We will be switching to the new UniProt website on Tuesday, June 28. Please explore and share your feedback.
Take me to UniProt BETA
UniProtKB - P55327 (TPD52_HUMAN)
Protein
Tumor protein D52
Gene
TPD52
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- calcium ion binding Source: UniProtKB
- protein homodimerization activity Source: UniProtKB
GO - Biological processi
- anatomical structure morphogenesis Source: ProtInc
- B cell differentiation Source: UniProtKB
- secretion Source: UniProtKB
Enzyme and pathway databases
PathwayCommonsi | P55327 |
Reactomei | R-HSA-432722, Golgi Associated Vesicle Biogenesis |
SignaLinki | P55327 |
SIGNORi | P55327 |
Names & Taxonomyi
Protein namesi | Recommended name: Tumor protein D52Alternative name(s): Protein N8 |
Gene namesi | Name:TPD52 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:12005, TPD52 |
MIMi | 604068, gene |
neXtProti | NX_P55327 |
VEuPathDBi | HostDB:ENSG00000076554 |
Subcellular locationi
Endoplasmic reticulum
- endoplasmic reticulum Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
- perinuclear region of cytoplasm Source: UniProtKB
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 7163 |
MalaCardsi | TPD52 |
OpenTargetsi | ENSG00000076554 |
PharmGKBi | PA36686 |
Miscellaneous databases
Pharosi | P55327, Tbio |
Genetic variation databases
BioMutai | TPD52 |
DMDMi | 215273966 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000185738 | 1 – 224 | Tumor protein D52Add BLAST | 224 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 36 | PhosphoserineBy similarity | 1 | |
Modified residuei | 40 | PhosphoserineBy similarity | 1 | |
Modified residuei | 176 | PhosphoserineBy similarity | 1 | |
Modified residuei | 223 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | P55327 |
jPOSTi | P55327 |
MassIVEi | P55327 |
MaxQBi | P55327 |
PaxDbi | P55327 |
PeptideAtlasi | P55327 |
PRIDEi | P55327 |
ProteomicsDBi | 12721 12722 12723 56847 [P55327-1] 56848 [P55327-2] 56849 [P55327-3] 56850 [P55327-4] 8547 |
TopDownProteomicsi | P55327-2 [P55327-2] P55327-4 [P55327-4] |
PTM databases
GlyGeni | P55327, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P55327 |
PhosphoSitePlusi | P55327 |
Expressioni
Tissue specificityi
Isoform 2 is expressed in colon, breast, prostate, pancreas and kidney tumor cell lines. Isoform 2 is expressed at high levels in kidney, prostate, brain, small intestine and pancreas, at moderate levels in placenta and colon, at low levels in lung, liver and heart, and at very low levels in spleen, thymus, peripheral mononuclear blood cells, testis and ovary.1 Publication
Developmental stagei
Isoform 2 is expressed at lower levels in fetal brain and kidney than in adult brain and kidney.1 Publication
Gene expression databases
Bgeei | ENSG00000076554, Expressed in frontal cortex and 244 other tissues |
ExpressionAtlasi | P55327, baseline and differential |
Genevisiblei | P55327, HS |
Organism-specific databases
HPAi | ENSG00000076554, Tissue enhanced (retina) |
Interactioni
Subunit structurei
Forms a homodimer or heterodimer with other members of the family. All isoforms interact with several 14-3-3 proteins.
Binary interactionsi
P55327
With | #Exp. | IntAct |
---|---|---|
TPD52L1 [Q16890] | 3 | EBI-782581,EBI-717470 |
Tpd52 [Q62393] from Mus musculus. | 2 | EBI-782581,EBI-782591 |
Isoform 2 [P55327-2]
GO - Molecular functioni
- protein homodimerization activity Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 113016, 82 interactors |
IntActi | P55327, 35 interactors |
MINTi | P55327 |
STRINGi | 9606.ENSP00000429309 |
Miscellaneous databases
RNActi | P55327, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 187 – 224 | DisorderedSequence analysisAdd BLAST | 38 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 62 – 114 | Sequence analysisAdd BLAST | 53 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 204 – 224 | Polar residuesSequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Belongs to the TPD52 family.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG4010, Eukaryota |
GeneTreei | ENSGT00940000155294 |
HOGENOMi | CLU_080743_0_1_1 |
InParanoidi | P55327 |
OMAi | CREMEFY |
OrthoDBi | 1225782at2759 |
PhylomeDBi | P55327 |
TreeFami | TF317562 |
Family and domain databases
InterProi | View protein in InterPro IPR007327, TPD52 |
PANTHERi | PTHR19307, PTHR19307, 1 hit |
Pfami | View protein in Pfam PF04201, TPD52, 1 hit |
s (8+)i Sequence
Sequence statusi: Complete.
