UniProtKB - P55288 (CAD11_MOUSE)
Protein
Cadherin-11
Gene
Cdh11
Organism
Mus musculus (Mouse)
Status
Functioni
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
GO - Molecular functioni
- cadherin binding Source: GO_Central
- calcium ion binding Source: GO_Central
GO - Biological processi
- adherens junction organization Source: GO_Central
- calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules Source: GO_Central
- cell-cell adhesion via plasma-membrane adhesion molecules Source: GO_Central
- cell-cell junction assembly Source: GO_Central
- cell morphogenesis Source: GO_Central
- corticospinal tract morphogenesis Source: MGI
- homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
- modulation of chemical synaptic transmission Source: SynGO
- multicellular organism development Source: GO_Central
Keywordsi
Biological process | Cell adhesion |
Ligand | Calcium, Metal-binding |
Enzyme and pathway databases
Reactomei | R-MMU-418990, Adherens junctions interactions |
Names & Taxonomyi
Protein namesi | Recommended name: Cadherin-11Alternative name(s): OSF-4 Osteoblast cadherin Short name: OB-cadherin |
Gene namesi | Name:Cdh11 Synonyms:Cad-11 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:99217, Cdh11 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- catenin complex Source: GO_Central
- plasma membrane Source: MGI
Other locations
- adherens junction Source: GO_Central
- cytoplasm Source: MGI
- glutamatergic synapse Source: SynGO
- integral component of membrane Source: UniProtKB-KW
- Schaffer collateral - CA1 synapse Source: SynGO
- synapse Source: SynGO
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 54 – 617 | ExtracellularSequence analysisAdd BLAST | 564 | |
Transmembranei | 618 – 640 | HelicalSequence analysisAdd BLAST | 23 | |
Topological domaini | 641 – 796 | CytoplasmicSequence analysisAdd BLAST | 156 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 24 | Sequence analysisAdd BLAST | 24 | |
PropeptideiPRO_0000003787 | 25 – 53 | Sequence analysisAdd BLAST | 29 | |
ChainiPRO_0000003788 | 54 – 796 | Cadherin-11Add BLAST | 743 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 455 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 540 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 788 | PhosphoserineCombined sources | 1 | |
Modified residuei | 791 | PhosphothreonineCombined sources | 1 |
Keywords - PTMi
Cleavage on pair of basic residues, Glycoprotein, PhosphoproteinProteomic databases
jPOSTi | P55288 |
MaxQBi | P55288 |
PaxDbi | P55288 |
PeptideAtlasi | P55288 |
PRIDEi | P55288 |
PTM databases
GlyConnecti | 2164, 5 N-Linked glycans (1 site) |
GlyGeni | P55288, 2 sites |
iPTMneti | P55288 |
PhosphoSitePlusi | P55288 |
Expressioni
Tissue specificityi
Selectively expressed in osteoblastic cell lines, precursor cell lines of osteoblasts, and primary osteoblastic cells from calvaria, as well as in lung, testis, and brain tissues at low levels.
Developmental stagei
In the testis, expression is highest in fetal gonad and decreases 8-fold in newborn.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000031673, Expressed in vault of skull and 377 other tissues |
Genevisiblei | P55288, MM |
Interactioni
Subunit structurei
Interacts with PCDH8.
