TPD52

Functionⁱ

GO - Molecular functionⁱ

calcium ion binding
Source: UniProtKB
Inferred from direct assayⁱ
- 15576473
protein heterodimerization activity
Source: UniProtKB
Inferred from direct assayⁱ
- 9484778
protein homodimerization activity
Source: UniProtKB
Inferred from direct assayⁱ
- 9484778

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

anatomical structure morphogenesis
Source: ProtInc
Traceable author statementⁱ
- 8632896
B cell differentiation
Source: UniProtKB
Inferred from expression patternⁱ
- 15576473
secretion
Source: UniProtKB
Traceable author statementⁱ
- 15576473

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactomeⁱ	R-HSA-432722 Golgi Associated Vesicle Biogenesis
SIGNORⁱ	P55327

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Tumor protein D52 Alternative name(s): Protein N8
Gene namesⁱ	Name:TPD52
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 8

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000076554.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:12005 TPD52
MIMⁱ	604068 gene
neXtProtⁱ	NX_P55327

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	7163
Open Targets More...OpenTargetsⁱ	ENSG00000076554
PharmGKBⁱ	PA36686

Polymorphism and mutation databases

BioMutaⁱ	TPD52
DMDMⁱ	215273966

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000185738	1 – 224	Tumor protein D52Add BLAST		224

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	36	PhosphoserineBy similarity	1
Modified residueⁱ	40	PhosphoserineBy similarity	1
Modified residueⁱ	176	PhosphoserineBy similarity	1
Modified residueⁱ	223	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	P55327
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P55327
PaxDbⁱ	P55327
PeptideAtlas More...PeptideAtlasⁱ	P55327
PRIDEⁱ	P55327
ProteomicsDBⁱ	56847 56848 [P55327-2] 56849 [P55327-3] 56850 [P55327-4]
TopDownProteomicsⁱ	P55327-2 [P55327-2] P55327-4 [P55327-4]

PTM databases

iPTMnetⁱ	P55327
PhosphoSitePlusⁱ	P55327

Expressionⁱ

Tissue specificityⁱ

Isoform 2 is expressed in colon, breast, prostate, pancreas and kidney tumor cell lines. Isoform 2 is expressed at high levels in kidney, prostate, brain, small intestine and pancreas, at moderate levels in placenta and colon, at low levels in lung, liver and heart, and at very low levels in spleen, thymus, peripheral mononuclear blood cells, testis and ovary.1 Publication

Developmental stageⁱ

Isoform 2 is expressed at lower levels in fetal brain and kidney than in adult brain and kidney.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000076554 Expressed in 232 organ(s), highest expression level in frontal cortex
CleanExⁱ	HS_TPD52
ExpressionAtlasⁱ	P55327 baseline and differential
Genevisibleⁱ	P55327 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA028427 HPA062167

HPAⁱ

HPA028427
HPA062167

Interactionⁱ

Subunit structureⁱ

Forms a homodimer or heterodimer with other members of the family. All isoforms interact with several 14-3-3 proteins.

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
Tpd52	Q62393	2	EBI-782581,EBI-782591	From Mus musculus.
TPD52L1	Q16890	3	EBI-782581,EBI-717470

GO - Molecular functionⁱ

protein heterodimerization activity
Source: UniProtKB
Inferred from direct assayⁱ
- 9484778
protein homodimerization activity
Source: UniProtKB
Inferred from direct assayⁱ
- 9484778

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	113016, 56 interactors
IntActⁱ	P55327, 17 interactors
Molecular INTeraction database More...MINTⁱ	P55327
STRINGⁱ	9606.ENSP00000368391

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P55327
SMRⁱ	P55327
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	62 – 114	Sequence analysisAdd BLAST		53

Sequence similaritiesⁱ

Belongs to the TPD52 family.Curated

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	KOG4010 Eukaryota ENOG4111M9H LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000015988
HOGENOMⁱ	HOG000231968
HOVERGENⁱ	HBG058643
InParanoidⁱ	P55327
OMAⁱ	MDFYEDY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0MLN
PhylomeDBⁱ	P55327
TreeFamⁱ	TF317562

Family and domain databases

InterProⁱ	View protein in InterPro IPR007327 TPD52
PANTHERⁱ	PTHR19307 PTHR19307, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04201 TPD52, 1 hit

