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Protein

Heterogeneous nuclear ribonucleoprotein H2

Gene

HNRNPH2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Binds poly(RG).

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding

Enzyme and pathway databases

ReactomeiR-HSA-72163 mRNA Splicing - Major Pathway
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA

Names & Taxonomyi

Protein namesi
Recommended name:
Heterogeneous nuclear ribonucleoprotein H2
Short name:
hnRNP H2
Alternative name(s):
FTP-3
Heterogeneous nuclear ribonucleoprotein H'
Short name:
hnRNP H'
Cleaved into the following chain:
Gene namesi
Name:HNRNPH2
Synonyms:FTP3, HNRPH2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000126945.8
HGNCiHGNC:5042 HNRNPH2
MIMi300610 gene
neXtProtiNX_P55795

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Mental retardation, X-linked, syndromic, Bain type (MRXSB)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of mental retardation, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRXSB patients manifest developmental delay, intellectual disability, autism, hypotonia, seizures, and dysmorphic facial features. Only females are affected.
See also OMIM:300986
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_077233206R → Q in MRXSB. 1 PublicationCorresponds to variant dbSNP:rs886039764EnsemblClinVar.1
Natural variantiVAR_077234206R → W in MRXSB. 1 PublicationCorresponds to variant dbSNP:rs886039763EnsemblClinVar.1
Natural variantiVAR_077235209P → L in MRXSB. 1 Publication1

Keywords - Diseasei

Disease mutation, Mental retardation

Organism-specific databases

DisGeNETi3188
MalaCardsiHNRNPH2
MIMi300986 phenotype
OpenTargetsiENSG00000126945
PharmGKBiPA162391316

Polymorphism and mutation databases

BioMutaiHNRNPH2
DMDMi2500576

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000818591 – 449Heterogeneous nuclear ribonucleoprotein H2Add BLAST449
Initiator methionineiRemoved; alternateBy similarity
ChainiPRO_00004343852 – 449Heterogeneous nuclear ribonucleoprotein H2, N-terminally processedAdd BLAST448

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1 Publication1
Modified residuei2N-acetylmethionine; in Heterogeneous nuclear ribonucleoprotein H2, N-terminally processedBy similarity1
Modified residuei23PhosphoserineBy similarity1
Cross-linki35Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei54PhosphoserineBy similarity1
Modified residuei63PhosphoserineBy similarity1
Cross-linki87Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei90PhosphoserineBy similarity1
Cross-linki98Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei233Dimethylated arginine; alternateBy similarity1
Modified residuei233Omega-N-methylarginine; alternateCombined sources1
Modified residuei246PhosphotyrosineBy similarity1
Modified residuei310PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP55795
MaxQBiP55795
PaxDbiP55795
PeptideAtlasiP55795
PRIDEiP55795
ProteomicsDBi56867

2D gel databases

REPRODUCTION-2DPAGEiIPI00026230

PTM databases

iPTMnetiP55795
PhosphoSitePlusiP55795
SwissPalmiP55795

Expressioni

Tissue specificityi

Expressed ubiquitously.

Gene expression databases

BgeeiENSG00000126945 Expressed in 238 organ(s), highest expression level in choroid plexus epithelium
CleanExiHS_HNRNPH2
GenevisibleiP55795 HS

Organism-specific databases

HPAiCAB004436
HPA000914
HPA001359
HPA016884

Interactioni

Subunit structurei

Interacts with TXNL4/DIM1.1 Publication

Binary interactionsi

Protein-protein interaction databases

BioGridi109429, 191 interactors
IntActiP55795, 95 interactors
MINTiP55795
STRINGi9606.ENSP00000361927

Structurei

Secondary structure

1449
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP55795
SMRiP55795
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP55795

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 90RRM 1PROSITE-ProRule annotationAdd BLAST80
Domaini111 – 188RRM 2PROSITE-ProRule annotationAdd BLAST78
Repeati234 – 2491-1Add BLAST16
Domaini289 – 364RRM 3PROSITE-ProRule annotationAdd BLAST76
Repeati354 – 3722-1Add BLAST19
Repeati374 – 3922-2Add BLAST19
Repeati418 – 4331-2Add BLAST16

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni234 – 4332 X 16 AA Gly-rich approximate repeatsAdd BLAST200
Regioni354 – 3922 X 19 AA perfect repeatsAdd BLAST39

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4211 Eukaryota
ENOG410Z6M0 LUCA
GeneTreeiENSGT00760000119102
HOGENOMiHOG000220896
HOVERGENiHBG055557
InParanoidiP55795
KOiK12898
OMAiGTADAYF
OrthoDBiEOG091G0CTJ
PhylomeDBiP55795
TreeFamiTF316157

