FOXA1

Functionⁱ

Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). Proposed to play a role in translating the epigenetic signatures into cell type-specific enhancer-driven transcriptional programs. Its differential recruitment to chromatin is dependent on distribution of histone H3 methylated at 'Lys-5' (H3K4me2) in estrogen-regulated genes. Involved in the development of multiple endoderm-derived organ systems such as liver, pancreas, lung and prostate; FOXA1 and FOXA2 seem to have at least in part redundant roles (By similarity). Modulates the transcriptional activity of nuclear hormone receptors. Is involved in ESR1-mediated transcription; required for ESR1 binding to the NKX2-1 promoter in breast cancer cells; binds to the RPRM promoter and is required for the estrogen-induced repression of RPRM. Involved in regulation of apoptosis by inhibiting the expression of BCL2. Involved in cell cycle regulation by activating expression of CDKN1B, alone or in conjunction with BRCA1. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis.By similarity5 Publications

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	169 – 260	Fork-headPROSITE-ProRule annotationAdd BLAST		92

GO - Molecular functionⁱ

DNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 9931457
DNA-binding transcription factor activity
Source: ProtInc
Traceable author statementⁱ
- 8652662
DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
protein domain specific binding Source: InterPro
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific Source: BHF-UCL
sequence-specific DNA binding Source: Ensembl
transcription factor binding Source: InterPro
transcription regulatory region DNA binding
Source: UniProtKB
Inferred from direct assayⁱ

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

alveolar secondary septum development Source: Ensembl
anatomical structure formation involved in morphogenesis Source: Ensembl
anatomical structure morphogenesis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
cell differentiation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
chromatin remodeling Source: UniProtKB
dopaminergic neuron differentiation
Source: ParkinsonsUK-UCL
Traceable author statementⁱ
- 24431302
dorsal/ventral neural tube patterning Source: Ensembl
epithelial cell maturation involved in prostate gland development Source: Ensembl
epithelial-mesenchymal signaling involved in prostate gland development Source: Ensembl
epithelial tube branching involved in lung morphogenesis Source: Ensembl
glucose homeostasis Source: Ensembl
hormone metabolic process Source: Ensembl
lung epithelial cell differentiation Source: Ensembl
negative regulation of epithelial to mesenchymal transition
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 20160041
negative regulation of transcription by RNA polymerase II Source: Ensembl
neuron fate specification Source: Ensembl
Notch signaling pathway Source: Ensembl
positive regulation of apoptotic process
Source: UniProtKB
Inferred from direct assayⁱ
- 19127412
positive regulation of cell-cell adhesion mediated by cadherin
Source: BHF-UCL
Inferred by curatorⁱ
- 20160041
positive regulation of DNA-binding transcription factor activity
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 16087863
positive regulation of intracellular estrogen receptor signaling pathway
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 16087863
positive regulation of mitotic cell cycle
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 16087863
positive regulation of neuron differentiation Source: Ensembl
positive regulation of smoothened signaling pathway Source: Ensembl
positive regulation of transcription by RNA polymerase II
Source: UniProtKB
Inferred from direct assayⁱ
- 16331276
- 19127412
prostate gland epithelium morphogenesis Source: Ensembl
prostate gland stromal morphogenesis Source: Ensembl
regulation of transcription by RNA polymerase II
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
respiratory basal cell differentiation Source: Ensembl
response to estradiol
Source: UniProtKB
Inferred from direct assayⁱ
- 16087863
secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, Chromatin regulator, Developmental protein, DNA-binding, Repressor
Biological process	Transcription, Transcription regulation

Enzyme and pathway databases

Reactomeⁱ	R-HSA-9018519 Estrogen-dependent gene expression
SignaLinkⁱ	P55317
SIGNORⁱ	P55317

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Hepatocyte nuclear factor 3-alpha Short name: HNF-3-alpha Short name: HNF-3A Alternative name(s): Forkhead box protein A1 Transcription factor 3A Short name: TCF-3A
Gene namesⁱ	Name:FOXA1 Synonyms:HNF3A, TCF3A
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 14

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000129514.5
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:5021 FOXA1
MIMⁱ	602294 gene
neXtProtⁱ	NX_P55317

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3169
Open Targets More...OpenTargetsⁱ	ENSG00000129514
PharmGKBⁱ	PA201090

Polymorphism and mutation databases

BioMutaⁱ	FOXA1
DMDMⁱ	296434509

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000091792	1 – 472	Hepatocyte nuclear factor 3-alphaAdd BLAST		472

