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UniProtKB - P55345 (ANM2_HUMAN)

Entry version 183 (07 Apr 2021)
Sequence version 1 (01 Nov 1997)
Previous versions | rss
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Protein

Protein arginine N-methyltransferase 2

Gene

PRMT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in proteins such as STAT3, FBL, histone H4. Acts as a coactivator (with NCOA2) of the androgen receptor (AR)-mediated transactivation. Acts as a coactivator (with estrogen) of estrogen receptor (ER)-mediated transactivation. Enhances PGR, PPARG, RARA-mediated transactivation. May inhibit NF-kappa-B transcription and promote apoptosis. Represses E2F1 transcriptional activity (in a RB1-dependent manner). May be involved in growth regulation.4 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=2.6 µM for AdoMet1 Publication
  2. KM=3.3 µM for H41 Publication
  1. Vmax=1.4 pmol/min/mg enzyme toward S-adenosyl-L-methionine (AdoMet)1 Publication
  2. Vmax=1.5 pmol/min/mg enzyme toward histone H41 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei112S-adenosyl-L-methionineBy similarity1
Binding sitei121S-adenosyl-L-methionineBy similarity1
Binding sitei145S-adenosyl-L-methionine; via carbonyl oxygenBy similarity1
Binding sitei168S-adenosyl-L-methionineBy similarity1
Binding sitei197S-adenosyl-L-methionineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei211By similarity1
Active sitei220By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMethyltransferase, Transferase
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		MetaCyc:HS08486-MONOMER

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		2.1.1.125, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P55345

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein arginine N-methyltransferase 2 (EC:2.1.1.3191 Publication)
Alternative name(s):
Histone-arginine N-methyltransferase PRMT2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PRMT2
Synonyms:HMT1, HRMT1L1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 21

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:5186, PRMT2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		601961, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P55345

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000160310.16

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		3275

Open Targets

More...OpenTargetsi		ENSG00000160310

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA29460

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P55345, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PRMT2

Domain mapping of disease mutations (DMDM)

More...DMDMi		2499805

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002123241 – 433Protein arginine N-methyltransferase 2Add BLAST433

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei61Asymmetric dimethylarginineCombined sources1
Modified residuei72Asymmetric dimethylarginineCombined sources1

Keywords - PTMi

Methylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P55345

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P55345

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P55345

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P55345

PeptideAtlas

More...PeptideAtlasi		P55345

PRoteomics IDEntifications database

More...PRIDEi		P55345

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		56853 [P55345-1]
56854 [P55345-2]
56855 [P55345-3]
6261
6262
6263

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P55345

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P55345

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P55345

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed. Highly expressed in androgen target organs such as heart, prostate, skeletal muscle, ovary and spinal cord.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000160310, Expressed in cortical plate and 241 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P55345, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P55345, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000160310, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Self-associates.

Interacts with RB1 and E2F1 (By similarity).

Interacts with NCOA6 coactivator.

Interacts (via SH3 domain) with PRMT8.

Interacts with AR.

Interacts with NFKBIA.

Interacts with ESR1, ESR2, PGR, PPARG, RARA, RXRA and THRB.

Interacts with HNRNPUL1.

By similarity6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		109511, 58 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P55345

Protein interaction database and analysis system

More...IntActi		P55345, 54 interactors

Molecular INTeraction database

More...MINTi		P55345

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000380759

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P55345, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1433
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P55345

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P55345

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini30 – 89SH3PROSITE-ProRule annotationAdd BLAST60
Domaini99 – 432SAM-dependent MTase PRMT-typePROSITE-ProRule annotationAdd BLAST334

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 277Interaction with ESR1Add BLAST277
Regioni83 – 207Interaction with RB1By similarityAdd BLAST125
Regioni133 – 275Interaction with ESR1Add BLAST143

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.PROSITE-ProRule annotation

Keywords - Domaini

SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1499, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000160683

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_017375_4_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P55345

