GFER

Functionⁱ

Isoform 1: FAD-dependent sulfhydryl oxidase that regenerates the redox-active disulfide bonds in CHCHD4/MIA40, a chaperone essential for disulfide bond formation and protein folding in the mitochondrial intermembrane space. The reduced form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with GFER/ERV1, resulting in regeneration of the essential disulfide bonds in CHCHD4/MIA40, while GFER/ERV1 becomes re-oxidized by donating electrons to cytochrome c or molecular oxygen.6 Publications

Isoform 2: May act as an autocrine hepatotrophic growth factor promoting liver regeneration.

Catalytic activityⁱ

2 R'C(R)SH + O₂ = R'C(R)S-S(R)CR' + H₂O₂.2 Publications

Cofactorⁱ

FADPROSITE-ProRule annotation2 Publications

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	111	FAD1 Publication		1
Binding siteⁱ	140	FAD1 Publication		1

Regions

Feature key	Position(s)	DescriptionActions	Length
Nucleotide bindingⁱ	99 – 107	FAD1 Publication	9
Nucleotide bindingⁱ	171 – 183	FAD1 PublicationAdd BLAST	13
Nucleotide bindingⁱ	194 – 195	FAD1 Publication	2

GO - Molecular functionⁱ

flavin adenine dinucleotide binding
Source: UniProtKB
Inferred from direct assayⁱ
- 22224850
flavin-linked sulfhydryl oxidase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
growth factor activity Source: UniProtKB-KW
protein disulfide oxidoreductase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 22224850

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Growth factor, Oxidoreductase
Ligand	FAD, Flavoprotein

Enzyme and pathway databases

BRENDAⁱ	1.8.3.2 2681
Reactomeⁱ	R-HSA-1268020 Mitochondrial protein import
SIGNORⁱ	P55789

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: FAD-linked sulfhydryl oxidase ALR (EC:1.8.3.2) Alternative name(s): Augmenter of liver regeneration Short name: hERV1 Hepatopoietin
Gene namesⁱ	Name:GFER Synonyms:ALR, HERV1, HPO
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 16

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000127554.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:4236 GFER
MIMⁱ	600924 gene
neXtProtⁱ	NX_P55789

Keywords - Cellular componentⁱ

Cytoplasm, Mitochondrion, Secreted

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Myopathy, mitochondrial progressive, with congenital cataract, hearing loss and developmental delay (MPMCHD)2 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA disease characterized by progressive myopathy and partial combined respiratory-chain deficiency, congenital cataract, sensorineural hearing loss, and developmental delay.

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_063435	194	R → H in MPMCHD; less stable than the wild-type protein within the mitochondria, increased rate of dissociation of FAD by about 45-fold. 2 PublicationsCorresponds to variant dbSNP:rs121908192EnsemblClinVar.		1

Keywords - Diseaseⁱ

Cataract, Deafness, Disease mutation, Primary mitochondrial disease

Organism-specific databases

DisGeNET More...DisGeNETⁱ	2671
MalaCards human disease database More...MalaCardsⁱ	GFER
MIMⁱ	613076 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000127554
Orphanetⁱ	330054 Congenital cataract-progressive muscular hypotonia-hearing loss-developmental delay syndrome
PharmGKBⁱ	PA28648

Chemistry databases

ChEMBLⁱ	CHEMBL1741189
Drug and drug target database More...DrugBankⁱ	DB03147 Flavin adenine dinucleotide

Polymorphism and mutation databases

BioMutaⁱ	GFER
DMDMⁱ	218511915

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000208548	1 – 205	FAD-linked sulfhydryl oxidase ALRAdd BLAST		205

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	59	PhosphoserineCombined sources	1
Disulfide bondⁱ	95	Interchain (with C-204)
Disulfide bondⁱ	142 ↔ 145	Redox-active
Disulfide bondⁱ	171 ↔ 188
Disulfide bondⁱ	204	Interchain (with C-95)

Keywords - PTMⁱ

Disulfide bond, Phosphoprotein

Proteomic databases

EPDⁱ	P55789
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P55789
PaxDbⁱ	P55789
PeptideAtlas More...PeptideAtlasⁱ	P55789
PRIDEⁱ	P55789
ProteomicsDBⁱ	56865 56866 [P55789-2]

