UniProtKB - P55773 (CCL23_HUMAN)
C-C motif chemokine 23
CCL23
Functioni
Shows chemotactic activity for monocytes, resting T-lymphocytes, and neutrophils, but not for activated lymphocytes. Inhibits proliferation of myeloid progenitor cells in colony formation assays. This protein can bind heparin. Binds CCR1. CCL23(19-99), CCL23(22-99), CCL23(27-99), CCL23(30-99) are more potent chemoattractants than the small-inducible cytokine A23.
1 PublicationGO - Molecular functioni
- CCR1 chemokine receptor binding Source: UniProtKB
- CCR chemokine receptor binding Source: GO_Central
- chemokine activity Source: UniProtKB
- heparin binding Source: UniProtKB-KW
GO - Biological processi
- cell-cell signaling Source: ProtInc
- cellular calcium ion homeostasis Source: ProtInc
- cellular response to interferon-gamma Source: GO_Central
- cellular response to interleukin-1 Source: GO_Central
- cellular response to tumor necrosis factor Source: GO_Central
- chemokine-mediated signaling pathway Source: GO_Central
- chemotaxis Source: ProtInc
- G protein-coupled receptor signaling pathway Source: GO_Central
- immune response Source: ProtInc
- inflammatory response Source: GO_Central
- lymphocyte chemotaxis Source: GO_Central
- monocyte chemotaxis Source: GO_Central
- negative regulation of C-C chemokine binding Source: UniProtKB
- negative regulation of cell population proliferation Source: ProtInc
- neutrophil chemotaxis Source: GO_Central
- positive regulation of ERK1 and ERK2 cascade Source: GO_Central
- positive regulation of GTPase activity Source: GO_Central
- signal transduction Source: ProtInc
Keywordsi
Molecular function | Cytokine, Heparin-binding |
Biological process | Chemotaxis, Inflammatory response |
Enzyme and pathway databases
PathwayCommonsi | P55773 |
Reactomei | R-HSA-416476, G alpha (q) signalling events [P55773-2] R-HSA-418594, G alpha (i) signalling events [P55773-2] R-HSA-444473, Formyl peptide receptors bind formyl peptides and many other ligands [P55773-2] |
SignaLinki | P55773 |
Names & Taxonomyi
Protein namesi | Recommended name: C-C motif chemokine 23Alternative name(s): CK-beta-8 Short name: CKB-8 Macrophage inflammatory protein 3 Short name: MIP-3 Myeloid progenitor inhibitory factor 1 Short name: MPIF-1 Small-inducible cytokine A23 Cleaved into the following 4 chains: |
Gene namesi | Name:CCL23 Synonyms:MIP3, MPIF1, SCYA23 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:10622, CCL23 |
MIMi | 602494, gene |
neXtProti | NX_P55773 |
VEuPathDBi | HostDB:ENSG00000274736 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular region Source: Reactome
- extracellular space Source: GO_Central
Keywords - Cellular componenti
SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 6368 |
PharmGKBi | PA35554 |
Miscellaneous databases
Pharosi | P55773, Tbio |
Genetic variation databases
BioMutai | CCL23 |
DMDMi | 308153623 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | 1 PublicationAdd BLAST | 21 | |
ChainiPRO_0000005229 | 22 – 120 | C-C motif chemokine 23Add BLAST | 99 | |
ChainiPRO_0000041847 | 40 – 120 | CCL23(19-99)Add BLAST | 81 | |
ChainiPRO_0000041848 | 43 – 120 | CCL23(22-99)Add BLAST | 78 | |
ChainiPRO_0000041849 | 48 – 120 | CCL23(27-99)Add BLAST | 73 | |
ChainiPRO_0000041850 | 51 – 120 | CCL23(30-99)Add BLAST | 70 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 54 ↔ 78 | |||
Disulfide bondi | 55 ↔ 94 | |||
Disulfide bondi | 65 ↔ 105 |
Keywords - PTMi