Sequences (8+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 8 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 8 described isoforms and 5 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P55327-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDCREMDLYE DYQSPFDFDA GVNKSYLYLS PSGNSSPPGS PTLQKFGLLR 
        60         70         80         90        100
TDPVPEEGED VAATISATET LSEEEQEELR RELAKVEEEI QTLSQVLAAK 
       110        120        130        140        150
EKHLAEIKRK LGINSLQELK QNIAKGWQDV TATSAYKKTS ETLSQAGQKA 
       160        170        180        190        200
SAAFSSVGSV ITKKLEDVKN SPTFKSFEEK VENLKSKVGG TKPAGGDFGE 
       210        220 
VLNSAANASA TTTEPLPEKT QESL

Length:224

Mass (Da):24,327

Last modified:November 25, 2008 - v2

Checksum:ⁱ4C8183C5914BB976

GO

Isoform 2 (identifier: P55327-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-46: MDCREMDLYEDYQSPFDFDAGVNKSYLYLSPSGNSSPPGSPTLQKF → MDRGEQ

« Hide

        10         20         30         40         50
MDRGEQGLLR TDPVPEEGED VAATISATET LSEEEQEELR RELAKVEEEI 
        60         70         80         90        100
QTLSQVLAAK EKHLAEIKRK LGINSLQELK QNIAKGWQDV TATSAYKKTS 
       110        120        130        140        150
ETLSQAGQKA SAAFSSVGSV ITKKLEDVKN SPTFKSFEEK VENLKSKVGG 
       160        170        180 
TKPAGGDFGE VLNSAANASA TTTEPLPEKT QESL

Show »

Length:184

Mass (Da):19,863

Checksum:ⁱ4821EC86D1C3339D

GO

Isoform 3 (identifier: P55327-3) [UniParc]FASTA Add to basket

Also known as: N8L

The sequence of this isoform differs from the canonical sequence as follows:
1-46: MDCREMDLYE...PPGSPTLQKF → MTPRESAPGR...RAGDMDRGEQ

« Hide

        10         20         30         40         50
MTPRESAPGR GRAAPPRPTP LGVGTSRESP AEARRSSARR GGRSEPGRAA 
        60         70         80         90        100
GGGAAEDTRR RAGDMDRGEQ GLLRTDPVPE EGEDVAATIS ATETLSEEEQ 
       110        120        130        140        150
EELRRELAKV EEEIQTLSQV LAAKEKHLAE IKRKLGINSL QELKQNIAKG 
       160        170        180        190        200
WQDVTATSAY KKTSETLSQA GQKASAAFSS VGSVITKKLE DVKNSPTFKS 
       210        220        230        240 
FEEKVENLKS KVGGTKPAGG DFGEVLNSAA NASATTTEPL PEKTQESL

Show »

Length:248

Mass (Da):26,382

Checksum:ⁱB7D203C4941A02B2

GO

Isoform 4 (identifier: P55327-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-46: MDCREMDLYEDYQSPFDFDAGVNKSYLYLSPSGNSSPPGSPTLQKF → MDRGEQ
169-169: K → KLQAFSHSFSIRSIQHSISMPAMR

« Hide

        10         20         30         40         50
MDRGEQGLLR TDPVPEEGED VAATISATET LSEEEQEELR RELAKVEEEI 
        60         70         80         90        100
QTLSQVLAAK EKHLAEIKRK LGINSLQELK QNIAKGWQDV TATSAYKKTS 
       110        120        130        140        150
ETLSQAGQKA SAAFSSVGSV ITKKLEDVKL QAFSHSFSIR SIQHSISMPA 
       160        170        180        190        200
MRNSPTFKSF EEKVENLKSK VGGTKPAGGD FGEVLNSAAN ASATTTEPLP 

EKTQESL

Note: No experimental confirmation available.

Show »

Length:207

Mass (Da):22,477

Checksum:ⁱ29027F1706989362

GO

Isoform 5 (identifier: P55327-5) [UniParc]FASTA Add to basket

Also known as: PrLZ-238

The sequence of this isoform differs from the canonical sequence as follows:
168-169: VK → VNIRSIQHSISMPAMR

« Hide

        10         20         30         40         50
MDCREMDLYE DYQSPFDFDA GVNKSYLYLS PSGNSSPPGS PTLQKFGLLR 
        60         70         80         90        100
TDPVPEEGED VAATISATET LSEEEQEELR RELAKVEEEI QTLSQVLAAK 
       110        120        130        140        150
EKHLAEIKRK LGINSLQELK QNIAKGWQDV TATSAYKKTS ETLSQAGQKA 
       160        170        180        190        200
SAAFSSVGSV ITKKLEDVNI RSIQHSISMP AMRNSPTFKS FEEKVENLKS 
       210        220        230 
KVGGTKPAGG DFGEVLNSAA NASATTTEPL PEKTQESL

