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Protein

Cadherin-12

Gene

CDH12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell adhesion
LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-418990 Adherens junctions interactions

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-12
Alternative name(s):
Brain cadherin
Short name:
BR-cadherin
Neural type cadherin 2
Short name:
N-cadherin 2
Gene namesi
Name:CDH12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000154162.13
HGNCiHGNC:1751 CDH12
MIMi600562 gene
neXtProtiNX_P55289

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini55 – 609ExtracellularSequence analysisAdd BLAST555
Transmembranei610 – 637HelicalSequence analysisAdd BLAST28
Topological domaini638 – 794CytoplasmicSequence analysisAdd BLAST157

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi1010
OpenTargetsiENSG00000154162
PharmGKBiPA26285

Polymorphism and mutation databases

BioMutaiCDH12
DMDMi158937438

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
PropeptideiPRO_000000379124 – 54Sequence analysisAdd BLAST31
ChainiPRO_000000379255 – 794Cadherin-12Add BLAST740

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi256N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi456N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi537N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi545N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei787PhosphoserineBy similarity1

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP55289
PeptideAtlasiP55289
PRIDEiP55289
ProteomicsDBi56839
TopDownProteomicsiP55289-2 [P55289-2]

PTM databases

iPTMnetiP55289
PhosphoSitePlusiP55289

Expressioni

Tissue specificityi

Brain.

Gene expression databases

BgeeiENSG00000154162 Expressed in 93 organ(s), highest expression level in dorsolateral prefrontal cortex
CleanExiHS_CDH12
GenevisibleiP55289 HS

Organism-specific databases

HPAiHPA029325

Interactioni

Protein-protein interaction databases

BioGridi107445, 1 interactor
IntActiP55289, 1 interactor
STRINGi9606.ENSP00000371689

Structurei

3D structure databases

ProteinModelPortaliP55289
SMRiP55289
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini55 – 160Cadherin 1PROSITE-ProRule annotationAdd BLAST106
Domaini161 – 269Cadherin 2PROSITE-ProRule annotationAdd BLAST109
Domaini270 – 384Cadherin 3PROSITE-ProRule annotationAdd BLAST115
Domaini385 – 487Cadherin 4PROSITE-ProRule annotationAdd BLAST103
Domaini488 – 609Cadherin 5PROSITE-ProRule annotationAdd BLAST122

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
GeneTreeiENSGT00760000118954
HOGENOMiHOG000231252
HOVERGENiHBG005217
InParanoidiP55289
KOiK06804
OMAiELYFLPV
OrthoDBiEOG091G023E
PhylomeDBiP55289
TreeFamiTF329887

Family and domain databases

Gene3Di4.10.900.10, 1 hit
InterProiView protein in InterPro
IPR002126 Cadherin
IPR015919 Cadherin-like
IPR020894 Cadherin_CS
IPR000233 Cadherin_cytoplasmic-dom
IPR027397 Catenin_binding_dom_sf
PfamiView protein in Pfam
PF00028 Cadherin, 5 hits
PF01049 Cadherin_C, 1 hit
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 5 hits
SUPFAMiSSF49313 SSF49313, 5 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 2 hits
PS50268 CADHERIN_2, 5 hits

