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Protein

Cyclin-dependent kinase 4 inhibitor D

Gene

CDKN2D

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Interacts strongly with CDK4 and CDK6 and inhibits them.2 Publications

GO - Molecular functioni

  • cyclin-dependent protein serine/threonine kinase inhibitor activity Source: BHF-UCL
  • protein kinase binding Source: BHF-UCL

GO - Biological processi

Keywordsi

Biological processCell cycle

Enzyme and pathway databases

ReactomeiR-HSA-2559580 Oxidative Stress Induced Senescence
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-HSA-2559585 Oncogene Induced Senescence
R-HSA-69231 Cyclin D associated events in G1
SIGNORiP55273

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 4 inhibitor D
Alternative name(s):
p19-INK4d
Gene namesi
Name:CDKN2D
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000129355.6
HGNCiHGNC:1790 CDKN2D
MIMi600927 gene
neXtProtiNX_P55273

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

DisGeNETi1032
MalaCardsiCDKN2D
OpenTargetsiENSG00000129355
Orphaneti618 Familial melanoma
PharmGKBiPA26323

Polymorphism and mutation databases

BioMutaiCDKN2D
DMDMi1705730

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001441881 – 166Cyclin-dependent kinase 4 inhibitor DAdd BLAST166

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionine1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP55273
PaxDbiP55273
PeptideAtlasiP55273
PRIDEiP55273
ProteomicsDBi56832

PTM databases

iPTMnetiP55273
PhosphoSitePlusiP55273

Expressioni

Gene expression databases

BgeeiENSG00000129355 Expressed in 166 organ(s), highest expression level in blood
CleanExiHS_CDKN2D
ExpressionAtlasiP55273 baseline and differential
GenevisibleiP55273 HS

Organism-specific databases

HPAiCAB011201
HPA043546

Interactioni

Subunit structurei

Interacts with CDK6.1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi107466, 19 interactors
DIPiDIP-6109N
IntActiP55273, 45 interactors
MINTiP55273
STRINGi9606.ENSP00000337056

Structurei

Secondary structure

1166
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP55273
SMRiP55273
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP55273

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati41 – 69ANK 1Add BLAST29
Repeati73 – 102ANK 2Add BLAST30
Repeati106 – 135ANK 3Add BLAST30
Repeati138 – 166ANK 4Add BLAST29

Sequence similaritiesi

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0504 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00390000004527
HOGENOMiHOG000290191
HOVERGENiHBG050870
InParanoidiP55273
KOiK06623
OMAiMMMGNSK
OrthoDBiEOG091G0PMC
PhylomeDBiP55273
TreeFamiTF333311

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
PfamiView protein in Pfam
PF12796 Ank_2, 2 hits
SMARTiView protein in SMART
SM00248 ANK, 4 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 1 hit

Sequencei

Sequence statusi: Complete.

P55273-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLLEEVRAGD RLSGAAARGD VQEVRRLLHR ELVHPDALNR FGKTALQVMM
60 70 80 90 100
FGSTAIALEL LKQGASPNVQ DTSGTSPVHD AARTGFLDTL KVLVEHGADV
110 120 130 140 150
NVPDGTGALP IHLAVQEGHT AVVSFLAAES DLHRRDARGL TPLELALQRG
160
AQDLVDILQG HMVAPL
Length:166
Mass (Da):17,700
Last modified:October 1, 1996 - v1
Checksum:i2FACD11CF56340DC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti159Q → P in AAA85436 (PubMed:7739548).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U49399 mRNA Translation: AAB03772.1
U20498 mRNA Translation: AAA85436.1
U40343 mRNA Translation: AAB18139.1
AF061327 Genomic DNA Translation: AAC27450.1
CR542158 mRNA Translation: CAG46955.1
AF518878 Genomic DNA Translation: AAM54045.1
BC001822 mRNA Translation: AAH01822.1
AF044171 Genomic DNA Translation: AAD02320.1
CCDSiCCDS12244.1
PIRiA57378
RefSeqiNP_001791.1, NM_001800.3
NP_524145.1, NM_079421.2
UniGeneiHs.435051

Genome annotation databases

EnsembliENST00000335766; ENSP00000337056; ENSG00000129355
ENST00000393599; ENSP00000377224; ENSG00000129355
GeneIDi1032
KEGGihsa:1032
UCSCiuc002mpa.4 human

Similar proteinsi

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U49399 mRNA Translation: AAB03772.1
U20498 mRNA Translation: AAA85436.1
U40343 mRNA Translation: AAB18139.1
AF061327 Genomic DNA Translation: AAC27450.1
CR542158 mRNA Translation: CAG46955.1
AF518878 Genomic DNA Translation: AAM54045.1
BC001822 mRNA Translation: AAH01822.1
AF044171 Genomic DNA Translation: AAD02320.1
CCDSiCCDS12244.1
PIRiA57378
RefSeqiNP_001791.1, NM_001800.3
NP_524145.1, NM_079421.2
UniGeneiHs.435051

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BD8X-ray1.80A7-162[»]
1BI8X-ray2.80B/D1-166[»]
ProteinModelPortaliP55273
SMRiP55273
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107466, 19 interactors
DIPiDIP-6109N
IntActiP55273, 45 interactors
MINTiP55273
STRINGi9606.ENSP00000337056

PTM databases

iPTMnetiP55273
PhosphoSitePlusiP55273

Polymorphism and mutation databases

BioMutaiCDKN2D
DMDMi1705730

Proteomic databases

MaxQBiP55273
PaxDbiP55273
PeptideAtlasiP55273
PRIDEiP55273
ProteomicsDBi56832

Protocols and materials databases

DNASUi1032
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000335766; ENSP00000337056; ENSG00000129355
ENST00000393599; ENSP00000377224; ENSG00000129355
GeneIDi1032
KEGGihsa:1032
UCSCiuc002mpa.4 human

Organism-specific databases

CTDi1032
DisGeNETi1032
EuPathDBiHostDB:ENSG00000129355.6
GeneCardsiCDKN2D
HGNCiHGNC:1790 CDKN2D
HPAiCAB011201
HPA043546
MalaCardsiCDKN2D
MIMi600927 gene
neXtProtiNX_P55273
OpenTargetsiENSG00000129355
Orphaneti618 Familial melanoma
PharmGKBiPA26323
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0504 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00390000004527
HOGENOMiHOG000290191
HOVERGENiHBG050870
InParanoidiP55273
KOiK06623
OMAiMMMGNSK
OrthoDBiEOG091G0PMC
PhylomeDBiP55273
TreeFamiTF333311

Enzyme and pathway databases

ReactomeiR-HSA-2559580 Oxidative Stress Induced Senescence
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-HSA-2559585 Oncogene Induced Senescence
R-HSA-69231 Cyclin D associated events in G1
SIGNORiP55273

Miscellaneous databases

EvolutionaryTraceiP55273
GeneWikiiCDKN2D
GenomeRNAii1032
PROiPR:P55273
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000129355 Expressed in 166 organ(s), highest expression level in blood
CleanExiHS_CDKN2D
ExpressionAtlasiP55273 baseline and differential
GenevisibleiP55273 HS

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
PfamiView protein in Pfam
PF12796 Ank_2, 2 hits
SMARTiView protein in SMART
SM00248 ANK, 4 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCDN2D_HUMAN
AccessioniPrimary (citable) accession number: P55273
Secondary accession number(s): Q13102, Q6FGE9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 12, 2018
This is version 166 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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