PTM databases

iPTMnetⁱ	P55789
PhosphoSitePlusⁱ	P55789

Expressionⁱ

Tissue specificityⁱ

Gene expression databases

Bgeeⁱ	ENSG00000127554 Expressed in 172 organ(s), highest expression level in mucosa of transverse colon
CleanExⁱ	HS_GFER
ExpressionAtlasⁱ	P55789 baseline and differential
Genevisibleⁱ	P55789 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA041227 HPA063553

HPAⁱ

HPA041227
HPA063553

Interactionⁱ

Subunit structureⁱ

Homodimer; disulfide-linked. May form heterodimers of isoform 1 and isoform 2 (PubMed:12180965, PubMed:20593814, PubMed:21383138, PubMed:22224850). Interacts with CHCHD4/MIA40 (PubMed:23676665, PubMed:21383138).5 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
PLEKHF2	Q9H8W4	3	EBI-718281,EBI-742388

With

Entry

#Exp.

IntAct

Notes

PLEKHF2

Q9H8W4

3

EBI-718281,EBI-742388

GO - Molecular functionⁱ

growth factor activity Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	108939, 58 interactors
IntActⁱ	P55789, 8 interactors
Molecular INTeraction database More...MINTⁱ	P55789
STRINGⁱ	9606.ENSP00000248114

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	86 – 88	Combined sources	3
Beta strandⁱ	93 – 95	Combined sources	3
Helixⁱ	99 – 115	Combined sources	17
Helixⁱ	123 – 139	Combined sources	17
Helixⁱ	143 – 155	Combined sources	13
Helixⁱ	163 – 180	Combined sources	18
Helixⁱ	188 – 190	Combined sources	3
Helixⁱ	191 – 195	Combined sources	5

Show more details

3D structure databases

ProteinModelPortalⁱ	P55789
SMRⁱ	P55789
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

P55789

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	95 – 195	ERV/ALR sulfhydryl oxidasePROSITE-ProRule annotationAdd BLAST		101

Phylogenomic databases

eggNOGⁱ	KOG3355 Eukaryota COG5054 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000001979
HOGENOMⁱ	HOG000195924
HOVERGENⁱ	HBG000235
InParanoidⁱ	P55789
KEGG Orthology (KO) More...KOⁱ	K17783
OMAⁱ	FWEERWR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0TRW
PhylomeDBⁱ	P55789
TreeFamⁱ	TF105271

Family and domain databases

Gene3Dⁱ	1.20.120.310, 1 hit
InterProⁱ	View protein in InterPro IPR039799 ALR/ERV IPR036774 ERV/ALR_sulphydryl_oxid_sf IPR017905 ERV/ALR_sulphydryl_oxidase
PANTHERⁱ	PTHR12645 PTHR12645, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04777 Evr1_Alr, 1 hit
SUPFAMⁱ	SSF69000 SSF69000, 1 hit
PROSITEⁱ	View protein in PROSITE PS51324 ERV_ALR, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P55789-1) [UniParc]FASTA Add to basket

Also known as: HPO-205, lfALR

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAPGERGRF HGGNLFFLPG GARSEMMDDL ATDARGRGAG RRDAAASAST 
        60         70         80         90        100
PAQAPTSDSP VAEDASRRRP CRACVDFKTW MRTQQKRDTK FREDCPPDRE 
       110        120        130        140        150
ELGRHSWAVL HTLAAYYPDL PTPEQQQDMA QFIHLFSKFY PCEECAEDLR 
       160        170        180        190        200
KRLCRNHPDT RTRACFTQWL CHLHNEVNRK LGKPDFDCSK VDERWRDGWK 

DGSCD

Length:205

Mass (Da):23,449

Last modified:December 16, 2008 - v2

Checksum:ⁱ43CBF8CCB5BA91C8

GO

Isoform 2 (identifier: P55789-2) [UniParc]FASTA Add to basket

Also known as: HPO-125, sfALR

The sequence of this isoform differs from the canonical sequence as follows:
1-80: Missing.

