LIM2

Functionⁱ

Present in the thicker 16-17 nm junctions of mammalian lens fiber cells, where it may contribute to cell junctional organization. Acts as a receptor for calmodulin. May play an important role in both lens development and cataractogenesis.

GO - Molecular functionⁱ

structural constituent of eye lens Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell-cell junction assembly
Source: UniProtKB
Non-traceable author statementⁱ
- 2584203
lens development in camera-type eye Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Eye lens protein

Molecular function

Eye lens protein

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Lens fiber membrane intrinsic protein Alternative name(s): MP18 MP19 MP20
Gene namesⁱ	Name:LIM2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000105370.7
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6610 LIM2
MIMⁱ	154045 gene
neXtProtⁱ	NX_P55344

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 3	CytoplasmicSequence analysis	3
Transmembraneⁱ	4 – 24	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	25 – 66	ExtracellularSequence analysisAdd BLAST	42
Transmembraneⁱ	67 – 87	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	88 – 98	CytoplasmicSequence analysisAdd BLAST	11
Transmembraneⁱ	99 – 119	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	120 – 140	ExtracellularSequence analysisAdd BLAST	21
Transmembraneⁱ	141 – 161	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	162 – 173	CytoplasmicSequence analysisAdd BLAST	12

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Cataract, multiple types 19 (CTRCT19)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionAn opacification of the crystalline lens of the eye that frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. In general, the more posteriorly located and dense an opacity, the greater the impact on visual function.

Keywords - Diseaseⁱ

Cataract, Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3982
MalaCards human disease database More...MalaCardsⁱ	LIM2
MIMⁱ	615277 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000105370
Orphanetⁱ	98994 Total early-onset cataract
PharmGKBⁱ	PA30384

Polymorphism and mutation databases

BioMutaⁱ	LIM2
DMDMⁱ	17433717

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000164664	1 – 173	Lens fiber membrane intrinsic proteinAdd BLAST		173

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	43	C-linked (Man) tryptophanBy similarity	1
Glycosylationⁱ	61	C-linked (Man) tryptophanBy similarity	1
Glycosylationⁱ	62	N-linked (GlcNAc...) asparagineSequence analysis	1
Modified residueⁱ	170	PhosphoserineBy similarity	1
Modified residueⁱ	171	PhosphothreonineBy similarity	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PeptideAtlas More...PeptideAtlasⁱ	P55344
PRIDEⁱ	P55344
ProteomicsDBⁱ	56851 56852 [P55344-2]

PTM databases

iPTMnetⁱ	P55344
PhosphoSitePlusⁱ	P55344

Expressionⁱ

Tissue specificityⁱ

Eye lens specific.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000105370 Expressed in 14 organ(s), highest expression level in lens of camera-type eye
CleanExⁱ	HS_LIM2
Genevisibleⁱ	P55344 HS

Interactionⁱ

Subunit structureⁱ

Seems to be associated with itself or another lens membrane component via disulfide bonds.

Protein-protein interaction databases

BioGridⁱ	110170, 1 interactor

BioGridⁱ

110170, 1 interactor

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P55344
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the PMP-22/EMP/MP20 family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00510000046994
HOGENOMⁱ	HOG000116021
HOVERGENⁱ	HBG003671
InParanoidⁱ	P55344
OMAⁱ	RYCLGSK
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0MCH
PhylomeDBⁱ	P55344
TreeFamⁱ	TF330587

Family and domain databases

InterProⁱ	View protein in InterPro IPR003935 LMIP IPR004031 PMP22/EMP/MP20/Claudin IPR004032 PMP22_EMP_MP20
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00822 PMP22_Claudin, 1 hit
PRINTSⁱ	PR01453 EPMEMFAMILY PR01457 LENSMEMPROT
PROSITEⁱ	View protein in PROSITE PS01222 PMP22_2, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: P55344-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MYSFMGGGLF CAWVGTILLV VAMATDHWMQ YRLSGSFAHQ GLWRYCLGNK 
        60         70         80         90        100
CYLQTDSIAY WNATRAFMIL SALCAISGII MGIMAFAHQP TFSRISRPFS 
       110        120        130        140        150
AGIMFFSSTL FVVLALAIYT GVTVSFLGRR FGDWRFSWSY ILGWVAVLMT 
       160        170 
FFAGIFYMCA YRVHECRRLS TPR