Show »

Length:238

Mass (Da):25,922

Checksum:ⁱ8E02245A52BF64C7

GO

Isoform 6 (identifier: P55327-6) [UniParc]FASTA Add to basket

Also known as: PrLZ-247

The sequence of this isoform differs from the canonical sequence as follows:
169-169: K → KLQAFSHSFSIRSIQHSISMPAMR

« Hide

        10         20         30         40         50
MDCREMDLYE DYQSPFDFDA GVNKSYLYLS PSGNSSPPGS PTLQKFGLLR 
        60         70         80         90        100
TDPVPEEGED VAATISATET LSEEEQEELR RELAKVEEEI QTLSQVLAAK 
       110        120        130        140        150
EKHLAEIKRK LGINSLQELK QNIAKGWQDV TATSAYKKTS ETLSQAGQKA 
       160        170        180        190        200
SAAFSSVGSV ITKKLEDVKL QAFSHSFSIR SIQHSISMPA MRNSPTFKSF 
       210        220        230        240 
EEKVENLKSK VGGTKPAGGD FGEVLNSAAN ASATTTEPLP EKTQESL

Show »

Length:247

Mass (Da):26,941

Checksum:ⁱF9526200A91B6ABB

GO

Isoform 7 (identifier: P55327-7) [UniParc]FASTA Add to basket

Also known as: PrLZ-233

The sequence of this isoform differs from the canonical sequence as follows:
169-169: K → KLQAFSHSFR

« Hide

        10         20         30         40         50
MDCREMDLYE DYQSPFDFDA GVNKSYLYLS PSGNSSPPGS PTLQKFGLLR 
        60         70         80         90        100
TDPVPEEGED VAATISATET LSEEEQEELR RELAKVEEEI QTLSQVLAAK 
       110        120        130        140        150
EKHLAEIKRK LGINSLQELK QNIAKGWQDV TATSAYKKTS ETLSQAGQKA 
       160        170        180        190        200
SAAFSSVGSV ITKKLEDVKL QAFSHSFRNS PTFKSFEEKV ENLKSKVGGT 
       210        220        230 
KPAGGDFGEV LNSAANASAT TTEPLPEKTQ ESL

Show »

Length:233

Mass (Da):25,401

Checksum:ⁱA722640EFE14A677

GO

Isoform 8 (identifier: P55327-8) [UniParc]FASTA Add to basket

Also known as: PrLZ-151

The sequence of this isoform differs from the canonical sequence as follows:
136-224: YKKTSETLSQ...PLPEKTQESL → RSKLLAAETELLCLLY

« Hide

        10         20         30         40         50
MDCREMDLYE DYQSPFDFDA GVNKSYLYLS PSGNSSPPGS PTLQKFGLLR 
        60         70         80         90        100
TDPVPEEGED VAATISATET LSEEEQEELR RELAKVEEEI QTLSQVLAAK 
       110        120        130        140        150
EKHLAEIKRK LGINSLQELK QNIAKGWQDV TATSARSKLL AAETELLCLL 

Y

Note: Interacts only with YWHAB and YWHAQ among 14-3-3 proteins.

Show »

Length:151

Mass (Da):16,853

Checksum:ⁱ5270A0BAF1F81B70

GO

Computationally mapped potential isoform sequencesⁱ

There are 5 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

E5RFR7	E5RFR7_HUMAN	Tumor protein D52 Tumor protein D52	TPD52	111	Annotation score:
H0YC44	H0YC44_HUMAN	Tumor protein D52 Tumor protein D52	TPD52	148	Annotation score:
E5RK35	E5RK35_HUMAN	Tumor protein D52 Tumor protein D52	TPD52	60	Annotation score:
E5RGI1	E5RGI1_HUMAN	Tumor protein D52 Tumor protein D52	TPD52	38	Annotation score:
E5RJ27	E5RJ27_HUMAN	Tumor protein D52 Tumor protein D52	TPD52	61	Annotation score:

Sequence cautionⁱ

The sequence BAD97351 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	74	E → K in BAD97351 (Ref. 9) Curated		1
Sequence conflictⁱ	165	L → P in CAG46831 (Ref. 6) Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_061860	52	D → Y. Corresponds to variant dbSNP:rs35099105Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_035751	1 – 46	MDCRE…TLQKF → MDRGEQ in isoform 2 and isoform 4. 7 PublicationsAdd BLAST	46
Alternative sequenceⁱVSP_037378	1 – 46	MDCRE…TLQKF → MTPRESAPGRGRAAPPRPTP LGVGTSRESPAEARRSSARR GGRSEPGRAAGGGAAEDTRR RAGDMDRGEQ in isoform 3. 1 PublicationAdd BLAST	46
Alternative sequenceⁱVSP_047718	136 – 224	YKKTS…TQESL → RSKLLAAETELLCLLY in isoform 8. 1 PublicationAdd BLAST	89
Alternative sequenceⁱVSP_047719	168 – 169	VK → VNIRSIQHSISMPAMR in isoform 5. 1 Publication	2
Alternative sequenceⁱVSP_043510	169	K → KLQAFSHSFSIRSIQHSISM PAMR in isoform 4 and isoform 6. 2 Publications	1
Alternative sequenceⁱVSP_047720	169	K → KLQAFSHSFR in isoform 7. 1 Publication	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U18914 mRNA Translation: AAC50183.1 S82081 mRNA Translation: AAB36475.1 AF202897 mRNA Translation: AAO22156.1 GQ499324 mRNA Translation: ACY08776.1 GQ499325 mRNA Translation: ACY08777.1 GQ499326 mRNA Translation: ACY08778.1 GQ499327 mRNA Translation: ACY08779.1 GQ499328 mRNA Translation: ACY08780.1 AK295468 mRNA Translation: BAH12078.1 AK296615 mRNA Translation: BAH12400.1 AK313135 mRNA Translation: BAG35954.1 CR542034 mRNA Translation: CAG46831.1 CR542064 mRNA Translation: CAG46861.1 BT019444 mRNA Translation: AAV38251.1 BX640835 mRNA Translation: CAE45908.1 AK223631 mRNA Translation: BAD97351.1 Different initiation. AC009686 Genomic DNA No translation available. AC018952 Genomic DNA No translation available. AC036214 Genomic DNA No translation available. AC104212 Genomic DNA No translation available. CH471068 Genomic DNA Translation: EAW87074.1 BC018117 mRNA Translation: AAH18117.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS34912.1 [P55327-1] CCDS47879.1 [P55327-4] CCDS55249.1 [P55327-2] CCDS75757.1 [P55327-5] CCDS75758.1 [P55327-7] CCDS75759.1 [P55327-6]
PIRⁱ	I38910
NCBI Reference Sequences More...RefSeqⁱ	NP_001020423.1, NM_001025252.2 [P55327-1] NP_001020424.1, NM_001025253.2 [P55327-4] NP_001274069.1, NM_001287140.1 [P55327-6] NP_001274071.1, NM_001287142.1 [P55327-5] NP_001274072.1, NM_001287143.1 [P55327-7] NP_001274073.1, NM_001287144.1 NP_005070.1, NM_005079.3 [P55327-2]
UniGeneⁱ	Hs.368433

Genome annotation databases

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
P55327	TPD52 isoform 8		PANTR		224	UniRef90_P55327
TPD52 isoform 18		PONAB		224
Uncharacterized protein		GORGO		224
tumor protein D52 isoform X3		BALAS		224
tumor protein D52 isoform X2		DELLE		224
+59
P55327-2	Isoform 3 of Tumor protein D52		HUMAN		248	UniRef90_P55327-3
UPI000387BAC9		HUMAN		145
P55327-3	Isoform 2 of Tumor protein D52		HUMAN		184	UniRef90_P55327-3
UPI000387BAC9		HUMAN		145
P55327-4	TPD52 isoform 4		PANTR		207	UniRef90_P55327-4
TPD52 isoform 5		PONAB		207
Uncharacterized protein		PANPA		207
Uncharacterized protein		GORGO		207
Tumor protein D52 isoform 2		CALJA		207
+23
P55327-5	Uncharacterized protein		AILME		252	UniRef90_P55327-5
Uncharacterized protein		SHEEP		251
Uncharacterized protein		CANLF		247
tumor protein D52 isoform X1		BALAS		247
Uncharacterized protein		COLAP		247
+137
P55327-6	Isoform 5 of Tumor protein D52		HUMAN		238	UniRef90_P55327-5
Uncharacterized protein		AILME		252
Uncharacterized protein		SHEEP		251
Uncharacterized protein		CANLF		247
tumor protein D52 isoform X1		BALAS		247
+137
P55327-7	Isoform 5 of Tumor protein D52		HUMAN		238	UniRef90_P55327-5
Uncharacterized protein		AILME		252
Uncharacterized protein		SHEEP		251
Uncharacterized protein		CANLF		247
tumor protein D52 isoform X1		BALAS		247
+137
P55327-8	TPD52 isoform 7		PANTR		151	UniRef90_A0A2J8M9Y1
TPD52 isoform 17		PONAB		151

