Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 180 (07 Oct 2020)
Sequence version 1 (01 Oct 1996)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Cyclin-dependent kinase 4 inhibitor D

Gene

CDKN2D

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Interacts strongly with CDK4 and CDK6 and inhibits them.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
P55273

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2559580, Oxidative Stress Induced Senescence
R-HSA-2559582, Senescence-Associated Secretory Phenotype (SASP)
R-HSA-2559585, Oncogene Induced Senescence
R-HSA-69231, Cyclin D associated events in G1

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P55273

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cyclin-dependent kinase 4 inhibitor D
Alternative name(s):
p19-INK4d
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CDKN2D
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000129355.6

Human Gene Nomenclature Database

More...
HGNCi
HGNC:1790, CDKN2D

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
600927, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P55273

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

DisGeNET

More...
DisGeNETi
1032

Open Targets

More...
OpenTargetsi
ENSG00000129355

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26323

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P55273, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CDKN2D

Domain mapping of disease mutations (DMDM)

More...
DMDMi
1705730

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001441881 – 166Cyclin-dependent kinase 4 inhibitor DAdd BLAST166

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionine1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P55273

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P55273

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P55273

PeptideAtlas

More...
PeptideAtlasi
P55273

PRoteomics IDEntifications database

More...
PRIDEi
P55273

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
56832

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P55273

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P55273

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000129355, Expressed in bone marrow and 178 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P55273, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P55273, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000129355, Tissue enhanced (blood, bone marrow)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CDK6.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details
P55273
With#Exp.IntAct
C1orf94 [Q6P1W5]5EBI-745859,EBI-946029
C5orf49 [A4QMS7]3EBI-745859,EBI-12039847
CCND3 [P30281]3EBI-745859,EBI-375013
CDK4 [P11802]23EBI-745859,EBI-295644
CDK6 [Q00534]22EBI-745859,EBI-295663
CGGBP1 [Q9UFW8]3EBI-745859,EBI-723153
CTBP1 - isoform 2 [Q13363-2]3EBI-745859,EBI-10171858
DDIT4L [Q96D03]3EBI-745859,EBI-742054
EIF4G1 - isoform 9 [Q04637-9]3EBI-745859,EBI-12012124
FAM228A [Q86W67]3EBI-745859,EBI-12958227
FAM86C1 - isoform 2 [Q9NVL1-2]3EBI-745859,EBI-12845222
GATAD2B [Q8WXI9]3EBI-745859,EBI-923440
GLYR1 - isoform 4 [Q49A26-4]3EBI-745859,EBI-12143817
GORASP2 [Q9H8Y8]3EBI-745859,EBI-739467
GSC2 [O15499]3EBI-745859,EBI-19954058
HSD17B14 [Q9BPX1]8EBI-745859,EBI-742664
IKZF3 [Q9UKT9]5EBI-745859,EBI-747204
INCA1 [Q0VD86]9EBI-745859,EBI-6509505
KRT75 [O95678]3EBI-745859,EBI-2949715
LNX1 [Q8TBB1]3EBI-745859,EBI-739832
LONRF1 [Q17RB8]3EBI-745859,EBI-2341787
MEI4 [A8MW99]3EBI-745859,EBI-19944212
MEOX2 [Q6FHY5]3EBI-745859,EBI-16439278
MSS51 [Q4VC12]3EBI-745859,EBI-11599933
MTF2 - isoform 4 [Q9Y483-4]3EBI-745859,EBI-10698053
NDUFB7 [P17568]3EBI-745859,EBI-1246238
NIF3L1 [Q9GZT8]3EBI-745859,EBI-740897
NME4 [O00746]3EBI-745859,EBI-744871
NR4A1 [P22736]4EBI-745859,EBI-721550
NR4A2 [F1D8N6]3EBI-745859,EBI-10214997
NR4A2 [P43354]4EBI-745859,EBI-2681738
NR4A3 [Q92570]3EBI-745859,EBI-13644623
PICK1 [Q9NRD5]3EBI-745859,EBI-79165
PRDX5 [P30044]3EBI-745859,EBI-722161
PRIMPOL [Q96LW4]3EBI-745859,EBI-10044038
PSMA1 [P25786]3EBI-745859,EBI-359352
REL - isoform 2 [Q04864-2]3EBI-745859,EBI-10829018
RUFY4 [Q6ZNE9]3EBI-745859,EBI-10181525
SAXO1 [Q8IYX7]3EBI-745859,EBI-3957636
SDCBP [O00560]3EBI-745859,EBI-727004
TCTEX1D2 [Q8WW35]3EBI-745859,EBI-2692044
THAP1 [Q9NVV9]3EBI-745859,EBI-741515
TSGA10IP [Q3SY00]3EBI-745859,EBI-10241197
UQCC2 [Q9BRT2]3EBI-745859,EBI-1054584
VGLL1 [Q99990]3EBI-745859,EBI-11983165
ZBTB32 [A0A0C4DGF1]3EBI-745859,EBI-10188476
ZNF396 - isoform 3 [Q96N95-3]3EBI-745859,EBI-12328453
ZNF620 [Q6ZNG0]3EBI-745859,EBI-4395669
ZNF688 [P0C7X2]3EBI-745859,EBI-4395732
ZNF774 [Q6NX45]3EBI-745859,EBI-10251462

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
107466, 71 interactors

Database of interacting proteins

More...
DIPi
DIP-6109N

Protein interaction database and analysis system

More...
IntActi
P55273, 53 interactors

Molecular INTeraction database

More...
MINTi
P55273

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000377224

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P55273, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1166
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P55273