Identification of Orthologs from Complete Genome Data

More...OMAi		KSFPMWR

Database for complete collections of gene phylogenies

More...PhylomeDBi		P55345

TreeFam database of animal gene trees

More...TreeFami		TF332196

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR025799, Arg_MeTrfase
IPR029063, SAM-dependent_MTases
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
IPR007848, Small_mtfrase_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF05175, MTS, 1 hit
PF00018, SH3_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00452, SH3DOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00326, SH3, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50044, SSF50044, 1 hit
SSF53335, SSF53335, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51678, SAM_MT_PRMT, 1 hit
PS50002, SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 7 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 7 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P55345-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATSGDCPRS ESQGEEPAEC SEAGLLQEGV QPEEFVAIAD YAATDETQLS 
        60         70         80         90        100
FLRGEKILIL RQTTADWWWG ERAGCCGYIP ANHVGKHVDE YDPEDTWQDE 
       110        120        130        140        150
EYFGSYGTLK LHLEMLADQP RTTKYHSVIL QNKESLTDKV ILDVGCGTGI 
       160        170        180        190        200
ISLFCAHYAR PRAVYAVEAS EMAQHTGQLV LQNGFADIIT VYQQKVEDVV 
       210        220        230        240        250
LPEKVDVLVS EWMGTCLLFE FMIESILYAR DAWLKEDGVI WPTMAALHLV 
       260        270        280        290        300
PCSADKDYRS KVLFWDNAYE FNLSALKSLA VKEFFSKPKY NHILKPEDCL 
       310        320        330        340        350
SEPCTILQLD MRTVQISDLE TLRGELRFDI RKAGTLHGFT AWFSVHFQSL 
       360        370        380        390        400
QEGQPPQVLS TGPFHPTTHW KQTLFMMDDP VPVHTGDVVT GSVVLQRNPV 
       410        420        430 
WRRHMSVALS WAVTSRQDPT SQKVGEKVFP IWR
Length:433
Mass (Da):49,042
Last modified:November 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6DEE0350C15ECD4F
GO
Isoform 2 (identifier: P55345-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     219-433: FEFMIESILY...VGEKVFPIWR → AAPLLSCRIL...LHLSWPIFLL

Show »
Length:284
Mass (Da):31,162
Checksum:i83703F72DDFA885B
GO
Isoform 3 (identifier: P55345-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     219-320: Missing.

Show »
Length:331
Mass (Da):37,167
Checksum:iB3FDADFE7F9133E9
GO
Isoform PRMT2Alpha (identifier: P55345-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     278-289: SLAVKEFFSKPK → LEKKSSPSGDDS
     290-433: Missing.

Note: Higher expression in breast cancer tissues.Curated
Show »
Length:289
Mass (Da):32,424
Checksum:i49DEAA4267BF98ED
GO
Isoform PRMT2Beta (identifier: P55345-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     219-301: FEFMIESILY...HILKPEDCLS → HHTLEADAVH...FGKQCAYLEG
     302-433: Missing.

Note: Higher expression in breast cancer tissues. Doesn't interact with ESR1.Curated
Show »
Length:301
Mass (Da):33,543
Checksum:iFBEC6C51A1CE8B64
GO
Isoform PRMT2Gamma (identifier: P55345-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     219-423: Missing.

Note: Higher expression in breast cancer tissues.Curated
Show »
Length:228
Mass (Da):25,494
Checksum:iC02A5A20FB63338C
GO
Isoform PRMT2L2 (identifier: P55345-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     278-433: Missing.

Show »
Length:277
Mass (Da):31,193
Checksum:i970E9AD5A09EB8CD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A8MXR3A8MXR3_HUMAN
Protein arginine N-methyltransferas...
PRMT2
253Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C2H9H7C2H9_HUMAN
Protein arginine N-methyltransferas...
PRMT2
194Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WYX1A0A087WYX1_HUMAN
Protein arginine N-methyltransferas...
PRMT2
161Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti256 – 260KDYRS → RIIVA in AAB48437 (PubMed:9196002).Curated5
Sequence conflicti402R → I in AAH00727 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_042680219 – 433FEFMI…FPIWR → AAPLLSCRILPCTCASGPLH VLLACCLPLPCTCASVPLHV LLACCLPVLRAPQPSGLHLS WPIFLL in isoform 2. 1 PublicationAdd BLAST215
Alternative sequenceiVSP_054927219 – 423Missing in isoform PRMT2Gamma. 1 PublicationAdd BLAST205
Alternative sequenceiVSP_043381219 – 320Missing in isoform 3. 1 PublicationAdd BLAST102
Alternative sequenceiVSP_054928219 – 301FEFMI…EDCLS → HHTLEADAVHDGRPSPCPYR RRGHGFSCVAEKPSVEKAHV CGSELGCHFQTRPHISKSWR KSLPHLEMTVDALFGKQCAY LEG in isoform PRMT2Beta. 1 PublicationAdd BLAST83
Alternative sequenceiVSP_054929278 – 433Missing in isoform PRMT2L2. 1 PublicationAdd BLAST156
Alternative sequenceiVSP_054930278 – 289SLAVK…FSKPK → LEKKSSPSGDDS in isoform PRMT2Alpha. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_054931290 – 433Missing in isoform PRMT2Alpha. 1 PublicationAdd BLAST144
Alternative sequenceiVSP_054932302 – 433Missing in isoform PRMT2Beta. 1 PublicationAdd BLAST132

