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Protein

Cadherin-11

Gene

CDH11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

GO - Molecular functioni

  • cadherin binding Source: GO_Central
  • calcium ion binding Source: GO_Central
  • cytoskeletal protein binding Source: GO_Central
  • protein homodimerization activity Source: GO_Central

GO - Biological processi

Keywordsi

Biological processCell adhesion
LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-418990 Adherens junctions interactions
SIGNORiP55287

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-11
Alternative name(s):
OSF-4
Osteoblast cadherin
Short name:
OB-cadherin
Gene namesi
Name:CDH11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000140937.13
HGNCiHGNC:1750 CDH11
MIMi600023 gene
neXtProtiNX_P55287

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini54 – 617ExtracellularSequence analysisAdd BLAST564
Transmembranei618 – 640HelicalSequence analysisAdd BLAST23
Topological domaini641 – 796CytoplasmicSequence analysisAdd BLAST156

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving CDH11 is a common genetic feature of aneurysmal bone cyst, a benign osseous neoplasm. Translocation t(16;17)(q22;p13) with USP6. The translocation generates a fusion gene in which the strong CDH11 promoter is fused to the entire USP6 coding sequence, resulting in USP6 transcriptional up-regulation.
Elsahy-Waters syndrome (ESWS)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive syndrome characterized by moderate mental retardation, hypospadias and characteristic craniofacial morphology, which includes brachycephaly, facial asymmetry, exotropia, hypertelorism, telechantus, broad nose, concave nasal ridge, underdeveloped mid-face, prognathism, and radicular dentin dysplasia.
See also OMIM:211380
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_080481232 – 796Missing in ESWS. 1 PublicationAdd BLAST565

Keywords - Diseasei

Deafness, Disease mutation, Mental retardation

Organism-specific databases

DisGeNETi1009
MalaCardsiCDH11
MIMi211380 phenotype
OpenTargetsiENSG00000140937
Orphaneti1299 Branchioskeletogenital syndrome
PharmGKBiPA26284

Polymorphism and mutation databases

BioMutaiCDH11
DMDMi146345381

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
PropeptideiPRO_000000378523 – 53Sequence analysisAdd BLAST31
ChainiPRO_000000378654 – 796Cadherin-11Add BLAST743

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi455N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi540N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei788PhosphoserineBy similarity1
Modified residuei791PhosphothreonineBy similarity1

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP55287
PaxDbiP55287
PeptideAtlasiP55287
PRIDEiP55287
ProteomicsDBi56837
56838 [P55287-2]

PTM databases

iPTMnetiP55287
PhosphoSitePlusiP55287

Expressioni

Tissue specificityi

Expressed mainly in brain but also found in other tissues. Expressed in neuroblasts.

Gene expression databases

BgeeiENSG00000140937 Expressed in 219 organ(s), highest expression level in placenta
CleanExiHS_CDH11
ExpressionAtlasiP55287 baseline and differential
GenevisibleiP55287 HS

Organism-specific databases

HPAiCAB013072

Interactioni

Subunit structurei

Interacts with PCDH8.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi107444, 5 interactors
CORUMiP55287
IntActiP55287, 5 interactors
MINTiP55287
STRINGi9606.ENSP00000268603

Structurei

3D structure databases

ProteinModelPortaliP55287
SMRiP55287
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini54 – 159Cadherin 1PROSITE-ProRule annotationAdd BLAST106
Domaini160 – 268Cadherin 2PROSITE-ProRule annotationAdd BLAST109
Domaini269 – 383Cadherin 3PROSITE-ProRule annotationAdd BLAST115
Domaini384 – 486Cadherin 4PROSITE-ProRule annotationAdd BLAST103
Domaini487 – 612Cadherin 5PROSITE-ProRule annotationAdd BLAST126

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
GeneTreeiENSGT00760000118954
HOVERGENiHBG005217
InParanoidiP55287
KOiK06803
OMAiHENYHAN
OrthoDBiEOG091G0241
PhylomeDBiP55287
TreeFamiTF329887

Family and domain databases

Gene3Di4.10.900.10, 1 hit
InterProiView protein in InterPro
IPR039808 Cadherin
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR000233 Cadherin_cytoplasmic-dom
IPR027397 Catenin_binding_dom_sf
PANTHERiPTHR24027 PTHR24027, 1 hit
PfamiView protein in Pfam
PF00028 Cadherin, 4 hits
PF01049 Cadherin_C, 1 hit
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 5 hits
SUPFAMiSSF49313 SSF49313, 5 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 3 hits
PS50268 CADHERIN_2, 5 hits