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	307	PhosphoserineCombined sources		1
Modified residueⁱ	331	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	P55317
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P55317
PaxDbⁱ	P55317
PeptideAtlas More...PeptideAtlasⁱ	P55317
PRIDEⁱ	P55317
ProteomicsDBⁱ	56845

PTM databases

iPTMnetⁱ	P55317
PhosphoSitePlusⁱ	P55317

Expressionⁱ

Tissue specificityⁱ

Highly expressed in prostate and ESR1-positive breast tumors. Overexpressed in esophageal and lung adenocarcinomas.3 Publications

Gene expression databases

Bgeeⁱ	ENSG00000129514 Expressed in 80 organ(s), highest expression level in prostate gland
CleanExⁱ	HS_FOXA1
ExpressionAtlasⁱ	P55317 baseline and differential

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB011595 HPA050505

HPAⁱ

CAB011595
HPA050505

Interactionⁱ

Subunit structureⁱ

Binds DNA as a monomer (By similarity). Interacts with FOXA2. Interacts with NKX2-1. Interacts with HDAC7. Interacts with the histone H3-H4 heterodimer. Associates with nucleosomes containing histone H2A. Interacts with AR. Interacts with NR0B2 (By similarity).By similarity

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
AR	P10275	3	EBI-3918034,EBI-608057

With

Entry

#Exp.

IntAct

Notes

AR

P10275

3

EBI-3918034,EBI-608057

GO - Molecular functionⁱ

protein domain specific binding Source: InterPro
transcription factor binding Source: InterPro

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	109411, 287 interactors
Database of interacting proteins More...DIPⁱ	DIP-57138N
ELMⁱ	P55317
IntActⁱ	P55317, 37 interactors
Molecular INTeraction database More...MINTⁱ	P55317
STRINGⁱ	9606.ENSP00000250448

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P55317
SMRⁱ	P55317
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Phylogenomic databases

eggNOGⁱ	KOG3563 Eukaryota COG5025 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118904
HOGENOMⁱ	HOG000231817
HOVERGENⁱ	HBG006621
InParanoidⁱ	P55317
KEGG Orthology (KO) More...KOⁱ	K09387
OMAⁱ	PHSMAHE
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0HW9
PhylomeDBⁱ	P55317
TreeFamⁱ	TF316127

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00059 FH, 1 hit
Gene3Dⁱ	1.10.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR013638 Fork-head_N IPR001766 Fork_head_dom IPR018533 Forkhead_box_C IPR018122 TF_fork_head_CS_1 IPR030456 TF_fork_head_CS_2 IPR036388 WH-like_DNA-bd_sf IPR036390 WH_DNA-bd_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00250 Forkhead, 1 hit PF08430 Forkhead_N, 1 hit PF09354 HNF_C, 1 hit
PRINTSⁱ	PR00053 FORKHEAD
SMARTⁱ	View protein in SMART SM00339 FH, 1 hit
SUPFAMⁱ	SSF46785 SSF46785, 1 hit
PROSITEⁱ	View protein in PROSITE PS00657 FORK_HEAD_1, 1 hit PS00658 FORK_HEAD_2, 1 hit PS50039 FORK_HEAD_3, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: P55317-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLGTVKMEGH ETSDWNSYYA DTQEAYSSVP VSNMNSGLGS MNSMNTYMTM 
        60         70         80         90        100
NTMTTSGNMT PASFNMSYAN PGLGAGLSPG AVAGMPGGSA GAMNSMTAAG 
       110        120        130        140        150
VTAMGTALSP SGMGAMGAQQ AASMNGLGPY AAAMNPCMSP MAYAPSNLGR 
       160        170        180        190        200
SRAGGGGDAK TFKRSYPHAK PPYSYISLIT MAIQQAPSKM LTLSEIYQWI 
       210        220        230        240        250
MDLFPYYRQN QQRWQNSIRH SLSFNDCFVK VARSPDKPGK GSYWTLHPDS 
       260        270        280        290        300
GNMFENGCYL RRQKRFKCEK QPGAGGGGGS GSGGSGAKGG PESRKDPSGA 
       310        320        330        340        350
SNPSADSPLH RGVHGKTGQL EGAPAPGPAA SPQTLDHSGA TATGGASELK 
       360        370        380        390        400
TPASSTAPPI SSGPGALASV PASHPAHGLA PHESQLHLKG DPHYSFNHPF 
       410        420        430        440        450
SINNLMSSSE QQHKLDFKAY EQALQYSPYG STLPASLPLG SASVTTRSPI 
       460        470 
EPSALEPAYY QGVYSRPVLN TS

Length:472

Mass (Da):49,148

Last modified:May 18, 2010 - v2

Checksum:ⁱB2489523459EEB4C

GO

Isoform 2 (identifier: P55317-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-33: Missing.