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X99209 mRNA Translation: CAA67599.1
U80213 mRNA Translation: AAB48437.1
AY786414 mRNA Translation: AAV48568.2
FJ436410 mRNA Translation: ACJ66866.1
FJ436411 mRNA Translation: ACJ66867.1
FJ436412 mRNA Translation: ACJ66868.1
U79286 mRNA Translation: AAB50221.1
CR541804 mRNA Translation: CAG46603.1
AK123650 mRNA Translation: BAG53931.1
AP000339 Genomic DNA No translation available.
AP000340 Genomic DNA No translation available.
CH471079 Genomic DNA Translation: EAX09259.1
CH471079 Genomic DNA Translation: EAX09265.1
BC000727 mRNA Translation: AAH00727.1
BC100026 mRNA Translation: AAI00027.1
AL109794 mRNA Translation: CAB52454.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS13737.1 [P55345-1]
CCDS56219.1 [P55345-2]
CCDS56220.1 [P55345-3]
CCDS68230.1 [P55345-4]
CCDS68231.1 [P55345-5]
CCDS74806.1 [P55345-6]

NCBI Reference Sequences

More...RefSeqi		NP_001229793.1, NM_001242864.2 [P55345-3]
NP_001229794.1, NM_001242865.2 [P55345-2]
NP_001229795.1, NM_001242866.2 [P55345-7]
NP_001273605.1, NM_001286676.1 [P55345-5]
NP_001273606.1, NM_001286677.1 [P55345-4]
NP_001273607.1, NM_001286678.1 [P55345-6]
NP_001526.2, NM_001535.4 [P55345-1]
NP_996845.1, NM_206962.3 [P55345-1]
XP_005261168.1, XM_005261111.3 [P55345-1]
XP_006724061.1, XM_006723998.3 [P55345-5]
XP_006724063.1, XM_006724000.2 [P55345-6]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000291705; ENSP00000291705; ENSG00000160310 [P55345-6]
ENST00000334494; ENSP00000335490; ENSG00000160310 [P55345-2]
ENST00000355680; ENSP00000347906; ENSG00000160310 [P55345-1]
ENST00000397637; ENSP00000380759; ENSG00000160310 [P55345-1]
ENST00000397638; ENSP00000380760; ENSG00000160310 [P55345-1]
ENST00000440086; ENSP00000397266; ENSG00000160310 [P55345-3]
ENST00000451211; ENSP00000411984; ENSG00000160310 [P55345-4]
ENST00000458387; ENSP00000407463; ENSG00000160310 [P55345-5]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		3275

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:3275

UCSC genome browser

More...UCSCi		uc002zjx.5, human [P55345-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99209 mRNA Translation: CAA67599.1
U80213 mRNA Translation: AAB48437.1
AY786414 mRNA Translation: AAV48568.2
FJ436410 mRNA Translation: ACJ66866.1
FJ436411 mRNA Translation: ACJ66867.1
FJ436412 mRNA Translation: ACJ66868.1
U79286 mRNA Translation: AAB50221.1
CR541804 mRNA Translation: CAG46603.1
AK123650 mRNA Translation: BAG53931.1
AP000339 Genomic DNA No translation available.
AP000340 Genomic DNA No translation available.
CH471079 Genomic DNA Translation: EAX09259.1
CH471079 Genomic DNA Translation: EAX09265.1
BC000727 mRNA Translation: AAH00727.1
BC100026 mRNA Translation: AAI00027.1
AL109794 mRNA Translation: CAB52454.1
CCDSiCCDS13737.1 [P55345-1]
CCDS56219.1 [P55345-2]
CCDS56220.1 [P55345-3]
CCDS68230.1 [P55345-4]
CCDS68231.1 [P55345-5]
CCDS74806.1 [P55345-6]
RefSeqiNP_001229793.1, NM_001242864.2 [P55345-3]
NP_001229794.1, NM_001242865.2 [P55345-2]
NP_001229795.1, NM_001242866.2 [P55345-7]
NP_001273605.1, NM_001286676.1 [P55345-5]
NP_001273606.1, NM_001286677.1 [P55345-4]
NP_001273607.1, NM_001286678.1 [P55345-6]
NP_001526.2, NM_001535.4 [P55345-1]
NP_996845.1, NM_206962.3 [P55345-1]
XP_005261168.1, XM_005261111.3 [P55345-1]
XP_006724061.1, XM_006723998.3 [P55345-5]
XP_006724063.1, XM_006724000.2 [P55345-6]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1X2PNMR-A33-87[»]
SMRiP55345
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi109511, 58 interactors
CORUMiP55345
IntActiP55345, 54 interactors
MINTiP55345
STRINGi9606.ENSP00000380759

