Entpd1

Functionⁱ

In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well.

Catalytic activityⁱ

A nucleoside 5'-triphosphate + 2 H₂O = a nucleoside 5'-phosphate + 2 phosphate.

Cofactorⁱ

Ca²⁺By similarity, Mg²⁺By similarity

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Active siteⁱ	174	Proton acceptorBy similarity		1

GO - Molecular functionⁱ

8-oxo-dGTP phosphohydrolase activity Source: UniProtKB-EC
adenosine-diphosphatase activity Source: MGI
ATPase activity Source: MGI
ATP binding Source: UniProtKB-KW
dATP phosphohydrolase activity Source: UniProtKB-EC
dCTP phosphohydrolase activity Source: UniProtKB-EC
dGTP phosphohydrolase activity Source: UniProtKB-EC
dTTP phosphohydrolase activity Source: UniProtKB-EC
dUTP phosphohydrolase activity Source: UniProtKB-EC
GTP phosphohydrolase activity Source: UniProtKB-EC
identical protein binding Source: MGI
nucleoside-diphosphatase activity
Source: MGI
Inferred from direct assayⁱ
- 11929769
nucleoside-triphosphatase activity
Source: MGI
Inferred from direct assayⁱ
- 11929769

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

G-protein coupled receptor signaling pathway
Source: MGI
Inferred from direct assayⁱ
- 11929769
negative regulation of ATP biosynthetic process Source: MGI
negative regulation of dopamine secretion Source: MGI
platelet activation
Source: MGI
Inferred from direct assayⁱ
- 11929769
protein homooligomerization Source: MGI
purine ribonucleoside diphosphate catabolic process
Source: MGI
Inferred from direct assayⁱ
- 11929769

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase
Ligand	ATP-binding, Calcium, Magnesium, Nucleotide-binding

Enzyme and pathway databases

BRENDAⁱ	3.6.1.5 3474
Reactomeⁱ	R-MMU-8850843 Phosphate bond hydrolysis by NTPDase proteins

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Ectonucleoside triphosphate diphosphohydrolase 1 (EC:3.6.1.5) Short name: NTPDase 1 Alternative name(s): Ecto-ATP diphosphohydrolase 1 Short name: Ecto-ATPDase 1 Short name: Ecto-ATPase 1 Ecto-apyrase Lymphoid cell activation antigen CD_antigen: CD39
Gene namesⁱ	Name:Entpd1 Synonyms:Cd39
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 19

Organism-specific databases

MGIⁱ	MGI:102805 Entpd1

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 16	CytoplasmicSequence analysisAdd BLAST	16
Transmembraneⁱ	17 – 37	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	38 – 478	ExtracellularSequence analysisAdd BLAST	441
Transmembraneⁱ	479 – 499	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	500 – 510	CytoplasmicSequence analysisAdd BLAST	11

Keywords - Cellular componentⁱ

Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000209903	1 – 510	Ectonucleoside triphosphate diphosphohydrolase 1Add BLAST		510

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	73	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	84 ↔ 108	By similarity
Glycosylationⁱ	226	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	254 ↔ 300	By similarity
Disulfide bondⁱ	281 ↔ 324	By similarity
Glycosylationⁱ	291	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	333	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	337 ↔ 342	By similarity
Disulfide bondⁱ	391 ↔ 414	By similarity
Glycosylationⁱ	428	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	457	N-linked (GlcNAc...) asparagineSequence analysis	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

EPDⁱ	P55772
PaxDbⁱ	P55772
PRIDEⁱ	P55772

PTM databases

iPTMnetⁱ	P55772
PhosphoSitePlusⁱ	P55772

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000048120
CleanExⁱ	MM_ENTPD1
ExpressionAtlasⁱ	P55772 baseline and differential
Genevisibleⁱ	P55772 MM

Interactionⁱ

Subunit structureⁱ

Homodimer; disulfide-linked.By similarity

GO - Molecular functionⁱ

identical protein binding Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000107850

STRINGⁱ

10090.ENSMUSP00000107850

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P55772
SMRⁱ	P55772
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the GDA1/CD39 NTPase family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG1386 Eukaryota COG5371 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074435
HOGENOMⁱ	HOG000059572
HOVERGENⁱ	HBG018982
InParanoidⁱ	P55772
KEGG Orthology (KO) More...KOⁱ	K01510
PhylomeDBⁱ	P55772
TreeFamⁱ	TF332859