« Hide

        10         20         30         40         50
MNSGLGSMNS MNTYMTMNTM TTSGNMTPAS FNMSYANPGL GAGLSPGAVA 
        60         70         80         90        100
GMPGGSAGAM NSMTAAGVTA MGTALSPSGM GAMGAQQAAS MNGLGPYAAA 
       110        120        130        140        150
MNPCMSPMAY APSNLGRSRA GGGGDAKTFK RSYPHAKPPY SYISLITMAI 
       160        170        180        190        200
QQAPSKMLTL SEIYQWIMDL FPYYRQNQQR WQNSIRHSLS FNDCFVKVAR 
       210        220        230        240        250
SPDKPGKGSY WTLHPDSGNM FENGCYLRRQ KRFKCEKQPG AGGGGGSGSG 
       260        270        280        290        300
GSGAKGGPES RKDPSGASNP SADSPLHRGV HGKTGQLEGA PAPGPAASPQ 
       310        320        330        340        350
TLDHSGATAT GGASELKTPA SSTAPPISSG PGALASVPAS HPAHGLAPHE 
       360        370        380        390        400
SQLHLKGDPH YSFNHPFSIN NLMSSSEQQH KLDFKAYEQA LQYSPYGSTL 
       410        420        430 
PASLPLGSAS VTTRSPIEPS ALEPAYYQGV YSRPVLNTS

Note: No experimental confirmation available.

Show »

Length:439

Mass (Da):45,468

Checksum:ⁱ170DF8E54E6FC73C

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	G3V4B9	G3V4B9_HUMAN		Hepatocyte nuclear factor 3-alpha Hepatocyte nuclear factor 3-alpha	FOXA1	36	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_015183	72	G → A2 Publications	1
Natural variantⁱVAR_013457	83	A → T1 PublicationCorresponds to variant dbSNP:rs7144658Ensembl.	1
Natural variantⁱVAR_055835	87	G → E. Corresponds to variant dbSNP:rs35220193Ensembl.	1
Natural variantⁱVAR_015184	124	M → MM2 Publications	1
Natural variantⁱVAR_015185	185	Q → R2 Publications	1
Natural variantⁱVAR_013458	448	S → N1 PublicationCorresponds to variant dbSNP:rs33984772Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_055094	1 – 33	Missing in isoform 2. 1 PublicationAdd BLAST		33

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U39840 mRNA Translation: AAB06493.1 AF176112, AF176111 Genomic DNA Translation: AAD51979.1 AF303743, AF303742 Genomic DNA Translation: AAG40847.1 AK313785 mRNA Translation: BAG36523.1 AK316360 mRNA Translation: BAH14731.1 AL121790 Genomic DNA No translation available. CH471078 Genomic DNA Translation: EAW65844.1 BC033890 mRNA Translation: AAH33890.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS9665.1 [P55317-1]
PIRⁱ	S70357
NCBI Reference Sequences More...RefSeqⁱ	NP_004487.2, NM_004496.3 [P55317-1] XP_016876735.1, XM_017021246.1 [P55317-2]
UniGeneⁱ	Hs.163484

Genome annotation databases

Ensemblⁱ	ENST00000250448; ENSP00000250448; ENSG00000129514 [P55317-1]
GeneIDⁱ	3169
KEGGⁱ	hsa:3169
UCSC genome browser More...UCSCⁱ	uc001wuf.5 human [P55317-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P55317	Hepatocyte nuclear factor 3-alpha		MOUSE		468	UniRef90_P35582
Hepatocyte nuclear factor 3-alpha		RAT		466
Uncharacterized protein		FELCA		536
Forkhead box A1		MUSPF		501
Putative forkhead/hnf-3-related transcription factor		DESRO		482
+62

Protein	Similar proteins		Species	Score	Length	Source
P55317	Hepatocyte nuclear factor 3-beta		MOUSE		459	UniRef50_P35583
Hepatocyte nuclear factor 3-alpha		RAT		466
Hepatocyte nuclear factor 3-beta	)	HUMAN		457
Uncharacterized protein		RABIT		471
Forkhead box A1		OTOGA		449
+289