« Hide

        10         20         30         40         50
MRTQQKRDTK FREDCPPDRE ELGRHSWAVL HTLAAYYPDL PTPEQQQDMA 
        60         70         80         90        100
QFIHLFSKFY PCEECAEDLR KRLCRNHPDT RTRACFTQWL CHLHNEVNRK 
       110        120 
LGKPDFDCSK VDERWRDGWK DGSCD

Show »

Length:125

Mass (Da):15,029

Checksum:ⁱ3F0B927DC64EF606

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

H3BQQ4	H3BQQ4_HUMAN	Sulfhydryl oxidase Sulfhydryl oxidase, EC 1.8.3.2	GFER hCG_42694	130	Annotation score:
H3BRD2	H3BRD2_HUMAN	Sulfhydryl oxidase Sulfhydryl oxidase, EC 1.8.3.2	GFER	139	Annotation score:
H3BRW3	H3BRW3_HUMAN	FAD-linked sulfhydryl oxidase ALR FAD-linked sulfhydryl oxidase ALR	GFER	109	Annotation score:

Sequence cautionⁱ

The sequence AAA96390 differs from that shown. Reason: Frameshift at position 70.Curated

The sequence AAD36986 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence AAD56538 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence AAH02429 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence AAH28348 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	30	L → S in AAA96390 (PubMed:10712775).Curated	1
Sequence conflictⁱ	127	Q → R in AAG38105 (Ref. 3) Curated	1
Sequence conflictⁱ	180	K → E in AAG38105 (Ref. 3) Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_061994	166	F → L. Corresponds to variant dbSNP:rs36041021EnsemblClinVar.		1
Natural variantⁱVAR_063435	194	R → H in MPMCHD; less stable than the wild-type protein within the mitochondria, increased rate of dissociation of FAD by about 45-fold. 2 PublicationsCorresponds to variant dbSNP:rs121908192EnsemblClinVar.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_040393	1 – 80	Missing in isoform 2. 2 PublicationsAdd BLAST		80

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF183892 Genomic DNA Translation: AAD56538.1 Different initiation. AF124604 mRNA Translation: AAD17328.1 AF306863 mRNA Translation: AAG38105.1 AY550027 mRNA Translation: AAS55642.1 AC005606 Genomic DNA No translation available. BC002429 mRNA Translation: AAH02429.1 Different initiation. BC028348 mRNA Translation: AAH28348.2 Different initiation. AF146394 Genomic DNA Translation: AAD36986.1 Different initiation. U31176 mRNA Translation: AAA96390.2 Frameshift.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS32368.1 [P55789-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_005253.3, NM_005262.2 [P55789-1]
UniGeneⁱ	Hs.27184

Genome annotation databases

Ensemblⁱ	ENST00000248114; ENSP00000248114; ENSG00000127554 [P55789-1]
GeneIDⁱ	2671
KEGGⁱ	hsa:2671
UCSC genome browser More...UCSCⁱ	uc002cob.4 human [P55789-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P55789	Isoform 2 of FAD-linked sulfhydryl oxidase ALR		HUMAN		125	UniRef100_P55789
Sulfhydryl oxidase (Fragment)		PONAB		139
Sulfhydryl oxidase (Fragment)		HUMAN		139

Protein	Similar proteins		Species	Score	Length	Source
P55789	Isoform 2 of FAD-linked sulfhydryl oxidase ALR		HUMAN		125	UniRef90_P55789
Sulfhydryl oxidase (Fragment)		PONAB		139
Sulfhydryl oxidase		CALJA		206
FAD-linked sulfhydryl oxidase ALR isoform X1		BALAS		206
Sulfhydryl oxidase		PROCO		206
+48

Protein	Similar proteins		Species	Score	Length	Source
P55789	FAD-linked sulfhydryl oxidase ALR		MOUSE		198	UniRef50_P55789
FAD-linked sulfhydryl oxidase ALR	)	RAT		198
Isoform 2 of FAD-linked sulfhydryl oxidase ALR		HUMAN		125
Sulfhydryl oxidase (Fragment)		PONAB		139
Sulfhydryl oxidase		NEOSC		206
+129

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF183892 Genomic DNA Translation: AAD56538.1 Different initiation. AF124604 mRNA Translation: AAD17328.1 AF306863 mRNA Translation: AAG38105.1 AY550027 mRNA Translation: AAS55642.1 AC005606 Genomic DNA No translation available. BC002429 mRNA Translation: AAH02429.1 Different initiation. BC028348 mRNA Translation: AAH28348.2 Different initiation. AF146394 Genomic DNA Translation: AAD36986.1 Different initiation. U31176 mRNA Translation: AAA96390.2 Frameshift.
CCDSⁱ	CCDS32368.1 [P55789-1]
RefSeqⁱ	NP_005253.3, NM_005262.2 [P55789-1]
UniGeneⁱ	Hs.27184

