CDH15

Functionⁱ

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. M-cadherin is part of the myogenic program and may provide a trigger for terminal muscle differentiation.

GO - Molecular functionⁱ

calcium ion binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

adherens junction organization Source: Reactome
cell adhesion
Source: ProtInc
Traceable author statementⁱ
- 9545347
homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
positive regulation of muscle cell differentiation Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Cell adhesion
Ligand	Calcium, Metal-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-375170 CDO in myogenesis R-HSA-418990 Adherens junctions interactions
SIGNORⁱ	P55291

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Cadherin-15 Alternative name(s): Cadherin-14 Muscle cadherin Short name: M-cadherin
Gene namesⁱ	Name:CDH15 Synonyms:CDH14, CDH3
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 16

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000129910.7
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:1754 CDH15
MIMⁱ	114019 gene
neXtProtⁱ	NX_P55291

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	61 – 606	ExtracellularSequence analysisAdd BLAST	546
Transmembraneⁱ	607 – 626	HelicalSequence analysisAdd BLAST	20
Topological domainⁱ	627 – 814	CytoplasmicSequence analysisAdd BLAST	188

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Involvement in diseaseⁱ

A chromosomal aberration involving CDH15 and KIRREL3 is found in a patient with severe mental retardation and dysmorphic facial features. Translocation t(11;16)(q24.2;q24).

Mental retardation, autosomal dominant 3 (MRD3)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period.

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	103	K → R: No effect on cell-cell adhesion. 1 Publication		1
Mutagenesisⁱ	109	M → T: No effect on cell-cell adhesion. 1 Publication		1

Keywords - Diseaseⁱ

Disease mutation, Mental retardation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	1013
MalaCards human disease database More...MalaCardsⁱ	CDH15
MIMⁱ	612580 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000129910
Orphanetⁱ	178469 Autosomal dominant non-syndromic intellectual disability
PharmGKBⁱ	PA26288

Polymorphism and mutation databases

BioMutaⁱ	CDH15
DMDMⁱ	1705553

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 21	Sequence analysisAdd BLAST	21
PropeptideⁱPRO_0000003805	22 – 60	Sequence analysisAdd BLAST	39
ChainⁱPRO_0000003806	61 – 814	Cadherin-15Add BLAST	754

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	227	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	531	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	538	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	576	N-linked (GlcNAc...) asparagineSequence analysis	1

Keywords - PTMⁱ

Cleavage on pair of basic residues, Glycoprotein

Proteomic databases

EPDⁱ	P55291
PaxDbⁱ	P55291
PeptideAtlas More...PeptideAtlasⁱ	P55291
PRIDEⁱ	P55291
ProteomicsDBⁱ	56843

PTM databases

iPTMnetⁱ	P55291
PhosphoSitePlusⁱ	P55291

Expressionⁱ

Tissue specificityⁱ

Expressed in the brain and cerebellum.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000129910 Expressed in 91 organ(s), highest expression level in right hemisphere of cerebellum
CleanExⁱ	HS_CDH15 HS_CDH3
Genevisibleⁱ	P55291 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA009139 HPA070961

HPAⁱ

HPA009139
HPA070961

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
SGTA	O43765	5	EBI-10215061,EBI-347996

With

Entry

#Exp.

IntAct

Notes

SGTA

O43765

5

EBI-10215061,EBI-347996

Protein-protein interaction databases

BioGridⁱ	107448, 7 interactors
IntActⁱ	P55291, 3 interactors
STRINGⁱ	9606.ENSP00000289746

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P55291
SMRⁱ	P55291
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	61 – 152	Cadherin 1PROSITE-ProRule annotationAdd BLAST	92
Domainⁱ	153 – 260	Cadherin 2PROSITE-ProRule annotationAdd BLAST	108
Domainⁱ	261 – 375	Cadherin 3PROSITE-ProRule annotationAdd BLAST	115
Domainⁱ	376 – 481	Cadherin 4PROSITE-ProRule annotationAdd BLAST	106
Domainⁱ	482 – 590	Cadherin 5PROSITE-ProRule annotationAdd BLAST	109

Domainⁱ

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Keywords - Domainⁱ

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3594 Eukaryota ENOG410XQHI LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118906
HOGENOMⁱ	HOG000231254
HOVERGENⁱ	HBG106438
InParanoidⁱ	P55291
KEGG Orthology (KO) More...KOⁱ	K06809
OMAⁱ	LKDGWYR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G02MA
PhylomeDBⁱ	P55291
TreeFamⁱ	TF316817

