6450
KEGGihsa:6450
UCSCiuc002yxz.4 human [P55822-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X93498 mRNA Translation: CAB57259.1
AL163279 Genomic DNA Translation: CAB90456.1
AL163280 Genomic DNA Translation: CAB90445.1
AF121781 Genomic DNA Translation: AAD12067.1
AF121897 Genomic DNA No translation available.
CH471079 Genomic DNA Translation: EAX09638.1
CH471079 Genomic DNA Translation: EAX09639.1
CH471079 Genomic DNA Translation: EAX09640.1
BC006371 mRNA Translation: AAH06371.1
BM474020 mRNA No translation available.
CCDSiCCDS13666.1 [P55822-1]
CCDS33560.1 [P55822-2]
RefSeqiNP_001001713.1, NM_001001713.1 [P55822-2]
NP_001304671.1, NM_001317742.1 [P55822-2]
NP_031367.1, NM_007341.2
UniGeneiHs.473847

3D structure databases

ProteinModelPortaliP55822
SMRiP55822
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112348, 6 interactors
IntActiP55822, 2 interactors
STRINGi9606.ENSP00000332513

PTM databases

iPTMnetiP55822
PhosphoSitePlusiP55822

Polymorphism and mutation databases

BioMutaiSH3BGR
DMDMi215274184

Proteomic databases

EPDiP55822
MaxQBiP55822
PaxDbiP55822
PeptideAtlasiP55822
PRIDEiP55822
ProteomicsDBi56872

Protocols and materials databases

DNASUi6450
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000333634; ENSP00000332513; ENSG00000185437 [P55822-1]
ENST00000380631; ENSP00000370005; ENSG00000185437 [P55822-2]
ENST00000380634; ENSP00000370008; ENSG00000185437 [P55822-2]
ENST00000380637; ENSP00000370011; ENSG00000185437 [P55822-2]
GeneIDi6450
KEGGihsa:6450
UCSCiuc002yxz.4 human [P55822-1]

Organism-specific databases

CTDi6450
DisGeNETi6450
EuPathDBiHostDB:ENSG00000185437.13
GeneCardsiSH3BGR
HGNCiHGNC:10822 SH3BGR
HPAiCAB003685
HPA030690
MIMi602230 gene
neXtProtiNX_P55822
OpenTargetsiENSG00000185437
PharmGKBiPA35730
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4023 Eukaryota
ENOG4111N7M LUCA
GeneTreeiENSGT00440000039098
HOGENOMiHOG000037924
HOVERGENiHBG054781
InParanoidiP55822
OMAiCNEDNRM
OrthoDBiEOG091G10PC
PhylomeDBiP55822
TreeFamiTF105574

Miscellaneous databases

ChiTaRSiSH3BGR human
GeneWikiiSH3BGR
GenomeRNAii6450
PROiPR:P55822
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000185437 Expressed in 209 organ(s), highest expression level in vastus lateralis
CleanExiHS_SH3BGR
ExpressionAtlasiP55822 baseline and differential
GenevisibleiP55822 HS

Family and domain databases

CDDicd03030 GRX_SH3BGR, 1 hit
InterProiView protein in InterPro
IPR006993 Glut_rich_SH3-bd
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF04908 SH3BGR, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSH3BG_HUMAN
AccessioniPrimary (citable) accession number: P55822
Secondary accession number(s): A6ND59, D3DSI2, Q9BRB8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 25, 2008
Last modified: November 7, 2018
This is version 149 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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