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3MBG	X-ray	1.85	A/B/C	81-205	[»]
	3O55	X-ray	1.90	A	81-205	[»]
	3TK0	X-ray	1.61	A	81-205	[»]
	3U2L	X-ray	1.95	A	91-205	[»]
	3U2M	X-ray	2.00	A	91-205	[»]
	3U5S	X-ray	1.50	A	82-203	[»]
	4LDK	X-ray	2.04	A	81-205	[»]
ProteinModelPortalⁱ	P55789
SMRⁱ	P55789
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	108939, 58 interactors
IntActⁱ	P55789, 8 interactors
MINTⁱ	P55789
STRINGⁱ	9606.ENSP00000248114

Chemistry databases

ChEMBLⁱ	CHEMBL1741189
DrugBankⁱ	DB03147 Flavin adenine dinucleotide

PTM databases

iPTMnetⁱ	P55789
PhosphoSitePlusⁱ	P55789

Polymorphism and mutation databases

BioMutaⁱ	GFER
DMDMⁱ	218511915

Proteomic databases

EPDⁱ	P55789
MaxQBⁱ	P55789
PaxDbⁱ	P55789
PeptideAtlasⁱ	P55789
PRIDEⁱ	P55789
ProteomicsDBⁱ	56865 56866 [P55789-2]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000248114; ENSP00000248114; ENSG00000127554 [P55789-1]
GeneIDⁱ	2671
KEGGⁱ	hsa:2671
UCSCⁱ	uc002cob.4 human [P55789-1]

Organism-specific databases

CTDⁱ	2671
DisGeNETⁱ	2671
EuPathDBⁱ	HostDB:ENSG00000127554.12
GeneCardsⁱ	GFER
H-InvDBⁱ	HIX0012707
HGNCⁱ	HGNC:4236 GFER
HPAⁱ	HPA041227 HPA063553
MalaCardsⁱ	GFER
MIMⁱ	600924 gene 613076 phenotype
neXtProtⁱ	NX_P55789
OpenTargetsⁱ	ENSG00000127554
Orphanetⁱ	330054 Congenital cataract-progressive muscular hypotonia-hearing loss-developmental delay syndrome
PharmGKBⁱ	PA28648
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3355 Eukaryota COG5054 LUCA
GeneTreeⁱ	ENSGT00390000001979
HOGENOMⁱ	HOG000195924
HOVERGENⁱ	HBG000235
InParanoidⁱ	P55789
KOⁱ	K17783
OMAⁱ	FWEERWR
OrthoDBⁱ	EOG091G0TRW
PhylomeDBⁱ	P55789
TreeFamⁱ	TF105271

Enzyme and pathway databases

BRENDAⁱ	1.8.3.2 2681
Reactomeⁱ	R-HSA-1268020 Mitochondrial protein import
SIGNORⁱ	P55789

Miscellaneous databases

EvolutionaryTraceⁱ	P55789
GeneWikiⁱ	GFER
GenomeRNAiⁱ	2671
Protein Ontology More...PROⁱ	PR:P55789
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000127554 Expressed in 172 organ(s), highest expression level in mucosa of transverse colon
CleanExⁱ	HS_GFER
ExpressionAtlasⁱ	P55789 baseline and differential
Genevisibleⁱ	P55789 HS

Family and domain databases

Gene3Dⁱ	1.20.120.310, 1 hit
InterProⁱ	View protein in InterPro IPR039799 ALR/ERV IPR036774 ERV/ALR_sulphydryl_oxid_sf IPR017905 ERV/ALR_sulphydryl_oxidase
PANTHERⁱ	PTHR12645 PTHR12645, 1 hit
Pfamⁱ	View protein in Pfam PF04777 Evr1_Alr, 1 hit
SUPFAMⁱ	SSF69000 SSF69000, 1 hit
PROSITEⁱ	View protein in PROSITE PS51324 ERV_ALR, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ALR_HUMAN
Accessionⁱ	P55789Primary (citable) accession number: P55789 Secondary accession number(s): Q53YM6 , Q8TAH6, Q9H290, Q9UK40
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	December 16, 2008
	Last modified:	November 7, 2018
	This is version 162 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - P55789 (ALR_HUMAN)

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FAD-linked sulfhydryl oxidase ALR

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Mitochondrion

Extracellular region or secreted

Other locations

Cytosol

Extracellular region or secreted

Mitochondrion

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