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UniProtKB - P55786 (PSA_HUMAN)

Entry version 192 (02 Dec 2020)
Sequence version 2 (31 Aug 2004)
Previous versions | rss
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Protein

Puromycin-sensitive aminopeptidase

Gene

NPEPPS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Aminopeptidase with broad substrate specificity for several peptides. Involved in proteolytic events essential for cell growth and viability. May act as regulator of neuropeptide activity. Plays a role in the antigen-processing pathway for MHC class I molecules. Involved in the N-terminal trimming of cytotoxic T-cell epitope precursors. Digests the poly-Q peptides found in many cellular proteins. Digests tau from normal brain more efficiently than tau from Alzheimer disease brain.5 Publications

Caution

It is uncertain whether Met-1 or Met-45 is the initiator. N-terminal sequencing in PubMed:10978616 suggests that Met-45 is used, followed by methionine initiator removal.Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Release of an N-terminal amino acid, preferentially alanine, from a wide range of peptides, amides and arylamides. EC:3.4.11.14

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Strongly inhibited by bestatin, leuhistin, actinonin, amastatin, 1,10-phenanthroline, DFP, PCMBS, Zn2+, Cd2+, Co2+, Cu2+, Hg2+, EDTA and puromycin. Not inhibited by PMSF, and only slightly inhibited by leupeptin and aprotinin. Activity is increased by Mg2+ and Ca2+.3 Publications

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=2.20 mM for Lys-p-NA2 Publications
  2. KM=0.25 mM for Leu-p-NA2 Publications
  3. KM=0.27 mM for Ala-p-NA2 Publications
  4. KM=0.80 mM for Met-p-NA2 Publications
  5. KM=0.47 mM for Pro-p-NA2 Publications
  6. KM=0.21 mM for Val-p-NA2 Publications
  7. KM=182 µM for Ala-MCA2 Publications
  8. KM=189 µM for Met-MCA2 Publications
  9. KM=220 µM for Lys-MCA2 Publications
  10. KM=91 µM for Leu-MCA2 Publications
  11. KM=167 µM for Phe-MCA2 Publications

    pH dependencei

    Optimum pH is 7.5. Stable from pH 5.0 to 8.0.2 Publications

    Temperature dependencei

    Stable up to 40 degrees Celsius.2 Publications

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei180SubstrateBy similarity1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi352Zinc; catalyticPROSITE-ProRule annotation1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei353Proton acceptorPROSITE-ProRule annotation1
    Metal bindingi356Zinc; catalyticPROSITE-ProRule annotation1
    Metal bindingi375Zinc; catalyticPROSITE-ProRule annotation1
    <p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei438Transition state stabilizerBy similarity1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    Complete GO annotation on QuickGO ...

    GO - Biological processi

    Complete GO annotation on QuickGO ...

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionAminopeptidase, Hydrolase, Metalloprotease, Protease
    LigandMetal-binding, Zinc

    Enzyme and pathway databases

    Pathway Commons web resource for biological pathway data

    More...    PathwayCommonsi    		P55786

    Reactome - a knowledgebase of biological pathways and processes

    More...    Reactomei    		R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...    SABIO-RKi    		P55786

    Protein family/group databases

    MEROPS protease database

    More...    MEROPSi    		M01.010

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Puromycin-sensitive aminopeptidase (EC:3.4.11.14)
    Short name:
    PSA
    Alternative name(s):
    Cytosol alanyl aminopeptidase
    Short name:
    AAP-S
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:NPEPPS
    Synonyms:PSA
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

    Organism-specific databases

    Eukaryotic Pathogen and Host Database Resources

    More...    EuPathDBi    		HostDB:ENSG00000141279.15

    Human Gene Nomenclature Database

    More...    HGNCi    		HGNC:7900, NPEPPS

    Online Mendelian Inheritance in Man (OMIM)