PTM databases

iPTMnetiP55345
PhosphoSitePlusiP55345
SwissPalmiP55345

Genetic variation databases

BioMutaiPRMT2
DMDMi2499805

Proteomic databases

EPDiP55345
jPOSTiP55345
MassIVEiP55345
PaxDbiP55345
PeptideAtlasiP55345
PRIDEiP55345
ProteomicsDBi56853 [P55345-1]
56854 [P55345-2]
56855 [P55345-3]
6261
6262
6263

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		10796, 451 antibodies

The DNASU plasmid repository

More...DNASUi		3275

Genome annotation databases

EnsembliENST00000291705; ENSP00000291705; ENSG00000160310 [P55345-6]
ENST00000334494; ENSP00000335490; ENSG00000160310 [P55345-2]
ENST00000355680; ENSP00000347906; ENSG00000160310 [P55345-1]
ENST00000397637; ENSP00000380759; ENSG00000160310 [P55345-1]
ENST00000397638; ENSP00000380760; ENSG00000160310 [P55345-1]
ENST00000440086; ENSP00000397266; ENSG00000160310 [P55345-3]
ENST00000451211; ENSP00000411984; ENSG00000160310 [P55345-4]
ENST00000458387; ENSP00000407463; ENSG00000160310 [P55345-5]
GeneIDi3275
KEGGihsa:3275
UCSCiuc002zjx.5, human [P55345-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		3275
DisGeNETi3275

GeneCards: human genes, protein and diseases

More...GeneCardsi		PRMT2
HGNCiHGNC:5186, PRMT2
HPAiENSG00000160310, Low tissue specificity
MIMi601961, gene
neXtProtiNX_P55345
OpenTargetsiENSG00000160310
PharmGKBiPA29460
VEuPathDBiHostDB:ENSG00000160310.16

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1499, Eukaryota
GeneTreeiENSGT00940000160683
HOGENOMiCLU_017375_4_0_1
InParanoidiP55345
OMAiKSFPMWR
PhylomeDBiP55345
TreeFamiTF332196

Enzyme and pathway databases

BioCyciMetaCyc:HS08486-MONOMER
BRENDAi2.1.1.125, 2681
PathwayCommonsiP55345

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		3275, 15 hits in 1000 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		PRMT2, human
EvolutionaryTraceiP55345

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		PRMT2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		3275
PharosiP55345, Tbio

Protein Ontology

More...PROi		PR:P55345
RNActiP55345, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000160310, Expressed in cortical plate and 241 other tissues
ExpressionAtlasiP55345, baseline and differential
GenevisibleiP55345, HS

Family and domain databases

InterProiView protein in InterPro
IPR025799, Arg_MeTrfase
IPR029063, SAM-dependent_MTases
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
IPR007848, Small_mtfrase_dom
PfamiView protein in Pfam
PF05175, MTS, 1 hit
PF00018, SH3_1, 1 hit
PRINTSiPR00452, SH3DOMAIN
SMARTiView protein in SMART
SM00326, SH3, 1 hit
SUPFAMiSSF50044, SSF50044, 1 hit
SSF53335, SSF53335, 1 hit
PROSITEiView protein in PROSITE
PS51678, SAM_MT_PRMT, 1 hit
PS50002, SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiANM2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P55345
Secondary accession number(s): B7U630
, B7U631, B7U632, P78350, Q498Y5, Q5U7D4, Q6FHF0, Q99781, Q9BW15, Q9UMC2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: April 7, 2021
This is version 183 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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