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Protein

Homeobox protein PKNOX1

Gene

PKNOX1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Activates transcription in the presence of PBX1A and HOXA1.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi259 – 321Homeobox; TALE-typePROSITE-ProRule annotationAdd BLAST63

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis
SIGNORiP55347

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein PKNOX1
Alternative name(s):
Homeobox protein PREP-1
PBX/knotted homeobox 1
Gene namesi
Name:PKNOX1
Synonyms:PREP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

EuPathDBiHostDB:ENSG00000160199.14
HGNCiHGNC:9022 PKNOX1
MIMi602100 gene
neXtProtiNX_P55347

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi5316
OpenTargetsiENSG00000160199
PharmGKBiPA33354

Polymorphism and mutation databases

DMDMi115311619

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000492481 – 436Homeobox protein PKNOX1Add BLAST436

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei33PhosphoserineBy similarity1
Modified residuei41PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP55347
PaxDbiP55347
PeptideAtlasiP55347
PRIDEiP55347
ProteomicsDBi56856
56857 [P55347-2]

2D gel databases

SWISS-2DPAGEiP55347

PTM databases

iPTMnetiP55347
PhosphoSitePlusiP55347

Expressioni

Tissue specificityi

Ubiquitous. Isoform 2 is expressed in all examined tissues except in bone marrow.2 Publications

Gene expression databases

BgeeiENSG00000160199 Expressed in 210 organ(s), highest expression level in left lobe of thyroid gland
CleanExiHS_PKNOX1
ExpressionAtlasiP55347 baseline and differential
GenevisibleiP55347 HS

Organism-specific databases

HPAiCAB004285
HPA057215
HPA065017

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi111333, 22 interactors
IntActiP55347, 19 interactors
MINTiP55347
STRINGi9606.ENSP00000291547

Structurei

Secondary structure

1436
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP55347
SMRiP55347
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP55347

Family & Domainsi

Sequence similaritiesi

Belongs to the TALE/MEIS homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0773 Eukaryota
ENOG410XPMQ LUCA
GeneTreeiENSGT00550000074260
HOGENOMiHOG000253922
HOVERGENiHBG055193
InParanoidiP55347
OMAiITAPVNM
OrthoDBiEOG091G09WJ
PhylomeDBiP55347
TreeFamiTF318093

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR001356 Homeobox_dom
IPR008422 Homeobox_KN_domain
IPR032453 PKNOX/Meis_N
PfamiView protein in Pfam
PF05920 Homeobox_KN, 1 hit
PF16493 Meis_PKNOX_N, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS50071 HOMEOBOX_2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P55347-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMATQTLSID SYQDGQQMQV VTELKTEQDP NCSEPDAEGV SPPPVESQTP
60 70 80 90 100
MDVDKQAIYR HPLFPLLALL FEKCEQSTQG SEGTTSASFD VDIENFVRKQ
110 120 130 140 150
EKEGKPFFCE DPETDNLMVK AIQVLRIHLL ELEKVNELCK DFCSRYIACL
160 170 180 190 200
KTKMNSETLL SGEPGSPYSP VQSQQIQSAI TGTISPQGIV VPASALQQGN
210 220 230 240 250
VAMATVAGGT VYQPVTVVTP QGQVVTQTLS PGTIRIQNSQ LQLQLNQDLS
260 270 280 290 300
ILHQDDGSSK NKRGVLPKHA TNVMRSWLFQ HIGHPYPTED EKKQIAAQTN
310 320 330 340 350
LTLLQVNNWF INARRRILQP MLDSSCSETP KTKKKTAQNR PVQRFWPDSI
360 370 380 390 400
ASGVAQPPPS ELTMSEGAVV TITTPVNMNV DSLQSLSSDG ATLAVQQVMM
410 420 430
AGQSEDESVD STEEDAGALA PAHISGLVLE NSDSLQ
Length:436
Mass (Da):47,607
Last modified:September 19, 2006 - v3
Checksum:i381E901F435AC5F2
GO
Isoform 2 (identifier: P55347-2) [UniParc]FASTAAdd to basket
Also known as: PKNOX1B

The sequence of this isoform differs from the canonical sequence as follows:
     368-436: AVVTITTPVN...LVLENSDSLQ → TGGRPRPDMV...SHRARPRMTS