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P55287-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKENYCLQAA LVCLGMLCHS HAFAPERRGH LRPSFHGHHE KGKEGQVLQR
60 70 80 90 100
SKRGWVWNQF FVIEEYTGPD PVLVGRLHSD IDSGDGNIKY ILSGEGAGTI
110 120 130 140 150
FVIDDKSGNI HATKTLDREE RAQYTLMAQA VDRDTNRPLE PPSEFIVKVQ
160 170 180 190 200
DINDNPPEFL HETYHANVPE RSNVGTSVIQ VTASDADDPT YGNSAKLVYS
210 220 230 240 250
ILEGQPYFSV EAQTGIIRTA LPNMDREAKE EYHVVIQAKD MGGHMGGLSG
260 270 280 290 300
TTKVTITLTD VNDNPPKFPQ SVYQMSVSEA AVPGEEVGRV KAKDPDIGEN
310 320 330 340 350
GLVTYNIVDG DGMESFEITT DYETQEGVIK LKKPVDFETK RAYSLKVEAA
360 370 380 390 400
NVHIDPKFIS NGPFKDTVTV KISVEDADEP PMFLAPSYIH EVQENAAAGT
410 420 430 440 450
VVGRVHAKDP DAANSPIRYS IDRHTDLDRF FTINPEDGFI KTTKPLDREE
460 470 480 490 500
TAWLNITVFA AEIHNRHQEA KVPVAIRVLD VNDNAPKFAA PYEGFICESD
510 520 530 540 550
QTKPLSNQPI VTISADDKDD TANGPRFIFS LPPEIIHNPN FTVRDNRDNT
560 570 580 590 600
AGVYARRGGF SRQKQDLYLL PIVISDGGIP PMSSTNTLTI KVCGCDVNGA
610 620 630 640 650
LLSCNAEAYI LNAGLSTGAL IAILACIVIL LVIVVLFVTL RRQKKEPLIV
660 670 680 690 700
FEEEDVRENI ITYDDEGGGE EDTEAFDIAT LQNPDGINGF IPRKDIKPEY
710 720 730 740 750
QYMPRPGLRP APNSVDVDDF INTRIQEADN DPTAPPYDSI QIYGYEGRGS
760 770 780 790
VAGSLSSLES ATTDSDLDYD YLQNWGPRFK KLADLYGSKD TFDDDS
Length:796
Mass (Da):87,965
Last modified:May 1, 2007 - v2
Checksum:iE17090EC95C59936
GO
Isoform 2 (identifier: P55287-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     632-693: VIVVLFVTLR...PDGINGFIPR → GCPSLMEPPS...TESPTTLTSL
     694-796: Missing.

Show »
Length:693
Mass (Da):76,457
Checksum:i7EBFA6CEB0EABFED
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BUU9H3BUU9_HUMAN
Cadherin-11
CDH11
670Annotation score:
H3BQH2H3BQH2_HUMAN
Cadherin-11
CDH11
222Annotation score:
A0A087X227A0A087X227_HUMAN
Cadherin-11
CDH11
62Annotation score:
H3BSM4H3BSM4_HUMAN
Cadherin-11
CDH11
65Annotation score:
H3BPQ2H3BPQ2_HUMAN
Cadherin-11
CDH11
70Annotation score:
H3BP26H3BP26_HUMAN
Cadherin-11
CDH11
53Annotation score:
H3BQB5H3BQB5_HUMAN
Cadherin-11
CDH11
34Annotation score:
H3BR78H3BR78_HUMAN
Cadherin-11
CDH11
22Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti271 – 272SV → RL in AAA35622 (PubMed:7982033).Curated2
Sequence conflicti271 – 272SV → RL no nucleotide entry (PubMed:2059658).Curated2
Sequence conflicti340K → E in AAA35622 (PubMed:7982033).Curated1
Sequence conflicti340K → E no nucleotide entry (PubMed:2059658).Curated1
Sequence conflicti471K → Q in AAA35622 (PubMed:7982033).Curated1
Sequence conflicti471K → Q no nucleotide entry (PubMed:2059658).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_080481232 – 796Missing in ESWS. 1 PublicationAdd BLAST565
Natural variantiVAR_031945255T → M. Corresponds to variant dbSNP:rs35195Ensembl.1
Natural variantiVAR_031946275M → I1 PublicationCorresponds to variant dbSNP:rs1130821Ensembl.1
Natural variantiVAR_031947373S → A2 PublicationsCorresponds to variant dbSNP:rs35213Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_000640632 – 693VIVVL…GFIPR → GCPSLMEPPSPREDMRLLYL GFQLMLFSYVKVNRRFCLLG VFIKLPFLYVVATESPTTLT SL in isoform 2. 1 PublicationAdd BLAST62
Alternative sequenceiVSP_000641694 – 796Missing in isoform 2. 1 PublicationAdd BLAST103