    More...    MIMi    		606793, gene

    neXtProt; the human protein knowledge platform

    More...    neXtProti    		NX_P55786

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi353E → A: Reduces catalytic activity by 25,000-fold to 100,000-fold. 1 Publication1
    Mutagenesisi353E → Q: Reduces catalytic activity by 5,000-fold to 15,000-fold. 1 Publication1
    Mutagenesisi353E → V: Reduces catalytic activity by 300,000-fold to 500,000-fold. 1 Publication1
    Mutagenesisi438Y → F: Reduces catalytic activity by 1,000-fold to 2,500-fold. 1 Publication1

    Organism-specific databases

    DisGeNET

    More...    DisGeNETi    		9520

    Open Targets

    More...    OpenTargetsi    		ENSG00000141279

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...    PharmGKBi    		PA31703

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...    Pharosi    		P55786, Tchem

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...    ChEMBLi    		CHEMBL2264

    Drug and drug target database

    More...    DrugBanki    		DB11638, Artenimol
    DB11781, Tosedostat

    IUPHAR/BPS Guide to PHARMACOLOGY

    More...    GuidetoPHARMACOLOGYi    		1575

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...    BioMutai    		NPEPPS

    Domain mapping of disease mutations (DMDM)

    More...    DMDMi    		51704228

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000951161 – 919Puromycin-sensitive aminopeptidaseAdd BLAST919

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei4643'-nitrotyrosineBy similarity1

    Keywords - PTMi

    Nitration

    Proteomic databases

    The CPTAC Assay portal

    More...    CPTACi    		CPTAC-415
    CPTAC-416

    Encyclopedia of Proteome Dynamics

    More...    EPDi    		P55786

    jPOST - Japan Proteome Standard Repository/Database

    More...    jPOSTi    		P55786

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...    MassIVEi    		P55786

    MaxQB - The MaxQuant DataBase

    More...    MaxQBi    		P55786

    PaxDb, a database of protein abundance averages across all three domains of life

    More...    PaxDbi    		P55786

    PeptideAtlas

    More...    PeptideAtlasi    		P55786

    PRoteomics IDEntifications database

    More...    PRIDEi    		P55786

    ProteomicsDB: a multi-organism proteome resource

    More...    ProteomicsDBi    		56864 [P55786-1]
    6572

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...    iPTMneti    		P55786

    MetOSite database of methionine sulfoxide sites

    More...    MetOSitei    		P55786

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...    PhosphoSitePlusi    		P55786

    SwissPalm database of S-palmitoylation events

    More...    SwissPalmi    		P55786

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Detected in liver, epithelium of renal tubules, epithelium of small and large intestine, gastric epithelial cells, and alveoli of the lung (at protein level).1 Publication

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...    Bgeei    		ENSG00000141279, Expressed in right hemisphere of cerebellum and 246 other tissues

    ExpressionAtlas, Differential and Baseline Expression

    More...    ExpressionAtlasi    		P55786, baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...    Genevisiblei    		P55786, HS

    Organism-specific databases

    Human Protein Atlas

    More...    HPAi    		ENSG00000141279, Low tissue specificity

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Monomer.

    1 Publication

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGRID)

    More...    BioGRIDi    		114897, 103 interactors

    Protein interaction database and analysis system

    More...    IntActi    		P55786, 24 interactors

    Molecular INTeraction database

    More...    MINTi    		P55786

    STRING: functional protein association networks

    More...    STRINGi    		9606.ENSP00000320324

    Chemistry databases

    BindingDB database of measured binding affinities

    More...    BindingDBi    		P55786

    Miscellaneous databases

    RNAct, Protein-RNA interaction predictions for model organisms.

    More...    RNActi    		P55786, protein

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...    SMRi    		P55786

    Database of comparative protein structure models

    More...    ModBasei    		Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni316 – 320Substrate bindingBy similarity5

    Motif

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi726 – 730Nuclear localization signalSequence analysis5

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the peptidase M1 family.Curated

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...    eggNOGi    		KOG1046, Eukaryota

    Ensembl GeneTree

    More...    GeneTreei    		ENSGT00940000155246

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...    HOGENOMi    		CLU_003705_0_1_1