This entry describes 8 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 8 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: P55327-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDCREMDLYE DYQSPFDFDA GVNKSYLYLS PSGNSSPPGS PTLQKFGLLR
60 70 80 90 100
TDPVPEEGED VAATISATET LSEEEQEELR RELAKVEEEI QTLSQVLAAK
110 120 130 140 150
EKHLAEIKRK LGINSLQELK QNIAKGWQDV TATSAYKKTS ETLSQAGQKA
160 170 180 190 200
SAAFSSVGSV ITKKLEDVKN SPTFKSFEEK VENLKSKVGG TKPAGGDFGE
210 220
VLNSAANASA TTTEPLPEKT QESL
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE5RFR7 | E5RFR7_HUMAN | Tumor protein D52 | TPD52 | 111 | Annotation score: | ||
E5RK35 | E5RK35_HUMAN | Tumor protein D52 | TPD52 | 60 | Annotation score: | ||
H0YC44 | H0YC44_HUMAN | Tumor protein D52 | TPD52 | 148 | Annotation score: | ||
E5RJ27 | E5RJ27_HUMAN | Tumor protein D52 | TPD52 | 61 | Annotation score: | ||
E5RGI1 | E5RGI1_HUMAN | Tumor protein D52 | TPD52 | 38 | Annotation score: |
Sequence cautioni
The sequence BAD97351 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 74 | E → K in BAD97351 (Ref. 9) Curated | 1 | |
Sequence conflicti | 165 | L → P in CAG46831 (Ref. 6) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_061860 | 52 | D → Y. Corresponds to variant dbSNP:rs35099105Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_035751 | 1 – 46 | MDCRE…TLQKF → MDRGEQ in isoform 2 and isoform 4. 7 PublicationsAdd BLAST | 46 | |
Alternative sequenceiVSP_037378 | 1 – 46 | MDCRE…TLQKF → MTPRESAPGRGRAAPPRPTP LGVGTSRESPAEARRSSARR GGRSEPGRAAGGGAAEDTRR RAGDMDRGEQ in isoform 3. 1 PublicationAdd BLAST | 46 | |
Alternative sequenceiVSP_047718 | 136 – 224 | YKKTS…TQESL → RSKLLAAETELLCLLY in isoform 8. 1 PublicationAdd BLAST | 89 | |
Alternative sequenceiVSP_047719 | 168 – 169 | VK → VNIRSIQHSISMPAMR in isoform 5. 1 Publication | 2 | |
Alternative sequenceiVSP_043510 | 169 | K → KLQAFSHSFSIRSIQHSISM PAMR in isoform 4 and isoform 6. 2 Publications | 1 | |
Alternative sequenceiVSP_047720 | 169 | K → KLQAFSHSFR in isoform 7. 1 Publication | 1 |
Sequence databases
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
3D structure databases
AlphaFoldDBi | P55327 |
SMRi | P55327 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 113016, 82 interactors |
IntActi | P55327, 35 interactors |
MINTi | P55327 |
STRINGi | 9606.ENSP00000429309 |
PTM databases
GlyGeni | P55327, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P55327 |
PhosphoSitePlusi | P55327 |
Genetic variation databases
BioMutai | TPD52 |
DMDMi | 215273966 |
Proteomic databases
EPDi | P55327 |
jPOSTi | P55327 |
MassIVEi | P55327 |
MaxQBi | P55327 |
PaxDbi | P55327 |
PeptideAtlasi | P55327 |
PRIDEi | P55327 |
ProteomicsDBi | 12721 12722 12723 56847 [P55327-1] 56848 [P55327-2] 56849 [P55327-3] 56850 [P55327-4] 8547 |
TopDownProteomicsi | P55327-2 [P55327-2] P55327-4 [P55327-4] |
Protocols and materials databases
Antibodypediai | 25297, 262 antibodies from 31 providers |
DNASUi | 7163 |
Genome annotation databases
Organism-specific databases
CTDi | 7163 |
DisGeNETi | 7163 |
GeneCardsi | TPD52 |
HGNCi | HGNC:12005, TPD52 |
HPAi | ENSG00000076554, Tissue enhanced (retina) |
MalaCardsi | TPD52 |
MIMi | 604068, gene |
neXtProti | NX_P55327 |
OpenTargetsi | ENSG00000076554 |
PharmGKBi | PA36686 |
VEuPathDBi | HostDB:ENSG00000076554 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4010, Eukaryota |
GeneTreei | ENSGT00940000155294 |
HOGENOMi | CLU_080743_0_1_1 |
InParanoidi | P55327 |
OMAi | CREMEFY |
OrthoDBi | 1225782at2759 |
PhylomeDBi | P55327 |
TreeFami | TF317562 |
Enzyme and pathway databases
PathwayCommonsi | P55327 |
Reactomei | R-HSA-432722, Golgi Associated Vesicle Biogenesis |
SignaLinki | P55327 |
SIGNORi | P55327 |
Miscellaneous databases
BioGRID-ORCSi | 7163, 9 hits in 1066 CRISPR screens |
ChiTaRSi | TPD52, human |
GeneWikii | TPD52 |
GenomeRNAii | 7163 |
Pharosi | P55327, Tbio |
PROi | PR:P55327 |
RNActi | P55327, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000076554, Expressed in frontal cortex and 244 other tissues |
ExpressionAtlasi | P55327, baseline and differential |
Genevisiblei | P55327, HS |
Family and domain databases
InterProi | View protein in InterPro IPR007327, TPD52 |
PANTHERi | PTHR19307, PTHR19307, 1 hit |
Pfami | View protein in Pfam PF04201, TPD52, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TPD52_HUMAN | |
Accessioni | P55327Primary (citable) accession number: P55327 Secondary accession number(s): B7Z414 Q9UCX8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | November 25, 2008 | |
Last modified: | May 25, 2022 | |
This is version 181 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families