Length:173

Mass (Da):19,674

Last modified:December 5, 2001 - v2

Checksum:ⁱ07DBA77184DA84AD

GO

Isoform 2 (identifier: P55344-2) [UniParc]FASTA Add to basket

Also known as: MP19ins

The sequence of this isoform differs from the canonical sequence as follows:
58-58: I → IGEPPGQGPGRAWGKSRADLGAQGHLYSRWRTLRLKEGKGATQ

« Hide

        10         20         30         40         50
MYSFMGGGLF CAWVGTILLV VAMATDHWMQ YRLSGSFAHQ GLWRYCLGNK 
        60         70         80         90        100
CYLQTDSIGE PPGQGPGRAW GKSRADLGAQ GHLYSRWRTL RLKEGKGATQ 
       110        120        130        140        150
AYWNATRAFM ILSALCAISG IIMGIMAFAH QPTFSRISRP FSAGIMFFSS 
       160        170        180        190        200
TLFVVLALAI YTGVTVSFLG RRFGDWRFSW SYILGWVAVL MTFFAGIFYM 
       210 
CAYRVHECRR LSTPR

Show »

Length:215

Mass (Da):24,188

Checksum:ⁱC275E85D7F1BE2D3

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	19	L → V AA sequence (PubMed:2584203).Curated		1
Sequence conflictⁱ	109	T → S (PubMed:8137630).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_069796	105	F → V in CTRCT19. 1 PublicationCorresponds to variant dbSNP:rs121913555Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_005073	58	I → IGEPPGQGPGRAWGKSRADL GAQGHLYSRWRTLRLKEGKG ATQ in isoform 2. 2 Publications		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L04193 Genomic DNA No translation available. AF305941 Genomic DNA Translation: AAG32328.1 AF340019 mRNA Translation: AAK26327.1 AF340020 mRNA Translation: AAK26328.1 CH471135 Genomic DNA Translation: EAW72010.1 BC069430 mRNA Translation: AAH69430.1 BC074916 mRNA Translation: AAH74916.1 BC074917 mRNA Translation: AAH74917.1 BC126139 mRNA Translation: AAI26140.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS12831.1 [P55344-2] CCDS59415.1 [P55344-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001155220.1, NM_001161748.1 [P55344-1] NP_085915.2, NM_030657.3 [P55344-2]
UniGeneⁱ	Hs.162754

Genome annotation databases

Ensemblⁱ	ENST00000221973; ENSP00000221973; ENSG00000105370 [P55344-2] ENST00000596399; ENSP00000472090; ENSG00000105370 [P55344-1]
GeneIDⁱ	3982
KEGGⁱ	hsa:3982
UCSC genome browser More...UCSCⁱ	uc002pwl.3 human [P55344-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P55344	Lens intrinsic membrane protein 2 (Fragment)		HUMAN		77	UniRef100_P55344
Lens intrinsic membrane protein 2 (Fragment)		HUMAN		73

Protein	Similar proteins		Species	Score	Length	Source
P55344	Lens fiber membrane intrinsic protein		BOVIN		173	UniRef90_P20274
Lens fiber membrane intrinsic protein		MOUSE		173
Lens fiber membrane intrinsic protein		RAT		173
Lens fiber membrane intrinsic protein		SHEEP		173
Lens fiber membrane intrinsic protein		wild yak		173
+66
P55344-2	Lens fiber membrane intrinsic protein		PANTR		215	UniRef90_P55344-2
Lens fiber membrane intrinsic protein		PANPA		215
Lens fiber membrane intrinsic protein		MACFA		215
Lens fiber membrane intrinsic protein		MACMU		215
Lens fiber membrane intrinsic protein		CERAT		215
+12