    InParanoid: Eukaryotic Ortholog Groups

    More...    InParanoidi    		P55786

    Identification of Orthologs from Complete Genome Data

    More...    OMAi    		MMEYVAI

    Database of Orthologous Groups

    More...    OrthoDBi    		1136568at2759

    Database for complete collections of gene phylogenies

    More...    PhylomeDBi    		P55786

    TreeFam database of animal gene trees

    More...    TreeFami    		TF300395

    Family and domain databases

    Conserved Domains Database

    More...    CDDi    		cd09601, M1_APN-Q_like, 1 hit

    Gene3D Structural and Functional Annotation of Protein Families

    More...    Gene3Di    		2.60.40.1730, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...    InterProi    		View protein in InterPro
    IPR042097, Aminopeptidase_N-like_N
    IPR024571, ERAP1-like_C_dom
    IPR034016, M1_APN-typ
    IPR001930, Peptidase_M1
    IPR014782, Peptidase_M1_dom

    Pfam protein domain database

    More...    Pfami    		View protein in Pfam
    PF11838, ERAP1_C, 1 hit
    PF01433, Peptidase_M1, 1 hit

    Protein Motif fingerprint database; a protein domain database

    More...    PRINTSi    		PR00756, ALADIPTASE

    Superfamily database of structural and functional annotation

    More...    SUPFAMi    		SSF63737, SSF63737, 1 hit

    PROSITE; a protein domain and family database

    More...    PROSITEi    		View protein in PROSITE
    PS00142, ZINC_PROTEASE, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 2 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: P55786-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MWLAAAAPSL ARRLLFLGPP PPPLLLLVFS RSSRRRLHSL GLAAMPEKRP 
            60         70         80         90        100
    FERLPADVSP INYSLCLKPD LLDFTFEGKL EAAAQVRQAT NQIVMNCADI 
           110        120        130        140        150
    DIITASYAPE GDEEIHATGF NYQNEDEKVT LSFPSTLQTG TGTLKIDFVG 
           160        170        180        190        200
    ELNDKMKGFY RSKYTTPSGE VRYAAVTQFE ATDARRAFPC WDEPAIKATF 
           210        220        230        240        250
    DISLVVPKDR VALSNMNVID RKPYPDDENL VEVKFARTPV MSTYLVAFVV 
           260        270        280        290        300
    GEYDFVETRS KDGVCVRVYT PVGKAEQGKF ALEVAAKTLP FYKDYFNVPY 
           310        320        330        340        350
    PLPKIDLIAI ADFAAGAMEN WGLVTYRETA LLIDPKNSCS SSRQWVALVV 
           360        370        380        390        400
    GHELAHQWFG NLVTMEWWTH LWLNEGFASW IEYLCVDHCF PEYDIWTQFV 
           410        420        430        440        450
    SADYTRAQEL DALDNSHPIE VSVGHPSEVD EIFDAISYSK GASVIRMLHD 
           460        470        480        490        500
    YIGDKDFKKG MNMYLTKFQQ KNAATEDLWE SLENASGKPI AAVMNTWTKQ 
           510        520        530        540        550
    MGFPLIYVEA EQVEDDRLLR LSQKKFCAGG SYVGEDCPQW MVPITISTSE 
           560        570        580        590        600
    DPNQAKLKIL MDKPEMNVVL KNVKPDQWVK LNLGTVGFYR TQYSSAMLES 
           610        620        630        640        650
    LLPGIRDLSL PPVDRLGLQN DLFSLARAGI ISTVEVLKVM EAFVNEPNYT 
           660        670        680        690        700
    VWSDLSCNLG ILSTLLSHTD FYEEIQEFVK DVFSPIGERL GWDPKPGEGH 
           710        720        730        740        750
    LDALLRGLVL GKLGKAGHKA TLEEARRRFK DHVEGKQILS ADLRSPVYLT 
           760        770        780        790        800
    VLKHGDGTTL DIMLKLHKQA DMQEEKNRIE RVLGATLLPD LIQKVLTFAL 
           810        820        830        840        850
    SEEVRPQDTV SVIGGVAGGS KHGRKAAWKF IKDNWEELYN RYQGGFLISR 
           860        870        880        890        900
    LIKLSVEGFA VDKMAGEVKA FFESHPAPSA ERTIQQCCEN ILLNAAWLKR 
           910 
    DAESIHQYLL QRKASPPTV
    Length:919
    Mass (Da):103,276
    Last modified:August 31, 2004 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i873C9BF75494A057
    GO
    Isoform 2 (identifier: P55786-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-44: Missing.
         181-216: Missing.