Protein	Similar proteins		Species	Score	Length	Source
P55327	tumor protein D52 isoform X2		DELLE		224	UniRef50_P55327
Uncharacterized protein		CALJA		224
tumor protein D52 isoform X4		Enhydra lutris kenyoni		224
tumor protein D52 isoform X1		Yangtze finless porpoise		224
Uncharacterized protein		Cebus capucinus imitator		224
+241
P55327-2	Isoform 3 of Tumor protein D52		HUMAN		248	UniRef50_P55327-3
Tumor protein D53 homolog		CHICK		210
Tumor protein D52		MOUSE		224
Tumor protein D53 isoform B		ALLMI		190
tumor protein D53 isoform X1		ALLSI		176
+310
P55327-3	Tumor protein D53 homolog		CHICK		210	UniRef50_P55327-3
Tumor protein D52		MOUSE		224
Isoform 2 of Tumor protein D52		HUMAN		184
Tumor protein D53 isoform B		ALLMI		190
tumor protein D53 isoform X1		ALLSI		176
+310
P55327-4	Tumor protein D53		MOUSE		204	UniRef50_P55327-4
Tumor protein D52 isoform 3		HETGA		207
Uncharacterized protein DKFZp459J1320		PONAB		207
Uncharacterized protein		PIG		207
Tumor protein D52 isoform 2		CALJA		207
+155
P55327-5	Uncharacterized protein		AILME		252	UniRef50_P55327-5
Uncharacterized protein		SHEEP		251
Uncharacterized protein		NOMLE		247
Uncharacterized protein		PROCO		247
Tumor protein D52		SAIBB		247
+297
P55327-6	Isoform 5 of Tumor protein D52		HUMAN		238	UniRef50_P55327-5
Uncharacterized protein		AILME		252
Uncharacterized protein		SHEEP		251
Uncharacterized protein		NOMLE		247
Uncharacterized protein		PROCO		247
+297
P55327-7	Isoform 5 of Tumor protein D52		HUMAN		238	UniRef50_P55327-5
Uncharacterized protein		AILME		252
Uncharacterized protein		SHEEP		251
Uncharacterized protein		NOMLE		247
Uncharacterized protein		PROCO		247
+297
P55327-8	Tumor protein D52 (Fragment)		HUMAN		148	UniRef50_H0YC44
tumor protein D52 isoform X2		NEOSC		144
Uncharacterized protein		ORNAN		158
TPD52 isoform 7		PANTR		151
TPD52 isoform 17		PONAB		151
+10

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U18914 mRNA Translation: AAC50183.1 S82081 mRNA Translation: AAB36475.1 AF202897 mRNA Translation: AAO22156.1 GQ499324 mRNA Translation: ACY08776.1 GQ499325 mRNA Translation: ACY08777.1 GQ499326 mRNA Translation: ACY08778.1 GQ499327 mRNA Translation: ACY08779.1 GQ499328 mRNA Translation: ACY08780.1 AK295468 mRNA Translation: BAH12078.1 AK296615 mRNA Translation: BAH12400.1 AK313135 mRNA Translation: BAG35954.1 CR542034 mRNA Translation: CAG46831.1 CR542064 mRNA Translation: CAG46861.1 BT019444 mRNA Translation: AAV38251.1 BX640835 mRNA Translation: CAE45908.1 AK223631 mRNA Translation: BAD97351.1 Different initiation. AC009686 Genomic DNA No translation available. AC018952 Genomic DNA No translation available. AC036214 Genomic DNA No translation available. AC104212 Genomic DNA No translation available. CH471068 Genomic DNA Translation: EAW87074.1 BC018117 mRNA Translation: AAH18117.1
CCDSⁱ	CCDS34912.1 [P55327-1] CCDS47879.1 [P55327-4] CCDS55249.1 [P55327-2] CCDS75757.1 [P55327-5] CCDS75758.1 [P55327-7] CCDS75759.1 [P55327-6]
PIRⁱ	I38910
RefSeqⁱ	NP_001020423.1, NM_001025252.2 [P55327-1] NP_001020424.1, NM_001025253.2 [P55327-4] NP_001274069.1, NM_001287140.1 [P55327-6] NP_001274071.1, NM_001287142.1 [P55327-5] NP_001274072.1, NM_001287143.1 [P55327-7] NP_001274073.1, NM_001287144.1 NP_005070.1, NM_005079.3 [P55327-2]
UniGeneⁱ	Hs.368433