Family and domain databases

Gene3Dⁱ	4.10.900.10, 1 hit
InterProⁱ	View protein in InterPro IPR002126 Cadherin IPR015919 Cadherin-like IPR020894 Cadherin_CS IPR000233 Cadherin_cytoplasmic-dom IPR027397 Catenin_binding_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00028 Cadherin, 4 hits PF01049 Cadherin_C, 1 hit
PRINTSⁱ	PR00205 CADHERIN
SMARTⁱ	View protein in SMART SM00112 CA, 4 hits
SUPFAMⁱ	SSF49313 SSF49313, 5 hits
PROSITEⁱ	View protein in PROSITE PS00232 CADHERIN_1, 2 hits PS50268 CADHERIN_2, 5 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P55291-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MDAAFLLVLG LLAQSLCLSL GVPGWRRPTT LYPWRRAPAL SRVRRAWVIP 
        60         70         80         90        100
PISVSENHKR LPYPLVQIKS DKQQLGSVIY SIQGPGVDEE PRGVFSIDKF 
       110        120        130        140        150
TGKVFLNAML DREKTDRFRL RAFALDLGGS TLEDPTDLEI VVVDQNDNRP 
       160        170        180        190        200
AFLQEAFTGR VLEGAVPGTY VTRAEATDAD DPETDNAALR FSILQQGSPE 
       210        220        230        240        250
LFSIDELTGE IRTVQVGLDR EVVAVYNLTL QVADMSGDGL TATASAIITL 
       260        270        280        290        300
DDINDNAPEF TRDEFFMEAI EAVSGVDVGR LEVEDRDLPG SPNWVARFTI 
       310        320        330        340        350
LEGDPDGQFT IRTDPKTNEG VLSIVKALDY ESCEHYELKV SVQNEAPLQA 
       360        370        380        390        400
AALRAERGQA KVRVHVQDTN EPPVFQENPL RTSLAEGAPP GTLVATFSAR 
       410        420        430        440        450
DPDTEQLQRL SYSKDYDPED WLQVDAATGR IQTQHVLSPA SPFLKGGWYR 
       460        470        480        490        500
AIVLAQDDAS QPRTATGTLS IEILEVNDHA PVLAPPPPGS LCSEPHQGPG 
       510        520        530        540        550
LLLGATDEDL PPHGAPFHFQ LSPRLPELGR NWSLSQVNVS HARLRPRHQV 
       560        570        580        590        600
PEGLHRLSLL LRDSGQPPQQ REQPLNVTVC RCGKDGVCLP GAAALLAGGT 
       610        620        630        640        650
GLSLGALVIV LASALLLLVL VLLVALRARF WKQSRGKGLL HGPQDDLRDN 
       660        670        680        690        700
VLNYDEQGGG EEDQDAYDIS QLRHPTALSL PLGPPPLRRD APQGRLHPQP 
       710        720        730        740        750
PRVLPTSPLD IADFINDGLE AADSDPSVPP YDTALIYDYE GDGSVAGTLS 
       760        770        780        790        800
SILSSQGDED QDYDYLRDWG PRFARLADMY GHPCGLEYGA RWDHQAREGL 
       810 
SPGALLPRHR GRTA

Length:814

Mass (Da):88,916

Last modified:October 1, 1996 - v1

Checksum:ⁱ618A817DBF2B3343

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_054966	8	V → L in MRD3; uncertain pathological significance. 1 PublicationCorresponds to variant dbSNP:rs567903921Ensembl.	1
Natural variantⁱVAR_054967	60	R → C in MRD3; affects cell-cell adhesion but not surface expression of the protein. 1 PublicationCorresponds to variant dbSNP:rs121434539EnsemblClinVar.	1
Natural variantⁱVAR_054968	92	R → W in MRD3; affects cell-cell adhesion but not surface expression of the protein. 1 PublicationCorresponds to variant dbSNP:rs121434540EnsemblClinVar.	1
Natural variantⁱVAR_054969	122	A → V in MRD3; affects cell-cell adhesion but not surface expression of the protein. 1 PublicationCorresponds to variant dbSNP:rs121434541EnsemblClinVar.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D83542 mRNA Translation: BAA12012.1 BC008951 mRNA Translation: AAH08951.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS10976.1
PIRⁱ	G02878
NCBI Reference Sequences More...RefSeqⁱ	NP_004924.1, NM_004933.2
UniGeneⁱ	Hs.148090

Genome annotation databases

Ensemblⁱ	ENST00000289746; ENSP00000289746; ENSG00000129910
GeneIDⁱ	1013
KEGGⁱ	hsa:1013
UCSC genome browser More...UCSCⁱ	uc002fmt.4 human