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P55289-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLTRNCLSLL LWVLFDGGLL TPLQPQPQQT LATEPRENVI HLPGQRSHFQ
60 70 80 90 100
RVKRGWVWNQ FFVLEEYVGS EPQYVGKLHS DLDKGEGTVK YTLSGDGAGT
110 120 130 140 150
VFTIDETTGD IHAIRSLDRE EKPFYTLRAQ AVDIETRKPL EPESEFIIKV
160 170 180 190 200
QDINDNEPKF LDGPYVATVP EMSPVGAYVL QVKATDADDP TYGNSARVVY
210 220 230 240 250
SILQGQPYFS IDPKTGVIRT ALPNMDREVK EQYQVLIQAK DMGGQLGGLA
260 270 280 290 300
GTTIVNITLT DVNDNPPRFP KSIFHLKVPE SSPIGSAIGR IRAVDPDFGQ
310 320 330 340 350
NAEIEYNIVP GDGGNLFDIV TDEDTQEGVI KLKKPLDFET KKAYTFKVEA
360 370 380 390 400
SNLHLDHRFH SAGPFKDTAT VKISVLDVDE PPVFSKPLYT MEVYEDTPVG
410 420 430 440 450
TIIGAVTAQD LDVGSSAVRY FIDWKSDGDS YFTIDGNEGT IATNELLDRE
460 470 480 490 500
STAQYNFSII ASKVSNPLLT SKVNILINVL DVNEFPPEIS VPYETAVCEN
510 520 530 540 550
AKPGQIIQIV SAADRDLSPA GQQFSFRLSP EAAIKPNFTV RDFRNNTAGI
560 570 580 590 600
ETRRNGYSRR QQELYFLPVV IEDSSYPVQS STNTMTIRVC RCDSDGTILS
610 620 630 640 650
CNVEAIFLPV GLSTGALIAI LLCIVILLAI VVLYVALRRQ KKKDTLMTSK
660 670 680 690 700
EDIRDNVIHY DDEGGGEEDT QAFDIGALRN PKVIEENKIR RDIKPDSLCL
710 720 730 740 750
PRQRPPMEDN TDIRDFIHQR LQENDVDPTA PPYDSLATYA YEGSGSVAES
760 770 780 790
LSSIDSLTTE ADQDYDYLTD WGPRFKVLAD MFGEEESYNP DKVT
Length:794
Mass (Da):88,332
Last modified:August 21, 2007 - v2
Checksum:i76DF39AB56E7BC2D
GO
Isoform 2 (identifier: P55289-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     176-215: Missing.

Note: No experimental confirmation available.
Show »
Length:754
Mass (Da):84,001
Checksum:i88AF2E3E7AB59C91
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti349E → D in AAB48539 (PubMed:7731968).Curated1
Sequence conflicti416S → G in AAA35623 (PubMed:7982033).Curated1
Sequence conflicti644D → H in AAA35623 (PubMed:7982033).Curated1
Sequence conflicti733Y → I in AAA35623 (PubMed:7982033).Curated1
Sequence conflicti761A → T in AAB48539 (PubMed:7731968).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04850568V → M1 PublicationCorresponds to variant dbSNP:rs4371716Ensembl.1
Natural variantiVAR_048506284I → V. Corresponds to variant dbSNP:rs17328673Ensembl.1
Natural variantiVAR_048507475I → T. Corresponds to variant dbSNP:rs12108814Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_056449176 – 215Missing in isoform 2. 1 PublicationAdd BLAST40

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L34057 mRNA Translation: AAA35623.1
L33477 mRNA Translation: AAB48539.1
AK295123 mRNA Translation: BAH11982.1
AK314800 mRNA Translation: BAG37328.1
AC022139 Genomic DNA No translation available.
AC026716 Genomic DNA No translation available.
AC034239 Genomic DNA No translation available.
AC091938 Genomic DNA No translation available.
AC093263 Genomic DNA No translation available.
AC108089 Genomic DNA No translation available.
AC109455 Genomic DNA No translation available.
AC138854 Genomic DNA No translation available.
AC138940 Genomic DNA No translation available.
AC139497 Genomic DNA No translation available.
AC140132 Genomic DNA No translation available.
AC140171 Genomic DNA No translation available.
CH471118 Genomic DNA Translation: EAX10736.1
BC047608 mRNA Translation: AAH47608.1
CCDSiCCDS3890.1 [P55289-1]
CCDS82991.1 [P55289-2]
PIRiI59372
RefSeqiNP_001304156.1, NM_001317227.1 [P55289-1]
NP_001304157.1, NM_001317228.1 [P55289-2]
NP_004052.2, NM_004061.4 [P55289-1]
XP_011512229.1, XM_011513927.2 [P55289-1]
XP_016864409.1, XM_017008920.1 [P55289-1]
XP_016864410.1, XM_017008921.1 [P55289-1]
UniGeneiHs.113684