Protein	Similar proteins		Species	Score	Length	Source
P55344	Lens fiber membrane intrinsic protein		BOVIN		173	UniRef50_P20274
Lens fiber membrane intrinsic protein		MOUSE		173
Lens fiber membrane intrinsic protein		RAT		173
Lens fiber membrane intrinsic protein		SHEEP		173
Lens fiber membrane intrinsic protein		wild yak		173
+98
P55344-2	Lens fiber membrane intrinsic protein		AOTNA		215	UniRef50_P55344-2
Lens fiber membrane intrinsic protein		CALJA		215
Lens fiber membrane intrinsic protein		PONAB		215
Lens fiber membrane intrinsic protein		PANTR		215
Lens fiber membrane intrinsic protein		PANPA		215
+116

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L04193 Genomic DNA No translation available. AF305941 Genomic DNA Translation: AAG32328.1 AF340019 mRNA Translation: AAK26327.1 AF340020 mRNA Translation: AAK26328.1 CH471135 Genomic DNA Translation: EAW72010.1 BC069430 mRNA Translation: AAH69430.1 BC074916 mRNA Translation: AAH74916.1 BC074917 mRNA Translation: AAH74917.1 BC126139 mRNA Translation: AAI26140.1
CCDSⁱ	CCDS12831.1 [P55344-2] CCDS59415.1 [P55344-1]
RefSeqⁱ	NP_001155220.1, NM_001161748.1 [P55344-1] NP_085915.2, NM_030657.3 [P55344-2]
UniGeneⁱ	Hs.162754

3D structure databases

ProteinModelPortalⁱ	P55344
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	110170, 1 interactor

BioGridⁱ

110170, 1 interactor

PTM databases

iPTMnetⁱ	P55344
PhosphoSitePlusⁱ	P55344

Polymorphism and mutation databases

BioMutaⁱ	LIM2
DMDMⁱ	17433717

Proteomic databases

PeptideAtlasⁱ	P55344
PRIDEⁱ	P55344
ProteomicsDBⁱ	56851 56852 [P55344-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	3982
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000221973; ENSP00000221973; ENSG00000105370 [P55344-2] ENST00000596399; ENSP00000472090; ENSG00000105370 [P55344-1]
GeneIDⁱ	3982
KEGGⁱ	hsa:3982
UCSCⁱ	uc002pwl.3 human [P55344-1]

Organism-specific databases

CTDⁱ	3982
DisGeNETⁱ	3982
EuPathDBⁱ	HostDB:ENSG00000105370.7
GeneCardsⁱ	LIM2
HGNCⁱ	HGNC:6610 LIM2
MalaCardsⁱ	LIM2
MIMⁱ	154045 gene 615277 phenotype
neXtProtⁱ	NX_P55344
OpenTargetsⁱ	ENSG00000105370
Orphanetⁱ	98994 Total early-onset cataract
PharmGKBⁱ	PA30384
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

GeneTreeⁱ	ENSGT00510000046994
HOGENOMⁱ	HOG000116021
HOVERGENⁱ	HBG003671
InParanoidⁱ	P55344
OMAⁱ	RYCLGSK
OrthoDBⁱ	EOG091G0MCH
PhylomeDBⁱ	P55344
TreeFamⁱ	TF330587

Miscellaneous databases

GeneWikiⁱ	LIM2
GenomeRNAiⁱ	3982
Protein Ontology More...PROⁱ	PR:P55344
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000105370 Expressed in 14 organ(s), highest expression level in lens of camera-type eye
CleanExⁱ	HS_LIM2
Genevisibleⁱ	P55344 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR003935 LMIP IPR004031 PMP22/EMP/MP20/Claudin IPR004032 PMP22_EMP_MP20
Pfamⁱ	View protein in Pfam PF00822 PMP22_Claudin, 1 hit
PRINTSⁱ	PR01453 EPMEMFAMILY PR01457 LENSMEMPROT
PROSITEⁱ	View protein in PROSITE PS01222 PMP22_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	LMIP_HUMAN
Accessionⁱ	P55344Primary (citable) accession number: P55344 Secondary accession number(s): Q6B083, Q9BXD0, Q9HAR5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	December 5, 2001
	Last modified:	November 7, 2018
	This is version 148 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM

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UniProtKB - P55344 (LMIP_HUMAN)

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Lens fiber membrane intrinsic protein

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