Show »
Length:405
Mass (Da):44,629
Checksum:i2413564513C5DE76
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EPN6E7EPN6_HUMAN
Homeobox protein PKNOX1
PKNOX1
319Annotation score:
H0YM69H0YM69_HUMAN
Homeobox protein PKNOX1
PKNOX1
61Annotation score:

Sequence cautioni

The sequence AAC51243 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA95533 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti153K → E in CAA73934 (PubMed:9479508).Curated1
Sequence conflicti347P → A in AAC51243 (PubMed:9143494).Curated1
Sequence conflicti430E → A in CAA73934 (PubMed:9479508).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049588126R → H. Corresponds to variant dbSNP:rs9976017Ensembl.1
Natural variantiVAR_049589216T → A. Corresponds to variant dbSNP:rs17115709Ensembl.1
Natural variantiVAR_036440265V → I in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs376883451Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_017260368 – 436AVVTI…SDSLQ → TGGRPRPDMVDHGVGIMNKR PGSGLLAVSHRARPRMTS in isoform 2. 1 PublicationAdd BLAST69

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U68727 mRNA Translation: AAC51243.1 Different initiation.
Y13613 mRNA Translation: CAA73934.1
AY142115 mRNA Translation: AAN34940.1
AP001748 Genomic DNA Translation: BAA95533.1 Different initiation.
CCDSiCCDS13692.1 [P55347-1]
RefSeqiNP_004562.2, NM_004571.4 [P55347-1]
UniGeneiHs.431043

Genome annotation databases

EnsembliENST00000291547; ENSP00000291547; ENSG00000160199 [P55347-1]
GeneIDi5316
KEGGihsa:5316

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U68727 mRNA Translation: AAC51243.1 Different initiation.
Y13613 mRNA Translation: CAA73934.1
AY142115 mRNA Translation: AAN34940.1
AP001748 Genomic DNA Translation: BAA95533.1 Different initiation.
CCDSiCCDS13692.1 [P55347-1]
RefSeqiNP_004562.2, NM_004571.4 [P55347-1]
UniGeneiHs.431043

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1X2NNMR-A260-319[»]
ProteinModelPortaliP55347
SMRiP55347
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111333, 22 interactors
IntActiP55347, 19 interactors
MINTiP55347
STRINGi9606.ENSP00000291547

PTM databases

iPTMnetiP55347
PhosphoSitePlusiP55347

Polymorphism and mutation databases

DMDMi115311619

2D gel databases

SWISS-2DPAGEiP55347

Proteomic databases

EPDiP55347
PaxDbiP55347
PeptideAtlasiP55347
PRIDEiP55347
ProteomicsDBi56856
56857 [P55347-2]

Protocols and materials databases

DNASUi5316
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000291547; ENSP00000291547; ENSG00000160199 [P55347-1]
GeneIDi5316
KEGGihsa:5316

Organism-specific databases

CTDi5316
DisGeNETi5316
EuPathDBiHostDB:ENSG00000160199.14
GeneCardsiPKNOX1
HGNCiHGNC:9022 PKNOX1
HPAiCAB004285
HPA057215
HPA065017
MIMi602100 gene
neXtProtiNX_P55347
OpenTargetsiENSG00000160199
PharmGKBiPA33354
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0773 Eukaryota
ENOG410XPMQ LUCA
GeneTreeiENSGT00550000074260
HOGENOMiHOG000253922
HOVERGENiHBG055193
InParanoidiP55347
OMAiITAPVNM
OrthoDBiEOG091G09WJ
PhylomeDBiP55347
TreeFamiTF318093

Enzyme and pathway databases

ReactomeiR-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis
SIGNORiP55347

Miscellaneous databases

ChiTaRSiPKNOX1 human
EvolutionaryTraceiP55347
GeneWikiiPKNOX1
GenomeRNAii5316
PROiPR:P55347
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000160199 Expressed in 210 organ(s), highest expression level in left lobe of thyroid gland
CleanExiHS_PKNOX1
ExpressionAtlasiP55347 baseline and differential
GenevisibleiP55347 HS

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR001356 Homeobox_dom
IPR008422 Homeobox_KN_domain
IPR032453 PKNOX/Meis_N
PfamiView protein in Pfam
PF05920 Homeobox_KN, 1 hit
PF16493 Meis_PKNOX_N, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPKNX1_HUMAN
AccessioniPrimary (citable) accession number: P55347
Secondary accession number(s): O00528, Q8IWT7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: September 19, 2006
Last modified: November 7, 2018
This is version 158 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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