By similarityGO - Molecular functioni
- cadherin binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 198632, 4 interactors |
DIPi | DIP-59088N |
IntActi | P55288, 2 interactors |
STRINGi | 10090.ENSMUSP00000074681 |
Miscellaneous databases
RNActi | P55288, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P55288 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P55288 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 54 – 159 | Cadherin 1PROSITE-ProRule annotationAdd BLAST | 106 | |
Domaini | 160 – 268 | Cadherin 2PROSITE-ProRule annotationAdd BLAST | 109 | |
Domaini | 269 – 383 | Cadherin 3PROSITE-ProRule annotationAdd BLAST | 115 | |
Domaini | 384 – 486 | Cadherin 4PROSITE-ProRule annotationAdd BLAST | 103 | |
Domaini | 487 – 612 | Cadherin 5PROSITE-ProRule annotationAdd BLAST | 126 |
Domaini
Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity
Keywords - Domaini
Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3594, Eukaryota |
GeneTreei | ENSGT00940000153691 |
HOGENOMi | CLU_005284_3_1_1 |
InParanoidi | P55288 |
OMAi | DMFEITT |
OrthoDBi | 188978at2759 |
PhylomeDBi | P55288 |
TreeFami | TF329887 |
Family and domain databases
Gene3Di | 4.10.900.10, 1 hit |
InterProi | View protein in InterPro IPR039808, Cadherin IPR002126, Cadherin-like_dom IPR015919, Cadherin-like_sf IPR020894, Cadherin_CS IPR000233, Cadherin_cytoplasmic-dom IPR027397, Catenin_binding_dom_sf |
PANTHERi | PTHR24027, PTHR24027, 1 hit |
Pfami | View protein in Pfam PF00028, Cadherin, 4 hits PF01049, Cadherin_C, 1 hit |
PRINTSi | PR00205, CADHERIN |
SMARTi | View protein in SMART SM00112, CA, 5 hits |
SUPFAMi | SSF49313, SSF49313, 5 hits |
PROSITEi | View protein in PROSITE PS00232, CADHERIN_1, 3 hits PS50268, CADHERIN_2, 5 hits |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P55288-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKENYCLQAA LVCLSMLYHS QAFALERRSH LHPSFHGHHE KGKEGQVLQR
60 70 80 90 100
SKRGWVWNQF FVIEEYTGPD PVLVGRLHSD IDSGDGNIKY ILSGEGAGTI
110 120 130 140 150
FVIDDKSGNI HATKTLDREE RAQYTLMAQA VDRDTNRPLE PPSEFIVKVQ
160 170 180 190 200
DINDNPPEFL HEIYHANVPE RSNVGTSVIQ VTASDADDPT YGNSAKLVYS
210 220 230 240 250
ILEGQPYFSV EAQTGIIRTA LPNMDREAKE EYHVVIQAKD MGGHMGGLSG
260 270 280 290 300
TTKVTITLTD VNDNPPKFPQ SVYQMSVSEA AVPGEEVGRV KAKDPDIGEN
310 320 330 340 350
GLVTYNIVDG DGIELFEITT DYETQDGVVK LKKPVDFETK RAYSLKIEAA
360 370 380 390 400
NVHIDPKFIS NGPFKDTVTV KISVEDADEP PMFLAPSYIH EVQENAAAGT
410 420 430 440 450
VVGRVHAKDP DAANSPIRYS IDRHTDLDRF FTINPEDGFI KTTKPLDREE
460 470 480 490 500
TAWLNISVFA AEIHNRHQET KVPVAIRVLD VNDNAPKFAA PYEGFICESD
510 520 530 540 550
HPKALSNQPI VTVSADDQDD TANGPRFIFS LPPEIMHNPN FTVRDNRDNT
560 570 580 590 600
AGVYARRGGF SRQKQDFYLL PIVISDGGIP PMSSTNTLTI KVCGCDVNGA
610 620 630 640 650
LLSCNAEAYI LNAGLSTGAL IAILACIVIL LVIVVLFVTL RRQKKEPLIV
660 670 680 690 700
FEEEDVRENI ITYDDEGGGE EDTEAFDIAT LQNPDGINGF IPRKDIKPEY
710 720 730 740 750
QYMPRPGLRP APNSVDVDDF INTRIQEADN DPTAPPYDSI QIYGYEGRGS
760 770 780 790
VAGSLSSLES ATTDSDLDYD YLQNWGPRFK KLADLYGSKD TFDDDS
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 462 | E → D in CAA54674 (PubMed:7750649).Curated | 1 | |
Sequence conflicti | 589 | T → L in BAA06730 (PubMed:7750650).Curated | 1 | |
Sequence conflicti | 655 | D → N in BAA06730 (PubMed:7750650).Curated | 1 | |
Sequence conflicti | 751 | V → M in CAA54674 (PubMed:7750649).Curated | 1 | |
Sequence conflicti | 777 | P → Q in BAA06730 (PubMed:7750650).Curated | 1 | |