    Show »
    Length:839
    Mass (Da):94,516
    Checksum:iA4D3EBEC951133E7
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    		Gene namesLengthAnnotation
    E9PLK3E9PLK3_HUMAN
    Aminopeptidase
    NPEPPS
    		915Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    E9PJ74E9PJ74_HUMAN
    Puromycin-sensitive aminopeptidase
    NPEPPS
    		158Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    E9PI82E9PI82_HUMAN
    Puromycin-sensitive aminopeptidase
    NPEPPS
    		127Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    E9PRQ5E9PRQ5_HUMAN
    Puromycin-sensitive aminopeptidase
    NPEPPS
    		172Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    H0YDG0H0YDG0_HUMAN
    Puromycin-sensitive aminopeptidase
    NPEPPS
    		169Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    H0YCQ5H0YCQ5_HUMAN
    Puromycin-sensitive aminopeptidase
    NPEPPS
    		65Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    E9PP11E9PP11_HUMAN
    Puromycin-sensitive aminopeptidase
    NPEPPS
    		201Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    E9PJF9E9PJF9_HUMAN
    Puromycin-sensitive aminopeptidase
    NPEPPS
    		134Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    E9PJY4E9PJY4_HUMAN
    Puromycin-sensitive aminopeptidase
    NPEPPS
    		141Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    E9PPZ2E9PPZ2_HUMAN
    Puromycin-sensitive aminopeptidase
    NPEPPS
    		178Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    There is more potential isoformShow all

    <p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence AAH65294 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
    The sequence CAA68964 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti184A → P in CAA68964 (PubMed:9048733).Curated1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0564461 – 44Missing in isoform 2. 1 PublicationAdd BLAST44
    Alternative sequenceiVSP_056447181 – 216Missing in isoform 2. 1 PublicationAdd BLAST36

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...    EMBLi

    GenBank nucleotide sequence database

    More...    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...    DDBJi
    Links Updated
    		Y07701 mRNA Translation: CAA68964.1 Different initiation.
    AK296887 mRNA Translation: BAH12449.1
    AC025682 Genomic DNA No translation available.
    BC065294 mRNA Translation: AAH65294.2 Different initiation.
    AJ132583 mRNA Translation: CAA10709.1
    AF252387 Genomic DNA Translation: AAF70086.1

    The Consensus CDS (CCDS) project

    More...    CCDSi    		CCDS45721.1 [P55786-1]

    NCBI Reference Sequences

    More...    RefSeqi    		NP_001317186.1, NM_001330257.1
    NP_006301.3, NM_006310.3 [P55786-1]

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...    Ensembli    		ENST00000322157; ENSP00000320324; ENSG00000141279 [P55786-1]

    Database of genes from NCBI RefSeq genomes

    More...    GeneIDi    		9520

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...    KEGGi    		hsa:9520

    UCSC genome browser

    More...    UCSCi    		uc002ilr.5, human [P55786-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    		Y07701 mRNA Translation: CAA68964.1 Different initiation.
    AK296887 mRNA Translation: BAH12449.1
    AC025682 Genomic DNA No translation available.
    BC065294 mRNA Translation: AAH65294.2 Different initiation.
    AJ132583 mRNA Translation: CAA10709.1
    AF252387 Genomic DNA Translation: AAF70086.1
    CCDSiCCDS45721.1 [P55786-1]
    RefSeqiNP_001317186.1, NM_001330257.1
    NP_006301.3, NM_006310.3 [P55786-1]

    3D structure databases

    SMRiP55786
    ModBaseiSearch...