Disulfide bondProteomic databases
MassIVEi | P55773 |
PeptideAtlasi | P55773 |
PRIDEi | P55773 |
ProteomicsDBi | 56861 [P55773-1] 56862 [P55773-2] |
PTM databases
PhosphoSitePlusi | P55773 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000274736, Expressed in endocervix and 134 other tissues |
ExpressionAtlasi | P55773, baseline and differential |
Genevisiblei | P55773, HS |
Organism-specific databases
HPAi | ENSG00000274736, Low tissue specificity |
Interactioni
GO - Molecular functioni
- CCR1 chemokine receptor binding Source: UniProtKB
- CCR chemokine receptor binding Source: GO_Central
- chemokine activity Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 112271, 4 interactors |
IntActi | P55773, 2 interactors |
Miscellaneous databases
RNActi | P55773, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | P55773 |
SMRi | P55773 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P55773 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
SignalPhylogenomic databases
HOGENOMi | CLU_141716_4_1_1 |
InParanoidi | P55773 |
OrthoDBi | 1575018at2759 |
PhylomeDBi | P55773 |
TreeFami | TF334888 |
Family and domain databases
InterProi | View protein in InterPro IPR039809, Chemokine_b/g/d IPR000827, Chemokine_CC_CS IPR001811, Chemokine_IL8-like_dom IPR036048, Interleukin_8-like_sf |
PANTHERi | PTHR12015, PTHR12015, 1 hit |
Pfami | View protein in Pfam PF00048, IL8, 1 hit |
SMARTi | View protein in SMART SM00199, SCY, 1 hit |
SUPFAMi | SSF54117, SSF54117, 1 hit |
PROSITEi | View protein in PROSITE PS00472, SMALL_CYTOKINES_CC, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MKVSVAALSC LMLVTALGSQ ARVTKDAETE FMMSKLPLEN PVLLDRFHAT
60 70 80 90 100
SADCCISYTP RSIPCSLLES YFETNSECSK PGVIFLTKKG RRFCANPSDK
110 120
QVQVCMRMLK LDTRIKTRKN
The sequence of this isoform differs from the canonical sequence as follows:
46-46: R → MLWRRKIGPQMTLSHAAG
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A087WV09 | A0A087WV09_HUMAN | C-C motif chemokine 23 | CCL23 | 13 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 12 – 44 | MLVTA…NPVLL → HAFLLPLVPGPGHKRCRDRV HECQSFHWKIQYFW (Ref. 1) CuratedAdd BLAST | 33 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_011916 | 106 | M → V. Corresponds to variant dbSNP:rs1003645Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_001063 | 46 | R → MLWRRKIGPQMTLSHAAG in isoform Long. 2 Publications | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U85767 mRNA Translation: AAB51134.1 U58913 mRNA Translation: AAD10846.1 U67128 mRNA Translation: AAD00161.1 AF088219 Genomic DNA Translation: AAC63326.1 AF088219 Genomic DNA Translation: AAC63327.1 AC244100 Genomic DNA No translation available. CH471147 Genomic DNA Translation: EAW80103.1 BC093970 mRNA Translation: AAH93970.1 BC143310 mRNA Translation: AAI43311.1 |
CCDSi | CCDS11305.1 [P55773-2] CCDS59282.1 [P55773-1] |
RefSeqi | NP_005055.3, NM_005064.5 NP_665905.2, NM_145898.3 |
Genome annotation databases
Ensembli | ENST00000610342.2; ENSP00000483546.1; ENSG00000276114.2 ENST00000612516.4; ENSP00000484748.1; ENSG00000274736.5 ENST00000615050.2; ENSP00000481357.1; ENSG00000274736.5 [P55773-2] ENST00000632633.1; ENSP00000488270.1; ENSG00000276114.2 |
GeneIDi | 6368 |
KEGGi | hsa:6368 |
MANE-Selecti | ENST00000615050.2; ENSP00000481357.1; NM_005064.6; NP_005055.3 [P55773-2] |
