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Entry version 205 (07 Oct 2020)
Sequence version 3 (23 Jan 2007)
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Protein

NHP2-like protein 1

Gene

SNU13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in pre-mRNA splicing as component of the spliceosome (PubMed:28781166). Binds to the 5'-stem-loop of U4 snRNA and thereby contributes to spliceosome assembly (PubMed:10545122, PubMed:17412961). The protein undergoes a conformational change upon RNA-binding (PubMed:17412961).3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRibonucleoprotein, RNA-binding
Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
P55769

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6790901, rRNA modification in the nucleus and cytosol
R-HSA-6791226, Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72163, mRNA Splicing - Major Pathway
R-HSA-72165, mRNA Splicing - Minor Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
NHP2-like protein 1
Alternative name(s):
High mobility group-like nuclear protein 2 homolog 1
OTK27
SNU13 homolog
Short name:
hSNU13
U4/U6.U5 small nuclear ribonucleoprotein SNU13Imported
U4/U6.U5 tri-snRNP 15.5 kDa protein
Cleaved into the following chain:
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SNU13Imported
Synonyms:NHP2L1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000100138.13

Human Gene Nomenclature Database

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HGNCi
HGNC:7819, SNU13

Online Mendelian Inheritance in Man (OMIM)

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MIMi
601304, gene
601876, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P55769

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi38G → K: Abolishes U4 snRNA-binding. 1 Publication1
Mutagenesisi57A → F: Abolishes U4 snRNA-binding. 1 Publication1
Mutagenesisi80Y → A: Reduces U4 snRNA-binding by about 50%. 1 Publication1
Mutagenesisi96 – 128Missing : Abolishes U4 snRNA-binding. 1 PublicationAdd BLAST33

Organism-specific databases

DisGeNET

More...
DisGeNETi
4809

Open Targets

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OpenTargetsi
ENSG00000100138

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA31621

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
P55769, Tbio

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB02494, (S)-3-phenyllactic acid
DB07374, Anisomycin

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SNU13

Domain mapping of disease mutations (DMDM)

More...
DMDMi
2500345

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004232601 – 128NHP2-like protein 1Add BLAST128
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved; alternateCombined sources1 Publication
ChainiPRO_00001367782 – 128NHP2-like protein 1, N-terminally processedAdd BLAST127

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei2N-acetylthreonine; in NHP2-like protein 1, N-terminally processedCombined sources1 Publication1
Modified residuei21N6-acetyllysineBy similarity1
Modified residuei122PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P55769

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P55769

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P55769

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P55769

PeptideAtlas

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PeptideAtlasi
P55769

PRoteomics IDEntifications database

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PRIDEi
P55769

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
56859

Consortium for Top Down Proteomics

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TopDownProteomicsi
P55769

2D gel databases

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

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SWISS-2DPAGEi
P55769

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P55769

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P55769

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P55769

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000100138, Expressed in testis and 249 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P55769, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P55769, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000100138, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Identified in the spliceosome B complex (PubMed:28781166).

Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, WDR57, SNRNP40, DDX23, CD2BP2, PPIH, NHP2L1, EFTUD2, SART1 and USP39 (PubMed:16723661, PubMed:26912367).

Interacts with RAD17 and PRPF31 (PubMed:10593953, PubMed:17412961, PubMed:21784869). The complex formed by SNU13 and PRPF31 binds U4 snRNA (PubMed:17412961). The complex formed by SNU13 and PRPF31 binds also U4atac snRNA, a characteristic component of specific, less abundant spliceosomal complexes (PubMed:21784869).

