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Protein

Cadherin-8

Gene

CDH8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

GO - Molecular functioni

  • cadherin binding Source: GO_Central
  • calcium ion binding Source: GO_Central
  • cytoskeletal protein binding Source: GO_Central
  • protein homodimerization activity Source: GO_Central

GO - Biological processi

Keywordsi

Biological processCell adhesion
LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-418990 Adherens junctions interactions

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-8
Gene namesi
Name:CDH8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000150394.13
HGNCiHGNC:1767 CDH8
MIMi603008 gene
neXtProtiNX_P55286

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini62 – 621ExtracellularSequence analysisAdd BLAST560
Transmembranei622 – 642HelicalSequence analysisAdd BLAST21
Topological domaini643 – 799CytoplasmicSequence analysisAdd BLAST157

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi1006
OpenTargetsiENSG00000150394
PharmGKBiPA26304

Polymorphism and mutation databases

BioMutaiCDH8
DMDMi13432121

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
PropeptideiPRO_000000377330 – 61Sequence analysisAdd BLAST32
ChainiPRO_000000377462 – 799Cadherin-8Add BLAST738

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi33N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi57N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi188N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi463N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi473N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi544N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei795PhosphoserineBy similarity1

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiP55286
PaxDbiP55286
PeptideAtlasiP55286
PRIDEiP55286
ProteomicsDBi56836
TopDownProteomicsiP55286

PTM databases

iPTMnetiP55286
PhosphoSitePlusiP55286

Expressioni

Tissue specificityi

Mainly expressed in brain. Found in certain nerve cell lines, such as retinoblasts, glioma cells and neuroblasts.

Gene expression databases

BgeeiENSG00000150394 Expressed in 135 organ(s), highest expression level in corpus callosum
CleanExiHS_CDH8
ExpressionAtlasiP55286 baseline and differential
GenevisibleiP55286 HS

Organism-specific databases

HPAiHPA014908

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi107441, 18 interactors
STRINGi9606.ENSP00000462701

Structurei

3D structure databases

ProteinModelPortaliP55286
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini62 – 167Cadherin 1PROSITE-ProRule annotationAdd BLAST106
Domaini168 – 276Cadherin 2PROSITE-ProRule annotationAdd BLAST109
Domaini277 – 391Cadherin 3PROSITE-ProRule annotationAdd BLAST115
Domaini392 – 494Cadherin 4PROSITE-ProRule annotationAdd BLAST103
Domaini495 – 616Cadherin 5PROSITE-ProRule annotationAdd BLAST122

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
GeneTreeiENSGT00760000118954
HOGENOMiHOG000231252
HOVERGENiHBG005217
InParanoidiP55286
KOiK06800
OMAiEEYFVVI
OrthoDBiEOG091G0241
PhylomeDBiP55286
TreeFamiTF329887

Family and domain databases

Gene3Di4.10.900.10, 1 hit
InterProiView protein in InterPro
IPR039808 Cadherin
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR000233 Cadherin_cytoplasmic-dom
IPR027397 Catenin_binding_dom_sf
PANTHERiPTHR24027 PTHR24027, 1 hit
PfamiView protein in Pfam
PF00028 Cadherin, 5 hits
PF01049 Cadherin_C, 1 hit
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 5 hits
SUPFAMiSSF49313 SSF49313, 5 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 3 hits
PS50268 CADHERIN_2, 5 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

P55286-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPERLAEMLL DLWTPLIILW ITLPPCIYMA PMNQSQVLMS GSPLELNSLG
60 70 80 90 100
EEQRILNRSK RGWVWNQMFV LEEFSGPEPI LVGRLHTDLD PGSKKIKYIL
110 120 130 140 150
SGDGAGTIFQ INDVTGDIHA IKRLDREEKA EYTLTAQAVD WETSKPLEPP
160 170 180 190 200
SEFIIKVQDI NDNAPEFLNG PYHATVPEMS ILGTSVTNVT ATDADDPVYG
210 220 230 240 250
NSAKLVYSIL EGQPYFSIEP ETAIIKTALP NMDREAKEEY LVVIQAKDMG
260 270 280 290 300
GHSGGLSGTT TLTVTLTDVN DNPPKFAQSL YHFSVPEDVV LGTAIGRVKA
310 320 330 340 350
NDQDIGENAQ SSYDIIDGDG TALFEITSDA QAQDGIIRLR KPLDFETKKS
360 370 380 390 400
YTLKVEAANV HIDPRFSGRG PFKDTATVKI VVEDADEPPV FSSPTYLLEV
410 420 430 440 450
HENAALNSVI GQVTARDPDI TSSPIRFSID RHTDLERQFN INADDGKITL
460 470 480 490 500
ATPLDRELSV WHNITIIATE IRNHSQISRV PVAIKVLDVN DNAPEFASEY
510 520 530 540 550
EAFLCENGKP GQVIQTVSAM DKDDPKNGHY FLYSLLPEMV NNPNFTIKKN
560 570 580 590 600
EDNSLSILAK HNGFNRQKQE VYLLPIIISD SGNPPLSSTS TLTIRVCGCS
610 620 630 640 650
NDGVVQSCNV EAYVLPIGLS MGALIAILAC IILLLVIVVL FVTLRRHKNE
660 670 680 690 700
PLIIKDDEDV RENIIRYDDE GGGEEDTEAF DIATLQNPDG INGFLPRKDI
710 720 730 740 750
KPDLQFMPRQ GLAPVPNGVD VDEFINVRLH EADNDPTAPP YDSIQIYGYE
760 770 780 790
GRGSVAGSLS SLESTTSDSD QNFDYLSDWG PRFKRLGELY SVGESDKET
Length:799
Mass (Da):88,253
Last modified:April 27, 2001 - v2
Checksum:i9B119B86039C6A0A
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
X6R3Y6X6R3Y6_HUMAN
Cadherin-8
CDH8
745Annotation score:
J3KRI5J3KRI5_HUMAN
Cadherin-8
CDH8
744Annotation score:
J3QLE6J3QLE6_HUMAN
Cadherin-8
CDH8
532Annotation score:
J3QKW5J3QKW5_HUMAN
Cadherin-8
CDH8
476Annotation score:
J3KTG8J3KTG8_HUMAN
Cadherin-8
CDH8
425Annotation score:
J3KT81J3KT81_HUMAN
Cadherin-8
CDH8
81Annotation score:

Sequence cautioni

The sequence AAA35628 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti355V → D in AAA35628 (PubMed:7982033).Curated1
Sequence conflicti648K → QK in AAA35628 (PubMed:7982033).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB035305 mRNA Translation: BAA87419.1
AK124734 mRNA Translation: BAG54083.1
BC113416 mRNA Translation: AAI13417.1
L34060 mRNA Translation: AAA35628.1 Different initiation.
CCDSiCCDS10802.1
RefSeqiNP_001787.2, NM_001796.4
UniGeneiHs.368322

Genome annotation databases

EnsembliENST00000577390; ENSP00000462701; ENSG00000150394
GeneIDi1006
KEGGihsa:1006
UCSCiuc002eog.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB035305 mRNA Translation: BAA87419.1
AK124734 mRNA Translation: BAG54083.1
BC113416 mRNA Translation: AAI13417.1
L34060 mRNA Translation: AAA35628.1 Different initiation.
CCDSiCCDS10802.1
RefSeqiNP_001787.2, NM_001796.4
UniGeneiHs.368322

3D structure databases

ProteinModelPortaliP55286
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107441, 18 interactors
STRINGi9606.ENSP00000462701

PTM databases

iPTMnetiP55286
PhosphoSitePlusiP55286

Polymorphism and mutation databases

BioMutaiCDH8
DMDMi13432121

Proteomic databases

EPDiP55286
PaxDbiP55286
PeptideAtlasiP55286
PRIDEiP55286
ProteomicsDBi56836
TopDownProteomicsiP55286

Protocols and materials databases

DNASUi1006
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000577390; ENSP00000462701; ENSG00000150394
GeneIDi1006
KEGGihsa:1006
UCSCiuc002eog.3 human

Organism-specific databases

CTDi1006
DisGeNETi1006
EuPathDBiHostDB:ENSG00000150394.13
GeneCardsiCDH8
HGNCiHGNC:1767 CDH8
HPAiHPA014908
MIMi603008 gene
neXtProtiNX_P55286
OpenTargetsiENSG00000150394
PharmGKBiPA26304
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
GeneTreeiENSGT00760000118954
HOGENOMiHOG000231252
HOVERGENiHBG005217
InParanoidiP55286
KOiK06800
OMAiEEYFVVI
OrthoDBiEOG091G0241
PhylomeDBiP55286
TreeFamiTF329887

Enzyme and pathway databases

ReactomeiR-HSA-418990 Adherens junctions interactions

Miscellaneous databases

ChiTaRSiCDH8 human
GeneWikiiCDH8
GenomeRNAii1006
PROiPR:P55286
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000150394 Expressed in 135 organ(s), highest expression level in corpus callosum
CleanExiHS_CDH8
ExpressionAtlasiP55286 baseline and differential
GenevisibleiP55286 HS

Family and domain databases

Gene3Di4.10.900.10, 1 hit
InterProiView protein in InterPro
IPR039808 Cadherin
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR000233 Cadherin_cytoplasmic-dom
IPR027397 Catenin_binding_dom_sf
PANTHERiPTHR24027 PTHR24027, 1 hit
PfamiView protein in Pfam
PF00028 Cadherin, 5 hits
PF01049 Cadherin_C, 1 hit
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 5 hits
SUPFAMiSSF49313 SSF49313, 5 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 3 hits
PS50268 CADHERIN_2, 5 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCADH8_HUMAN
AccessioniPrimary (citable) accession number: P55286
Secondary accession number(s): B3KWC1, Q14DC6, Q9ULB2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: April 27, 2001
Last modified: November 7, 2018
This is version 155 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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