3D structure databases

ProteinModelPortalⁱ	P55327
SMRⁱ	P55327
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	113016, 56 interactors
IntActⁱ	P55327, 17 interactors
MINTⁱ	P55327
STRINGⁱ	9606.ENSP00000368391

PTM databases

iPTMnetⁱ	P55327
PhosphoSitePlusⁱ	P55327

Polymorphism and mutation databases

BioMutaⁱ	TPD52
DMDMⁱ	215273966

Proteomic databases

EPDⁱ	P55327
MaxQBⁱ	P55327
PaxDbⁱ	P55327
PeptideAtlasⁱ	P55327
PRIDEⁱ	P55327
ProteomicsDBⁱ	56847 56848 [P55327-2] 56849 [P55327-3] 56850 [P55327-4]
TopDownProteomicsⁱ	P55327-2 [P55327-2] P55327-4 [P55327-4]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	7163
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000379096; ENSP00000368390; ENSG00000076554 [P55327-2] ENST00000379097; ENSP00000368391; ENSG00000076554 [P55327-1] ENST00000448733; ENSP00000410222; ENSG00000076554 [P55327-5] ENST00000517427; ENSP00000429351; ENSG00000076554 [P55327-7] ENST00000517462; ENSP00000429708; ENSG00000076554 [P55327-8] ENST00000518937; ENSP00000429915; ENSG00000076554 [P55327-4] ENST00000520527; ENSP00000429309; ENSG00000076554 [P55327-6]
GeneIDⁱ	7163
KEGGⁱ	hsa:7163
UCSCⁱ	uc003ybr.3 human [P55327-1]

Organism-specific databases

CTDⁱ	7163
DisGeNETⁱ	7163
EuPathDBⁱ	HostDB:ENSG00000076554.15
GeneCardsⁱ	TPD52
H-InvDBⁱ	HIX0152680
HGNCⁱ	HGNC:12005 TPD52
HPAⁱ	HPA028427 HPA062167
MIMⁱ	604068 gene
neXtProtⁱ	NX_P55327
OpenTargetsⁱ	ENSG00000076554
PharmGKBⁱ	PA36686
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4010 Eukaryota ENOG4111M9H LUCA
GeneTreeⁱ	ENSGT00390000015988
HOGENOMⁱ	HOG000231968
HOVERGENⁱ	HBG058643
InParanoidⁱ	P55327
OMAⁱ	MDFYEDY
OrthoDBⁱ	EOG091G0MLN
PhylomeDBⁱ	P55327
TreeFamⁱ	TF317562

Enzyme and pathway databases

Reactomeⁱ	R-HSA-432722 Golgi Associated Vesicle Biogenesis
SIGNORⁱ	P55327

Miscellaneous databases

ChiTaRSⁱ	TPD52 human
GeneWikiⁱ	TPD52
GenomeRNAiⁱ	7163
Protein Ontology More...PROⁱ	PR:P55327
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000076554 Expressed in 232 organ(s), highest expression level in frontal cortex
CleanExⁱ	HS_TPD52
ExpressionAtlasⁱ	P55327 baseline and differential
Genevisibleⁱ	P55327 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR007327 TPD52
PANTHERⁱ	PTHR19307 PTHR19307, 1 hit
Pfamⁱ	View protein in Pfam PF04201 TPD52, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TPD52_HUMAN
Accessionⁱ	P55327Primary (citable) accession number: P55327 Secondary accession number(s): B7Z414 Q9UCX8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
	Last sequence update:	November 25, 2008
	Last modified:	September 12, 2018
	This is version 161 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P55327 (TPD52_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Tumor protein D52

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endoplasmic reticulum

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