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UniProtKB - P55795 (HNRH2_HUMAN)

Entry version 220 (02 Jun 2021)
Sequence version 1 (01 Nov 1997)
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Protein

Heterogeneous nuclear ribonucleoprotein H2

Gene

HNRNPH2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Binds poly(RG).

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRibonucleoprotein, RNA-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P55795

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-72163, mRNA Splicing - Major Pathway
R-HSA-72203, Processing of Capped Intron-Containing Pre-mRNA

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Heterogeneous nuclear ribonucleoprotein H2
Short name:
hnRNP H2
Alternative name(s):
FTP-3
Heterogeneous nuclear ribonucleoprotein H'
Short name:
hnRNP H'
Cleaved into the following chain:
Heterogeneous nuclear ribonucleoprotein H2, N-terminally processed
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HNRNPH2
Synonyms:FTP3, HNRPH2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:5042, HNRNPH2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		300610, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P55795

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000126945.8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Mental retardation, X-linked, syndromic, Bain type (MRXSB)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA form of mental retardation, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRXSB patients manifest developmental delay, intellectual disability, autism, hypotonia, seizures, and dysmorphic facial features. Only females are affected.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_077233206R → Q in MRXSB. 1 PublicationCorresponds to variant dbSNP:rs886039764EnsemblClinVar.1
Natural variantiVAR_077234206R → W in MRXSB. 1 PublicationCorresponds to variant dbSNP:rs886039763EnsemblClinVar.1
Natural variantiVAR_077235209P → L in MRXSB. 1 PublicationCorresponds to variant dbSNP:rs1555988417EnsemblClinVar.1

Keywords - Diseasei

Disease variant, Mental retardation

Organism-specific databases

DisGeNET

More...DisGeNETi		3188

MalaCards human disease database

More...MalaCardsi		HNRNPH2
MIMi300986, phenotype

Open Targets

More...OpenTargetsi		ENSG00000126945

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162391316

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P55795, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4296005

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		HNRNPH2

Domain mapping of disease mutations (DMDM)

More...DMDMi		2500576

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000818591 – 449Heterogeneous nuclear ribonucleoprotein H2Add BLAST449
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved; alternateBy similarity
ChainiPRO_00004343852 – 449Heterogeneous nuclear ribonucleoprotein H2, N-terminally processedAdd BLAST448

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1 Publication1
Modified residuei2N-acetylmethionine; in Heterogeneous nuclear ribonucleoprotein H2, N-terminally processedBy similarity1
Modified residuei23PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki35Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei54PhosphoserineBy similarity1
Modified residuei63PhosphoserineBy similarity1
Cross-linki87Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei90PhosphoserineBy similarity1
Cross-linki98Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei233Dimethylated arginine; alternateBy similarity1
Modified residuei233Omega-N-methylarginine; alternateCombined sources1
Modified residuei246PhosphotyrosineBy similarity1
Modified residuei310PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P55795

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P55795

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P55795

MaxQB - The MaxQuant DataBase

More...MaxQBi		P55795

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P55795

PeptideAtlas

More...PeptideAtlasi		P55795

PRoteomics IDEntifications database

More...PRIDEi		P55795

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		56867

2D gel databases

REPRODUCTION-2DPAGE

More...REPRODUCTION-2DPAGEi		IPI00026230

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P55795

MetOSite database of methionine sulfoxide sites

More...MetOSitei		P55795

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P55795

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P55795

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed ubiquitously.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000126945, Expressed in islet of Langerhans and 251 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P55795, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P55795, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000126945, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with TXNL4/DIM1.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		109429, 237 interactors

Protein interaction database and analysis system

More...IntActi		P55795, 104 interactors

Molecular INTeraction database

More...MINTi		P55795

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000361927

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P55795, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1449
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P55795

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P55795

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini11 – 90RRM 1PROSITE-ProRule annotationAdd BLAST80
Domaini111 – 188RRM 2PROSITE-ProRule annotationAdd BLAST78
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati234 – 2491-1Add BLAST16
Domaini289 – 364RRM 3PROSITE-ProRule annotationAdd BLAST76
Repeati354 – 3722-1Add BLAST19
Repeati374 – 3922-2Add BLAST19
Repeati418 – 4331-2Add BLAST16

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni234 – 4332 X 16 AA Gly-rich approximate repeatsAdd BLAST200
Regioni354 – 3922 X 19 AA perfect repeatsAdd BLAST39

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4211, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000153503

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_032003_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P55795

Identification of Orthologs from Complete Genome Data

More...OMAi		DEDQFDG

Database of Orthologous Groups

More...OrthoDBi		603679at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P55795

TreeFam database of animal gene trees

More...TreeFami		TF316157

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.70.330, 3 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR000504, RRM_dom
IPR012996, Znf_CHHC