Cross-referencesⁱ

Web resourcesⁱ

Wikipedia

Hepatocyte nuclear factors entry

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U39840 mRNA Translation: AAB06493.1 AF176112, AF176111 Genomic DNA Translation: AAD51979.1 AF303743, AF303742 Genomic DNA Translation: AAG40847.1 AK313785 mRNA Translation: BAG36523.1 AK316360 mRNA Translation: BAH14731.1 AL121790 Genomic DNA No translation available. CH471078 Genomic DNA Translation: EAW65844.1 BC033890 mRNA Translation: AAH33890.1
CCDSⁱ	CCDS9665.1 [P55317-1]
PIRⁱ	S70357
RefSeqⁱ	NP_004487.2, NM_004496.3 [P55317-1] XP_016876735.1, XM_017021246.1 [P55317-2]
UniGeneⁱ	Hs.163484

3D structure databases

ProteinModelPortalⁱ	P55317
SMRⁱ	P55317
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	109411, 287 interactors
DIPⁱ	DIP-57138N
ELMⁱ	P55317
IntActⁱ	P55317, 37 interactors
MINTⁱ	P55317
STRINGⁱ	9606.ENSP00000250448

PTM databases

iPTMnetⁱ	P55317
PhosphoSitePlusⁱ	P55317

Polymorphism and mutation databases

BioMutaⁱ	FOXA1
DMDMⁱ	296434509

Proteomic databases

EPDⁱ	P55317
MaxQBⁱ	P55317
PaxDbⁱ	P55317
PeptideAtlasⁱ	P55317
PRIDEⁱ	P55317
ProteomicsDBⁱ	56845

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	3169
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000250448; ENSP00000250448; ENSG00000129514 [P55317-1]
GeneIDⁱ	3169
KEGGⁱ	hsa:3169
UCSCⁱ	uc001wuf.5 human [P55317-1]

Organism-specific databases

CTDⁱ	3169
DisGeNETⁱ	3169
EuPathDBⁱ	HostDB:ENSG00000129514.5
GeneCardsⁱ	FOXA1
H-InvDBⁱ	HIX0011609
HGNCⁱ	HGNC:5021 FOXA1
HPAⁱ	CAB011595 HPA050505
MIMⁱ	602294 gene
neXtProtⁱ	NX_P55317
OpenTargetsⁱ	ENSG00000129514
PharmGKBⁱ	PA201090
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3563 Eukaryota COG5025 LUCA
GeneTreeⁱ	ENSGT00760000118904
HOGENOMⁱ	HOG000231817
HOVERGENⁱ	HBG006621
InParanoidⁱ	P55317
KOⁱ	K09387
OMAⁱ	PHSMAHE
OrthoDBⁱ	EOG091G0HW9
PhylomeDBⁱ	P55317
TreeFamⁱ	TF316127

Enzyme and pathway databases

Reactomeⁱ	R-HSA-9018519 Estrogen-dependent gene expression
SignaLinkⁱ	P55317
SIGNORⁱ	P55317

Miscellaneous databases

ChiTaRSⁱ	FOXA1 human
GeneWikiⁱ	FOXA1
GenomeRNAiⁱ	3169
Protein Ontology More...PROⁱ	PR:P55317
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000129514 Expressed in 80 organ(s), highest expression level in prostate gland
CleanExⁱ	HS_FOXA1
ExpressionAtlasⁱ	P55317 baseline and differential

Family and domain databases

CDDⁱ	cd00059 FH, 1 hit
Gene3Dⁱ	1.10.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR013638 Fork-head_N IPR001766 Fork_head_dom IPR018533 Forkhead_box_C IPR018122 TF_fork_head_CS_1 IPR030456 TF_fork_head_CS_2 IPR036388 WH-like_DNA-bd_sf IPR036390 WH_DNA-bd_sf
Pfamⁱ	View protein in Pfam PF00250 Forkhead, 1 hit PF08430 Forkhead_N, 1 hit PF09354 HNF_C, 1 hit
PRINTSⁱ	PR00053 FORKHEAD
SMARTⁱ	View protein in SMART SM00339 FH, 1 hit
SUPFAMⁱ	SSF46785 SSF46785, 1 hit
PROSITEⁱ	View protein in PROSITE PS00657 FORK_HEAD_1, 1 hit PS00658 FORK_HEAD_2, 1 hit PS50039 FORK_HEAD_3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	FOXA1_HUMAN
Accessionⁱ	P55317Primary (citable) accession number: P55317 Secondary accession number(s): B2R9H6, B7ZAP5, Q9H2A0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
	Last sequence update:	May 18, 2010
	Last modified:	November 7, 2018
	This is version 181 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM

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UniProtKB - P55317 (FOXA1_HUMAN)

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Hepatocyte nuclear factor 3-alpha

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

Family and domain databases

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

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Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