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L34056 mRNA Translation: AAA35622.1
D21254 mRNA Translation: BAA04798.1
D21255 mRNA Translation: BAA04799.1
AK291251 mRNA Translation: BAF83940.1
AC010533 Genomic DNA No translation available.
AF060370, AF060369 Genomic DNA Translation: AAD27755.1
AF060370, AF060369 Genomic DNA Translation: AAD27756.1
CCDSiCCDS10803.1 [P55287-1]
CCDS81993.1 [P55287-2]
PIRiA38992
RefSeqiNP_001295321.1, NM_001308392.1 [P55287-2]
NP_001788.2, NM_001797.3 [P55287-1]
XP_005255818.1, XM_005255761.3
XP_005255819.1, XM_005255762.2 [P55287-1]
XP_005255820.1, XM_005255763.2 [P55287-1]
XP_011521105.1, XM_011522803.2 [P55287-1]
UniGeneiHs.116471
Hs.596112

Genome annotation databases

EnsembliENST00000268603; ENSP00000268603; ENSG00000140937 [P55287-1]
ENST00000394156; ENSP00000377711; ENSG00000140937 [P55287-2]
GeneIDi1009
KEGGihsa:1009
UCSCiuc002eoi.4 human [P55287-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L34056 mRNA Translation: AAA35622.1
D21254 mRNA Translation: BAA04798.1
D21255 mRNA Translation: BAA04799.1
AK291251 mRNA Translation: BAF83940.1
AC010533 Genomic DNA No translation available.
AF060370, AF060369 Genomic DNA Translation: AAD27755.1
AF060370, AF060369 Genomic DNA Translation: AAD27756.1
CCDSiCCDS10803.1 [P55287-1]
CCDS81993.1 [P55287-2]
PIRiA38992
RefSeqiNP_001295321.1, NM_001308392.1 [P55287-2]
NP_001788.2, NM_001797.3 [P55287-1]
XP_005255818.1, XM_005255761.3
XP_005255819.1, XM_005255762.2 [P55287-1]
XP_005255820.1, XM_005255763.2 [P55287-1]
XP_011521105.1, XM_011522803.2 [P55287-1]
UniGeneiHs.116471
Hs.596112

3D structure databases

ProteinModelPortaliP55287
SMRiP55287
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107444, 5 interactors
CORUMiP55287
IntActiP55287, 5 interactors
MINTiP55287
STRINGi9606.ENSP00000268603

PTM databases

iPTMnetiP55287
PhosphoSitePlusiP55287

Polymorphism and mutation databases

BioMutaiCDH11
DMDMi146345381

Proteomic databases

MaxQBiP55287
PaxDbiP55287
PeptideAtlasiP55287
PRIDEiP55287
ProteomicsDBi56837
56838 [P55287-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000268603; ENSP00000268603; ENSG00000140937 [P55287-1]
ENST00000394156; ENSP00000377711; ENSG00000140937 [P55287-2]
GeneIDi1009
KEGGihsa:1009
UCSCiuc002eoi.4 human [P55287-1]

Organism-specific databases

CTDi1009
DisGeNETi1009
EuPathDBiHostDB:ENSG00000140937.13
GeneCardsiCDH11
H-InvDBiHIX0013098
HGNCiHGNC:1750 CDH11
HPAiCAB013072
MalaCardsiCDH11
MIMi211380 phenotype
600023 gene
neXtProtiNX_P55287
OpenTargetsiENSG00000140937
Orphaneti1299 Branchioskeletogenital syndrome
PharmGKBiPA26284
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
GeneTreeiENSGT00760000118954
HOVERGENiHBG005217
InParanoidiP55287
KOiK06803
OMAiHENYHAN
OrthoDBiEOG091G0241
PhylomeDBiP55287
TreeFamiTF329887

Enzyme and pathway databases

ReactomeiR-HSA-418990 Adherens junctions interactions
SIGNORiP55287

Miscellaneous databases

ChiTaRSiCDH11 human
GeneWikiiCDH11
GenomeRNAii1009
PROiPR:P55287
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000140937 Expressed in 219 organ(s), highest expression level in placenta
CleanExiHS_CDH11
ExpressionAtlasiP55287 baseline and differential
GenevisibleiP55287 HS

Family and domain databases

Gene3Di4.10.900.10, 1 hit
InterProiView protein in InterPro
IPR039808 Cadherin
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR000233 Cadherin_cytoplasmic-dom
IPR027397 Catenin_binding_dom_sf
PANTHERiPTHR24027 PTHR24027, 1 hit
PfamiView protein in Pfam
PF00028 Cadherin, 4 hits
PF01049 Cadherin_C, 1 hit
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 5 hits
SUPFAMiSSF49313 SSF49313, 5 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 3 hits
PS50268 CADHERIN_2, 5 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCAD11_HUMAN
AccessioniPrimary (citable) accession number: P55287
Secondary accession number(s): A8K5D6
, A8MZC8, B7WP28, Q15065, Q15066, Q9UQ93, Q9UQ94
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 1, 2007
Last modified: November 7, 2018
This is version 158 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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