UniProtKB - P55772 (ENTP1_MOUSE)
Protein
Ectonucleoside triphosphate diphosphohydrolase 1
Gene
Entpd1
Organism
Mus musculus (Mouse)
Status
Functioni
In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well.
Catalytic activityi
- EC:3.6.1.5
Cofactori
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 174 | Proton acceptorBy similarity | 1 |
GO - Molecular functioni
- 8-oxo-dGTP phosphohydrolase activity Source: UniProtKB-EC
- adenosine-diphosphatase activity Source: MGI
- ATPase activity Source: MGI
- ATP binding Source: UniProtKB-KW
- dATP phosphohydrolase activity Source: UniProtKB-EC
- dCTP phosphohydrolase activity Source: UniProtKB-EC
- dGTP phosphohydrolase activity Source: UniProtKB-EC
- dTTP phosphohydrolase activity Source: UniProtKB-EC
- dUTP phosphohydrolase activity Source: UniProtKB-EC
- GTP phosphohydrolase activity Source: UniProtKB-EC
- identical protein binding Source: MGI
- nucleoside-diphosphatase activity Source: MGI
- nucleoside-triphosphatase activity Source: MGI
GO - Biological processi
- G protein-coupled receptor signaling pathway Source: MGI
- negative regulation of ATP biosynthetic process Source: MGI
- negative regulation of dopamine secretion Source: MGI
- platelet activation Source: MGI
- purine ribonucleoside diphosphate catabolic process Source: MGI
Keywordsi
Molecular function | Hydrolase |
Ligand | ATP-binding, Calcium, Magnesium, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 3.6.1.5, 3474 |
Reactomei | R-MMU-8850843, Phosphate bond hydrolysis by NTPDase proteins |
SABIO-RKi | P55772 |
Names & Taxonomyi
Protein namesi | Recommended name: Ectonucleoside triphosphate diphosphohydrolase 1 (EC:3.6.1.5)Short name: NTPDase 1 Alternative name(s): Ecto-ATP diphosphohydrolase 1 Short name: Ecto-ATPDase 1 Short name: Ecto-ATPase 1 Ecto-apyrase Lymphoid cell activation antigen CD_antigen: CD39 |
Gene namesi | Name:Entpd1 Synonyms:Cd39 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:102805, Entpd1 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Extracellular region or secreted
- basement membrane Source: MGI
- extracellular space Source: MGI
Plasma Membrane
- basolateral plasma membrane Source: MGI
- synaptic membrane Source: MGI
Other locations
- cell surface Source: MGI
- integral component of membrane Source: UniProtKB-KW
- neuron projection Source: MGI
- neuronal cell body Source: MGI
- postsynaptic density Source: MGI
- synaptic vesicle Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 16 | CytoplasmicSequence analysisAdd BLAST | 16 | |
Transmembranei | 17 – 37 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 38 – 478 | ExtracellularSequence analysisAdd BLAST | 441 | |
Transmembranei | 479 – 499 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 500 – 510 | CytoplasmicSequence analysisAdd BLAST | 11 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000209903 | 1 – 510 | Ectonucleoside triphosphate diphosphohydrolase 1Add BLAST | 510 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 73 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 84 ↔ 108 | By similarity | ||
Glycosylationi | 226 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 254 ↔ 300 | By similarity | ||
Disulfide bondi | 281 ↔ 324 | By similarity | ||
Glycosylationi | 291 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 333 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 337 ↔ 342 | By similarity | ||
Disulfide bondi | 391 ↔ 414 | By similarity | ||
Glycosylationi | 428 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 457 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
EPDi | P55772 |
jPOSTi | P55772 |
PaxDbi | P55772 |
PRIDEi | P55772 |
PTM databases
GlyGeni | P55772, 6 sites |
iPTMneti | P55772 |
PhosphoSitePlusi | P55772 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000048120, Expressed in ectoplacental cone and 240 other tissues |
ExpressionAtlasi | P55772, baseline and differential |
Genevisiblei | P55772, MM |
Interactioni
Subunit structurei
Homodimer; disulfide-linked.