6 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei61Interaction with U4 snRNA and U4atac snRNA2 Publications1
Sitei86Interaction with U4 snRNA and U4atac snRNA2 Publications1

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
110874, 210 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P55769

Protein interaction database and analysis system

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IntActi
P55769, 45 interactors

Molecular INTeraction database

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MINTi
P55769

STRING: functional protein association networks

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STRINGi
9606.ENSP00000383949

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
P55769, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1128
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

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BMRBi
P55769

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P55769

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
P55769

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni36 – 48Interaction with U4 snRNA and U4atac snRNA2 PublicationsAdd BLAST13
Regioni96 – 128Important for U4 snRNA-binding1 PublicationAdd BLAST33

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3387, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00550000074840

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_084513_4_1_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P55769

KEGG Orthology (KO)

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KOi
K12845

Database of Orthologous Groups

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OrthoDBi
1497609at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P55769

TreeFam database of animal gene trees

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TreeFami
TF300184

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.1330.30, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR002415, H/ACA_rnp_Nhp2_euk
IPR029064, L30e-like
IPR004038, Ribosomal_L7Ae/L30e/S12e/Gad45
IPR018492, Ribosomal_L7Ae/L8/Nhp2
IPR004037, Ribosomal_L7Ae_CS

Pfam protein domain database

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Pfami
View protein in Pfam
PF01248, Ribosomal_L7Ae, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00881, L7ARS6FAMILY
PR00883, NUCLEARHMG

Superfamily database of structural and functional annotation

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SUPFAMi
SSF55315, SSF55315, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS01082, RIBOSOMAL_L7AE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

P55769-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTEADVNPKA YPLADAHLTK KLLDLVQQSC NYKQLRKGAN EATKTLNRGI
60 70 80 90 100
SEFIVMAADA EPLEIILHLP LLCEDKNVPY VFVRSKQALG RACGVSRPVI
110 120
ACSVTIKEGS QLKQQIQSIQ QSIERLLV
Length:128
Mass (Da):14,174
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i78849EBB497089ED
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1AHD1B1AHD1_HUMAN
Ribonucloprotein
SNU13
132Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3IUA2A0A3B3IUA2_HUMAN
Ribonucloprotein
SNU13
272Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3IRU2A0A3B3IRU2_HUMAN
NHP2 non-histone chromosome protein...
SNU13 NHP2L1, hCG_41538
73Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3ISH1A0A3B3ISH1_HUMAN
NHP2-like protein 1
SNU13
41Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3ISH9A0A3B3ISH9_HUMAN
NHP2-like protein 1
SNU13
21Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3ISK4A0A3B3ISK4_HUMAN
NHP2-like protein 1
SNU13
67Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03415519T → N. Corresponds to variant dbSNP:rs1802521Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D50420 mRNA Translation: BAA23363.1
AF155235 mRNA Translation: AAF06959.1
AF091076 mRNA Translation: AAC72945.1
CR456531 mRNA Translation: CAG30417.1
Z83840 Genomic DNA No translation available.
BC005358 mRNA Translation: AAH05358.1
BC019282 mRNA Translation: AAH19282.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS14022.1
CCDS33653.1

NCBI Reference Sequences

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RefSeqi
NP_001003796.1, NM_001003796.1
NP_004999.1, NM_005008.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000215956; ENSP00000215956; ENSG00000100138
ENST00000401959; ENSP00000383949; ENSG00000100138
ENST00000648674; ENSP00000497142; ENSG00000100138