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P55273

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati41 – 69ANK 1Add BLAST29
Repeati73 – 102ANK 2Add BLAST30
Repeati106 – 135ANK 3Add BLAST30
Repeati138 – 166ANK 4Add BLAST29

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0504, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159801

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000134_37_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P55273

KEGG Orthology (KO)

More...
KOi
K06623

Identification of Orthologs from Complete Genome Data

More...
OMAi
KHANVSG

Database of Orthologous Groups

More...
OrthoDBi
1453965at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P55273

TreeFam database of animal gene trees

More...
TreeFami
TF333311

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796, Ank_2, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248, ANK, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403, SSF48403, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P55273-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLLEEVRAGD RLSGAAARGD VQEVRRLLHR ELVHPDALNR FGKTALQVMM
60 70 80 90 100
FGSTAIALEL LKQGASPNVQ DTSGTSPVHD AARTGFLDTL KVLVEHGADV
110 120 130 140 150
NVPDGTGALP IHLAVQEGHT AVVSFLAAES DLHRRDARGL TPLELALQRG
160
AQDLVDILQG HMVAPL
Length:166
Mass (Da):17,700
Last modified:October 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2FACD11CF56340DC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti159Q → P in AAA85436 (PubMed:7739548).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U49399 mRNA Translation: AAB03772.1
U20498 mRNA Translation: AAA85436.1
U40343 mRNA Translation: AAB18139.1
AF061327 Genomic DNA Translation: AAC27450.1
CR542158 mRNA Translation: CAG46955.1
AF518878 Genomic DNA Translation: AAM54045.1
BC001822 mRNA Translation: AAH01822.1
AF044171 Genomic DNA Translation: AAD02320.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS12244.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A57378

NCBI Reference Sequences

More...
RefSeqi
NP_001791.1, NM_001800.3
NP_524145.1, NM_079421.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000335766; ENSP00000337056; ENSG00000129355
ENST00000393599; ENSP00000377224; ENSG00000129355

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1032

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:1032

UCSC genome browser

More...
UCSCi
uc002mpa.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U49399 mRNA Translation: AAB03772.1
U20498 mRNA Translation: AAA85436.1
U40343 mRNA Translation: AAB18139.1
AF061327 Genomic DNA Translation: AAC27450.1
CR542158 mRNA Translation: CAG46955.1
AF518878 Genomic DNA Translation: AAM54045.1
BC001822 mRNA Translation: AAH01822.1
AF044171 Genomic DNA Translation: AAD02320.1
CCDSiCCDS12244.1
PIRiA57378
RefSeqiNP_001791.1, NM_001800.3
NP_524145.1, NM_079421.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BD8X-ray1.80A7-162[»]
1BI8X-ray2.80B/D1-166[»]
SMRiP55273
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi107466, 71 interactors
DIPiDIP-6109N
IntActiP55273, 53 interactors
MINTiP55273
STRINGi9606.ENSP00000377224

PTM databases

iPTMnetiP55273
PhosphoSitePlusiP55273

Polymorphism and mutation databases

BioMutaiCDKN2D
DMDMi1705730

Proteomic databases

MassIVEiP55273
MaxQBiP55273
PaxDbiP55273
PeptideAtlasiP55273
PRIDEiP55273
ProteomicsDBi56832

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
4404, 282 antibodies

The DNASU plasmid repository

More...
DNASUi
1032

Genome annotation databases

EnsembliENST00000335766; ENSP00000337056; ENSG00000129355
ENST00000393599; ENSP00000377224; ENSG00000129355
GeneIDi1032
KEGGihsa:1032
UCSCiuc002mpa.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1032
DisGeNETi1032
EuPathDBiHostDB:ENSG00000129355.6

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CDKN2D
HGNCiHGNC:1790, CDKN2D
HPAiENSG00000129355, Tissue enhanced (blood, bone marrow)
MIMi600927, gene
neXtProtiNX_P55273
OpenTargetsiENSG00000129355
PharmGKBiPA26323

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0504, Eukaryota
GeneTreeiENSGT00940000159801
HOGENOMiCLU_000134_37_0_1
InParanoidiP55273
KOiK06623
OMAiKHANVSG
OrthoDBi1453965at2759
PhylomeDBiP55273
TreeFamiTF333311

Enzyme and pathway databases

PathwayCommonsiP55273
ReactomeiR-HSA-2559580, Oxidative Stress Induced Senescence
R-HSA-2559582, Senescence-Associated Secretory Phenotype (SASP)
R-HSA-2559585, Oncogene Induced Senescence
R-HSA-69231, Cyclin D associated events in G1
SIGNORiP55273

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
1032, 4 hits in 873 CRISPR screens
EvolutionaryTraceiP55273

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
CDKN2D

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
1032
PharosiP55273, Tbio

Protein Ontology

More...
PROi
PR:P55273
RNActiP55273, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000129355, Expressed in bone marrow and 178 other tissues
ExpressionAtlasiP55273, baseline and differential
GenevisibleiP55273, HS

Family and domain databases

Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
PfamiView protein in Pfam
PF12796, Ank_2, 2 hits
SMARTiView protein in SMART
SM00248, ANK, 4 hits
SUPFAMiSSF48403, SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCDN2D_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P55273
Secondary accession number(s): Q13102, Q6FGE9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 7, 2020
This is version 180 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again