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Protein

Serine carboxypeptidase II-2

Gene

CXP;2-2

Organism
Hordeum vulgare (Barley)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei149By similarity1
Active sitei350By similarity1
Active sitei403By similarity1

GO - Molecular functioni

Keywordsi

Molecular functionCarboxypeptidase, Hydrolase, Protease

Protein family/group databases

ESTHERihorvu-cp22 Carboxypeptidase_S10
MEROPSiS10.A32

Names & Taxonomyi

Protein namesi
Recommended name:
Serine carboxypeptidase II-2 (EC:3.4.16.6)
Alternative name(s):
CP-MII.2
Cleaved into the following 2 chains:
Gene namesi
Name:CXP;2-2
OrganismiHordeum vulgare (Barley)
Taxonomic identifieri4513 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladePooideaeTriticodaeTriticeaeHordeinaeHordeum

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000004317‹1 – 256Serine carboxypeptidase II-2 chain AAdd BLAST›256
PropeptideiPRO_0000004318257 – 270Linker peptideBy similarityAdd BLAST14
ChainiPRO_0000004319271 – 436Serine carboxypeptidase II-2 chain BAdd BLAST166

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi56 ↔ 313Interchain (between A and B chains)By similarity
Glycosylationi107N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi217 ↔ 229By similarity
Disulfide bondi253 ↔ 281Interchain (between A and B chains)By similarity

Post-translational modificationi

The linker peptide is endoproteolytically excised during enzyme maturation.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PRIDEiP55748

Expressioni

Developmental stagei

Expressed in the germinating embryo. Low levels in the developing aleurone and embryo. Also found in the roots and shoots of the growing seedling.

Gene expression databases

ExpressionAtlasiP55748 baseline and differential

Interactioni

Subunit structurei

Carboxypeptidase II is a dimer, where each monomer is composed of two chains linked by a disulfide bond.By similarity

Structurei

3D structure databases

ProteinModelPortaliP55748
SMRiP55748
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Phylogenomic databases

eggNOGiKOG1282 Eukaryota
COG2939 LUCA

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR001563 Peptidase_S10
IPR033124 Ser_caboxypep_his_AS
IPR018202 Ser_caboxypep_ser_AS
PANTHERiPTHR11802 PTHR11802, 1 hit
PfamiView protein in Pfam
PF00450 Peptidase_S10, 1 hit
PRINTSiPR00724 CRBOXYPTASEC
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00560 CARBOXYPEPT_SER_HIS, 1 hit
PS00131 CARBOXYPEPT_SER_SER, 1 hit

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55748-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
VPRVPGQAFD ASFAHYAGYV TVSEDRGAAL FYWFFEAAHD PASKPLLLWL
60 70 80 90 100
NGGPGCSSIA FGVGEEVGPF HVNADGKGVH MNPYSWNQVA NILFLDSPVG
110 120 130 140 150
VGYSYSNTSA DILSNGDERT AKDSLVFLTK WLERFPQYKE REFYLTGESY
160 170 180 190 200
AGHYVPQLAQ AIKRHHEATG DKSINLKGYM VGNALTDDFH DHYGIFQYMW
210 220 230 240 250
TTGLISDQTY KLLNIFCDFE SFVHTSPQCD KILDIASTEA GNIDSYSIFT
260 270 280 290 300
PTCHSSFASS RNKVVKRLRS VGKMGEQYDP CTEKHSIVYF NLHEVQKALH
310 320 330 340 350
VNPVIGKSKW ETCSEVINTN WKDCERSVLH IYHELIQYGL RIWMFSGDTD
360 370 380 390 400
AVIPVTSTRY SIDALKLPTV TPWHAWYDDD GEVGGWTQGY KGLNFVTVRG
410 420 430
AGHEVPLHRP KQALTLIKSF LAGRPMPVLS DLRSDM
Length:436
Mass (Da):48,952
Last modified:November 1, 1997 - v1
Checksum:iE0F82D97E0C34DC9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78878 mRNA Translation: CAB59202.1

Similar proteinsi

Entry informationi

Entry nameiCBP22_HORVU
AccessioniPrimary (citable) accession number: P55748
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 23, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

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