Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Hepatocyte nuclear factor 3-gamma

Gene

FOXA3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor that is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites (By similarity). Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; binds to and activates transcription from the G6PC promoter. Binds to the CYP3A4 promoter and activates its transcription in cooperation with CEBPA. Binds to the CYP3A7 promoter together with members of the CTF/NF-I family. Involved in regulation of neuronal-specific transcription. May be involved in regulation of spermatogenesis.By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi116 – 207Fork-headPROSITE-ProRule annotationAdd BLAST92

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Chromatin regulator, Developmental protein, DNA-binding
Biological processDifferentiation, Spermatogenesis, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-210745 Regulation of gene expression in beta cells

Names & Taxonomyi

Protein namesi
Recommended name:
Hepatocyte nuclear factor 3-gamma
Short name:
HNF-3-gamma
Short name:
HNF-3G
Alternative name(s):
Fork head-related protein FKH H3
Forkhead box protein A3
Transcription factor 3G
Short name:
TCF-3G
Gene namesi
Name:FOXA3
Synonyms:HNF3G, TCF3G
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000170608.2
HGNCiHGNC:5023 FOXA3
MIMi602295 gene
neXtProtiNX_P55318

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi3171
OpenTargetsiENSG00000170608
PharmGKBiPA201092

Polymorphism and mutation databases

BioMutaiFOXA3
DMDMi8247938

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000918001 – 350Hepatocyte nuclear factor 3-gammaAdd BLAST350

Proteomic databases

EPDiP55318
MaxQBiP55318
PaxDbiP55318
PeptideAtlasiP55318
PRIDEiP55318
ProteomicsDBi56846

PTM databases

iPTMnetiP55318
PhosphoSitePlusiP55318

Expressioni

Tissue specificityi

Expressed in erythroleukemia and hepatoma cell lines and in liver and pancreas. Not expressed in any other cell lines or tissues examined.1 Publication

Developmental stagei

Detected in prenatal liver nuclear extracts (12.4-27 weeks estimated gestational age). Not detected in postnatal liver samples.1 Publication

Gene expression databases

BgeeiENSG00000170608
CleanExiHS_FOXA3
ExpressionAtlasiP55318 baseline and differential
GenevisibleiP55318 HS

Organism-specific databases

HPAiCAB015154
HPA054034

Interactioni

Subunit structurei

Interacts with FOXA2.2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109413, 50 interactors
IntActiP55318, 43 interactors
MINTiP55318
STRINGi9606.ENSP00000304004

Structurei

Secondary structure

1350
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi122 – 131Combined sources10
Helixi140 – 150Combined sources11
Helixi152 – 155Combined sources4
Helixi158 – 171Combined sources14
Beta strandi175 – 178Combined sources4
Beta strandi190 – 193Combined sources4
Helixi195 – 197Combined sources3
Beta strandi206 – 208Combined sources3

3D structure databases

ProteinModelPortaliP55318
SMRiP55318
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG3563 Eukaryota
COG5025 LUCA
GeneTreeiENSGT00760000118904
HOGENOMiHOG000231817
HOVERGENiHBG006621
InParanoidiP55318
KOiK08038
OMAiDPHYNFN
OrthoDBiEOG091G0HW9
PhylomeDBiP55318
TreeFamiTF316127

Family and domain databases

CDDicd00059 FH, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR013638 Fork-head_N
IPR001766 Fork_head_dom
IPR018122 TF_fork_head_CS_1
IPR030456 TF_fork_head_CS_2
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00250 Forkhead, 1 hit
PF08430 Forkhead_N, 1 hit
PRINTSiPR00053 FORKHEAD
SMARTiView protein in SMART
SM00339 FH, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00657 FORK_HEAD_1, 1 hit
PS00658 FORK_HEAD_2, 1 hit
PS50039 FORK_HEAD_3, 1 hit

Sequencei

Sequence statusi: Complete.

P55318-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGSVKMEAH DLAEWSYYPE AGEVYSPVTP VPTMAPLNSY MTLNPLSSPY
60 70 80 90 100
PPGGLPASPL PSGPLAPPAP AAPLGPTFPG LGVSGGSSSS GYGAPGPGLV
110 120 130 140 150
HGKEMPKGYR RPLAHAKPPY SYISLITMAI QQAPGKMLTL SEIYQWIMDL
160 170 180 190 200
FPYYRENQQR WQNSIRHSLS FNDCFVKVAR SPDKPGKGSY WALHPSSGNM
210 220 230 240 250
FENGCYLRRQ KRFKLEEKVK KGGSGAATTT RNGTGSAAST TTPAATVTSP
260 270 280 290 300
PQPPPPAPEP EAQGGEDVGA LDCGSPASST PYFTGLELPG ELKLDAPYNF
310 320 330 340 350
NHPFSINNLM SEQTPAPPKL DVGFGGYGAE GGEPGVYYQG LYSRSLLNAS
Length:350
Mass (Da):37,140
Last modified:May 30, 2000 - v2
Checksum:i07657D41B0867101
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti52Missing in AAA58477 (PubMed:8499623).Curated1
Sequence conflicti83V → L in AAA58477 (PubMed:8499623).Curated1
Sequence conflicti107K → M in BAD97193 (Ref. 4) Curated1
Sequence conflicti111 – 113RPL → AP in AAA58477 (PubMed:8499623).Curated3
Sequence conflicti137M → V in AAA58477 (PubMed:8499623).Curated1
Sequence conflicti156E → D in AAA58477 (PubMed:8499623).Curated1
Sequence conflicti227 – 228AT → S in AAA58477 (PubMed:8499623).Curated2
Sequence conflicti291E → D in AAA58477 (PubMed:8499623).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00885991G → R. Corresponds to variant dbSNP:rs758330593Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L12141 mRNA Translation: AAA58477.1
AF176114, AF176113 Genomic DNA Translation: AAD51980.1
BT006720 mRNA Translation: AAP35366.1
AK223473 mRNA Translation: BAD97193.1
EU275778 Genomic DNA Translation: ABX44664.1
CH471126 Genomic DNA Translation: EAW57394.1
BC016024 mRNA Translation: AAH16024.1
CCDSiCCDS12677.1
PIRiC48924
RefSeqiNP_004488.2, NM_004497.2
UniGeneiHs.36137

Genome annotation databases

EnsembliENST00000302177; ENSP00000304004; ENSG00000170608
GeneIDi3171
KEGGihsa:3171
UCSCiuc002pdr.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiFOXA3_HUMAN
AccessioniPrimary (citable) accession number: P55318
Secondary accession number(s): A9LYI5, Q53F16, Q9UMW9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 30, 2000
Last modified: June 20, 2018
This is version 171 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health