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Protein

Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial

Gene

OXCT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: succinyl-CoA degradation

This protein is involved in step 1 of the subpathway that synthesizes acetoacetyl-CoA from succinyl-CoA.
Proteins known to be involved in this subpathway in this organism are:
  1. Succinyl-CoA:3-ketoacid-coenzyme A transferase (OXCT), Succinyl-CoA:3-ketoacid-coenzyme A transferase (BQ8482_310142), Succinyl-CoA:3-ketoacid-coenzyme A transferase (OXCT1), Succinyl-CoA:3-ketoacid-coenzyme A transferase, Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial (OXCT1), Succinyl-CoA:3-ketoacid coenzyme A transferase 2, mitochondrial (OXCT2)
This subpathway is part of the pathway succinyl-CoA degradation, which is itself part of Ketone metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetoacetyl-CoA from succinyl-CoA, the pathway succinyl-CoA degradation and in Ketone metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei3445-glutamyl coenzyme A thioester intermediatePROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • 3-oxoacid CoA-transferase activity Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:HS01447-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.8.3.5 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-77108 Utilization of Ketone Bodies

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00929;UER00894

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial (EC:2.8.3.5)
Alternative name(s):
3-oxoacid CoA-transferase 1
Somatic-type succinyl-CoA:3-oxoacid CoA-transferase
Short name:
SCOT-s
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:OXCT1
Synonyms:OXCT, SCOT
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000083720.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:8527 OXCT1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
601424 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P55809

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Succinyl-CoA:3-oxoacid CoA transferase deficiency (SCOTD)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder of ketone body metabolism, characterized by episodic ketoacidosis. Patients are usually asymptomatic between episodes.
See also OMIM:245050
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_000696133V → E in SCOTD. 1 PublicationCorresponds to variant dbSNP:rs267606930EnsemblClinVar.1
Natural variantiVAR_065564215A → V in SCOTD; partial loss of activity. 1 PublicationCorresponds to variant dbSNP:rs201752548Ensembl.1
Natural variantiVAR_010337219G → E in SCOTD. 1 PublicationCorresponds to variant dbSNP:rs121909302EnsemblClinVar.1
Natural variantiVAR_010338221V → M in SCOTD. 1 PublicationCorresponds to variant dbSNP:rs121909303EnsemblClinVar.1
Natural variantiVAR_065565226S → N in SCOTD; loss of activity. 1 PublicationCorresponds to variant dbSNP:rs368841359Ensembl.1
Natural variantiVAR_010339324G → E in SCOTD. 1 PublicationCorresponds to variant dbSNP:rs121909301EnsemblClinVar.1
Natural variantiVAR_065566327L → P in SCOTD; partial loss of activity. 1 Publication1
Natural variantiVAR_065567404V → F in SCOTD; loss of activity. 1 Publication1
Natural variantiVAR_065568405S → P in SCOTD; loss of activity. 1 Publication1
Natural variantiVAR_000697456C → F in SCOTD. 1 PublicationCorresponds to variant dbSNP:rs121909300EnsemblClinVar.1
Natural variantiVAR_065569468R → C in SCOTD; partial loss of activity; the mutant retains half of the activity of the wild-type at 30 degrees. 1 PublicationCorresponds to variant dbSNP:rs1327401976Ensembl.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
5019

MalaCards human disease database

More...
MalaCardsi
OXCT1
MIMi245050 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000083720

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
832 Succinyl-CoA:3-ketoacid CoA transferase deficiency

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA32855

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB02731 Ethylmercurithiosalicylic acid
DB00139 Succinic acid

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
OXCT1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
2492998

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 39Mitochondrion1 PublicationAdd BLAST39
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000241340 – 520Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrialAdd BLAST481

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei170PhosphoserineCombined sources1
Modified residuei185N6-succinyllysineBy similarity1
Modified residuei418N6-succinyllysineBy similarity1
Modified residuei421N6-succinyllysineBy similarity1
Modified residuei455N6-succinyllysineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P55809

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P55809

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P55809

PeptideAtlas

More...
PeptideAtlasi
P55809

PRoteomics IDEntifications database

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PRIDEi
P55809

ProteomicsDB human proteome resource

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ProteomicsDBi
56871

2D gel databases

University College Dublin 2-DE Proteome Database

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UCD-2DPAGEi
P55809

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P55809

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P55809

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Abundant in heart, followed in order by kidney, brain, and muscle, whereas in liver it is undetectable; also detectable in leukocytes and fibroblasts.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000083720 Expressed in 233 organ(s), highest expression level in middle temporal gyrus

CleanEx database of gene expression profiles

More...
CleanExi
HS_OXCT1

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P55809 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P55809 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA012047
HPA061425

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
111059, 64 interactors

Protein interaction database and analysis system

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IntActi
P55809, 34 interactors

Molecular INTeraction database

More...
MINTi
P55809

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000196371

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1520
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P55809

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P55809

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P55809

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the 3-oxoacid CoA-transferase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3822 Eukaryota
COG1788 LUCA
COG2057 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000009130