Database of genes from NCBI RefSeq genomes

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GeneIDi
4809

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:4809

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50420 mRNA Translation: BAA23363.1
AF155235 mRNA Translation: AAF06959.1
AF091076 mRNA Translation: AAC72945.1
CR456531 mRNA Translation: CAG30417.1
Z83840 Genomic DNA No translation available.
BC005358 mRNA Translation: AAH05358.1
BC019282 mRNA Translation: AAH19282.1
CCDSiCCDS14022.1
CCDS33653.1
RefSeqiNP_001003796.1, NM_001003796.1
NP_004999.1, NM_005008.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1E7KX-ray2.90A/B1-128[»]
2JNBNMR-A1-128[»]
2OZBX-ray2.60A/D1-128[»]
3JCRelectron microscopy7.00I1-128[»]
3SIUX-ray2.63A/D1-128[»]
3SIVX-ray3.30A/D/G/J1-128[»]
5O9Zelectron microscopy4.50O1-128[»]
6AH0electron microscopy5.70M1-128[»]
6AHDelectron microscopy3.80M1-128[»]
6QW6electron microscopy2.924D1-128[»]
6QX9electron microscopy3.284D1-128[»]
BMRBiP55769
SMRiP55769
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi110874, 210 interactors
CORUMiP55769
IntActiP55769, 45 interactors
MINTiP55769
STRINGi9606.ENSP00000383949

Chemistry databases

DrugBankiDB02494, (S)-3-phenyllactic acid
DB07374, Anisomycin

PTM databases

iPTMnetiP55769
PhosphoSitePlusiP55769
SwissPalmiP55769

Polymorphism and mutation databases

BioMutaiSNU13
DMDMi2500345

2D gel databases

SWISS-2DPAGEiP55769

Proteomic databases

EPDiP55769
jPOSTiP55769
MassIVEiP55769
PaxDbiP55769
PeptideAtlasiP55769
PRIDEiP55769
ProteomicsDBi56859
TopDownProteomicsiP55769

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
27035, 102 antibodies

The DNASU plasmid repository

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DNASUi
4809

Genome annotation databases

EnsembliENST00000215956; ENSP00000215956; ENSG00000100138
ENST00000401959; ENSP00000383949; ENSG00000100138
ENST00000648674; ENSP00000497142; ENSG00000100138
GeneIDi4809
KEGGihsa:4809

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
4809
DisGeNETi4809
EuPathDBiHostDB:ENSG00000100138.13

GeneCards: human genes, protein and diseases

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GeneCardsi
SNU13
HGNCiHGNC:7819, SNU13
HPAiENSG00000100138, Low tissue specificity
MIMi601304, gene
601876, gene
neXtProtiNX_P55769
OpenTargetsiENSG00000100138
PharmGKBiPA31621

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG3387, Eukaryota
GeneTreeiENSGT00550000074840
HOGENOMiCLU_084513_4_1_1
InParanoidiP55769
KOiK12845
OrthoDBi1497609at2759
PhylomeDBiP55769
TreeFamiTF300184

Enzyme and pathway databases

PathwayCommonsiP55769
ReactomeiR-HSA-6790901, rRNA modification in the nucleus and cytosol
R-HSA-6791226, Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72163, mRNA Splicing - Major Pathway
R-HSA-72165, mRNA Splicing - Minor Pathway

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
4809, 759 hits in 878 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SNU13, human
EvolutionaryTraceiP55769

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
NHP2L1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
4809
PharosiP55769, Tbio

Protein Ontology

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PROi
PR:P55769
RNActiP55769, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000100138, Expressed in testis and 249 other tissues
ExpressionAtlasiP55769, baseline and differential
GenevisibleiP55769, HS

Family and domain databases

Gene3Di3.30.1330.30, 1 hit
InterProiView protein in InterPro
IPR002415, H/ACA_rnp_Nhp2_euk
IPR029064, L30e-like
IPR004038, Ribosomal_L7Ae/L30e/S12e/Gad45
IPR018492, Ribosomal_L7Ae/L8/Nhp2
IPR004037, Ribosomal_L7Ae_CS
PfamiView protein in Pfam
PF01248, Ribosomal_L7Ae, 1 hit
PRINTSiPR00881, L7ARS6FAMILY
PR00883, NUCLEARHMG
SUPFAMiSSF55315, SSF55315, 1 hit
PROSITEiView protein in PROSITE
PS01082, RIBOSOMAL_L7AE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNH2L1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P55769
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: October 7, 2020
This is version 205 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  7. Ribosomal proteins
    Ribosomal proteins families and list of entries
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