UniProtKB - P55317 (FOXA1_HUMAN)
Hepatocyte nuclear factor 3-alpha
FOXA1
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 169 – 260 | Fork-headPROSITE-ProRule annotationAdd BLAST | 92 |
GO - Molecular functioni
- chromatin binding Source: Ensembl
- DNA binding Source: UniProtKB
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: BHF-UCL
- DNA-binding transcription factor activity Source: ProtInc
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- protein domain specific binding Source: InterPro
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: Ensembl
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
- transcription factor binding Source: InterPro
- transcription regulatory region sequence-specific DNA binding Source: UniProtKB
GO - Biological processi
- alveolar secondary septum development Source: Ensembl
- anatomical structure formation involved in morphogenesis Source: Ensembl
- anatomical structure morphogenesis Source: GO_Central
- cell differentiation Source: GO_Central
- chromatin remodeling Source: UniProtKB
- dopaminergic neuron differentiation Source: ParkinsonsUK-UCL
- dorsal/ventral neural tube patterning Source: Ensembl
- epithelial cell maturation involved in prostate gland development Source: Ensembl
- epithelial-mesenchymal signaling involved in prostate gland development Source: Ensembl
- epithelial tube branching involved in lung morphogenesis Source: Ensembl
- glucose homeostasis Source: Ensembl
- hormone metabolic process Source: Ensembl
- lung epithelial cell differentiation Source: Ensembl
- negative regulation of epithelial to mesenchymal transition Source: BHF-UCL
- negative regulation of transcription by RNA polymerase II Source: Ensembl
- neuron fate specification Source: Ensembl
- Notch signaling pathway Source: Ensembl
- positive regulation of apoptotic process Source: UniProtKB
- positive regulation of cell-cell adhesion mediated by cadherin Source: BHF-UCL
- positive regulation of DNA-binding transcription factor activity Source: UniProtKB
- positive regulation of intracellular estrogen receptor signaling pathway Source: UniProtKB
- positive regulation of mitotic cell cycle Source: UniProtKB
- positive regulation of neuron differentiation Source: Ensembl
- positive regulation of smoothened signaling pathway Source: Ensembl
- positive regulation of transcription by RNA polymerase II Source: UniProtKB
- prostate gland epithelium morphogenesis Source: Ensembl
- prostate gland stromal morphogenesis Source: Ensembl
- regulation of transcription by RNA polymerase II Source: GO_Central
- respiratory basal cell differentiation Source: Ensembl
- response to estradiol Source: UniProtKB
- secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development Source: Ensembl
Keywordsi
Molecular function | Activator, Chromatin regulator, Developmental protein, DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | P55317 |
Reactomei | R-HSA-9018519, Estrogen-dependent gene expression |
SignaLinki | P55317 |
SIGNORi | P55317 |
Names & Taxonomyi
Protein namesi | Recommended name: Hepatocyte nuclear factor 3-alphaShort name: HNF-3-alpha Short name: HNF-3A Alternative name(s): Forkhead box protein A1 Transcription factor 3A Short name: TCF-3A |
Gene namesi | Name:FOXA1 Synonyms:HNF3A, TCF3A |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:5021, FOXA1 |
MIMi | 602294, gene |
neXtProti | NX_P55317 |
VEuPathDBi | HostDB:ENSG00000129514.5 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation2 Publications
Nucleus
- fibrillar center Source: HPA
- nuclear chromatin Source: NTNU_SB
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Other locations
- microvillus Source: Ensembl
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 3169 |
OpenTargetsi | ENSG00000129514 |
PharmGKBi | PA201090 |
Miscellaneous databases
Pharosi | P55317, Tbio |
Genetic variation databases
BioMutai | FOXA1 |
DMDMi | 296434509 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000091792 | 1 – 472 | Hepatocyte nuclear factor 3-alphaAdd BLAST | 472 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 307 | PhosphoserineCombined sources | 1 | |
Modified residuei | 331 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | P55317 |
MassIVEi | P55317 |
MaxQBi | P55317 |
PaxDbi | P55317 |
PeptideAtlasi | P55317 |
PRIDEi | P55317 |
ProteomicsDBi | 56845 [P55317-1] 7076 |
PTM databases
iPTMneti | P55317 |
PhosphoSitePlusi | P55317 |
SwissPalmi | P55317 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000129514, Expressed in prostate gland and 105 other tissues |
ExpressionAtlasi | P55317, baseline and differential |
Organism-specific databases
HPAi | ENSG00000129514, Tissue enhanced (liver, prostate) |
Interactioni
Subunit structurei
Binds DNA as a monomer (By similarity).
Interacts with FOXA2.
Interacts with NKX2-1.