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00076, RRM_1, 3 hits
PF08080, zf-RNPHF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00360, RRM, 3 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF54928, SSF54928, 3 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50102, RRM, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P55795-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMLSTEGREG FVVKVRGLPW SCSADEVMRF FSDCKIQNGT SGIRFIYTRE 
        60         70         80         90        100
GRPSGEAFVE LESEEEVKLA LKKDRETMGH RYVEVFKSNS VEMDWVLKHT 
       110        120        130        140        150
GPNSPDTAND GFVRLRGLPF GCSKEEIVQF FSGLEIVPNG MTLPVDFQGR 
       160        170        180        190        200
STGEAFVQFA SQEIAEKALK KHKERIGHRY IEIFKSSRAE VRTHYDPPRK 
       210        220        230        240        250
LMAMQRPGPY DRPGAGRGYN SIGRGAGFER MRRGAYGGGY GGYDDYGGYN 
       260        270        280        290        300
DGYGFGSDRF GRDLNYCFSG MSDHRYGDGG SSFQSTTGHC VHMRGLPYRA 
       310        320        330        340        350
TENDIYNFFS PLNPMRVHIE IGPDGRVTGE ADVEFATHED AVAAMAKDKA 
       360        370        380        390        400
NMQHRYVELF LNSTAGTSGG AYDHSYVELF LNSTAGASGG AYGSQMMGGM 
       410        420        430        440 
GLSNQSSYGG PASQQLSGGY GGGYGGQSSM SGYDQVLQEN SSDYQSNLA
Length:449
Mass (Da):49,264
Last modified:November 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC892523A638F07C7
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_077233206R → Q in MRXSB. 1 PublicationCorresponds to variant dbSNP:rs886039764EnsemblClinVar.1
Natural variantiVAR_077234206R → W in MRXSB. 1 PublicationCorresponds to variant dbSNP:rs886039763EnsemblClinVar.1
Natural variantiVAR_077235209P → L in MRXSB. 1 PublicationCorresponds to variant dbSNP:rs1555988417EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U01923 mRNA No translation available.
U78027 Genomic DNA Translation: AAB64202.1
AL035422 Genomic DNA No translation available.
CH471115 Genomic DNA Translation: EAX02864.1
BC130343 mRNA Translation: AAI30344.1
BC130345 mRNA Translation: AAI30346.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS14485.1

NCBI Reference Sequences

More...RefSeqi		NP_001027565.1, NM_001032393.2
NP_062543.1, NM_019597.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000316594; ENSP00000361927; ENSG00000126945

Database of genes from NCBI RefSeq genomes

More...GeneIDi		3188

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:3188

UCSC genome browser

More...UCSCi		uc004ehm.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U01923 mRNA No translation available.
U78027 Genomic DNA Translation: AAB64202.1
AL035422 Genomic DNA No translation available.
CH471115 Genomic DNA Translation: EAX02864.1
BC130343 mRNA Translation: AAI30344.1
BC130345 mRNA Translation: AAI30346.1
CCDSiCCDS14485.1
RefSeqiNP_001027565.1, NM_001032393.2
NP_062543.1, NM_019597.4

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WEZNMR-A281-369[»]
1WG5NMR-A103-193[»]
6DG1NMR-A94-194[»]
SMRiP55795
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi109429, 237 interactors
IntActiP55795, 104 interactors
MINTiP55795
STRINGi9606.ENSP00000361927

Chemistry databases

ChEMBLiCHEMBL4296005

PTM databases

iPTMnetiP55795
MetOSiteiP55795
PhosphoSitePlusiP55795
SwissPalmiP55795

Genetic variation databases

BioMutaiHNRNPH2
DMDMi2500576

2D gel databases

REPRODUCTION-2DPAGEiIPI00026230

Proteomic databases

EPDiP55795
jPOSTiP55795
MassIVEiP55795
MaxQBiP55795
PaxDbiP55795
PeptideAtlasiP55795
PRIDEiP55795
ProteomicsDBi56867

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		343, 139 antibodies

The DNASU plasmid repository

More...DNASUi		3188

Genome annotation databases

EnsembliENST00000316594; ENSP00000361927; ENSG00000126945
GeneIDi3188
KEGGihsa:3188
UCSCiuc004ehm.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		3188
DisGeNETi3188

GeneCards: human genes, protein and diseases

More...GeneCardsi		HNRNPH2
HGNCiHGNC:5042, HNRNPH2
HPAiENSG00000126945, Low tissue specificity
MalaCardsiHNRNPH2
MIMi300610, gene
300986, phenotype
neXtProtiNX_P55795
OpenTargetsiENSG00000126945
PharmGKBiPA162391316
VEuPathDBiHostDB:ENSG00000126945.8

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4211, Eukaryota
GeneTreeiENSGT00940000153503
HOGENOMiCLU_032003_1_0_1
InParanoidiP55795
OMAiDEDQFDG
OrthoDBi603679at2759
PhylomeDBiP55795
TreeFamiTF316157

Enzyme and pathway databases

PathwayCommonsiP55795
ReactomeiR-HSA-72163, mRNA Splicing - Major Pathway
R-HSA-72203, Processing of Capped Intron-Containing Pre-mRNA

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		3188, 10 hits in 623 CRISPR screens
EvolutionaryTraceiP55795

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		HNRPH2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		3188
PharosiP55795, Tbio

Protein Ontology

More...PROi		PR:P55795
RNActiP55795, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000126945, Expressed in islet of Langerhans and 251 other tissues
ExpressionAtlasiP55795, baseline and differential
GenevisibleiP55795, HS

Family and domain databases

Gene3Di3.30.70.330, 3 hits
InterProiView protein in InterPro
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR000504, RRM_dom
IPR012996, Znf_CHHC
PfamiView protein in Pfam
PF00076, RRM_1, 3 hits
PF08080, zf-RNPHF, 1 hit
SMARTiView protein in SMART
SM00360, RRM, 3 hits
SUPFAMiSSF54928, SSF54928, 3 hits
PROSITEiView protein in PROSITE
PS50102, RRM, 3 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHNRH2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P55795
Secondary accession number(s): A1L400, Q9HHA7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: June 2, 2021
This is version 220 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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