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Protein

C-C motif chemokine 18

Gene

CCL18

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Chemotactic factor that attracts lymphocytes but not monocytes or granulocytes. May be involved in B-cell migration into B-cell follicles in lymph nodes. Attracts naive T-lymphocytes toward dendritic cells and activated macrophages in lymph nodes, has chemotactic activity for naive T-cells, CD4+ and CD8+ T-cells and thus may play a role in both humoral and cell-mediated immunity responses.2 Publications

GO - Molecular functioni

  • CCR chemokine receptor binding Source: GO_Central
  • chemokine activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processChemotaxis, Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 18
Alternative name(s):
Alternative macrophage activation-associated CC chemokine 1
Short name:
AMAC-1
CC chemokine PARC
Dendritic cell chemokine 1
Short name:
DC-CK1
Macrophage inflammatory protein 4
Short name:
MIP-4
Pulmonary and activation-regulated chemokine
Small-inducible cytokine A18
Cleaved into the following 3 chains:
Gene namesi
Name:CCL18
Synonyms:AMAC1, DCCK1, MIP4, PARC, SCYA18
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000275385.1
HGNCiHGNC:10616 CCL18
MIMi603757 gene
neXtProtiNX_P55774

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi6362
OpenTargetsiENSG00000275385
PharmGKBiPA35549

Polymorphism and mutation databases

BioMutaiCCL18
DMDMi2493666

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 201 PublicationAdd BLAST20
ChainiPRO_000000521221 – 89C-C motif chemokine 18Add BLAST69
ChainiPRO_000004185121 – 88CCL18(1-68)Add BLAST68
ChainiPRO_000004185223 – 89CCL18(3-69)Add BLAST67
ChainiPRO_000004185324 – 89CCL18(4-69)Add BLAST66

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi30 ↔ 541 Publication
Disulfide bondi31 ↔ 701 Publication

Post-translational modificationi

The Cys-30/Cys-54 disulfide bond is required for activity.

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP55774
PeptideAtlasiP55774
PRIDEiP55774
ProteomicsDBi56863

Expressioni

Tissue specificityi

Expressed at high levels in lung, lymph nodes, placenta, bone marrow, dendritic cells present in germinal centers and T-cell areas of secondary lymphoid organs and macrophages derived from peripheral blood monocytes. Not expressed by peripheral blood monocytes and a monocyte-to-macrophage differentiation is a prerequisite for expression. Expressed in synovial fluids from patients with rheumatoid and septic arthritis and in ovarian carcinoma ascitic fluid.1 Publication

Inductioni

Specifically induced in macrophages by IL4/interleukin-4, IL13/interleukin-13, and IL10/interleukin-10. Expression is inhibited by IFNG/IFN-gamma while glucocorticoids exert a slightly positive synergistic effect in combination with IL4/interleukin-4. Strongly induced in several human cell lines, including monocytic U-937 cells, by phorbol myristate acetate (PMA). Induced in PBMC by staphylococcal enterotoxins SEA and SEB.1 Publication

Gene expression databases

BgeeiENSG00000275385 Expressed in 141 organ(s), highest expression level in lung
CleanExiHS_AMAC1
HS_CCL18
GenevisibleiP55774 HS

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PITPNM3Q9BZ714EBI-711240,EBI-2815766

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112265, 6 interactors
IntActiP55774, 8 interactors
STRINGi9606.ENSP00000004921

Structurei

Secondary structure

189
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP55774
SMRiP55774
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J0XH Eukaryota
ENOG410ZUYI LUCA
GeneTreeiENSGT00900000140870
HOGENOMiHOG000036685
InParanoidiP55774
KOiK21094
OMAiKEFCCLV
OrthoDBiEOG091G14Y2
PhylomeDBiP55774
TreeFamiTF334888

Family and domain databases

InterProiView protein in InterPro
IPR039809 Chemokine_b/g/d
IPR000827 Chemokine_CC_CS
IPR001811 Chemokine_IL8-like_dom
IPR036048 Interleukin_8-like_sf
PANTHERiPTHR12015 PTHR12015, 1 hit
PfamiView protein in Pfam
PF00048 IL8, 1 hit
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00472 SMALL_CYTOKINES_CC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55774-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKGLAAALLV LVCTMALCSC AQVGTNKELC CLVYTSWQIP QKFIVDYSET
60 70 80
SPQCPKPGVI LLTKRGRQIC ADPNKKWVQK YISDLKLNA
Length:89
Mass (Da):9,849
Last modified:November 1, 1997 - v1
Checksum:iC287B94B9C0518E4
GO