Family and domain databases

InterProⁱ	View protein in InterPro IPR000407 GDA1_CD39_NTPase
PANTHERⁱ	PTHR11782 PTHR11782, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01150 GDA1_CD39, 1 hit
PROSITEⁱ	View protein in PROSITE PS01238 GDA1_CD39_NTPASE, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P55772-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MEDIKDSKVK RFCSKNILII LGFTSILAVI ALIAVGLTQN KPLPENVKYG 
        60         70         80         90        100
IVLDAGSSHT NLYIYKWPAE KENDTGVVQQ LEECQVKGPG ISKYAQKTDE 
       110        120        130        140        150
IGAYLAECME LSTELIPTSK HHQTPVYLGA TAGMRLLRME SEQSADEVLA 
       160        170        180        190        200
AVSTSLKSYP FDFQGAKIIT GQEEGAYGWI TINYLLGRFT QEQSWLSLIS 
       210        220        230        240        250
DSQKQETFGA LDLGGASTQI TFVPQNSTIE SPENSLQFRL YGEDYTVYTH 
       260        270        280        290        300
SFLCYGKDQA LWQKLAKDIQ VSSGGVLKDP CFNPGYEKVV NVSELYGTPC 
       310        320        330        340        350
TKRFEKKLPF DQFRIQGTGD YEQCHQSILE LFNNSHCPYS QCAFNGVFLP 
       360        370        380        390        400
PLHGSFGAFS AFYFVMDFFK KVAKNSVISQ EKMTEITKNF CSKSWEETKT 
       410        420        430        440        450
SYPSVKEKYL SEYCFSGAYI LSLLQGYNFT DSSWEQIHFM GKIKDSNAGW 
       460        470        480        490        500
TLGYMLNLTN MIPAEQPLSP PLPHSTYIGL MVLFSLLLVA VAITGLFIYS 
       510
KPSYFWKEAV

Length:510

Mass (Da):57,205

Last modified:November 1, 1997 - v1

Checksum:ⁱ8E6A6113D2E13930

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF037366 mRNA Translation: AAB92259.1 AF041818 AF041817 Genomic DNA Translation: AAC83203.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS50434.1
NCBI Reference Sequences More...RefSeqⁱ	NP_033978.1, NM_009848.4
UniGeneⁱ	Mm.2824

Genome annotation databases

Ensemblⁱ	ENSMUST00000112231; ENSMUSP00000107850; ENSMUSG00000048120
GeneIDⁱ	12495
KEGGⁱ	mmu:12495
UCSC genome browser More...UCSCⁱ	uc008hlf.2 mouse

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
P55772	Uncharacterized protein		MOUSE		510
UPI000A310F31		MUSPA		539
UPI000A31A569		MUSCR		539
Ectonucleoside triphosphate diphosphohydrolase 1		RAT		511
Ectonucleoside triphosphate diphosphohydrolase 1		MOUSE		539
+5

Protein	Similar proteins		Species	Score	Length
P55772	Ectonucleoside triphosphate diphosphohydrolase 1	)	RAT		511
UPI000A31A569		MUSCR		539
UPI000A310F31		MUSPA		539
Ectonucleoside triphosphate diphosphohydrolase 1		MOUSE		539
ectonucleoside triphosphate diphosphohydrolase 1 isoform X3		DIPOR		469
+22

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF037366 mRNA Translation: AAB92259.1 AF041818 AF041817 Genomic DNA Translation: AAC83203.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS50434.1
NCBI Reference Sequences More...RefSeqⁱ	NP_033978.1, NM_009848.4
UniGeneⁱ	Mm.2824

3D structure databases

ProteinModelPortalⁱ	P55772
SMRⁱ	P55772
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000107850

STRINGⁱ

10090.ENSMUSP00000107850

PTM databases

iPTMnetⁱ	P55772
PhosphoSitePlusⁱ	P55772

Proteomic databases

EPDⁱ	P55772
PaxDbⁱ	P55772
PRIDEⁱ	P55772

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000112231; ENSMUSP00000107850; ENSMUSG00000048120
GeneIDⁱ	12495
KEGGⁱ	mmu:12495
UCSC genome browser More...UCSCⁱ	uc008hlf.2 mouse

Organism-specific databases

CTDⁱ	953
MGIⁱ	MGI:102805 Entpd1

Phylogenomic databases

eggNOGⁱ	KOG1386 Eukaryota COG5371 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074435
HOGENOMⁱ	HOG000059572
HOVERGENⁱ	HBG018982
InParanoidⁱ	P55772
KEGG Orthology (KO) More...KOⁱ	K01510
PhylomeDBⁱ	P55772
TreeFamⁱ	TF332859

Enzyme and pathway databases

BRENDAⁱ	3.6.1.5 3474
Reactomeⁱ	R-MMU-8850843 Phosphate bond hydrolysis by NTPDase proteins

Miscellaneous databases

ChiTaRSⁱ	Entpd1 mouse
Protein Ontology More...PROⁱ	PR:P55772
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000048120
CleanExⁱ	MM_ENTPD1
ExpressionAtlasⁱ	P55772 baseline and differential
Genevisibleⁱ	P55772 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR000407 GDA1_CD39_NTPase
PANTHERⁱ	PTHR11782 PTHR11782, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01150 GDA1_CD39, 1 hit
PROSITEⁱ	View protein in PROSITE PS01238 GDA1_CD39_NTPASE, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ENTP1_MOUSE
Accessionⁱ	P55772Primary (citable) accession number: P55772
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	November 1, 1997
	Last modified:	June 20, 2018
	This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P55772 (ENTP1_MOUSE)

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Ectonucleoside triphosphate diphosphohydrolase 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Extracellular region or secreted

Plasma Membrane

Other locations

Topology

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