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000221244

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG002310

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P55809

KEGG Orthology (KO)

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KOi
K01027

Identification of Orthologs from Complete Genome Data

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OMAi
NPAYSGE

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0D3X

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P55809

TreeFam database of animal gene trees

More...
TreeFami
TF313991

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012792 3-oxoacid_CoA-transf_A
IPR012791 3-oxoacid_CoA-transf_B
IPR014388 3-oxoacid_CoA-transferase
IPR004165 CoA_trans_fam_I
IPR004164 CoA_transf_AS
IPR004163 CoA_transf_BS
IPR037171 NagB/RpiA_transferase-like

The PANTHER Classification System

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PANTHERi
PTHR13707 PTHR13707, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF01144 CoA_trans, 2 hits

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000858 SCOT-t, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00882 CoA_trans, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF100950 SSF100950, 2 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR02429 pcaI_scoA_fam, 1 hit
TIGR02428 pcaJ_scoB_fam, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01273 COA_TRANSF_1, 1 hit
PS01274 COA_TRANSF_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P55809-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAALKLLSSG LRLCASARGS GATWYKGCVC SFSTSAHRHT KFYTDPVEAV
60 70 80 90 100
KDIPDGATVL VGGFGLCGIP ENLIDALLKT GVKGLTAVSN NAGVDNFGLG
110 120 130 140 150
LLLRSKQIKR MVSSYVGENA EFERQYLSGE LEVELTPQGT LAERIRAGGA
160 170 180 190 200
GVPAFYTPTG YGTLVQEGGS PIKYNKDGSV AIASKPREVR EFNGQHFILE
210 220 230 240 250
EAITGDFALV KAWKADRAGN VIFRKSARNF NLPMCKAAET TVVEVEEIVD
260 270 280 290 300
IGAFAPEDIH IPQIYVHRLI KGEKYEKRIE RLSIRKEGDG EAKSAKPGDD
310 320 330 340 350
VRERIIKRAA LEFEDGMYAN LGIGIPLLAS NFISPNITVH LQSENGVLGL
360 370 380 390 400
GPYPRQHEAD ADLINAGKET VTILPGASFF SSDESFAMIR GGHVDLTMLG
410 420 430 440 450
AMQVSKYGDL ANWMIPGKMV KGMGGAMDLV SSAKTKVVVT MEHSAKGNAH
460 470 480 490 500
KIMEKCTLPL TGKQCVNRII TEKAVFDVDK KKGLTLIELW EGLTVDDVQK
510 520
STGCDFAVSP KLMPMQQIAN
Length:520
Mass (Da):56,158
Last modified:November 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i54DA790FB8EDA546
GO
Isoform 2 (identifier: P55809-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-397: Missing.

Note: No experimental confirmation available.
Show »
Length:123
Mass (Da):13,358
Checksum:i5B36DC7CF0E0B843
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PDW2E9PDW2_HUMAN
Succinyl-CoA:3-ketoacid coenzyme A ...
OXCT1
334Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti95D → G in BAG35249 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00069558T → M2 PublicationsCorresponds to variant dbSNP:rs75134564EnsemblClinVar.1
Natural variantiVAR_000696133V → E in SCOTD. 1 PublicationCorresponds to variant dbSNP:rs267606930EnsemblClinVar.1
Natural variantiVAR_065564215A → V in SCOTD; partial loss of activity. 1 PublicationCorresponds to variant dbSNP:rs201752548Ensembl.1
Natural variantiVAR_010337219G → E in SCOTD. 1 PublicationCorresponds to variant dbSNP:rs121909302EnsemblClinVar.1
Natural variantiVAR_010338221V → M in SCOTD. 1 PublicationCorresponds to variant dbSNP:rs121909303EnsemblClinVar.1
Natural variantiVAR_065565226S → N in SCOTD; loss of activity. 1 PublicationCorresponds to variant dbSNP:rs368841359Ensembl.1
Natural variantiVAR_010339324G → E in SCOTD. 1 PublicationCorresponds to variant dbSNP:rs121909301EnsemblClinVar.1
Natural variantiVAR_065566327L → P in SCOTD; partial loss of activity. 1 Publication1
Natural variantiVAR_065567404V → F in SCOTD; loss of activity. 1 Publication1
Natural variantiVAR_065568405S → P in SCOTD; loss of activity. 1 Publication1
Natural variantiVAR_000697456C → F in SCOTD. 1 PublicationCorresponds to variant dbSNP:rs121909300EnsemblClinVar.1
Natural variantiVAR_065569468R → C in SCOTD; partial loss of activity; the mutant retains half of the activity of the wild-type at 30 degrees. 1 PublicationCorresponds to variant dbSNP:rs1327401976Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0563101 – 397Missing in isoform 2. 1 PublicationAdd BLAST397

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
U62961 mRNA Translation: AAB07366.1
AB029576 Genomic DNA Translation: BAB13733.1
AK298352 mRNA Translation: BAH12764.1
AK312327 mRNA Translation: BAG35249.1
AK315902 mRNA Translation: BAH14273.1
AC008817 Genomic DNA No translation available.
AC034222 Genomic DNA No translation available.
AC114946 Genomic DNA No translation available.
BC009001 mRNA Translation: AAH09001.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS3937.1 [P55809-1]