Interacts with HDAC7.
Interacts with the histone H3-H4 heterodimer. Associates with nucleosomes containing histone H2A.
Interacts with AR.
Interacts with NR0B2 (By similarity).
By similarityBinary interactionsi
P55317
With | #Exp. | IntAct |
---|---|---|
AR [P10275] | 3 | EBI-3918034,EBI-608057 |
GO - Molecular functioni
- protein domain specific binding Source: InterPro
- transcription factor binding Source: InterPro
Protein-protein interaction databases
BioGRIDi | 109411, 291 interactors |
DIPi | DIP-57138N |
ELMi | P55317 |
IntActi | P55317, 39 interactors |
MINTi | P55317 |
STRINGi | 9606.ENSP00000250448 |
Miscellaneous databases
RNActi | P55317, protein |
Family & Domainsi
Phylogenomic databases
eggNOGi | KOG3563, Eukaryota |
GeneTreei | ENSGT00940000162043 |
HOGENOMi | CLU_027910_4_1_1 |
InParanoidi | P55317 |
OMAi | GHESSDW |
OrthoDBi | 1181467at2759 |
PhylomeDBi | P55317 |
TreeFami | TF316127 |
Family and domain databases
CDDi | cd00059, FH, 1 hit |
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR013638, Fork-head_N IPR001766, Fork_head_dom IPR018533, Forkhead_box_C IPR018122, TF_fork_head_CS_1 IPR030456, TF_fork_head_CS_2 IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF00250, Forkhead, 1 hit PF08430, Forkhead_N, 1 hit PF09354, HNF_C, 1 hit |
PRINTSi | PR00053, FORKHEAD |
SMARTi | View protein in SMART SM00339, FH, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS00657, FORK_HEAD_1, 1 hit PS00658, FORK_HEAD_2, 1 hit PS50039, FORK_HEAD_3, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MLGTVKMEGH ETSDWNSYYA DTQEAYSSVP VSNMNSGLGS MNSMNTYMTM
60 70 80 90 100
NTMTTSGNMT PASFNMSYAN PGLGAGLSPG AVAGMPGGSA GAMNSMTAAG
110 120 130 140 150
VTAMGTALSP SGMGAMGAQQ AASMNGLGPY AAAMNPCMSP MAYAPSNLGR
160 170 180 190 200
SRAGGGGDAK TFKRSYPHAK PPYSYISLIT MAIQQAPSKM LTLSEIYQWI
210 220 230 240 250
MDLFPYYRQN QQRWQNSIRH SLSFNDCFVK VARSPDKPGK GSYWTLHPDS
260 270 280 290 300
GNMFENGCYL RRQKRFKCEK QPGAGGGGGS GSGGSGAKGG PESRKDPSGA
310 320 330 340 350
SNPSADSPLH RGVHGKTGQL EGAPAPGPAA SPQTLDHSGA TATGGASELK
360 370 380 390 400
TPASSTAPPI SSGPGALASV PASHPAHGLA PHESQLHLKG DPHYSFNHPF
410 420 430 440 450
SINNLMSSSE QQHKLDFKAY EQALQYSPYG STLPASLPLG SASVTTRSPI
460 470
EPSALEPAYY QGVYSRPVLN TS
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketG3V4B9 | G3V4B9_HUMAN | Hepatocyte nuclear factor 3-alpha | FOXA1 | 36 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_015183 | 72 | G → A2 Publications | 1 | |
Natural variantiVAR_013457 | 83 | A → T1 PublicationCorresponds to variant dbSNP:rs7144658Ensembl. | 1 | |
Natural variantiVAR_055835 | 87 | G → E. Corresponds to variant dbSNP:rs35220193Ensembl. | 1 | |
Natural variantiVAR_015184 | 124 | M → MM2 Publications | 1 | |
Natural variantiVAR_015185 | 185 | Q → R2 Publications | 1 | |
Natural variantiVAR_013458 | 448 | S → N1 PublicationCorresponds to variant dbSNP:rs33984772Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_055094 | 1 – 33 | Missing in isoform 2. 1 PublicationAdd BLAST | 33 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U39840 mRNA Translation: AAB06493.1 AF176112, AF176111 Genomic DNA Translation: AAD51979.1 AF303743, AF303742 Genomic DNA Translation: AAG40847.1 AK313785 mRNA Translation: BAG36523.1 AK316360 mRNA Translation: BAH14731.1 AL121790 Genomic DNA No translation available. CH471078 Genomic DNA Translation: EAW65844.1 BC033890 mRNA Translation: AAH33890.1 |
CCDSi | CCDS9665.1 [P55317-1] |
PIRi | S70357 |
RefSeqi | NP_004487.2, NM_004496.3 [P55317-1] XP_016876735.1, XM_017021246.1 [P55317-2] |
Genome annotation databases
Ensembli | ENST00000250448; ENSP00000250448; ENSG00000129514 [P55317-1] |
