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Entry version 33 (23 May 2018)
Sequence version 1 (01 Nov 1997)
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Protein

Cytotoxicity-associated immunodominant antigen

Gene

cagA

Organism
Helicobacter pylori (Campylobacter pylori)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be necessary for the transcription, folding, export, or function of the cytotoxin.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cytotoxicity-associated immunodominant antigen
Alternative name(s):
120 kDa protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:cagA
Synonyms:cai
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHelicobacter pylori (Campylobacter pylori)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri210 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000895941 – 1182Cytotoxicity-associated immunodominant antigenAdd BLAST1182

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
P55746

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P55746

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi878 – 885Poly-Asn8

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005169 CagA
IPR004355 IVSec_CagA

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03507 CagA, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01553 TYPE4SSCAGA

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P55746-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTNETIDQQP QTEAAFNPQQ FINNLQVAFL KVDNAVASYD PDQKPIVDKN
60 70 80 90 100
DRDNRQAFEG ISQLREEYSN KAIKNPTKKN QYFSDFINKS NDLINKDNLI
110 120 130 140 150
VVESSTKSFQ KFGDQRYRIF TSWVSHQNDP SKINTRCIRN FMEHTIQPPI
160 170 180 190 200
PDDKEKAEFL KSAKQSFAGI IIGNQIRTDQ KFMGVFDESL KERQEAEKNG
210 220 230 240 250
GPTGGDWLDI FLSFIFDKKQ SSDVKEAINQ EPLPHVQPDI ATSTTHIQGL
260 270 280 290 300
PPESRDLLDE RGNFSKFTLG DMEMLDVEGV ADMDPNYKFN QLLIHNNTLS
310 320 330 340 350
SVLMGSHDGI EPEKVSLLYA GNGGFGAKHD WNATVGYKDQ QGNNVATIIN
360 370 380 390 400
VHMKNGSGLV IAGGEKGINN PSFYLYKEDQ LTGSQRALSQ EEIQNKIDFM
410 420 430 440 450
EFLAQNNAKL DSLSEKEKEK FRNEIKDFQK DSKPYLDALG NDRIAFVSKK
460 470 480 490 500
DPKHSALITE FNKGDLSYTL KVMGKKQIKA LDREKNVTLQ GNLKHDGVMF
510 520 530 540 550
VNYSNFKYTN ASKSPNKGVG VTNGVSHLEA GFSKVAVFNL PNLNNLAITS
560 570 580 590 600
VVRRDLEDKL IAKGLSPQEA NKLVKDFLSS NKELVGKALN FNKAVAEAKN
610 620 630 640 650
TGNYDEVKRA QKDLEKSLKK REHLEKGDVA KNLESKSGNK NKMEAKAQAN
660 670 680 690 700
SQKDEIFALI NKEANRDARA IAYAQNLKGI KRELSDKLEN INKDLKDFSK
710 720 730 740 750
SFDGFKNGKN KDFSKAEETL KALKGSVKDL GINPEWISKV ENLNAALNEF
760 770 780 790 800
KNGKNKDFSK VTQAKSDQEN SIKDVIINQK ITDKVDELNQ AVSVAKIACD
810 820 830 840 850
FSGVEQALAD LKNFSKEQLA QQAQKNESFN VGKSEIYQSV KNGVNGTLVG
860 870 880 890 900
NGLSGIEATA LAKNFSDIKK ELNEKFKNFN NNNNNGLKNG GEPIYAQVNK
910 920 930 940 950
KKTGQVASPE EPIYAQVAKK VTKKIDQLNQ AATSGFGGVG QAGFPLKRHD
960 970 980 990 1000
KVEDLSKVGR SVSPEPIYAT IDDLGGSFPL KRHDKVDDLS KVGLSRNQEL
1010 1020 1030 1040 1050
TQKIDNLSQA VSEAKAGFFG NLEQTIDKLK DFTKNNPVNL WAESAKKVPA
1060 1070 1080 1090 1100
SLSAKLDNYA TNSHTRINSN IQNGAINEKA TGTERQKNPE WLKLVNDKIV
1110 1120 1130 1140 1150
AHNVGSVPLS EYDNIGFSQK NMKDYSDSFK FSTKLNNAVK DIKSGFTQFL
1160 1170 1180
ANAFSTGYYS MARENAEHGI KNANTKGGFQ KS
Length:1,182
Mass (Da):131,504
Last modified:November 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC916817E2EE57BB4
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L11714 Genomic DNA No translation available.

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L11714 Genomic DNA No translation available.

3D structure databases

SMRiP55746
ModBaseiSearch...

Proteomic databases

PRIDEiP55746

Family and domain databases

InterProiView protein in InterPro
IPR005169 CagA
IPR004355 IVSec_CagA
PfamiView protein in Pfam
PF03507 CagA, 1 hit
PRINTSiPR01553 TYPE4SSCAGA

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCGA2_HELPX
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P55746
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 23, 2018
This is version 33 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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