UCSCi | uc002hks.3, human [P55773-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Wikipedia CCL23 entry |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U85767 mRNA Translation: AAB51134.1 U58913 mRNA Translation: AAD10846.1 U67128 mRNA Translation: AAD00161.1 AF088219 Genomic DNA Translation: AAC63326.1 AF088219 Genomic DNA Translation: AAC63327.1 AC244100 Genomic DNA No translation available. CH471147 Genomic DNA Translation: EAW80103.1 BC093970 mRNA Translation: AAH93970.1 BC143310 mRNA Translation: AAI43311.1 |
CCDSi | CCDS11305.1 [P55773-2] CCDS59282.1 [P55773-1] |
RefSeqi | NP_005055.3, NM_005064.5 NP_665905.2, NM_145898.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1G91 | NMR | - | A | 45-120 | [»] | |
AlphaFoldDBi | P55773 | |||||
SMRi | P55773 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 112271, 4 interactors |
IntActi | P55773, 2 interactors |
PTM databases
PhosphoSitePlusi | P55773 |
Genetic variation databases
BioMutai | CCL23 |
DMDMi | 308153623 |
Proteomic databases
MassIVEi | P55773 |
PeptideAtlasi | P55773 |
PRIDEi | P55773 |
ProteomicsDBi | 56861 [P55773-1] 56862 [P55773-2] |
Protocols and materials databases
Antibodypediai | 73206, 304 antibodies from 30 providers |
DNASUi | 6368 |
Genome annotation databases
Ensembli | ENST00000610342.2; ENSP00000483546.1; ENSG00000276114.2 ENST00000612516.4; ENSP00000484748.1; ENSG00000274736.5 ENST00000615050.2; ENSP00000481357.1; ENSG00000274736.5 [P55773-2] ENST00000632633.1; ENSP00000488270.1; ENSG00000276114.2 |
GeneIDi | 6368 |
KEGGi | hsa:6368 |
MANE-Selecti | ENST00000615050.2; ENSP00000481357.1; NM_005064.6; NP_005055.3 [P55773-2] |
UCSCi | uc002hks.3, human [P55773-1] |
Organism-specific databases
CTDi | 6368 |
DisGeNETi | 6368 |
GeneCardsi | CCL23 |
HGNCi | HGNC:10622, CCL23 |
HPAi | ENSG00000274736, Low tissue specificity |
MIMi | 602494, gene |
neXtProti | NX_P55773 |
PharmGKBi | PA35554 |
VEuPathDBi | HostDB:ENSG00000274736 |
GenAtlasi | Search... |
Phylogenomic databases
HOGENOMi | CLU_141716_4_1_1 |
InParanoidi | P55773 |
OrthoDBi | 1575018at2759 |
PhylomeDBi | P55773 |
TreeFami | TF334888 |
Enzyme and pathway databases
PathwayCommonsi | P55773 |
Reactomei | R-HSA-416476, G alpha (q) signalling events [P55773-2] R-HSA-418594, G alpha (i) signalling events [P55773-2] R-HSA-444473, Formyl peptide receptors bind formyl peptides and many other ligands [P55773-2] |
SignaLinki | P55773 |
Miscellaneous databases
BioGRID-ORCSi | 6368, 12 hits in 1058 CRISPR screens |
EvolutionaryTracei | P55773 |
GenomeRNAii | 6368 |
Pharosi | P55773, Tbio |
PROi | PR:P55773 |
RNActi | P55773, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000274736, Expressed in endocervix and 134 other tissues |
ExpressionAtlasi | P55773, baseline and differential |
Genevisiblei | P55773, HS |
Family and domain databases
InterProi | View protein in InterPro IPR039809, Chemokine_b/g/d IPR000827, Chemokine_CC_CS IPR001811, Chemokine_IL8-like_dom IPR036048, Interleukin_8-like_sf |
PANTHERi | PTHR12015, PTHR12015, 1 hit |
Pfami | View protein in Pfam PF00048, IL8, 1 hit |
SMARTi | View protein in SMART SM00199, SCY, 1 hit |
SUPFAMi | SSF54117, SSF54117, 1 hit |
PROSITEi | View protein in PROSITE PS00472, SMALL_CYTOKINES_CC, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CCL23_HUMAN | |
Accessioni | P55773Primary (citable) accession number: P55773 Secondary accession number(s): B7ZKQ3 Q52LD4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | February 23, 2022 | |
Last modified: | May 25, 2022 | |
This is version 184 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families