Keywords - Coding sequence diversityⁱ

Chromosomal rearrangement

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P55291	Cadherin 15		CHLSB		813	UniRef90_P55291
Uncharacterized protein		MACNE		813
Uncharacterized protein		CERAT		813
Cadherin 15		CALJA		813
Uncharacterized protein		PAPAN		813
+24

Protein	Similar proteins		Species	Score	Length	Source
P55291	Cadherin-15		MOUSE		784	UniRef50_P55291
Uncharacterized protein		MACNE		813
Uncharacterized protein		Cebus capucinus imitator		813
Cadherin 15		CALJA		813
Uncharacterized protein		CERAT		813
+115

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D83542 mRNA Translation: BAA12012.1 BC008951 mRNA Translation: AAH08951.1
CCDSⁱ	CCDS10976.1
PIRⁱ	G02878
RefSeqⁱ	NP_004924.1, NM_004933.2
UniGeneⁱ	Hs.148090

3D structure databases

ProteinModelPortalⁱ	P55291
SMRⁱ	P55291
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	107448, 7 interactors
IntActⁱ	P55291, 3 interactors
STRINGⁱ	9606.ENSP00000289746

PTM databases

iPTMnetⁱ	P55291
PhosphoSitePlusⁱ	P55291

Polymorphism and mutation databases

BioMutaⁱ	CDH15
DMDMⁱ	1705553

Proteomic databases

EPDⁱ	P55291
PaxDbⁱ	P55291
PeptideAtlasⁱ	P55291
PRIDEⁱ	P55291
ProteomicsDBⁱ	56843

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	1013
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000289746; ENSP00000289746; ENSG00000129910
GeneIDⁱ	1013
KEGGⁱ	hsa:1013
UCSCⁱ	uc002fmt.4 human

Organism-specific databases

CTDⁱ	1013
DisGeNETⁱ	1013
EuPathDBⁱ	HostDB:ENSG00000129910.7
GeneCardsⁱ	CDH15
HGNCⁱ	HGNC:1754 CDH15
HPAⁱ	HPA009139 HPA070961
MalaCardsⁱ	CDH15
MIMⁱ	114019 gene 612580 phenotype
neXtProtⁱ	NX_P55291
OpenTargetsⁱ	ENSG00000129910
Orphanetⁱ	178469 Autosomal dominant non-syndromic intellectual disability
PharmGKBⁱ	PA26288
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3594 Eukaryota ENOG410XQHI LUCA
GeneTreeⁱ	ENSGT00760000118906
HOGENOMⁱ	HOG000231254
HOVERGENⁱ	HBG106438
InParanoidⁱ	P55291
KOⁱ	K06809
OMAⁱ	LKDGWYR
OrthoDBⁱ	EOG091G02MA
PhylomeDBⁱ	P55291
TreeFamⁱ	TF316817

Enzyme and pathway databases

Reactomeⁱ	R-HSA-375170 CDO in myogenesis R-HSA-418990 Adherens junctions interactions
SIGNORⁱ	P55291

Miscellaneous databases

GeneWikiⁱ	CDH15
GenomeRNAiⁱ	1013
Protein Ontology More...PROⁱ	PR:P55291
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000129910 Expressed in 91 organ(s), highest expression level in right hemisphere of cerebellum
CleanExⁱ	HS_CDH15 HS_CDH3
Genevisibleⁱ	P55291 HS

Family and domain databases

Gene3Dⁱ	4.10.900.10, 1 hit
InterProⁱ	View protein in InterPro IPR002126 Cadherin IPR015919 Cadherin-like IPR020894 Cadherin_CS IPR000233 Cadherin_cytoplasmic-dom IPR027397 Catenin_binding_dom_sf
Pfamⁱ	View protein in Pfam PF00028 Cadherin, 4 hits PF01049 Cadherin_C, 1 hit
PRINTSⁱ	PR00205 CADHERIN
SMARTⁱ	View protein in SMART SM00112 CA, 4 hits
SUPFAMⁱ	SSF49313 SSF49313, 5 hits
PROSITEⁱ	View protein in PROSITE PS00232 CADHERIN_1, 2 hits PS50268 CADHERIN_2, 5 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CAD15_HUMAN
Accessionⁱ	P55291Primary (citable) accession number: P55291
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
	Last sequence update:	October 1, 1996
	Last modified:	September 12, 2018
	This is version 163 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniRef

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Supporting data

UniProtKB - P55291 (CAD15_HUMAN)

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Cadherin-15

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Cytosol

Extracellular region or secreted

Golgi apparatus

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