Genome annotation databases

EnsembliENST00000382254; ENSP00000371689; ENSG00000154162 [P55289-1]
ENST00000504376; ENSP00000423577; ENSG00000154162 [P55289-1]
ENST00000522262; ENSP00000428786; ENSG00000154162 [P55289-2]
GeneIDi1010
KEGGihsa:1010
UCSCiuc003jgk.3 human [P55289-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L34057 mRNA Translation: AAA35623.1
L33477 mRNA Translation: AAB48539.1
AK295123 mRNA Translation: BAH11982.1
AK314800 mRNA Translation: BAG37328.1
AC022139 Genomic DNA No translation available.
AC026716 Genomic DNA No translation available.
AC034239 Genomic DNA No translation available.
AC091938 Genomic DNA No translation available.
AC093263 Genomic DNA No translation available.
AC108089 Genomic DNA No translation available.
AC109455 Genomic DNA No translation available.
AC138854 Genomic DNA No translation available.
AC138940 Genomic DNA No translation available.
AC139497 Genomic DNA No translation available.
AC140132 Genomic DNA No translation available.
AC140171 Genomic DNA No translation available.
CH471118 Genomic DNA Translation: EAX10736.1
BC047608 mRNA Translation: AAH47608.1
CCDSiCCDS3890.1 [P55289-1]
CCDS82991.1 [P55289-2]
PIRiI59372
RefSeqiNP_001304156.1, NM_001317227.1 [P55289-1]
NP_001304157.1, NM_001317228.1 [P55289-2]
NP_004052.2, NM_004061.4 [P55289-1]
XP_011512229.1, XM_011513927.2 [P55289-1]
XP_016864409.1, XM_017008920.1 [P55289-1]
XP_016864410.1, XM_017008921.1 [P55289-1]
UniGeneiHs.113684

3D structure databases

ProteinModelPortaliP55289
SMRiP55289
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107445, 1 interactor
IntActiP55289, 1 interactor
STRINGi9606.ENSP00000371689

PTM databases

iPTMnetiP55289
PhosphoSitePlusiP55289

Polymorphism and mutation databases

BioMutaiCDH12
DMDMi158937438

Proteomic databases

PaxDbiP55289
PeptideAtlasiP55289
PRIDEiP55289
ProteomicsDBi56839
TopDownProteomicsiP55289-2 [P55289-2]

Protocols and materials databases

DNASUi1010
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000382254; ENSP00000371689; ENSG00000154162 [P55289-1]
ENST00000504376; ENSP00000423577; ENSG00000154162 [P55289-1]
ENST00000522262; ENSP00000428786; ENSG00000154162 [P55289-2]
GeneIDi1010
KEGGihsa:1010
UCSCiuc003jgk.3 human [P55289-1]

Organism-specific databases

CTDi1010
DisGeNETi1010
EuPathDBiHostDB:ENSG00000154162.13
GeneCardsiCDH12
H-InvDBiHIX0164254
HIX0164262
HIX0164263
HGNCiHGNC:1751 CDH12
HPAiHPA029325
MIMi600562 gene
neXtProtiNX_P55289
OpenTargetsiENSG00000154162
PharmGKBiPA26285
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
GeneTreeiENSGT00760000118954
HOGENOMiHOG000231252
HOVERGENiHBG005217
InParanoidiP55289
KOiK06804
OMAiELYFLPV
OrthoDBiEOG091G023E
PhylomeDBiP55289
TreeFamiTF329887

Enzyme and pathway databases

ReactomeiR-HSA-418990 Adherens junctions interactions

Miscellaneous databases

ChiTaRSiCDH12 human
GeneWikiiCDH12
GenomeRNAii1010
PROiPR:P55289
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000154162 Expressed in 93 organ(s), highest expression level in dorsolateral prefrontal cortex
CleanExiHS_CDH12
GenevisibleiP55289 HS

Family and domain databases

Gene3Di4.10.900.10, 1 hit
InterProiView protein in InterPro
IPR002126 Cadherin
IPR015919 Cadherin-like
IPR020894 Cadherin_CS
IPR000233 Cadherin_cytoplasmic-dom
IPR027397 Catenin_binding_dom_sf
PfamiView protein in Pfam
PF00028 Cadherin, 5 hits
PF01049 Cadherin_C, 1 hit
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 5 hits
SUPFAMiSSF49313 SSF49313, 5 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 2 hits
PS50268 CADHERIN_2, 5 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCAD12_HUMAN
AccessioniPrimary (citable) accession number: P55289
Secondary accession number(s): B2RBT1, B7Z2U6, Q86UD2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: August 21, 2007
Last modified: September 12, 2018
This is version 155 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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