Sequence conflicti | 782 | L → P in BAA06730 (PubMed:7750650).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X77557 mRNA Translation: CAA54674.1 D31963 mRNA Translation: BAA06730.1 D21253 mRNA Translation: BAA04797.1 BC046314 mRNA Translation: AAH46314.1 |
CCDSi | CCDS22571.1 |
PIRi | A53584 I48277 I49556 |
RefSeqi | NP_033996.4, NM_009866.5 XP_006530686.1, XM_006530623.3 XP_006530687.1, XM_006530624.2 XP_006530689.1, XM_006530626.3 |
Genome annotation databases
Ensembli | ENSMUST00000075190; ENSMUSP00000074681; ENSMUSG00000031673 |
GeneIDi | 12552 |
KEGGi | mmu:12552 |
UCSCi | uc009mzu.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X77557 mRNA Translation: CAA54674.1 D31963 mRNA Translation: BAA06730.1 D21253 mRNA Translation: BAA04797.1 BC046314 mRNA Translation: AAH46314.1 |
CCDSi | CCDS22571.1 |
PIRi | A53584 I48277 I49556 |
RefSeqi | NP_033996.4, NM_009866.5 XP_006530686.1, XM_006530623.3 XP_006530687.1, XM_006530624.2 XP_006530689.1, XM_006530626.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2A4C | X-ray | 2.90 | A/B | 54-151 | [»] | |
2A4E | X-ray | 3.20 | A | 54-260 | [»] | |
6CGB | X-ray | 2.99 | A | 54-155 | [»] | |
SMRi | P55288 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 198632, 4 interactors |
DIPi | DIP-59088N |
IntActi | P55288, 2 interactors |
STRINGi | 10090.ENSMUSP00000074681 |
Chemistry databases
ChEMBLi | CHEMBL2163173 |
PTM databases
GlyConnecti | 2164, 5 N-Linked glycans (1 site) |
GlyGeni | P55288, 2 sites |
iPTMneti | P55288 |
PhosphoSitePlusi | P55288 |
Proteomic databases
jPOSTi | P55288 |
MaxQBi | P55288 |
PaxDbi | P55288 |
PeptideAtlasi | P55288 |
PRIDEi | P55288 |
Protocols and materials databases
Antibodypediai | 4584, 806 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000075190; ENSMUSP00000074681; ENSMUSG00000031673 |
GeneIDi | 12552 |
KEGGi | mmu:12552 |
UCSCi | uc009mzu.1, mouse |
Organism-specific databases
CTDi | 1009 |
MGIi | MGI:99217, Cdh11 |
Phylogenomic databases
eggNOGi | KOG3594, Eukaryota |
GeneTreei | ENSGT00940000153691 |
HOGENOMi | CLU_005284_3_1_1 |
InParanoidi | P55288 |
OMAi | DMFEITT |
OrthoDBi | 188978at2759 |
PhylomeDBi | P55288 |
TreeFami | TF329887 |
Enzyme and pathway databases
Reactomei | R-MMU-418990, Adherens junctions interactions |
Miscellaneous databases
BioGRID-ORCSi | 12552, 4 hits in 18 CRISPR screens |
ChiTaRSi | Cdh11, mouse |
EvolutionaryTracei | P55288 |
PROi | PR:P55288 |
RNActi | P55288, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000031673, Expressed in vault of skull and 377 other tissues |
Genevisiblei | P55288, MM |
Family and domain databases
Gene3Di | 4.10.900.10, 1 hit |
InterProi | View protein in InterPro IPR039808, Cadherin IPR002126, Cadherin-like_dom IPR015919, Cadherin-like_sf IPR020894, Cadherin_CS IPR000233, Cadherin_cytoplasmic-dom IPR027397, Catenin_binding_dom_sf |
PANTHERi | PTHR24027, PTHR24027, 1 hit |
Pfami | View protein in Pfam PF00028, Cadherin, 4 hits PF01049, Cadherin_C, 1 hit |
PRINTSi | PR00205, CADHERIN |
SMARTi | View protein in SMART SM00112, CA, 5 hits |
SUPFAMi | SSF49313, SSF49313, 5 hits |
PROSITEi | View protein in PROSITE PS00232, CADHERIN_1, 3 hits PS50268, CADHERIN_2, 5 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CAD11_MOUSE | |
Accessioni | P55288Primary (citable) accession number: P55288 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | October 1, 1996 | |
Last modified: | December 2, 2020 | |
This is version 159 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references