NCBI Reference Sequences

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RefSeqi
NP_000427.1, NM_000436.3 [P55809-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.278277

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000196371; ENSP00000196371; ENSG00000083720 [P55809-1]
ENST00000510634; ENSP00000423144; ENSG00000083720 [P55809-2]
ENST00000512084; ENSP00000421143; ENSG00000083720 [P55809-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
5019

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:5019

UCSC genome browser

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UCSCi
uc003jmn.4 human [P55809-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U62961 mRNA Translation: AAB07366.1
AB029576 Genomic DNA Translation: BAB13733.1
AK298352 mRNA Translation: BAH12764.1
AK312327 mRNA Translation: BAG35249.1
AK315902 mRNA Translation: BAH14273.1
AC008817 Genomic DNA No translation available.
AC034222 Genomic DNA No translation available.
AC114946 Genomic DNA No translation available.
BC009001 mRNA Translation: AAH09001.1
CCDSiCCDS3937.1 [P55809-1]
RefSeqiNP_000427.1, NM_000436.3 [P55809-1]
UniGeneiHs.278277

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3DLXX-ray2.20A/B/C/D40-520[»]
ProteinModelPortaliP55809
SMRiP55809
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111059, 64 interactors
IntActiP55809, 34 interactors
MINTiP55809
STRINGi9606.ENSP00000196371

Chemistry databases

DrugBankiDB02731 Ethylmercurithiosalicylic acid
DB00139 Succinic acid

PTM databases

iPTMnetiP55809
PhosphoSitePlusiP55809

Polymorphism and mutation databases

BioMutaiOXCT1
DMDMi2492998

2D gel databases

UCD-2DPAGEiP55809

Proteomic databases

EPDiP55809
MaxQBiP55809
PaxDbiP55809
PeptideAtlasiP55809
PRIDEiP55809
ProteomicsDBi56871

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
5019
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000196371; ENSP00000196371; ENSG00000083720 [P55809-1]
ENST00000510634; ENSP00000423144; ENSG00000083720 [P55809-2]
ENST00000512084; ENSP00000421143; ENSG00000083720 [P55809-2]
GeneIDi5019
KEGGihsa:5019
UCSCiuc003jmn.4 human [P55809-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
5019
DisGeNETi5019
EuPathDBiHostDB:ENSG00000083720.12

GeneCards: human genes, protein and diseases

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GeneCardsi
OXCT1
HGNCiHGNC:8527 OXCT1
HPAiHPA012047
HPA061425
MalaCardsiOXCT1
MIMi245050 phenotype
601424 gene
neXtProtiNX_P55809
OpenTargetsiENSG00000083720
Orphaneti832 Succinyl-CoA:3-ketoacid CoA transferase deficiency
PharmGKBiPA32855

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3822 Eukaryota
COG1788 LUCA
COG2057 LUCA
GeneTreeiENSGT00390000009130
HOGENOMiHOG000221244
HOVERGENiHBG002310
InParanoidiP55809
KOiK01027
OMAiNPAYSGE
OrthoDBiEOG091G0D3X
PhylomeDBiP55809
TreeFamiTF313991

Enzyme and pathway databases

UniPathwayi
UPA00929;UER00894

BioCyciMetaCyc:HS01447-MONOMER
BRENDAi2.8.3.5 2681
ReactomeiR-HSA-77108 Utilization of Ketone Bodies

Miscellaneous databases

EvolutionaryTraceiP55809

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
OXCT1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
5019

Protein Ontology

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PROi
PR:P55809

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000083720 Expressed in 233 organ(s), highest expression level in middle temporal gyrus
CleanExiHS_OXCT1
ExpressionAtlasiP55809 baseline and differential
GenevisibleiP55809 HS

Family and domain databases

InterProiView protein in InterPro
IPR012792 3-oxoacid_CoA-transf_A
IPR012791 3-oxoacid_CoA-transf_B
IPR014388 3-oxoacid_CoA-transferase
IPR004165 CoA_trans_fam_I
IPR004164 CoA_transf_AS
IPR004163 CoA_transf_BS
IPR037171 NagB/RpiA_transferase-like
PANTHERiPTHR13707 PTHR13707, 1 hit
PfamiView protein in Pfam
PF01144 CoA_trans, 2 hits
PIRSFiPIRSF000858 SCOT-t, 1 hit
SMARTiView protein in SMART
SM00882 CoA_trans, 2 hits
SUPFAMiSSF100950 SSF100950, 2 hits
TIGRFAMsiTIGR02429 pcaI_scoA_fam, 1 hit
TIGR02428 pcaJ_scoB_fam, 1 hit
PROSITEiView protein in PROSITE
PS01273 COA_TRANSF_1, 1 hit
PS01274 COA_TRANSF_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSCOT1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P55809
Secondary accession number(s): B2R5V2, B7Z528
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: December 5, 2018
This is version 175 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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