By similarityGO - Molecular functioni
- identical protein binding Source: MGI
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000107850 |
Miscellaneous databases
RNActi | P55772, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the GDA1/CD39 NTPase family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1386, Eukaryota |
GeneTreei | ENSGT01010000222402 |
HOGENOMi | CLU_010246_2_3_1 |
InParanoidi | P55772 |
OMAi | DPCFHSG |
OrthoDBi | 1337265at2759 |
PhylomeDBi | P55772 |
TreeFami | TF332859 |
Family and domain databases
InterProi | View protein in InterPro IPR000407, GDA1_CD39_NTPase |
PANTHERi | PTHR11782, PTHR11782, 1 hit |
Pfami | View protein in Pfam PF01150, GDA1_CD39, 1 hit |
PROSITEi | View protein in PROSITE PS01238, GDA1_CD39_NTPASE, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
P55772-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEDIKDSKVK RFCSKNILII LGFTSILAVI ALIAVGLTQN KPLPENVKYG
60 70 80 90 100
IVLDAGSSHT NLYIYKWPAE KENDTGVVQQ LEECQVKGPG ISKYAQKTDE
110 120 130 140 150
IGAYLAECME LSTELIPTSK HHQTPVYLGA TAGMRLLRME SEQSADEVLA
160 170 180 190 200
AVSTSLKSYP FDFQGAKIIT GQEEGAYGWI TINYLLGRFT QEQSWLSLIS
210 220 230 240 250
DSQKQETFGA LDLGGASTQI TFVPQNSTIE SPENSLQFRL YGEDYTVYTH
260 270 280 290 300
SFLCYGKDQA LWQKLAKDIQ VSSGGVLKDP CFNPGYEKVV NVSELYGTPC
310 320 330 340 350
TKRFEKKLPF DQFRIQGTGD YEQCHQSILE LFNNSHCPYS QCAFNGVFLP
360 370 380 390 400
PLHGSFGAFS AFYFVMDFFK KVAKNSVISQ EKMTEITKNF CSKSWEETKT
410 420 430 440 450
SYPSVKEKYL SEYCFSGAYI LSLLQGYNFT DSSWEQIHFM GKIKDSNAGW
460 470 480 490 500
TLGYMLNLTN MIPAEQPLSP PLPHSTYIGL MVLFSLLLVA VAITGLFIYS
510
KPSYFWKEAV
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ8CDV7 | Q8CDV7_MOUSE | Ectonucleoside triphosphate diphosp... | Entpd1 | 539 | Annotation score: | ||
D6RHQ2 | D6RHQ2_MOUSE | Ectonucleoside triphosphate diphosp... | Entpd1 | 288 | Annotation score: | ||
F7B9M9 | F7B9M9_MOUSE | Ectonucleoside triphosphate diphosp... | Entpd1 | 235 | Annotation score: | ||
D6RFA9 | D6RFA9_MOUSE | Ectonucleoside triphosphate diphosp... | Entpd1 | 63 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF037366 mRNA Translation: AAB92259.1 AF041818 , AF041812, AF041813, AF041814, AF041815, AF041816, AF041817 Genomic DNA Translation: AAC83203.1 |
CCDSi | CCDS50434.1 |
RefSeqi | NP_033978.1, NM_009848.4 |
Genome annotation databases
Ensembli | ENSMUST00000112231; ENSMUSP00000107850; ENSMUSG00000048120 |
GeneIDi | 12495 |
KEGGi | mmu:12495 |
UCSCi | uc008hlf.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF037366 mRNA Translation: AAB92259.1 AF041818 , AF041812, AF041813, AF041814, AF041815, AF041816, AF041817 Genomic DNA Translation: AAC83203.1 |
CCDSi | CCDS50434.1 |
RefSeqi | NP_033978.1, NM_009848.4 |
3D structure databases
SMRi | P55772 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000107850 |
PTM databases
GlyGeni | P55772, 6 sites |
iPTMneti | P55772 |
PhosphoSitePlusi | P55772 |
Proteomic databases
EPDi | P55772 |
jPOSTi | P55772 |
PaxDbi | P55772 |
PRIDEi | P55772 |
Protocols and materials databases
Antibodypediai | 2888, 871 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000112231; ENSMUSP00000107850; ENSMUSG00000048120 |
GeneIDi | 12495 |
KEGGi | mmu:12495 |
UCSCi | uc008hlf.2, mouse |
Organism-specific databases
CTDi | 953 |
MGIi | MGI:102805, Entpd1 |
Phylogenomic databases
eggNOGi | KOG1386, Eukaryota |
GeneTreei | ENSGT01010000222402 |
HOGENOMi | CLU_010246_2_3_1 |
InParanoidi | P55772 |
OMAi | DPCFHSG |
OrthoDBi | 1337265at2759 |
PhylomeDBi | P55772 |
TreeFami | TF332859 |
Enzyme and pathway databases
BRENDAi | 3.6.1.5, 3474 |
Reactomei | R-MMU-8850843, Phosphate bond hydrolysis by NTPDase proteins |
SABIO-RKi | P55772 |
Miscellaneous databases
BioGRID-ORCSi | 12495, 0 hits in 14 CRISPR screens |
ChiTaRSi | Entpd1, mouse |
PROi | PR:P55772 |
RNActi | P55772, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000048120, Expressed in ectoplacental cone and 240 other tissues |
ExpressionAtlasi | P55772, baseline and differential |
Genevisiblei | P55772, MM |
Family and domain databases
InterProi | View protein in InterPro IPR000407, GDA1_CD39_NTPase |
PANTHERi | PTHR11782, PTHR11782, 1 hit |
Pfami | View protein in Pfam PF01150, GDA1_CD39, 1 hit |
PROSITEi | View protein in PROSITE PS01238, GDA1_CD39_NTPASE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ENTP1_MOUSE | |
Accessioni | P55772Primary (citable) accession number: P55772 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1997 | |
Last modified: | February 10, 2021 | |
This is version 148 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families