Family and domain databases

Gene3Di3.30.70.330, 3 hits
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR012996 Znf_CHHC
PfamiView protein in Pfam
PF00076 RRM_1, 3 hits
PF08080 zf-RNPHF, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 3 hits
SUPFAMiSSF54928 SSF54928, 3 hits
PROSITEiView protein in PROSITE
PS50102 RRM, 3 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55795-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMLSTEGREG FVVKVRGLPW SCSADEVMRF FSDCKIQNGT SGIRFIYTRE
60 70 80 90 100
GRPSGEAFVE LESEEEVKLA LKKDRETMGH RYVEVFKSNS VEMDWVLKHT
110 120 130 140 150
GPNSPDTAND GFVRLRGLPF GCSKEEIVQF FSGLEIVPNG MTLPVDFQGR
160 170 180 190 200
STGEAFVQFA SQEIAEKALK KHKERIGHRY IEIFKSSRAE VRTHYDPPRK
210 220 230 240 250
LMAMQRPGPY DRPGAGRGYN SIGRGAGFER MRRGAYGGGY GGYDDYGGYN
260 270 280 290 300
DGYGFGSDRF GRDLNYCFSG MSDHRYGDGG SSFQSTTGHC VHMRGLPYRA
310 320 330 340 350
TENDIYNFFS PLNPMRVHIE IGPDGRVTGE ADVEFATHED AVAAMAKDKA
360 370 380 390 400
NMQHRYVELF LNSTAGTSGG AYDHSYVELF LNSTAGASGG AYGSQMMGGM
410 420 430 440
GLSNQSSYGG PASQQLSGGY GGGYGGQSSM SGYDQVLQEN SSDYQSNLA
Length:449
Mass (Da):49,264
Last modified:November 1, 1997 - v1
Checksum:iC892523A638F07C7
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_077233206R → Q in MRXSB. 1 PublicationCorresponds to variant dbSNP:rs886039764EnsemblClinVar.1
Natural variantiVAR_077234206R → W in MRXSB. 1 PublicationCorresponds to variant dbSNP:rs886039763EnsemblClinVar.1
Natural variantiVAR_077235209P → L in MRXSB. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U01923 mRNA No translation available.
U78027 Genomic DNA Translation: AAB64202.1
AL035422 Genomic DNA No translation available.
CH471115 Genomic DNA Translation: EAX02864.1
BC130343 mRNA Translation: AAI30344.1
BC130345 mRNA Translation: AAI30346.1
CCDSiCCDS14485.1
RefSeqiNP_001027565.1, NM_001032393.2
NP_062543.1, NM_019597.4
UniGeneiHs.432485

Genome annotation databases

EnsembliENST00000316594; ENSP00000361927; ENSG00000126945
GeneIDi3188
KEGGihsa:3188
UCSCiuc004ehm.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U01923 mRNA No translation available.
U78027 Genomic DNA Translation: AAB64202.1
AL035422 Genomic DNA No translation available.
CH471115 Genomic DNA Translation: EAX02864.1
BC130343 mRNA Translation: AAI30344.1
BC130345 mRNA Translation: AAI30346.1
CCDSiCCDS14485.1
RefSeqiNP_001027565.1, NM_001032393.2
NP_062543.1, NM_019597.4
UniGeneiHs.432485

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WEZNMR-A281-369[»]
1WG5NMR-A103-193[»]
6DG1NMR-A94-194[»]
ProteinModelPortaliP55795
SMRiP55795
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109429, 191 interactors
IntActiP55795, 95 interactors
MINTiP55795
STRINGi9606.ENSP00000361927

PTM databases

iPTMnetiP55795
PhosphoSitePlusiP55795
SwissPalmiP55795

Polymorphism and mutation databases

BioMutaiHNRNPH2
DMDMi2500576

2D gel databases

REPRODUCTION-2DPAGEiIPI00026230

Proteomic databases

EPDiP55795
MaxQBiP55795
PaxDbiP55795
PeptideAtlasiP55795
PRIDEiP55795
ProteomicsDBi56867

Protocols and materials databases

DNASUi3188
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000316594; ENSP00000361927; ENSG00000126945
GeneIDi3188
KEGGihsa:3188
UCSCiuc004ehm.4 human

Organism-specific databases

CTDi3188
DisGeNETi3188
EuPathDBiHostDB:ENSG00000126945.8
GeneCardsiHNRNPH2
HGNCiHGNC:5042 HNRNPH2
HPAiCAB004436
HPA000914
HPA001359
HPA016884
MalaCardsiHNRNPH2
MIMi300610 gene
300986 phenotype
neXtProtiNX_P55795
OpenTargetsiENSG00000126945
PharmGKBiPA162391316
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4211 Eukaryota
ENOG410Z6M0 LUCA
GeneTreeiENSGT00760000119102
HOGENOMiHOG000220896
HOVERGENiHBG055557
InParanoidiP55795
KOiK12898
OMAiGTADAYF
OrthoDBiEOG091G0CTJ
PhylomeDBiP55795
TreeFamiTF316157

Enzyme and pathway databases

ReactomeiR-HSA-72163 mRNA Splicing - Major Pathway
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA

Miscellaneous databases

EvolutionaryTraceiP55795
GeneWikiiHNRPH2
GenomeRNAii3188
PROiPR:P55795
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000126945 Expressed in 238 organ(s), highest expression level in choroid plexus epithelium
CleanExiHS_HNRNPH2
GenevisibleiP55795 HS

Family and domain databases

Gene3Di3.30.70.330, 3 hits
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR012996 Znf_CHHC
PfamiView protein in Pfam
PF00076 RRM_1, 3 hits
PF08080 zf-RNPHF, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 3 hits
SUPFAMiSSF54928 SSF54928, 3 hits
PROSITEiView protein in PROSITE
PS50102 RRM, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiHNRH2_HUMAN
AccessioniPrimary (citable) accession number: P55795
Secondary accession number(s): A1L400, Q9HHA7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 7, 2018
This is version 200 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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