Mass spectrometryi

Molecular mass is 7849.4 Da from positions 21 - 89. Determined by ESI. 1 Publication
Molecular mass is 7652.1 Da from positions 23 - 89. Determined by ESI. 1 Publication
Molecular mass is 7552.0 Da from positions 24 - 89. Determined by ESI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB000221 mRNA Translation: BAA21670.1
Y13710 mRNA Translation: CAA74039.1
AB012113 Genomic DNA Translation: BAA34368.1
AF082214, AF082212, AF082213 Genomic DNA Translation: AAC32287.1
AF111198 Genomic DNA Translation: AAD30390.1
CR407660 mRNA Translation: CAG28588.1
AB451458 mRNA Translation: BAG70272.1
CH471147 Genomic DNA Translation: EAW80102.1
BC069700 mRNA Translation: AAH69700.1
BC096124 mRNA Translation: AAH96124.1
BC096125 mRNA Translation: AAH96125.1
BC096126 mRNA Translation: AAH96126.1
BC096127 mRNA Translation: AAH96127.1
CCDSiCCDS11306.1
RefSeqiNP_002979.1, NM_002988.3
UniGeneiHs.143961

Genome annotation databases

EnsembliENST00000614828; ENSP00000483144; ENSG00000278167
ENST00000615723; ENSP00000483347; ENSG00000278006
ENST00000616054; ENSP00000479955; ENSG00000275385
GeneIDi6362
KEGGihsa:6362
UCSCiuc002hku.4 human

Similar proteinsi

Cross-referencesi

Web resourcesi

Wikipedia

CCL18 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB000221 mRNA Translation: BAA21670.1
Y13710 mRNA Translation: CAA74039.1
AB012113 Genomic DNA Translation: BAA34368.1
AF082214, AF082212, AF082213 Genomic DNA Translation: AAC32287.1
AF111198 Genomic DNA Translation: AAD30390.1
CR407660 mRNA Translation: CAG28588.1
AB451458 mRNA Translation: BAG70272.1
CH471147 Genomic DNA Translation: EAW80102.1
BC069700 mRNA Translation: AAH69700.1
BC096124 mRNA Translation: AAH96124.1
BC096125 mRNA Translation: AAH96125.1
BC096126 mRNA Translation: AAH96126.1
BC096127 mRNA Translation: AAH96127.1
CCDSiCCDS11306.1
RefSeqiNP_002979.1, NM_002988.3
UniGeneiHs.143961

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4MHEX-ray2.10A/B/C/D21-89[»]
ProteinModelPortaliP55774
SMRiP55774
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112265, 6 interactors
IntActiP55774, 8 interactors
STRINGi9606.ENSP00000004921

Polymorphism and mutation databases

BioMutaiCCL18
DMDMi2493666

Proteomic databases

PaxDbiP55774
PeptideAtlasiP55774
PRIDEiP55774
ProteomicsDBi56863

Protocols and materials databases

DNASUi6362
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000614828; ENSP00000483144; ENSG00000278167
ENST00000615723; ENSP00000483347; ENSG00000278006
ENST00000616054; ENSP00000479955; ENSG00000275385
GeneIDi6362
KEGGihsa:6362
UCSCiuc002hku.4 human

Organism-specific databases

CTDi6362
DisGeNETi6362
EuPathDBiHostDB:ENSG00000275385.1
GeneCardsiCCL18
HGNCiHGNC:10616 CCL18
MIMi603757 gene
neXtProtiNX_P55774
OpenTargetsiENSG00000275385
PharmGKBiPA35549
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J0XH Eukaryota
ENOG410ZUYI LUCA
GeneTreeiENSGT00900000140870
HOGENOMiHOG000036685
InParanoidiP55774
KOiK21094
OMAiKEFCCLV
OrthoDBiEOG091G14Y2
PhylomeDBiP55774
TreeFamiTF334888

Miscellaneous databases

ChiTaRSiCCL18 human
GenomeRNAii6362
PROiPR:P55774
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000275385 Expressed in 141 organ(s), highest expression level in lung
CleanExiHS_AMAC1
HS_CCL18
GenevisibleiP55774 HS

Family and domain databases

InterProiView protein in InterPro
IPR039809 Chemokine_b/g/d
IPR000827 Chemokine_CC_CS
IPR001811 Chemokine_IL8-like_dom
IPR036048 Interleukin_8-like_sf
PANTHERiPTHR12015 PTHR12015, 1 hit
PfamiView protein in Pfam
PF00048 IL8, 1 hit
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00472 SMALL_CYTOKINES_CC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCCL18_HUMAN
AccessioniPrimary (citable) accession number: P55774
Secondary accession number(s): B5BUM2, Q53X71
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 7, 2018
This is version 155 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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