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Protein

C-C motif chemokine 23

Gene

CCL23

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Shows chemotactic activity for monocytes, resting T-lymphocytes, and neutrophils, but not for activated lymphocytes. Inhibits proliferation of myeloid progenitor cells in colony formation assays. This protein can bind heparin. Binds CCR1. CCL23(19-99), CCL23(22-99), CCL23(27-99), CCL23(30-99) are more potent chemoattractants than the small-inducible cytokine A23.1 Publication

GO - Molecular functioni

  • CCR1 chemokine receptor binding Source: UniProtKB
  • chemokine activity Source: UniProtKB
  • heparin binding Source: UniProtKB-KW

GO - Biological processi

  • cell-cell signaling Source: ProtInc
  • cellular calcium ion homeostasis Source: ProtInc
  • cellular response to interferon-gamma Source: GO_Central
  • cellular response to interleukin-1 Source: GO_Central
  • cellular response to tumor necrosis factor Source: GO_Central
  • chemokine-mediated signaling pathway Source: GO_Central
  • chemotaxis Source: ProtInc
  • G-protein coupled receptor signaling pathway Source: Reactome
  • immune response Source: ProtInc
  • inflammatory response Source: GO_Central
  • lymphocyte chemotaxis Source: GO_Central
  • monocyte chemotaxis Source: GO_Central
  • negative regulation of C-C chemokine binding Source: UniProtKB
  • negative regulation of cell proliferation Source: ProtInc
  • neutrophil chemotaxis Source: GO_Central
  • positive regulation of ERK1 and ERK2 cascade Source: GO_Central
  • positive regulation of GTPase activity Source: GO_Central
  • signal transduction Source: ProtInc

Keywordsi

Molecular functionCytokine, Heparin-binding
Biological processChemotaxis, Inflammatory response

Enzyme and pathway databases

ReactomeiR-HSA-416476 G alpha (q) signalling events
R-HSA-418594 G alpha (i) signalling events
R-HSA-444473 Formyl peptide receptors bind formyl peptides and many other ligands

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 23
Alternative name(s):
CK-beta-8
Short name:
CKB-8
Macrophage inflammatory protein 3
Short name:
MIP-3
Myeloid progenitor inhibitory factor 1
Short name:
MPIF-1
Small-inducible cytokine A23
Cleaved into the following 4 chains:
Gene namesi
Name:CCL23
Synonyms:MIP3, MPIF1, SCYA23
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000274736.4
HGNCiHGNC:10622 CCL23
MIMi602494 gene
neXtProtiNX_P55773

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi6368
PharmGKBiPA35554

Polymorphism and mutation databases

BioMutaiCCL23
DMDMi308153623

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 211 PublicationAdd BLAST21
ChainiPRO_000000522922 – 120C-C motif chemokine 23Add BLAST99
ChainiPRO_000004184740 – 120CCL23(19-99)Add BLAST81
ChainiPRO_000004184843 – 120CCL23(22-99)Add BLAST78
ChainiPRO_000004184948 – 120CCL23(27-99)Add BLAST73
ChainiPRO_000004185051 – 120CCL23(30-99)Add BLAST70

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi54 ↔ 78
Disulfide bondi55 ↔ 94
Disulfide bondi65 ↔ 105

Keywords - PTMi

Disulfide bond

Proteomic databases

PeptideAtlasiP55773
PRIDEiP55773
ProteomicsDBi56861
56862 [P55773-2]

PTM databases

PhosphoSitePlusiP55773

Expressioni

Tissue specificityi

High levels in adult lung, liver, skeletal muscle and pancreas. Moderate levels in fetal liver, adult bone marrow and placenta. The short form is the major species and the longer form was detected only in very low abundance. CCL23(19-99), CCL23(22-99), CCL23(27-99), CCL23(30-99) are found in high levels in synovial fluids from rheumatoid patients.1 Publication

Gene expression databases

BgeeiENSG00000274736
CleanExiHS_CCL23
ExpressionAtlasiP55773 baseline and differential
GenevisibleiP55773 HS