    Protein-protein interaction databases

    BioGRIDi114897, 103 interactors
    IntActiP55786, 24 interactors
    MINTiP55786
    STRINGi9606.ENSP00000320324

    Chemistry databases

    BindingDBiP55786
    ChEMBLiCHEMBL2264
    DrugBankiDB11638, Artenimol
    DB11781, Tosedostat
    GuidetoPHARMACOLOGYi1575

    Protein family/group databases

    MEROPSiM01.010

    PTM databases

    iPTMnetiP55786
    MetOSiteiP55786
    PhosphoSitePlusiP55786
    SwissPalmiP55786

    Polymorphism and mutation databases

    BioMutaiNPEPPS
    DMDMi51704228

    Proteomic databases

    CPTACiCPTAC-415
    CPTAC-416
    EPDiP55786
    jPOSTiP55786
    MassIVEiP55786
    MaxQBiP55786
    PaxDbiP55786
    PeptideAtlasiP55786
    PRIDEiP55786
    ProteomicsDBi56864 [P55786-1]
    6572

    Protocols and materials databases

    Antibodypedia a portal for validated antibodies

    More...    Antibodypediai    		8552, 272 antibodies

    Genome annotation databases

    EnsembliENST00000322157; ENSP00000320324; ENSG00000141279 [P55786-1]
    GeneIDi9520
    KEGGihsa:9520
    UCSCiuc002ilr.5, human [P55786-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...    CTDi    		9520
    DisGeNETi9520
    EuPathDBiHostDB:ENSG00000141279.15

    GeneCards: human genes, protein and diseases

    More...    GeneCardsi    		NPEPPS
    HGNCiHGNC:7900, NPEPPS
    HPAiENSG00000141279, Low tissue specificity
    MIMi606793, gene
    neXtProtiNX_P55786
    OpenTargetsiENSG00000141279
    PharmGKBiPA31703

    GenAtlas: human gene database

    More...    GenAtlasi    		Search...

    Phylogenomic databases

    eggNOGiKOG1046, Eukaryota
    GeneTreeiENSGT00940000155246
    HOGENOMiCLU_003705_0_1_1
    InParanoidiP55786
    OMAiMMEYVAI
    OrthoDBi1136568at2759
    PhylomeDBiP55786
    TreeFamiTF300395

    Enzyme and pathway databases

    PathwayCommonsiP55786
    ReactomeiR-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation
    SABIO-RKiP55786

    Miscellaneous databases

    BioGRID ORCS database of CRISPR phenotype screens

    More...    BioGRID-ORCSi    		9520, 255 hits in 847 CRISPR screens

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...    ChiTaRSi    		NPEPPS, human

    The Gene Wiki collection of pages on human genes and proteins

    More...    GeneWikii    		NPEPPS

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...    GenomeRNAii    		9520
    PharosiP55786, Tchem

    Protein Ontology

    More...    PROi    		PR:P55786
    RNActiP55786, protein

    The Stanford Online Universal Resource for Clones and ESTs

    More...    SOURCEi    		Search...

    Gene expression databases

    BgeeiENSG00000141279, Expressed in right hemisphere of cerebellum and 246 other tissues
    ExpressionAtlasiP55786, baseline and differential
    GenevisibleiP55786, HS

    Family and domain databases

    CDDicd09601, M1_APN-Q_like, 1 hit
    Gene3Di2.60.40.1730, 1 hit
    InterProiView protein in InterPro
    IPR042097, Aminopeptidase_N-like_N
    IPR024571, ERAP1-like_C_dom
    IPR034016, M1_APN-typ
    IPR001930, Peptidase_M1
    IPR014782, Peptidase_M1_dom
    PfamiView protein in Pfam
    PF11838, ERAP1_C, 1 hit
    PF01433, Peptidase_M1, 1 hit
    PRINTSiPR00756, ALADIPTASE
    SUPFAMiSSF63737, SSF63737, 1 hit
    PROSITEiView protein in PROSITE
    PS00142, ZINC_PROTEASE, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...    ProtoNeti    		Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...    MobiDBi    		Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPSA_HUMAN
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P55786
    Secondary accession number(s): B7Z463
    , Q6P145, Q9NP16, Q9UEM2
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: August 31, 2004
    Last modified: December 2, 2020
    This is version 192 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing, Reference proteome

    Documents

    1. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families
    3. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    4. Peptidase families
      Classification of peptidase families and list of entries
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