GeneIDi | 3169 |
KEGGi | hsa:3169 |
UCSCi | uc001wuf.5, human [P55317-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Wikipedia Hepatocyte nuclear factors entry |
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U39840 mRNA Translation: AAB06493.1 AF176112, AF176111 Genomic DNA Translation: AAD51979.1 AF303743, AF303742 Genomic DNA Translation: AAG40847.1 AK313785 mRNA Translation: BAG36523.1 AK316360 mRNA Translation: BAH14731.1 AL121790 Genomic DNA No translation available. CH471078 Genomic DNA Translation: EAW65844.1 BC033890 mRNA Translation: AAH33890.1 |
CCDSi | CCDS9665.1 [P55317-1] |
PIRi | S70357 |
RefSeqi | NP_004487.2, NM_004496.3 [P55317-1] XP_016876735.1, XM_017021246.1 [P55317-2] |
3D structure databases
SMRi | P55317 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 109411, 291 interactors |
DIPi | DIP-57138N |
ELMi | P55317 |
IntActi | P55317, 39 interactors |
MINTi | P55317 |
STRINGi | 9606.ENSP00000250448 |
PTM databases
iPTMneti | P55317 |
PhosphoSitePlusi | P55317 |
SwissPalmi | P55317 |
Genetic variation databases
BioMutai | FOXA1 |
DMDMi | 296434509 |
Proteomic databases
jPOSTi | P55317 |
MassIVEi | P55317 |
MaxQBi | P55317 |
PaxDbi | P55317 |
PeptideAtlasi | P55317 |
PRIDEi | P55317 |
ProteomicsDBi | 56845 [P55317-1] 7076 |
Protocols and materials databases
Antibodypediai | 23304, 1435 antibodies |
DNASUi | 3169 |
Genome annotation databases
Ensembli | ENST00000250448; ENSP00000250448; ENSG00000129514 [P55317-1] |
GeneIDi | 3169 |
KEGGi | hsa:3169 |
UCSCi | uc001wuf.5, human [P55317-1] |
Organism-specific databases
CTDi | 3169 |
DisGeNETi | 3169 |
GeneCardsi | FOXA1 |
HGNCi | HGNC:5021, FOXA1 |
HPAi | ENSG00000129514, Tissue enhanced (liver, prostate) |
MIMi | 602294, gene |
neXtProti | NX_P55317 |
OpenTargetsi | ENSG00000129514 |
PharmGKBi | PA201090 |
VEuPathDBi | HostDB:ENSG00000129514.5 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3563, Eukaryota |
GeneTreei | ENSGT00940000162043 |
HOGENOMi | CLU_027910_4_1_1 |
InParanoidi | P55317 |
OMAi | GHESSDW |
OrthoDBi | 1181467at2759 |
PhylomeDBi | P55317 |
TreeFami | TF316127 |
Enzyme and pathway databases
PathwayCommonsi | P55317 |
Reactomei | R-HSA-9018519, Estrogen-dependent gene expression |
SignaLinki | P55317 |
SIGNORi | P55317 |
Miscellaneous databases
BioGRID-ORCSi | 3169, 49 hits in 903 CRISPR screens |
ChiTaRSi | FOXA1, human |
GeneWikii | FOXA1 |
GenomeRNAii | 3169 |
Pharosi | P55317, Tbio |
PROi | PR:P55317 |
RNActi | P55317, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000129514, Expressed in prostate gland and 105 other tissues |
ExpressionAtlasi | P55317, baseline and differential |
Family and domain databases
CDDi | cd00059, FH, 1 hit |
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR013638, Fork-head_N IPR001766, Fork_head_dom IPR018533, Forkhead_box_C IPR018122, TF_fork_head_CS_1 IPR030456, TF_fork_head_CS_2 IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF00250, Forkhead, 1 hit PF08430, Forkhead_N, 1 hit PF09354, HNF_C, 1 hit |
PRINTSi | PR00053, FORKHEAD |
SMARTi | View protein in SMART SM00339, FH, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS00657, FORK_HEAD_1, 1 hit PS00658, FORK_HEAD_2, 1 hit PS50039, FORK_HEAD_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FOXA1_HUMAN | |
Accessioni | P55317Primary (citable) accession number: P55317 Secondary accession number(s): B2R9H6, B7ZAP5, Q9H2A0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | May 18, 2010 | |
Last modified: | February 10, 2021 | |
This is version 197 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human entries with genetic variants
List of human entries with genetic variants