Organism-specific databases

HPAiHPA042015

Interactioni

GO - Molecular functioni

  • CCR1 chemokine receptor binding Source: UniProtKB
  • chemokine activity Source: UniProtKB

Protein-protein interaction databases

BioGridi112271, 3 interactors

Structurei

Secondary structure

1120
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi48 – 50Combined sources3
Helixi65 – 67Combined sources3
Beta strandi70 – 73Combined sources4
Beta strandi78 – 80Combined sources3
Beta strandi83 – 86Combined sources4
Beta strandi92 – 95Combined sources4
Helixi100 – 109Combined sources10
Turni113 – 115Combined sources3

3D structure databases

ProteinModelPortaliP55773
SMRiP55773
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP55773

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000036685
HOVERGENiHBG017871
InParanoidiP55773
KOiK05511
OrthoDBiEOG091G14Y2
PhylomeDBiP55773
TreeFamiTF334888

Family and domain databases

InterProiView protein in InterPro
IPR000827 Chemokine_CC_CS
IPR001811 Chemokine_IL8-like_dom
IPR036048 Interleukin_8-like_sf
PfamiView protein in Pfam
PF00048 IL8, 1 hit
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00472 SMALL_CYTOKINES_CC, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Short (identifier: P55773-1) [UniParc]FASTAAdd to basket
Also known as: CKB-8

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKVSVAALSC LMLVTALGSQ ARVTKDAETE FMMSKLPLEN PVLLDRFHAT
60 70 80 90 100
SADCCISYTP RSIPCSLLES YFETNSECSK PGVIFLTKKG RRFCANPSDK
110 120
QVQVCVRMLK LDTRIKTRKN
Length:120
Mass (Da):13,411
Last modified:October 5, 2010 - v3
Checksum:i6CA622DD3A4B3A1A
GO
Isoform Long (identifier: P55773-2) [UniParc]FASTAAdd to basket
Also known as: CKB-8-1

The sequence of this isoform differs from the canonical sequence as follows:
     46-46: R → MLWRRKIGPQMTLSHAAG

Show »
Length:137
Mass (Da):15,290
Checksum:i932413D6B2E52C5D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti12 – 44MLVTA…NPVLL → HAFLLPLVPGPGHKRCRDRV HECQSFHWKIQYFW (Ref. 1) CuratedAdd BLAST33

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_011916106V → M6 PublicationsCorresponds to variant dbSNP:rs1003645Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00106346R → MLWRRKIGPQMTLSHAAG in isoform Long. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U85767 mRNA Translation: AAB51134.1
U58913 mRNA Translation: AAD10846.1
U67128 mRNA Translation: AAD00161.1
AF088219 Genomic DNA Translation: AAC63326.1
AF088219 Genomic DNA Translation: AAC63327.1
AC069363 Genomic DNA No translation available.
CH471147 Genomic DNA Translation: EAW80103.1
BC093970 mRNA Translation: AAH93970.1
BC143310 mRNA Translation: AAI43311.1
CCDSiCCDS11305.1 [P55773-2]
CCDS59282.1 [P55773-1]
RefSeqiNP_005055.3, NM_005064.5
NP_665905.2, NM_145898.3
UniGeneiHs.169191

Genome annotation databases

EnsembliENST00000610342; ENSP00000483546; ENSG00000276114 [P55773-2]
ENST00000612516; ENSP00000484748; ENSG00000274736
ENST00000615050; ENSP00000481357; ENSG00000274736
ENST00000632633; ENSP00000488270; ENSG00000276114 [P55773-1]
GeneIDi6368
KEGGihsa:6368
UCSCiuc002hks.3 human [P55773-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCCL23_HUMAN
AccessioniPrimary (citable) accession number: P55773
Secondary accession number(s): B7ZKQ3
, O00174, O75950, Q52LD4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 5, 2010
Last modified: June 20, 2018
This is version 163 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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